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The map label for this gene is guaA

Identifier: 110679988

GI number: 110679988

Start: 2648777

End: 2650345

Strand: Direct

Name: guaA

Synonym: RD1_2778

Alternate gene names: 110679988

Gene position: 2648777-2650345 (Clockwise)

Preceding gene: 110679986

Following gene: 110679989

Centisome position: 64.09

GC content: 59.02

Gene sequence:

>1569_bases
ATGAGCACATCTGATCACGACCGCCTTCTTATCATTGATTTCGGCAGCCAGGTGACGCAATTGATTGCGCGTCGCCTGCG
TGAGCTGAATGTCTATTGCGAAATTCACCCCTTTAATCTGGTGGATGACGCCTTTCTGGATGCCTTCGGTGCGAAAGCCG
TGATCTTCTCGGGGGGGCCCTCTTCTGTTTTCGCCGATGGTGCTCCGATGCCCCCGGCCAGCGTCTTTGAGCGCGGTGTG
CCGATCCTGGGCATTTGCTATGGTCAGCAGGTGATGATGCACTGCCTCGGCGGCAAGGTGGAACGCGGGCATGGCACGGC
GGAGTTCGGGCGCGCCTATGTCACCCCGACCGCGCAAAAGCTGGACATGCTGCAGGGGTGGTTTGAAACCGATCAGGACC
GCGAACAGGTCTGGATGAGTCACGGCGATCACGTCAGCCAGATCGCCCCCGGTTTTGAAGTGTTCGGCACCTCGCCCAAT
GCGCCTTTTGCAATCACGGCTGATACAACACGCCATTTCTATGCGGTGCAGTTCCATCCCGAAGTCCACCACACGCCCAA
TGGGGCCAGATTATACGAAAATTTTGTGCGGCTGGCCGGTTTCAAAGGCGATTGGACCATGGGTGCCTACCGCGAGGAAG
CCATCGCAAAGATTCGCGAACAGGTTGGCAGTGGCCGGGTGATCTGCGCCCTTTCGGGCGGCGTTGACAGTTCGGTCGCC
GCCGTTCTGATCCATGAAGCCATCGGGGATCAGCTGACCTGCGTCTATGTGGATCACGGGCTCATGCGCAAAGACGAATC
GGCACAGGTCGTCGGCATGTTCCGTGAACACTACAACCTGCCGCTGATCCATGCGGATGAATCGGACCTGTTTCTGGGCA
AGCTGGAGGGCGTCAGCGACCCCGAAACCAAGCGCAAAATCATCGGCGGTTTGTTCATCGAGGTTTTCGAGAAATACGCG
AAGGAAATCGGCGGTGCCGATTTCCTGGCACAGGGCACGCTCTACCCGGATGTGATCGAATCGGTCAGCTTCTCCGGTGG
CCCTTCGGTCACGATCAAATCGCATCACAACGTCGGCGGGCTGCCGGAGCGGATGAACATGCAACTGGTCGAACCGCTGC
GCGAACTTTTCAAGGATGAGGTGCGCGCGCTGGGTCACGAGTTGGGCCTGCCTGCAAGCTTCATCGGCCGCCATCCTTTC
CCCGGGCCCGGTCTCGCCATCCGCTGCCCCGGCGAGATCACCCGCGAAAAACTCGATATCCTGCGCGAGGCCGATGCCGT
CTATATCGACCAGATCCGTAAACACGGGCTCTACGATGAAATCTGGCAGGCCTTTGTGGCGATCCTGCCCGTGCGCACCG
TGGGTGTGATGGGCGACGGGCGCACCTATGATTTCGCCTGCGCCCTGCGCGCTGTCACATCCGTGGACGGTATGACCGCT
GACTATTATCCCTTCACACATGAGTTTCTCGGAGAGACCGCAACACGCATCATCAACGAGGTGCCCGGCATCAACCGCGT
GACCTACGATATCACCTCAAAACCACCCGGCACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
ACCTCTCCTTATCATCAATCGTTGAAAAAGAGGCCCCGGCGGCCAAAGCCCCCGCAATCTCAGGCTTGCCACGCCTGCGC
AGGCGGCATACTCAGCGCGT

Downstream 100 bases:

>100_bases
CCAAACAGGGCCGGGGTTCGATCATCCCGGTTGTACCGGTATGAGCGCGACACTGAAAGCCATGCTGTGGATGTTCGGAT
CCATTGCGTCCTTTTCCACG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSTSDHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNLVDDAFLDAFGAKAVIFSGGPSSVFADGAPMPPASVFERGV
PILGICYGQQVMMHCLGGKVERGHGTAEFGRAYVTPTAQKLDMLQGWFETDQDREQVWMSHGDHVSQIAPGFEVFGTSPN
APFAITADTTRHFYAVQFHPEVHHTPNGARLYENFVRLAGFKGDWTMGAYREEAIAKIREQVGSGRVICALSGGVDSSVA
AVLIHEAIGDQLTCVYVDHGLMRKDESAQVVGMFREHYNLPLIHADESDLFLGKLEGVSDPETKRKIIGGLFIEVFEKYA
KEIGGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGHELGLPASFIGRHPF
PGPGLAIRCPGEITREKLDILREADAVYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDFACALRAVTSVDGMTA
DYYPFTHEFLGETATRIINEVPGINRVTYDITSKPPGTIEWE

Sequences:

>Translated_522_residues
MSTSDHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNLVDDAFLDAFGAKAVIFSGGPSSVFADGAPMPPASVFERGV
PILGICYGQQVMMHCLGGKVERGHGTAEFGRAYVTPTAQKLDMLQGWFETDQDREQVWMSHGDHVSQIAPGFEVFGTSPN
APFAITADTTRHFYAVQFHPEVHHTPNGARLYENFVRLAGFKGDWTMGAYREEAIAKIREQVGSGRVICALSGGVDSSVA
AVLIHEAIGDQLTCVYVDHGLMRKDESAQVVGMFREHYNLPLIHADESDLFLGKLEGVSDPETKRKIIGGLFIEVFEKYA
KEIGGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGHELGLPASFIGRHPF
PGPGLAIRCPGEITREKLDILREADAVYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDFACALRAVTSVDGMTA
DYYPFTHEFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
>Mature_521_residues
STSDHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNLVDDAFLDAFGAKAVIFSGGPSSVFADGAPMPPASVFERGVP
ILGICYGQQVMMHCLGGKVERGHGTAEFGRAYVTPTAQKLDMLQGWFETDQDREQVWMSHGDHVSQIAPGFEVFGTSPNA
PFAITADTTRHFYAVQFHPEVHHTPNGARLYENFVRLAGFKGDWTMGAYREEAIAKIREQVGSGRVICALSGGVDSSVAA
VLIHEAIGDQLTCVYVDHGLMRKDESAQVVGMFREHYNLPLIHADESDLFLGKLEGVSDPETKRKIIGGLFIEVFEKYAK
EIGGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGHELGLPASFIGRHPFP
GPGLAIRCPGEITREKLDILREADAVYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDFACALRAVTSVDGMTAD
YYPFTHEFLGETATRIINEVPGINRVTYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=556, Percent_Identity=35.9712230215827, Blast_Score=275, Evalue=6e-74,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=51.8304431599229, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71992717, Length=577, Percent_Identity=35.528596187175, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI71992710, Length=577, Percent_Identity=35.528596187175, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI133901714, Length=577, Percent_Identity=35.528596187175, Blast_Score=294, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=50.6692160611855, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=34.4765342960289, Blast_Score=269, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_ROSDO (Q165N4)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682995.1
- ProteinModelPortal:   Q165N4
- SMR:   Q165N4
- STRING:   Q165N4
- GeneID:   4195529
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2778
- NMPDR:   fig|375451.6.peg.2577
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q165N4
- ProtClustDB:   PRK00074
- BioCyc:   RDEN375451:RD1_2778-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- InterPro:   IPR004506
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF03054 tRNA_Me_trans

EC number: =6.3.5.2

Molecular weight: Translated: 57574; Mature: 57443

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 179-179 ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSDHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNLVDDAFLDAFGAKAVIFSGGP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHCCCCEEEECCCC
SSVFADGAPMPPASVFERGVPILGICYGQQVMMHCLGGKVERGHGTAEFGRAYVTPTAQK
CCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHCCCEECCCCCHHHCCEEECCCHHH
LDMLQGWFETDQDREQVWMSHGDHVSQIAPGFEVFGTSPNAPFAITADTTRHFYAVQFHP
HHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEEEECC
EVHHTPNGARLYENFVRLAGFKGDWTMGAYREEAIAKIREQVGSGRVICALSGGVDSSVA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
AVLIHEAIGDQLTCVYVDHGLMRKDESAQVVGMFREHYNLPLIHADESDLFLGKLEGVSD
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCC
PETKRKIIGGLFIEVFEKYAKEIGGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCC
LPERMNMQLVEPLRELFKDEVRALGHELGLPASFIGRHPFPGPGLAIRCPGEITREKLDI
CCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCHHHHHHHHHH
LREADAVYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDFACALRAVTSVDGMTA
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCC
DYYPFTHEFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
STSDHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPFNLVDDAFLDAFGAKAVIFSGGP
CCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHCCCCEEEECCCC
SSVFADGAPMPPASVFERGVPILGICYGQQVMMHCLGGKVERGHGTAEFGRAYVTPTAQK
CCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHCCCEECCCCCHHHCCEEECCCHHH
LDMLQGWFETDQDREQVWMSHGDHVSQIAPGFEVFGTSPNAPFAITADTTRHFYAVQFHP
HHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEEEECC
EVHHTPNGARLYENFVRLAGFKGDWTMGAYREEAIAKIREQVGSGRVICALSGGVDSSVA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
AVLIHEAIGDQLTCVYVDHGLMRKDESAQVVGMFREHYNLPLIHADESDLFLGKLEGVSD
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCC
PETKRKIIGGLFIEVFEKYAKEIGGADFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCC
LPERMNMQLVEPLRELFKDEVRALGHELGLPASFIGRHPFPGPGLAIRCPGEITREKLDI
CCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCHHHHHHHHHH
LREADAVYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDFACALRAVTSVDGMTA
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCC
DYYPFTHEFLGETATRIINEVPGINRVTYDITSKPPGTIEWE
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA