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The map label for this gene is zwf [H]

Identifier: 110679937

GI number: 110679937

Start: 2593081

End: 2594544

Strand: Reverse

Name: zwf [H]

Synonym: RD1_2722

Alternate gene names: 110679937

Gene position: 2594544-2593081 (Counterclockwise)

Preceding gene: 110679939

Following gene: 110679936

Centisome position: 62.77

GC content: 59.08

Gene sequence:

>1464_bases
ATGGTTTCACGCGTCATACCGGTTGATCCCTTCGATCTGGTTGTTTTCGGCGGCACGGGTGACCTTGCCCGCCGCAAGAT
CCTGCCGGCCTTGTTTCGACGCTTTTGCGCGGGGCAGATGCCTGAAACGGCCCGTATCATCGGGGCGGCACGATCGGACA
TGTCCGATGCCTCCTACACGCAAATGGTCGCGGATGCGCTGCGCGAATTCAGCCCCGGCGCGCAAAGTCATGCGGACCGG
CTGAGGGATTTTCTTGGCGTTATCTCTTACGTCCGGATTGACGCCATGGGCGAGGCCGGCTGGGCGGAGCTGACCCAAAA
GATCACCTCGGTGGACCGGGTTGAGGCCTATTATTTTTCCGTCGCGCCCTCCTTGTTCGGCCCGCTGGCGGAGCGTTTGC
AAGGACATGGGCTGGCGGACAGAAACGCGCGGATCGTCGTGGAAAAACCTTTTGGACGCGATCTTGAAACGGCCAAGGCG
CTGAATGCCACGCTCGCGCGCTATTTTGACGAAACACAGATTTATCGGATTGATCACTACCTTGGCAAGGAAACCGTGCA
GAACCTTATGGCTGTGCGCTTTGGCAATATGCTGTTTGAACCGTTGTGGAACAGCCAGTTTGTTGATCATATTCAGATCA
CGGTCGCCGAAACGGTGGGCGTTGGCGGGCGCGGTGAATACTATGACCGGGCAGGGGCGATGCGCGACATGGTGCAAAAC
CATCTGATGCAGCTTTTGTGCCTGATCGCGATGGAACCTCCGGCACGCTTTGACCCTGATGCGGTGCGCGACGAAAAGCT
CAAGGTCATCCGCGCTCTGGAGCCGGTAGAGCCGCATCACATCGTGCGCGGCCAATACAACGCCGACCCGGATGATGCCG
ACACCTATCCCGACTACCGCACCGCCGTGGGCAACCCGCGTTCAAGAACGGAAAGTTTCGTGGCGCTGAAAACCCATATT
GCCAACTGGCGGTGGGCCGGGACGCCGTTTTATCTGCGCACCGGCAAGCGCATGCGGGAACGCTCCAGCGAGATATCCAT
CGTGTTCAAGGAAACCCCGCACTCCATCTTTGCCGAAGATGCCGGGCGGCATCGCAATGTCCTGTCAATCAAGCTGCAGC
CAAATGAAGGCATCACGCTCGGTGTGACGATCAAGGAGCCCGGACCGGGAGGGATGCGGTTGATCGACGTACCGCTGGAT
ATGACATTTGCCGAAGCGCTTGGTCCGGATGGCGGTGAGACGGTGGATGCCTATGAGCGCTTGATCATGGATGTGATCCG
GGGCAACCAGACGTTGTTCATGCGCGGTGATGAGGTTGAGGCGGCGTGGGATTGGACCGATCCGATTATTCAGGGCTGGA
CGGATCGGGGCGATGTGCCAAAACCCTATGACAGCCTGAGCGACGGGCCGGATGCATCCGCGCAGCTGCTGGTGCGGGAC
AAGAGAGAATGGCGAAAGATCTGA

Upstream 100 bases:

>100_bases
CTGATTTACGCGCACAGTGTTGTGAACGCTTTACCATTGGCCCATGTTTGCGCTAACACACGCCGGAGCCGAATCCGGCC
TGCAACATGAGGTGCCCATC

Downstream 100 bases:

>100_bases
ACCATGCAAATCATTGAGTATATCGACCGGGATCTTGCGGCCATTGGCGTGGCCGACACGCTGGCCAGCGGGTTGAAAAA
AGCGCTGTCGATACAGGAAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MVSRVIPVDPFDLVVFGGTGDLARRKILPALFRRFCAGQMPETARIIGAARSDMSDASYTQMVADALREFSPGAQSHADR
LRDFLGVISYVRIDAMGEAGWAELTQKITSVDRVEAYYFSVAPSLFGPLAERLQGHGLADRNARIVVEKPFGRDLETAKA
LNATLARYFDETQIYRIDHYLGKETVQNLMAVRFGNMLFEPLWNSQFVDHIQITVAETVGVGGRGEYYDRAGAMRDMVQN
HLMQLLCLIAMEPPARFDPDAVRDEKLKVIRALEPVEPHHIVRGQYNADPDDADTYPDYRTAVGNPRSRTESFVALKTHI
ANWRWAGTPFYLRTGKRMRERSSEISIVFKETPHSIFAEDAGRHRNVLSIKLQPNEGITLGVTIKEPGPGGMRLIDVPLD
MTFAEALGPDGGETVDAYERLIMDVIRGNQTLFMRGDEVEAAWDWTDPIIQGWTDRGDVPKPYDSLSDGPDASAQLLVRD
KREWRKI

Sequences:

>Translated_487_residues
MVSRVIPVDPFDLVVFGGTGDLARRKILPALFRRFCAGQMPETARIIGAARSDMSDASYTQMVADALREFSPGAQSHADR
LRDFLGVISYVRIDAMGEAGWAELTQKITSVDRVEAYYFSVAPSLFGPLAERLQGHGLADRNARIVVEKPFGRDLETAKA
LNATLARYFDETQIYRIDHYLGKETVQNLMAVRFGNMLFEPLWNSQFVDHIQITVAETVGVGGRGEYYDRAGAMRDMVQN
HLMQLLCLIAMEPPARFDPDAVRDEKLKVIRALEPVEPHHIVRGQYNADPDDADTYPDYRTAVGNPRSRTESFVALKTHI
ANWRWAGTPFYLRTGKRMRERSSEISIVFKETPHSIFAEDAGRHRNVLSIKLQPNEGITLGVTIKEPGPGGMRLIDVPLD
MTFAEALGPDGGETVDAYERLIMDVIRGNQTLFMRGDEVEAAWDWTDPIIQGWTDRGDVPKPYDSLSDGPDASAQLLVRD
KREWRKI
>Mature_487_residues
MVSRVIPVDPFDLVVFGGTGDLARRKILPALFRRFCAGQMPETARIIGAARSDMSDASYTQMVADALREFSPGAQSHADR
LRDFLGVISYVRIDAMGEAGWAELTQKITSVDRVEAYYFSVAPSLFGPLAERLQGHGLADRNARIVVEKPFGRDLETAKA
LNATLARYFDETQIYRIDHYLGKETVQNLMAVRFGNMLFEPLWNSQFVDHIQITVAETVGVGGRGEYYDRAGAMRDMVQN
HLMQLLCLIAMEPPARFDPDAVRDEKLKVIRALEPVEPHHIVRGQYNADPDDADTYPDYRTAVGNPRSRTESFVALKTHI
ANWRWAGTPFYLRTGKRMRERSSEISIVFKETPHSIFAEDAGRHRNVLSIKLQPNEGITLGVTIKEPGPGGMRLIDVPLD
MTFAEALGPDGGETVDAYERLIMDVIRGNQTLFMRGDEVEAAWDWTDPIIQGWTDRGDVPKPYDSLSDGPDASAQLLVRD
KREWRKI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=35.7588357588358, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=35.7588357588358, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI52145310, Length=487, Percent_Identity=28.1314168377823, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788158, Length=484, Percent_Identity=42.9752066115703, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=36.2704918032787, Blast_Score=306, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=33.0561330561331, Blast_Score=275, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=35.6687898089172, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=35.6687898089172, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221513548, Length=487, Percent_Identity=29.1581108829569, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54719; Mature: 54719

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRVIPVDPFDLVVFGGTGDLARRKILPALFRRFCAGQMPETARIIGAARSDMSDASYT
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
QMVADALREFSPGAQSHADRLRDFLGVISYVRIDAMGEAGWAELTQKITSVDRVEAYYFS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VAPSLFGPLAERLQGHGLADRNARIVVEKPFGRDLETAKALNATLARYFDETQIYRIDHY
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHH
LGKETVQNLMAVRFGNMLFEPLWNSQFVDHIQITVAETVGVGGRGEYYDRAGAMRDMVQN
HCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEHHHCCCCCCCHHHHHHHHHHHHHH
HLMQLLCLIAMEPPARFDPDAVRDEKLKVIRALEPVEPHHIVRGQYNADPDDADTYPDYR
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHH
TAVGNPRSRTESFVALKTHIANWRWAGTPFYLRTGKRMRERSSEISIVFKETPHSIFAED
HHCCCCHHHHHHHHHHHHHHCCCEECCCCEEEECCHHHHHCCCCEEEEEECCCCHHHHHC
AGRHRNVLSIKLQPNEGITLGVTIKEPGPGGMRLIDVPLDMTFAEALGPDGGETVDAYER
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHH
LIMDVIRGNQTLFMRGDEVEAAWDWTDPIIQGWTDRGDVPKPYDSLSDGPDASAQLLVRD
HHHHHHCCCCEEEEECCCCCEECCCCCHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHC
KREWRKI
HHHHCCC
>Mature Secondary Structure
MVSRVIPVDPFDLVVFGGTGDLARRKILPALFRRFCAGQMPETARIIGAARSDMSDASYT
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
QMVADALREFSPGAQSHADRLRDFLGVISYVRIDAMGEAGWAELTQKITSVDRVEAYYFS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VAPSLFGPLAERLQGHGLADRNARIVVEKPFGRDLETAKALNATLARYFDETQIYRIDHY
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHH
LGKETVQNLMAVRFGNMLFEPLWNSQFVDHIQITVAETVGVGGRGEYYDRAGAMRDMVQN
HCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEHHHCCCCCCCHHHHHHHHHHHHHH
HLMQLLCLIAMEPPARFDPDAVRDEKLKVIRALEPVEPHHIVRGQYNADPDDADTYPDYR
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCHH
TAVGNPRSRTESFVALKTHIANWRWAGTPFYLRTGKRMRERSSEISIVFKETPHSIFAED
HHCCCCHHHHHHHHHHHHHHCCCEECCCCEEEECCHHHHHCCCCEEEEEECCCCHHHHHC
AGRHRNVLSIKLQPNEGITLGVTIKEPGPGGMRLIDVPLDMTFAEALGPDGGETVDAYER
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHH
LIMDVIRGNQTLFMRGDEVEAAWDWTDPIIQGWTDRGDVPKPYDSLSDGPDASAQLLVRD
HHHHHHCCCCEEEEECCCCCEECCCCCHHHHCCCCCCCCCCCHHCCCCCCCCCHHHHHHC
KREWRKI
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]