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The map label for this gene is hisI

Identifier: 110679836

GI number: 110679836

Start: 2491200

End: 2491586

Strand: Direct

Name: hisI

Synonym: RD1_2607

Alternate gene names: 110679836

Gene position: 2491200-2491586 (Clockwise)

Preceding gene: 110679833

Following gene: 110679840

Centisome position: 60.27

GC content: 58.14

Gene sequence:

>387_bases
ATGTCTGACGCAGCAAATGATACCAAGGTCCGTTTTGATCCTGAGAGGCTTACCTTCAATGAGGCCGGTTTGGTGCCGGC
TATTGCGCAAGATGCTGAAACCTCTGAGGTTTTGATGTTGGCTTGGATGAACGCCGAGAGCATTGCGCGCACGCTTCGCA
CGGGGCGAGTGACCTACTGGAGCCGGTCACGGCAGGCGTTCTGGGTCAAGGGTGAAACCAGCGGCCATGTTCAGGAACTT
GTTGATTTGCGGATAGACTGCGACCGCGACTGCCTGCTTGTGCTGCTGCGTCAGACGGGTCCTGCCTGCCACACCGGGCG
TCGCAGCTGTTTTTACACCGGGGTGCGTGACGGGCATGAACAGGAACTGATGACCCCGCAGGACTAG

Upstream 100 bases:

>100_bases
ATTAGATCAGTATCCGTGGCCATGGCTGTATTCTCGGTTTCGTTTGTCTGCCCCTCCATACATAAGGGGCAAGGAAGAAG
ATGCAAAAAGGTTTTTCGGC

Downstream 100 bases:

>100_bases
ACCGCAAGCCCGACCATGGCCCTGATGTCCTGCGGCGCGCACCCCTCGTCGCGGAATTTTGCCAAAGCCCGCGCATCATC
ACGTTTGGCCAACCGCTTGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 128; Mature: 127

Protein sequence:

>128_residues
MSDAANDTKVRFDPERLTFNEAGLVPAIAQDAETSEVLMLAWMNAESIARTLRTGRVTYWSRSRQAFWVKGETSGHVQEL
VDLRIDCDRDCLLVLLRQTGPACHTGRRSCFYTGVRDGHEQELMTPQD

Sequences:

>Translated_128_residues
MSDAANDTKVRFDPERLTFNEAGLVPAIAQDAETSEVLMLAWMNAESIARTLRTGRVTYWSRSRQAFWVKGETSGHVQEL
VDLRIDCDRDCLLVLLRQTGPACHTGRRSCFYTGVRDGHEQELMTPQD
>Mature_127_residues
SDAANDTKVRFDPERLTFNEAGLVPAIAQDAETSEVLMLAWMNAESIARTLRTGRVTYWSRSRQAFWVKGETSGHVQELV
DLRIDCDRDCLLVLLRQTGPACHTGRRSCFYTGVRDGHEQELMTPQD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=51.685393258427, Blast_Score=106, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=38.8888888888889, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_ROSDO (Q166D6)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682843.1
- ProteinModelPortal:   Q166D6
- SMR:   Q166D6
- STRING:   Q166D6
- GeneID:   4194967
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2607
- NMPDR:   fig|375451.6.peg.2422
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   CLSK933610
- BioCyc:   RDEN375451:RD1_2607-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14489; Mature: 14358

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAANDTKVRFDPERLTFNEAGLVPAIAQDAETSEVLMLAWMNAESIARTLRTGRVTYW
CCCCCCCCEEEECHHHEEECCCCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHCCCEEEE
SRSRQAFWVKGETSGHVQELVDLRIDCDRDCLLVLLRQTGPACHTGRRSCFYTGVRDGHE
ECCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCC
QELMTPQD
CCCCCCCC
>Mature Secondary Structure 
SDAANDTKVRFDPERLTFNEAGLVPAIAQDAETSEVLMLAWMNAESIARTLRTGRVTYW
CCCCCCCEEEECHHHEEECCCCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHCCCEEEE
SRSRQAFWVKGETSGHVQELVDLRIDCDRDCLLVLLRQTGPACHTGRRSCFYTGVRDGHE
ECCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCC
QELMTPQD
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA