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The map label for this gene is acrE [H]

Identifier: 110679771

GI number: 110679771

Start: 2423053

End: 2424219

Strand: Reverse

Name: acrE [H]

Synonym: RD1_2534

Alternate gene names: 110679771

Gene position: 2424219-2423053 (Counterclockwise)

Preceding gene: 110679772

Following gene: 110679770

Centisome position: 58.65

GC content: 59.47

Gene sequence:

>1167_bases
ATGACATATCGGACGTCACTTTTACATACCGTGCAGCGCGGGATCATTCTTGTCGCTTGCCTGGCGTTGACCATTGGCCT
TTCGACGACAAGCGCGCAGTCTCAAGACGGCTCGAATCCCCCCCCGAAAGTCGTCATTGCTGCTGCCTACAGCGAAGAAC
TGACGCGGGAGGCGACCTTTGTGGGGCGAGGTGAGGCCTCGGCGAAAACCGATCTGATTGCACGTGTCACGGGGATCATC
ACTGAGATGGTGGTGCAAGACGGGGCCACTGTCAAAGAAGGCGATGTGATTTTCCGTATTGAACCAGACACCTATCAGGC
CGAGTTGCAGGCGCAACAAGCTGCCGTGCAGCGGGCGGATGCAAATGTGAAACTGGCGGAAATCGAACTGGTGCGCAAAA
CGGAACTGCTCAGACGCGAGGCGATTGCCGAATCCGAACTTGATATCGCACAGGCGAACGCCGCTGTGGCCAAGGCGGAT
CTGCTGGCAGCACAGGCGGCCTTGCGCGAAGCCGAGTTGAACCTTGAGCGCACCGACATCACCGCGCCGTTTGACGGACG
CATTGGCCGCTCAAGCATCAGCCTTGGCGCTTTGGTGGGGCCGTCAACGGGGCCGCTCGCGACGCTGGTGCAGGAATCGC
CGATGTATGTCACGTTTTCCCTGTCAGAACCGCAGCTGCTCGGCGTGCTTGAGCGTCTGGAAACCGGCATGGAAGAATTG
ATCGCCAGCGGGGCCTCGCCCAATGTCTTCATCCGGCTTCCCGACGGGACTATGCTGGAGGAACCGGGCACAATCGTTTT
TCTGGACAACCGGATCAATCCCGCAACCGGCACCATCTCGCTGCGGGCAGAGTTTGAGAATACCCGCCGCATGATCCTTG
ACGGGGGGTTCATCTCAGTCGTCATCGAAGCGCTGGAGCCGACATTAAGCGTTCTGATTCCGCAAAATGCGGTGCAGCGC
GACCAGCGCGGTGATTTCGTTCTGGTCGTGACGGACCAACAGCTTGTTGAGCAAAGATATGTGGTGCTGGGCCCGCAGGC
AGAAACCGCCGTCGTTGTCTCCGAGGGGCTGCGCGAGGGTGAAAGTGTGATCGTGGAGGGCTTGCAGCGCGTGCGCCCCG
GTATCGAGGTCAACGCCGTTTTGACCGGCACAAGCGATGTGAACTGA

Upstream 100 bases:

>100_bases
TGGTCGCCAAGCCAGACAGCCTTTACAAGTTTTGGTTGCGCCTTGCGTTAACGCGCCGATGCCAGCAAAGTGCAGCGTAA
TGATCGAACCCGGAGAATCC

Downstream 100 bases:

>100_bases
CCTGATGCTTTCAACAGTTTTCATCAAGCGCCCCAAGATGGCCATTGTGATTTCAACGGTCCTCACGCTCATGGGTCTGG
TTGCCTACTCGGTGATCCCG

Product: RND efflux transporter, MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTYRTSLLHTVQRGIILVACLALTIGLSTTSAQSQDGSNPPPKVVIAAAYSEELTREATFVGRGEASAKTDLIARVTGII
TEMVVQDGATVKEGDVIFRIEPDTYQAELQAQQAAVQRADANVKLAEIELVRKTELLRREAIAESELDIAQANAAVAKAD
LLAAQAALREAELNLERTDITAPFDGRIGRSSISLGALVGPSTGPLATLVQESPMYVTFSLSEPQLLGVLERLETGMEEL
IASGASPNVFIRLPDGTMLEEPGTIVFLDNRINPATGTISLRAEFENTRRMILDGGFISVVIEALEPTLSVLIPQNAVQR
DQRGDFVLVVTDQQLVEQRYVVLGPQAETAVVVSEGLREGESVIVEGLQRVRPGIEVNAVLTGTSDVN

Sequences:

>Translated_388_residues
MTYRTSLLHTVQRGIILVACLALTIGLSTTSAQSQDGSNPPPKVVIAAAYSEELTREATFVGRGEASAKTDLIARVTGII
TEMVVQDGATVKEGDVIFRIEPDTYQAELQAQQAAVQRADANVKLAEIELVRKTELLRREAIAESELDIAQANAAVAKAD
LLAAQAALREAELNLERTDITAPFDGRIGRSSISLGALVGPSTGPLATLVQESPMYVTFSLSEPQLLGVLERLETGMEEL
IASGASPNVFIRLPDGTMLEEPGTIVFLDNRINPATGTISLRAEFENTRRMILDGGFISVVIEALEPTLSVLIPQNAVQR
DQRGDFVLVVTDQQLVEQRYVVLGPQAETAVVVSEGLREGESVIVEGLQRVRPGIEVNAVLTGTSDVN
>Mature_387_residues
TYRTSLLHTVQRGIILVACLALTIGLSTTSAQSQDGSNPPPKVVIAAAYSEELTREATFVGRGEASAKTDLIARVTGIIT
EMVVQDGATVKEGDVIFRIEPDTYQAELQAQQAAVQRADANVKLAEIELVRKTELLRREAIAESELDIAQANAAVAKADL
LAAQAALREAELNLERTDITAPFDGRIGRSSISLGALVGPSTGPLATLVQESPMYVTFSLSEPQLLGVLERLETGMEELI
ASGASPNVFIRLPDGTMLEEPGTIVFLDNRINPATGTISLRAEFENTRRMILDGGFISVVIEALEPTLSVLIPQNAVQRD
QRGDFVLVVTDQQLVEQRYVVLGPQAETAVVVSEGLREGESVIVEGLQRVRPGIEVNAVLTGTSDVN

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=348, Percent_Identity=33.9080459770115, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1786668, Length=369, Percent_Identity=34.1463414634146, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1789929, Length=382, Percent_Identity=28.5340314136126, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87082036, Length=345, Percent_Identity=27.8260869565217, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87081951, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790519, Length=218, Percent_Identity=30.2752293577982, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789637, Length=182, Percent_Identity=32.4175824175824, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41582; Mature: 41451

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRTSLLHTVQRGIILVACLALTIGLSTTSAQSQDGSNPPPKVVIAAAYSEELTREATF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHE
VGRGEASAKTDLIARVTGIITEMVVQDGATVKEGDVIFRIEPDTYQAELQAQQAAVQRAD
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCC
ANVKLAEIELVRKTELLRREAIAESELDIAQANAAVAKADLLAAQAALREAELNLERTDI
CCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TAPFDGRIGRSSISLGALVGPSTGPLATLVQESPMYVTFSLSEPQLLGVLERLETGMEEL
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
IASGASPNVFIRLPDGTMLEEPGTIVFLDNRINPATGTISLRAEFENTRRMILDGGFISV
HHCCCCCEEEEECCCCCEECCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCHHHH
VIEALEPTLSVLIPQNAVQRDQRGDFVLVVTDQQLVEQRYVVLGPQAETAVVVSEGLREG
HHHHHCCHHEEEECCHHHHHCCCCCEEEEEECHHHHHCCEEEECCCCCEEHEEHHHHCCH
ESVIVEGLQRVRPGIEVNAVLTGTSDVN
HHHHHHHHHHHCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TYRTSLLHTVQRGIILVACLALTIGLSTTSAQSQDGSNPPPKVVIAAAYSEELTREATF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHE
VGRGEASAKTDLIARVTGIITEMVVQDGATVKEGDVIFRIEPDTYQAELQAQQAAVQRAD
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHCC
ANVKLAEIELVRKTELLRREAIAESELDIAQANAAVAKADLLAAQAALREAELNLERTDI
CCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
TAPFDGRIGRSSISLGALVGPSTGPLATLVQESPMYVTFSLSEPQLLGVLERLETGMEEL
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
IASGASPNVFIRLPDGTMLEEPGTIVFLDNRINPATGTISLRAEFENTRRMILDGGFISV
HHCCCCCEEEEECCCCCEECCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEECCHHHH
VIEALEPTLSVLIPQNAVQRDQRGDFVLVVTDQQLVEQRYVVLGPQAETAVVVSEGLREG
HHHHHCCHHEEEECCHHHHHCCCCCEEEEEECHHHHHCCEEEECCCCCEEHEEHHHHCCH
ESVIVEGLQRVRPGIEVNAVLTGTSDVN
HHHHHHHHHHHCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]