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The map label for this gene is hbd [H]

Identifier: 110679760

GI number: 110679760

Start: 2409764

End: 2411233

Strand: Direct

Name: hbd [H]

Synonym: RD1_2523

Alternate gene names: 110679760

Gene position: 2409764-2411233 (Clockwise)

Preceding gene: 110679759

Following gene: 110679761

Centisome position: 58.3

GC content: 58.64

Gene sequence:

>1470_bases
GTGACACATAGGGCAGCGATCATCGGTGGCGGTGTCATCGGCGGCGGTTGGGCGGCGCGCTTTTTGCTGAACGGTTGGGA
TGTGCAGGTTTTTGACCCTGATCCCGAGGCGGAACGCAAGATCGGGCAAGTGCTCGCCAACGCGCGGCGCAGCCTGCCGG
GCCTGACGGATGTGGCGCTTCCCCCAGAGGGGCGTTTGCAGTTTTGCGAAACGCTGCAAGAGGCAGTGGAGCATGCGGAC
TGGATACAGGAAAGCGTGCCTGAACGCCTTGATATCAAGCATGAAACACTGGCCGACATTCAAAAGATGTGCCGCGCGGA
TGCGGTGATCGGCTCATCCACATCGGGTTTCAAACCCTCCCAATTGCAAGAGGGCGCGGCACGACCCGGGCAGATCATGG
TGTGTCACCCGTTCAACCCGGTTTACCTTTTGCCGCTGGTCGAAGTCGTCACAACACCGGCGAACACCGCTGAAAGCGTG
GAGGGCGTCAAGACGCTCTTGCAAGAGGTGGGGATGTATCCGCTGCATCTGAAAAAGGAAATCGACGCGCATGTGGCTGA
TCGTTTTCTCGAAGCGGTCTGGCGCGAGGCGCTTTGGCTGGTGAAAGACGGCATCGCCACGACCGCTGAAATCGACGATG
CGATCCGTTATGGCTTCGGTATTCGCTGGGCGCAGATGGGGCTGTTTGAAACCTATCGGGTTGCGGGCGGAGAAGCCGGC
ATGAAGCATTTCATGGCCCAATTCGGTCCCGCATTGAAATGGCCCTGGACCAAGCTGATGGATGTGCCGGAGTTTAACGA
CGATCTTGTTGATCTGATTGCCGGGCAGTCCGACGCGCAATCGGGCGCATATACGATCCAGGAATTGGAACAAATCAGAG
ACGGTAACCTTGTTGCCATGATGCGTGCGCTCAAAACCCAGAACTGGGGTGTGGGGGCCTTGCTGGCGCAACACGAAGAT
CGTCTGCGCAACGCGGATGCGGTATCTTCACCCCTCGATCACACCGCACCGGTTGTCACGGGCAACCGTGTCGTGCCGCT
GGATTGGACGGATTACAACGGGCATATGAATGAGGCGCGGTATCTGCAGGCTTTCGCGGATGCGACGGACCGTTTCATGG
CGATCATCGGCTGCGATGCGGACTATATTGCCGCCGGTCACAGCTATTTCACCGCCGAGACGCACATCCGGCATCTGGAT
GAGGTGAACGCAGGACAGATCATTCGCATCGAGACAACGGCATTGGGCGGCGGGGGCAAAAAGTTGCATCTGTGGCATGA
GATGTATGTGGGGGGGAAACTGATCGCCACGGGGGAGCATTTTCTTTTGCATGTGGACCTCAAGACCCGCAAGGCTGCGC
CGGCAAGCTCGGCAGTGGATAAGGCCCTGAAAAAATGGATAGACGCACATGGCAAGCGGCCACTTCCGGAGGGGGTAGGG
CGCGCAATCAGATCATCCGCACCGCGCTGA

Upstream 100 bases:

>100_bases
TTGACCGGGATGGCTTTGTGCCCCCTGACCGGGCACAAGCCGCACGCGATATCATGGAATTTTACGGATGGGATGTCCGC
ACCTTGGAAAGGACAGTGTT

Downstream 100 bases:

>100_bases
AACGACAGGCTGTGATCCAGCGGAGCGAGCTTGCGCTCGCATTACATTTTTTGTCCGCATCGTGGATAGGTTGGGGGACA
GGGATTTGAGGGCTCAGGCA

Product: bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTHRAAIIGGGVIGGGWAARFLLNGWDVQVFDPDPEAERKIGQVLANARRSLPGLTDVALPPEGRLQFCETLQEAVEHAD
WIQESVPERLDIKHETLADIQKMCRADAVIGSSTSGFKPSQLQEGAARPGQIMVCHPFNPVYLLPLVEVVTTPANTAESV
EGVKTLLQEVGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTAEIDDAIRYGFGIRWAQMGLFETYRVAGGEAG
MKHFMAQFGPALKWPWTKLMDVPEFNDDLVDLIAGQSDAQSGAYTIQELEQIRDGNLVAMMRALKTQNWGVGALLAQHED
RLRNADAVSSPLDHTAPVVTGNRVVPLDWTDYNGHMNEARYLQAFADATDRFMAIIGCDADYIAAGHSYFTAETHIRHLD
EVNAGQIIRIETTALGGGGKKLHLWHEMYVGGKLIATGEHFLLHVDLKTRKAAPASSAVDKALKKWIDAHGKRPLPEGVG
RAIRSSAPR

Sequences:

>Translated_489_residues
MTHRAAIIGGGVIGGGWAARFLLNGWDVQVFDPDPEAERKIGQVLANARRSLPGLTDVALPPEGRLQFCETLQEAVEHAD
WIQESVPERLDIKHETLADIQKMCRADAVIGSSTSGFKPSQLQEGAARPGQIMVCHPFNPVYLLPLVEVVTTPANTAESV
EGVKTLLQEVGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTAEIDDAIRYGFGIRWAQMGLFETYRVAGGEAG
MKHFMAQFGPALKWPWTKLMDVPEFNDDLVDLIAGQSDAQSGAYTIQELEQIRDGNLVAMMRALKTQNWGVGALLAQHED
RLRNADAVSSPLDHTAPVVTGNRVVPLDWTDYNGHMNEARYLQAFADATDRFMAIIGCDADYIAAGHSYFTAETHIRHLD
EVNAGQIIRIETTALGGGGKKLHLWHEMYVGGKLIATGEHFLLHVDLKTRKAAPASSAVDKALKKWIDAHGKRPLPEGVG
RAIRSSAPR
>Mature_488_residues
THRAAIIGGGVIGGGWAARFLLNGWDVQVFDPDPEAERKIGQVLANARRSLPGLTDVALPPEGRLQFCETLQEAVEHADW
IQESVPERLDIKHETLADIQKMCRADAVIGSSTSGFKPSQLQEGAARPGQIMVCHPFNPVYLLPLVEVVTTPANTAESVE
GVKTLLQEVGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTAEIDDAIRYGFGIRWAQMGLFETYRVAGGEAGM
KHFMAQFGPALKWPWTKLMDVPEFNDDLVDLIAGQSDAQSGAYTIQELEQIRDGNLVAMMRALKTQNWGVGALLAQHEDR
LRNADAVSSPLDHTAPVVTGNRVVPLDWTDYNGHMNEARYLQAFADATDRFMAIIGCDADYIAAGHSYFTAETHIRHLDE
VNAGQIIRIETTALGGGGKKLHLWHEMYVGGKLIATGEHFLLHVDLKTRKAAPASSAVDKALKKWIDAHGKRPLPEGVGR
AIRSSAPR

Specific function: Unknown

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=277, Percent_Identity=32.129963898917, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI296179429, Length=240, Percent_Identity=25.8333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI296179427, Length=257, Percent_Identity=24.124513618677, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=25.6544502617801, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787661, Length=218, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=245, Percent_Identity=24.0816326530612, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI193203623, Length=245, Percent_Identity=24.0816326530612, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=276, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17563036, Length=229, Percent_Identity=27.5109170305677, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=241, Percent_Identity=26.1410788381743, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129993, Length=317, Percent_Identity=29.3375394321767, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45549573, Length=257, Percent_Identity=30.7392996108949, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53738; Mature: 53607

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRAAIIGGGVIGGGWAARFLLNGWDVQVFDPDPEAERKIGQVLANARRSLPGLTDVAL
CCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PPEGRLQFCETLQEAVEHADWIQESVPERLDIKHETLADIQKMCRADAVIGSSTSGFKPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLQEGAARPGQIMVCHPFNPVYLLPLVEVVTTPANTAESVEGVKTLLQEVGMYPLHLKKE
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHH
IDAHVADRFLEAVWREALWLVKDGIATTAEIDDAIRYGFGIRWAQMGLFETYRVAGGEAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MKHFMAQFGPALKWPWTKLMDVPEFNDDLVDLIAGQSDAQSGAYTIQELEQIRDGNLVAM
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
MRALKTQNWGVGALLAQHEDRLRNADAVSSPLDHTAPVVTGNRVVPLDWTDYNGHMNEAR
HHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCEEECCEEEEECCCCCCCCCCHHH
YLQAFADATDRFMAIIGCDADYIAAGHSYFTAETHIRHLDEVNAGQIIRIETTALGGGGK
HHHHHHHHHHHEEEEEECCCHHHHCCCCEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCC
KLHLWHEMYVGGKLIATGEHFLLHVDLKTRKAAPASSAVDKALKKWIDAHGKRPLPEGVG
EEEEEEHHHCCCEEEEECCEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
RAIRSSAPR
HHHHCCCCC
>Mature Secondary Structure 
THRAAIIGGGVIGGGWAARFLLNGWDVQVFDPDPEAERKIGQVLANARRSLPGLTDVAL
CCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PPEGRLQFCETLQEAVEHADWIQESVPERLDIKHETLADIQKMCRADAVIGSSTSGFKPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
QLQEGAARPGQIMVCHPFNPVYLLPLVEVVTTPANTAESVEGVKTLLQEVGMYPLHLKKE
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEHHHH
IDAHVADRFLEAVWREALWLVKDGIATTAEIDDAIRYGFGIRWAQMGLFETYRVAGGEAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MKHFMAQFGPALKWPWTKLMDVPEFNDDLVDLIAGQSDAQSGAYTIQELEQIRDGNLVAM
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHH
MRALKTQNWGVGALLAQHEDRLRNADAVSSPLDHTAPVVTGNRVVPLDWTDYNGHMNEAR
HHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCEEECCEEEEECCCCCCCCCCHHH
YLQAFADATDRFMAIIGCDADYIAAGHSYFTAETHIRHLDEVNAGQIIRIETTALGGGGK
HHHHHHHHHHHEEEEEECCCHHHHCCCCEEEHHHHHHHHHCCCCCCEEEEEEEEECCCCC
KLHLWHEMYVGGKLIATGEHFLLHVDLKTRKAAPASSAVDKALKKWIDAHGKRPLPEGVG
EEEEEEHHHCCCEEEEECCEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
RAIRSSAPR
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA