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The map label for this gene is moeA [H]

Identifier: 110679693

GI number: 110679693

Start: 2334703

End: 2335986

Strand: Direct

Name: moeA [H]

Synonym: RD1_2448

Alternate gene names: 110679693

Gene position: 2334703-2335986 (Clockwise)

Preceding gene: 110679692

Following gene: 110679696

Centisome position: 56.49

GC content: 59.19

Gene sequence:

>1284_bases
ATGACATATCTTCCAAGGGACATGCCCACTGGCTGTGGGTGTGATGACCTTAAAACCACGTCCAAATGGATCAGCATCGA
CGAAGCCTTTGATCGGATATCGCGTCACGTCTTCCCCATCGCGCGCGCGGAAACGCTACCGATCCAAAATGCGAAAGGTC
GTGTGCTTGCAAATGAGGTTTGCGCCAAAGGCGACATGCCGCGCTTTGACCACGCTGCCATGGATGGATACGCGGTCGAC
AGCACAGCATTTGCAGGCGACGGGCCATGGCTGTTTCCGGTGACGGGTCGGATTGCTGCGGGCGATGCTCCTGGCACAGG
ATGCGCCTCTGCAGATGCCTGCCGGATCTTCACCGGAGCGCCGCTTCCTGAGCGGTATGACAGCGTGATCATGCAGGAGA
GGGCAGAGAAAATCGGAAACCTGATCCGGTTTGATACCCGTCCGGAACCGCGCGAAAACGTGCGTCAAAGAGGGGAGGAG
TATCAATCAGGCGCTGCAATCCTGTCGGCGGGCACAGTCCTGACACCGGGCGCGATCGCGGCCTGTGCCTCTGCCGGGCA
CGGGAAGGTCACGGTGCACAAGCGCGTGCGCGTGGCGCTCATCGCAACCGGGTCGGAGGTCGCCACACCGGGAATGCAGG
AGTTGGAGGAAGGTCAAATCTGGGACGTCAACACGCCGATGCTGCACGCCCTTCTGTCCCGCCCGGATGTCGATCTGAAC
GATATCATCCGGGTCAAGGATAGTTTGCACGACATTCGTGATGCCATGCAATCCGCCGCTGAAAACGCAGACCTCGTTGT
CACGACTGGTGGTGTCTCGGTCGGTGATGAAGATCATCTGCATGGTGCCGTTCAGGCCGCAGGCGGTAGTGTGATTTTTG
CAGGTGTTGCGATGAAACCGGGCAAACCCGTCACACTTGGACGGATCGGCAACGCAACATGGCTTGGGCTGCCCGGAAAC
CCCGGCTCCGCCTTTGTGACATGGTCGATCTTTGGCGAGGGCGTTCTGAATGCGCTGTCCGGACGGCAGCGGACAATGCC
GAAACGCCGCCATGTGCTGTTGGGACATGATCTGTTCAGGAAAGCGGGTCGATGTGAGATCCGCGCCGCTTGCATCGTCG
GTATCGCTGGCGATGGACGCGATGTCATCGAATGCACATCAGGCGGGACCTCCGGACAGGTTTCTCACTACGCAACGGCA
GATGGCTTTGCCTTCCTTCCTTCCGAGTTGGACCAGATGCCGGCGGGCACGTTGGTCGAATTTCTTCCCTTTTGCACAAA
CTGA

Upstream 100 bases:

>100_bases
GCCGAGTTGCGCTTGGCGATGTTTCAGCGGCGTCTTTCAGACTTTCGCGACCACAGGGCATGTGGCGCATGACGCGTTAC
AAAGGAGAGCGGGGCCTATC

Downstream 100 bases:

>100_bases
GAACTGACATGCACATCGCTTACACAATGGCCCCCGGGCGGGGCGACACCGACCTTCTCCTGCACCGGGTAGCGCAATCG
ATCATCAAGGCAGGGTATTG

Product: molybdopterin biosynthesis protein moeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTYLPRDMPTGCGCDDLKTTSKWISIDEAFDRISRHVFPIARAETLPIQNAKGRVLANEVCAKGDMPRFDHAAMDGYAVD
STAFAGDGPWLFPVTGRIAAGDAPGTGCASADACRIFTGAPLPERYDSVIMQERAEKIGNLIRFDTRPEPRENVRQRGEE
YQSGAAILSAGTVLTPGAIAACASAGHGKVTVHKRVRVALIATGSEVATPGMQELEEGQIWDVNTPMLHALLSRPDVDLN
DIIRVKDSLHDIRDAMQSAAENADLVVTTGGVSVGDEDHLHGAVQAAGGSVIFAGVAMKPGKPVTLGRIGNATWLGLPGN
PGSAFVTWSIFGEGVLNALSGRQRTMPKRRHVLLGHDLFRKAGRCEIRAACIVGIAGDGRDVIECTSGGTSGQVSHYATA
DGFAFLPSELDQMPAGTLVEFLPFCTN

Sequences:

>Translated_427_residues
MTYLPRDMPTGCGCDDLKTTSKWISIDEAFDRISRHVFPIARAETLPIQNAKGRVLANEVCAKGDMPRFDHAAMDGYAVD
STAFAGDGPWLFPVTGRIAAGDAPGTGCASADACRIFTGAPLPERYDSVIMQERAEKIGNLIRFDTRPEPRENVRQRGEE
YQSGAAILSAGTVLTPGAIAACASAGHGKVTVHKRVRVALIATGSEVATPGMQELEEGQIWDVNTPMLHALLSRPDVDLN
DIIRVKDSLHDIRDAMQSAAENADLVVTTGGVSVGDEDHLHGAVQAAGGSVIFAGVAMKPGKPVTLGRIGNATWLGLPGN
PGSAFVTWSIFGEGVLNALSGRQRTMPKRRHVLLGHDLFRKAGRCEIRAACIVGIAGDGRDVIECTSGGTSGQVSHYATA
DGFAFLPSELDQMPAGTLVEFLPFCTN
>Mature_426_residues
TYLPRDMPTGCGCDDLKTTSKWISIDEAFDRISRHVFPIARAETLPIQNAKGRVLANEVCAKGDMPRFDHAAMDGYAVDS
TAFAGDGPWLFPVTGRIAAGDAPGTGCASADACRIFTGAPLPERYDSVIMQERAEKIGNLIRFDTRPEPRENVRQRGEEY
QSGAAILSAGTVLTPGAIAACASAGHGKVTVHKRVRVALIATGSEVATPGMQELEEGQIWDVNTPMLHALLSRPDVDLND
IIRVKDSLHDIRDAMQSAAENADLVVTTGGVSVGDEDHLHGAVQAAGGSVIFAGVAMKPGKPVTLGRIGNATWLGLPGNP
GSAFVTWSIFGEGVLNALSGRQRTMPKRRHVLLGHDLFRKAGRCEIRAACIVGIAGDGRDVIECTSGGTSGQVSHYATAD
GFAFLPSELDQMPAGTLVEFLPFCTN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=28.428927680798, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=28.428927680798, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1787049, Length=398, Percent_Identity=36.1809045226131, Blast_Score=227, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25147659, Length=400, Percent_Identity=29.75, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17136978, Length=376, Percent_Identity=30.0531914893617, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24638841, Length=376, Percent_Identity=30.0531914893617, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45261; Mature: 45130

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLPRDMPTGCGCDDLKTTSKWISIDEAFDRISRHVFPIARAETLPIQNAKGRVLANEV
CCCCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHH
CAKGDMPRFDHAAMDGYAVDSTAFAGDGPWLFPVTGRIAAGDAPGTGCASADACRIFTGA
HCCCCCCCCCHHHCCCEEECCCEECCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECC
PLPERYDSVIMQERAEKIGNLIRFDTRPEPRENVRQRGEEYQSGAAILSAGTVLTPGAIA
CCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCEECCHHHH
ACASAGHGKVTVHKRVRVALIATGSEVATPGMQELEEGQIWDVNTPMLHALLSRPDVDLN
HHHCCCCCEEEEEEEEEEEEEECCCHHCCCCHHHHCCCCEEECCHHHHHHHHCCCCCCHH
DIIRVKDSLHDIRDAMQSAAENADLVVTTGGVSVGDEDHLHGAVQAAGGSVIFAGVAMKP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECC
GKPVTLGRIGNATWLGLPGNPGSAFVTWSIFGEGVLNALSGRQRTMPKRRHVLLGHDLFR
CCCEEEEECCCEEEEECCCCCCCEEEEEEEHHHHHHHHHCCHHHCCCHHHEEEECHHHHH
KAGRCEIRAACIVGIAGDGRDVIECTSGGTSGQVSHYATADGFAFLPSELDQMPAGTLVE
CCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCCEECCHHHHHCCHHHHHH
FLPFCTN
HHHHCCC
>Mature Secondary Structure 
TYLPRDMPTGCGCDDLKTTSKWISIDEAFDRISRHVFPIARAETLPIQNAKGRVLANEV
CCCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHH
CAKGDMPRFDHAAMDGYAVDSTAFAGDGPWLFPVTGRIAAGDAPGTGCASADACRIFTGA
HCCCCCCCCCHHHCCCEEECCCEECCCCCEEEEECCEEECCCCCCCCCCCCCCEEEEECC
PLPERYDSVIMQERAEKIGNLIRFDTRPEPRENVRQRGEEYQSGAAILSAGTVLTPGAIA
CCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCEECCHHHH
ACASAGHGKVTVHKRVRVALIATGSEVATPGMQELEEGQIWDVNTPMLHALLSRPDVDLN
HHHCCCCCEEEEEEEEEEEEEECCCHHCCCCHHHHCCCCEEECCHHHHHHHHCCCCCCHH
DIIRVKDSLHDIRDAMQSAAENADLVVTTGGVSVGDEDHLHGAVQAAGGSVIFAGVAMKP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECC
GKPVTLGRIGNATWLGLPGNPGSAFVTWSIFGEGVLNALSGRQRTMPKRRHVLLGHDLFR
CCCEEEEECCCEEEEECCCCCCCEEEEEEEHHHHHHHHHCCHHHCCCHHHEEEECHHHHH
KAGRCEIRAACIVGIAGDGRDVIECTSGGTSGQVSHYATADGFAFLPSELDQMPAGTLVE
CCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCCEECCHHHHHCCHHHHHH
FLPFCTN
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]