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The map label for this gene is fumC [H]

Identifier: 110679538

GI number: 110679538

Start: 2173361

End: 2174752

Strand: Reverse

Name: fumC [H]

Synonym: RD1_2273

Alternate gene names: 110679538

Gene position: 2174752-2173361 (Counterclockwise)

Preceding gene: 110679541

Following gene: 110679537

Centisome position: 52.62

GC content: 59.2

Gene sequence:

>1392_bases
ATGACCCAGACCCGCACAGAAACCGACAGTTTTGGCCCCCTCGAGGTCCCTGCCGATAAATACTGGGGTGCACAGACGCA
GCGCTCGATCATGAATTTTCCCATAGGTTGGGAAAAACAACCCGTTGCGATTGTCCGTGCCTTGGGGGTGATCAAACAGG
CTTGTGCCCAGGCAAATGTTGAACTGGGAAAACTTGACGCTGCGCGCGGGGAGGCGATCATTCAGGCCGCCAGCGAGGTG
GTCGCAGGCAAGTTTGACGACAATTTCCCACTGGTTGTGTGGCAGACAGGGTCCGGGACCCAGTCGAACATGAACGCCAA
TGAGGTCATCGCCAACCGCGCGATTGAGATCATGGGTGGGGTGATCGGCACCAAGGATCCGGTGCATCCGAATGATCACT
GCAACATGGGGCAATCGTCCAACGATACCTTTCCCACGGCGATGCACATTTCGACCGCCATGACGGCCCGCGATGTGCTG
TTGCCGGGGTTGGAAAAACTGCATGCCGCGCTTGAGGTCAAGATCGCCCAGTTCGACGGTATCATCAAAATCGGACGCAC
CCATACGCAGGACGCGACCCCTCTGACCCTCAGTCAGGAATTCTCCGGCTATGCGCATCAGGTGGCCATGGGCATCCAGC
GCGTCAAGGACGCCTTGGGTCGGATTTACGAGCTGGCACAGGGCGGCACCGCCGTGGGCACCGGTCTCAATACGCCTGTC
GGCTGGGACGTGATGGTTGCAAAAAACATGGCTGATATCACCGGCCTGCCCTTTGTCACCGCGCCCAACAAGTTCGAGGC
CCTCGCCGCGCATGACGCCATGGTTGAGATGTCCGGCGCGCTGAAGGTCGTTGCCGCCAGCCTGTTCAAGATCGCCAATG
ACATTCGCCTGCTCGGCTCCGGGCCGCGCTGCGGCTTGGGCGAGTTGGTGCTGCCTGAAAACGAACCCGGATCGTCGATC
ATGCCGGGCAAGGTCAATCCGACACAATGCGAAGCGCTGACACAGGTGTGTGCGCATGTCTTCGGCAATGACGCTGCGGT
CGGTTTCGCCGGGTCGCAAGGGCATTTCGAACTGAACGTGTACAAACCGATGATGTCGTACAACGTATTGCAATCCATGC
AGCTTTTGGGCGATGCGGCATCGACCTTTACGGATAATCTCGTGGACGGGCTGACGGCGGATGCGGATCGCATCGAACGC
CTGATGCGCGAGAGCCTGATGCTGGTCACAGCGCTGGCCCCGGAAATCGGCTATGACAACGCCACCAAAGTCGCCAAGAC
GGCGCATAAAAACGGCACGACCCTCAAGGAAGAGGCGATCGCGCTGGGGTTTGTCGATGCCGAGACGTTTGAACGGGTCG
TGCGCCCCGAAAACATGATCGGGCCCAAATGA

Upstream 100 bases:

>100_bases
TTGGTTTGGCAAACAATGCCCGTGACGCGCCGTCGCCCTGTTGCACGAGCCCCCCCGCAGCGCTAAACCGCTGTACAAAG
CCAGTGTAACGGAGCGCAGA

Downstream 100 bases:

>100_bases
GCACGCCCATCAACCTCAACAAGGTCCGCAAAGAGCGGGCCCGGGCGTCACGCAAGGCGCAGGCTGATGAAAACGCCGCG
CGATTTGGCCAGAGCAAATC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTQTRTETDSFGPLEVPADKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKQACAQANVELGKLDAARGEAIIQAASEV
VAGKFDDNFPLVVWQTGSGTQSNMNANEVIANRAIEIMGGVIGTKDPVHPNDHCNMGQSSNDTFPTAMHISTAMTARDVL
LPGLEKLHAALEVKIAQFDGIIKIGRTHTQDATPLTLSQEFSGYAHQVAMGIQRVKDALGRIYELAQGGTAVGTGLNTPV
GWDVMVAKNMADITGLPFVTAPNKFEALAAHDAMVEMSGALKVVAASLFKIANDIRLLGSGPRCGLGELVLPENEPGSSI
MPGKVNPTQCEALTQVCAHVFGNDAAVGFAGSQGHFELNVYKPMMSYNVLQSMQLLGDAASTFTDNLVDGLTADADRIER
LMRESLMLVTALAPEIGYDNATKVAKTAHKNGTTLKEEAIALGFVDAETFERVVRPENMIGPK

Sequences:

>Translated_463_residues
MTQTRTETDSFGPLEVPADKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKQACAQANVELGKLDAARGEAIIQAASEV
VAGKFDDNFPLVVWQTGSGTQSNMNANEVIANRAIEIMGGVIGTKDPVHPNDHCNMGQSSNDTFPTAMHISTAMTARDVL
LPGLEKLHAALEVKIAQFDGIIKIGRTHTQDATPLTLSQEFSGYAHQVAMGIQRVKDALGRIYELAQGGTAVGTGLNTPV
GWDVMVAKNMADITGLPFVTAPNKFEALAAHDAMVEMSGALKVVAASLFKIANDIRLLGSGPRCGLGELVLPENEPGSSI
MPGKVNPTQCEALTQVCAHVFGNDAAVGFAGSQGHFELNVYKPMMSYNVLQSMQLLGDAASTFTDNLVDGLTADADRIER
LMRESLMLVTALAPEIGYDNATKVAKTAHKNGTTLKEEAIALGFVDAETFERVVRPENMIGPK
>Mature_462_residues
TQTRTETDSFGPLEVPADKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKQACAQANVELGKLDAARGEAIIQAASEVV
AGKFDDNFPLVVWQTGSGTQSNMNANEVIANRAIEIMGGVIGTKDPVHPNDHCNMGQSSNDTFPTAMHISTAMTARDVLL
PGLEKLHAALEVKIAQFDGIIKIGRTHTQDATPLTLSQEFSGYAHQVAMGIQRVKDALGRIYELAQGGTAVGTGLNTPVG
WDVMVAKNMADITGLPFVTAPNKFEALAAHDAMVEMSGALKVVAASLFKIANDIRLLGSGPRCGLGELVLPENEPGSSIM
PGKVNPTQCEALTQVCAHVFGNDAAVGFAGSQGHFELNVYKPMMSYNVLQSMQLLGDAASTFTDNLVDGLTADADRIERL
MRESLMLVTALAPEIGYDNATKVAKTAHKNGTTLKEEAIALGFVDAETFERVVRPENMIGPK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=65.7266811279826, Blast_Score=619, Evalue=1e-177,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=55.5555555555556, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=55.9652928416486, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.3947939262473, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=65.1612903225806, Blast_Score=621, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=66.1585365853659, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=64.4251626898048, Blast_Score=598, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=63.6363636363636, Blast_Score=606, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=63.6363636363636, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=60.6911447084233, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=58.6206896551724, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=50.8620689655172, Blast_Score=486, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49405; Mature: 49274

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTRTETDSFGPLEVPADKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKQACAQANV
CCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ELGKLDAARGEAIIQAASEVVAGKFDDNFPLVVWQTGSGTQSNMNANEVIANRAIEIMGG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
VIGTKDPVHPNDHCNMGQSSNDTFPTAMHISTAMTARDVLLPGLEKLHAALEVKIAQFDG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEHHHCC
IIKIGRTHTQDATPLTLSQEFSGYAHQVAMGIQRVKDALGRIYELAQGGTAVGTGLNTPV
EEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GWDVMVAKNMADITGLPFVTAPNKFEALAAHDAMVEMSGALKVVAASLFKIANDIRLLGS
CCEEEEECCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GPRCGLGELVLPENEPGSSIMPGKVNPTQCEALTQVCAHVFGNDAAVGFAGSQGHFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEE
YKPMMSYNVLQSMQLLGDAASTFTDNLVDGLTADADRIERLMRESLMLVTALAPEIGYDN
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ATKVAKTAHKNGTTLKEEAIALGFVDAETFERVVRPENMIGPK
HHHHHHHHCCCCCCHHHHHHEEEEECHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQTRTETDSFGPLEVPADKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKQACAQANV
CCCCCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ELGKLDAARGEAIIQAASEVVAGKFDDNFPLVVWQTGSGTQSNMNANEVIANRAIEIMGG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHC
VIGTKDPVHPNDHCNMGQSSNDTFPTAMHISTAMTARDVLLPGLEKLHAALEVKIAQFDG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEHHHCC
IIKIGRTHTQDATPLTLSQEFSGYAHQVAMGIQRVKDALGRIYELAQGGTAVGTGLNTPV
EEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GWDVMVAKNMADITGLPFVTAPNKFEALAAHDAMVEMSGALKVVAASLFKIANDIRLLGS
CCEEEEECCHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GPRCGLGELVLPENEPGSSIMPGKVNPTQCEALTQVCAHVFGNDAAVGFAGSQGHFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEE
YKPMMSYNVLQSMQLLGDAASTFTDNLVDGLTADADRIERLMRESLMLVTALAPEIGYDN
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ATKVAKTAHKNGTTLKEEAIALGFVDAETFERVVRPENMIGPK
HHHHHHHHCCCCCCHHHHHHEEEEECHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]