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The map label for this gene is purM

Identifier: 110679518

GI number: 110679518

Start: 2155570

End: 2156616

Strand: Direct

Name: purM

Synonym: RD1_2252

Alternate gene names: 110679518

Gene position: 2155570-2156616 (Clockwise)

Preceding gene: 110679517

Following gene: 110679519

Centisome position: 52.15

GC content: 60.84

Gene sequence:

>1047_bases
ATGAATTTGCCGAAAAACGGGATGACTTACGCCGATGCCGGTGTGGATATAGACGCTGGAAATGCGCTTGTGGACCGGAT
CAAACCGGCAGCCAAGCGCACCAACAGATCCGGCGTCATGGCGGGCTTGGGCGGTTTTGGTGCGCTGTTTGATCTGAAGG
ATGCAGGGTACACGGACCCTATTCTTGTGGCTGCCACGGACGGTGTCGGCACGAAACTGCGGATCGCCATTGATACCGGC
CATGTGGACGGTGTGGGAATTGACCTTGTGGCGATGTGTGTGAACGACCTCGTCTGCCAGGGGGCGGAGCCGTTATTTTT
TCTTGATTACTTTGCAACGGGTGCATTGGAAACCGACAAGGCTGCGCGCATTATCGAAGGCATCGCGTTGGGATGTGAGC
GTGCCGGTTGCGCCCTGATCGGCGGCGAGACAGCAGAGATGCCGGGCATGTATCCTGCCGGTGATTTTGATCTGGCGGGG
TTTTCTGTCGGCGCGATGGAGCGGGGCGCCGCACTTCCGGCGCATGTGGCGCAGGGCGACGTGTTGCTGGGCCTTGCCTC
TGATGGTGTGCATTCCAACGGCTACAGCCTTGTGCGCAAACTGGTCGAAGTCTCCGGGTTGTCGTGGGATGCGCCATGCC
CGTGGGCCGAACAGTCCCTGGGGGCGGAACTGCTGACCCCGACGCGGTTGTATGTAAAACAGGCGCTGGCGGCGATTGAT
GCAGGGGGCGTGCATGCGCTGGCGCATATCACCGGGGGTGGCTTGACGGAAAACCTGCCGCGCGTTTTGCCCGAGGGGCT
GGGGGCGGATATTGATCTGAGCACGTGGTCGCTGCCTGCGGTTTTCGGCTGGATGGCGCAGACGGGCGGCATGCAGGAAG
CTGAAATGCTCAAGACATTCAACTGCGGGATCGGCATGATCCTCGTCGTGGCGCAAGAAGAGGCCGACAAGCTGACACAG
TTGCTGGCCAGTCTGGGCGAGGATGTCGCGCGCATCGGACATGTCAGCGCGCGAGAGGGTGTGCGCTATTCCGGCACGCT
TTTGTGA

Upstream 100 bases:

>100_bases
TGTGCACGGCGTCAAGGGGCTGCGTGATCTGCTTTGGATTGCAGTTCGCTCAGATATGATTTACCCCGCCTTTAACCATG
CTCACGCAGGAGAGAGCGCC

Downstream 100 bases:

>100_bases
CAAAACGGGTCGCTATTTTCATTTCCGGCGGGGGGTCGAACATGATCCGCCTGCTGGACAGCATGACCGGGGATCATCCC
GCGCGCGTCTGCGTTGTCTT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNLPKNGMTYADAGVDIDAGNALVDRIKPAAKRTNRSGVMAGLGGFGALFDLKDAGYTDPILVAATDGVGTKLRIAIDTG
HVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGALETDKAARIIEGIALGCERAGCALIGGETAEMPGMYPAGDFDLAG
FSVGAMERGAALPAHVAQGDVLLGLASDGVHSNGYSLVRKLVEVSGLSWDAPCPWAEQSLGAELLTPTRLYVKQALAAID
AGGVHALAHITGGGLTENLPRVLPEGLGADIDLSTWSLPAVFGWMAQTGGMQEAEMLKTFNCGIGMILVVAQEEADKLTQ
LLASLGEDVARIGHVSAREGVRYSGTLL

Sequences:

>Translated_348_residues
MNLPKNGMTYADAGVDIDAGNALVDRIKPAAKRTNRSGVMAGLGGFGALFDLKDAGYTDPILVAATDGVGTKLRIAIDTG
HVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGALETDKAARIIEGIALGCERAGCALIGGETAEMPGMYPAGDFDLAG
FSVGAMERGAALPAHVAQGDVLLGLASDGVHSNGYSLVRKLVEVSGLSWDAPCPWAEQSLGAELLTPTRLYVKQALAAID
AGGVHALAHITGGGLTENLPRVLPEGLGADIDLSTWSLPAVFGWMAQTGGMQEAEMLKTFNCGIGMILVVAQEEADKLTQ
LLASLGEDVARIGHVSAREGVRYSGTLL
>Mature_348_residues
MNLPKNGMTYADAGVDIDAGNALVDRIKPAAKRTNRSGVMAGLGGFGALFDLKDAGYTDPILVAATDGVGTKLRIAIDTG
HVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGALETDKAARIIEGIALGCERAGCALIGGETAEMPGMYPAGDFDLAG
FSVGAMERGAALPAHVAQGDVLLGLASDGVHSNGYSLVRKLVEVSGLSWDAPCPWAEQSLGAELLTPTRLYVKQALAAID
AGGVHALAHITGGGLTENLPRVLPEGLGADIDLSTWSLPAVFGWMAQTGGMQEAEMLKTFNCGIGMILVVAQEEADKLTQ
LLASLGEDVARIGHVSAREGVRYSGTLL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=54.093567251462, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=54.093567251462, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=54.093567251462, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=55.0595238095238, Blast_Score=360, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=45.8333333333333, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321203, Length=340, Percent_Identity=54.1176470588235, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24582400, Length=296, Percent_Identity=43.5810810810811, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ROSDO (Q167K4)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682525.1
- ProteinModelPortal:   Q167K4
- SMR:   Q167K4
- STRING:   Q167K4
- GeneID:   4196483
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2252
- NMPDR:   fig|375451.6.peg.2101
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q167K4
- ProtClustDB:   PRK05385
- BioCyc:   RDEN375451:RD1_2252-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35957; Mature: 35957

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPKNGMTYADAGVDIDAGNALVDRIKPAAKRTNRSGVMAGLGGFGALFDLKDAGYTDP
CCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCCCEECCCCCHHEEECCCCCCCCC
ILVAATDGVGTKLRIAIDTGHVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGALETDK
EEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCHH
AARIIEGIALGCERAGCALIGGETAEMPGMYPAGDFDLAGFSVGAMERGAALPAHVAQGD
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHCCCCCCHHHCCCC
VLLGLASDGVHSNGYSLVRKLVEVSGLSWDAPCPWAEQSLGAELLTPTRLYVKQALAAID
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHCCHHHHHHHHHHHHHC
AGGVHALAHITGGGLTENLPRVLPEGLGADIDLSTWSLPAVFGWMAQTGGMQEAEMLKTF
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
NCGIGMILVVAQEEADKLTQLLASLGEDVARIGHVSAREGVRYSGTLL
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MNLPKNGMTYADAGVDIDAGNALVDRIKPAAKRTNRSGVMAGLGGFGALFDLKDAGYTDP
CCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCCCEECCCCCHHEEECCCCCCCCC
ILVAATDGVGTKLRIAIDTGHVDGVGIDLVAMCVNDLVCQGAEPLFFLDYFATGALETDK
EEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCHH
AARIIEGIALGCERAGCALIGGETAEMPGMYPAGDFDLAGFSVGAMERGAALPAHVAQGD
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHCCCCCCHHHCCCC
VLLGLASDGVHSNGYSLVRKLVEVSGLSWDAPCPWAEQSLGAELLTPTRLYVKQALAAID
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHCCHHHHHHHHHHHHHC
AGGVHALAHITGGGLTENLPRVLPEGLGADIDLSTWSLPAVFGWMAQTGGMQEAEMLKTF
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
NCGIGMILVVAQEEADKLTQLLASLGEDVARIGHVSAREGVRYSGTLL
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA