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The map label for this gene is mdtA [H]

Identifier: 110679478

GI number: 110679478

Start: 2108829

End: 2109968

Strand: Reverse

Name: mdtA [H]

Synonym: RD1_2207

Alternate gene names: 110679478

Gene position: 2109968-2108829 (Counterclockwise)

Preceding gene: 110679481

Following gene: 110679477

Centisome position: 51.05

GC content: 61.67

Gene sequence:

>1140_bases
ATGACCGGACCAACAAAGCAGACTTGGACAAGAAAGGTGTTGGGCACAACGGCGCGCATGATCCTGACCGTTAGTTTCAT
TGGGATCGCGGGTTTTGCTGTGGTCATGGGCGTAGGCCTTTTGAGCGACCGCGCGCGCGCTGTGCCGGAACCCGAAGCTG
CCCGCCCCCTGCCCGTTCATGTGCAGACGATCGAGATGAAGCAGGGCTATACCACCCCGCGCCACTTTACCGGTCAGATC
GAGGCGCGCGCAAATGTGTCCCTGTCCTTTGAATTGGGGGGGCGCATTGTCAGCCTGTCGGTCGATGAGGGCGACAGCGT
CGTGGCAGGGCAGGAAATTGCCCGCCTTGATACCGATCTGCTGGATGCAGAGGCAACCCGGCTCAGCGCGTCGCGGGGCG
CGGTTGCCGCACAACTCAGCTCCGCAGAGGCGCGTTTGACCCGCGCGATTGAGCTGCAACGACAAGGATTTACCAGTCAG
GCGCGGCTTGATGATGCACTGGCTGCGCGCGATGAATTGACCAACCGCATCGCCGAAATCGACGCCGCACTGAAATCGGT
ACAGATCAATCTTGAGAAATCGGTGATCTATGCGCCTTTTGACGGGCAGGTCGGGATGCAGAACGTGGATGCTGCAGAAA
CCATTCAGGCCGGGCAACCCATCGTGCGGATCATGGAAACCTCCGCGCCGGAACTGCGGGTCGGCTTGCCGCTCGATATC
GCTGCGGATGACCTCAGGTCGGTGGAGATCTCCCTTGGTGGCACGCTCCACCCTGCAAAACTGTCGCGCATCCGGCCTGA
TATCGACCCGATCACCCGAACCCGCACCGCCCTGTTTTCGCTGGAGAAACCGGGAAACCTGCTGTTCGGGCAAAGCGCAT
CCCTCGTCCTGCGCTCGGACATCAAGGCGCAGGGTGCCTGGGTGCCAGTTGATGCGCTGCAATCCGGTGAAGGCAGCGTC
TGGACGCTGATGCTGGTGGTCGAGGACAGGCTGCAACCCGCAGCCGTGGAAATCCTTCATATCGAAGACCAGCGCGCCTA
TGTGCGCGGCACCTTTGAGCAGGGCAGCGTTTTCGTCACCACAGGCGCGCACCGCGTGGTGCCCGGTCAGAGCGTCAGCG
TTCTGACGCAGGAGGGCTGA

Upstream 100 bases:

>100_bases
TACTCTCTTCCATAATCCATTCTGTTTCAGAATACGTAACCCTTGTCAAAGTAAGAAGTTCTAACATATGTTAGAGGTGC
TAACTTGAGTGAGAGTTGAG

Downstream 100 bases:

>100_bases
CGCGTGGAAACGCTGACCTTTCGCCACCCCCGGCTTGTCGCGCTGATCATTCTGGTCCTTGTCTCGGCGGGGTTGTCCTC
CTTCCTGTCGCTGGGCCGTC

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTGPTKQTWTRKVLGTTARMILTVSFIGIAGFAVVMGVGLLSDRARAVPEPEAARPLPVHVQTIEMKQGYTTPRHFTGQI
EARANVSLSFELGGRIVSLSVDEGDSVVAGQEIARLDTDLLDAEATRLSASRGAVAAQLSSAEARLTRAIELQRQGFTSQ
ARLDDALAARDELTNRIAEIDAALKSVQINLEKSVIYAPFDGQVGMQNVDAAETIQAGQPIVRIMETSAPELRVGLPLDI
AADDLRSVEISLGGTLHPAKLSRIRPDIDPITRTRTALFSLEKPGNLLFGQSASLVLRSDIKAQGAWVPVDALQSGEGSV
WTLMLVVEDRLQPAAVEILHIEDQRAYVRGTFEQGSVFVTTGAHRVVPGQSVSVLTQEG

Sequences:

>Translated_379_residues
MTGPTKQTWTRKVLGTTARMILTVSFIGIAGFAVVMGVGLLSDRARAVPEPEAARPLPVHVQTIEMKQGYTTPRHFTGQI
EARANVSLSFELGGRIVSLSVDEGDSVVAGQEIARLDTDLLDAEATRLSASRGAVAAQLSSAEARLTRAIELQRQGFTSQ
ARLDDALAARDELTNRIAEIDAALKSVQINLEKSVIYAPFDGQVGMQNVDAAETIQAGQPIVRIMETSAPELRVGLPLDI
AADDLRSVEISLGGTLHPAKLSRIRPDIDPITRTRTALFSLEKPGNLLFGQSASLVLRSDIKAQGAWVPVDALQSGEGSV
WTLMLVVEDRLQPAAVEILHIEDQRAYVRGTFEQGSVFVTTGAHRVVPGQSVSVLTQEG
>Mature_378_residues
TGPTKQTWTRKVLGTTARMILTVSFIGIAGFAVVMGVGLLSDRARAVPEPEAARPLPVHVQTIEMKQGYTTPRHFTGQIE
ARANVSLSFELGGRIVSLSVDEGDSVVAGQEIARLDTDLLDAEATRLSASRGAVAAQLSSAEARLTRAIELQRQGFTSQA
RLDDALAARDELTNRIAEIDAALKSVQINLEKSVIYAPFDGQVGMQNVDAAETIQAGQPIVRIMETSAPELRVGLPLDIA
ADDLRSVEISLGGTLHPAKLSRIRPDIDPITRTRTALFSLEKPGNLLFGQSASLVLRSDIKAQGAWVPVDALQSGEGSVW
TLMLVVEDRLQPAAVEILHIEDQRAYVRGTFEQGSVFVTTGAHRVVPGQSVSVLTQEG

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=325, Percent_Identity=25.8461538461538, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40659; Mature: 40528

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPTKQTWTRKVLGTTARMILTVSFIGIAGFAVVMGVGLLSDRARAVPEPEAARPLPVH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEE
VQTIEMKQGYTTPRHFTGQIEARANVSLSFELGGRIVSLSVDEGDSVVAGQEIARLDTDL
EEEEEECCCCCCCCCCCEEEEEEEEEEEEEEECCEEEEEEECCCCCEECCHHHHHHHHHH
LDAEATRLSASRGAVAAQLSSAEARLTRAIELQRQGFTSQARLDDALAARDELTNRIAEI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DAALKSVQINLEKSVIYAPFDGQVGMQNVDAAETIQAGQPIVRIMETSAPELRVGLPLDI
HHHHHHEEEEEECEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCC
AADDLRSVEISLGGTLHPAKLSRIRPDIDPITRTRTALFSLEKPGNLLFGQSASLVLRSD
CCCCCEEEEEEECCEECHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEECCCCCEEEEEC
IKAQGAWVPVDALQSGEGSVWTLMLVVEDRLQPAAVEILHIEDQRAYVRGTFEQGSVFVT
CCCCCCEEEHHHHCCCCCCEEEEEEEEECCCCCCEEEEEEEECCCEEEEEEECCCCEEEE
TGAHRVVPGQSVSVLTQEG
ECCEEECCCCCEEEEECCC
>Mature Secondary Structure 
TGPTKQTWTRKVLGTTARMILTVSFIGIAGFAVVMGVGLLSDRARAVPEPEAARPLPVH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEE
VQTIEMKQGYTTPRHFTGQIEARANVSLSFELGGRIVSLSVDEGDSVVAGQEIARLDTDL
EEEEEECCCCCCCCCCCEEEEEEEEEEEEEEECCEEEEEEECCCCCEECCHHHHHHHHHH
LDAEATRLSASRGAVAAQLSSAEARLTRAIELQRQGFTSQARLDDALAARDELTNRIAEI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DAALKSVQINLEKSVIYAPFDGQVGMQNVDAAETIQAGQPIVRIMETSAPELRVGLPLDI
HHHHHHEEEEEECEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCC
AADDLRSVEISLGGTLHPAKLSRIRPDIDPITRTRTALFSLEKPGNLLFGQSASLVLRSD
CCCCCEEEEEEECCEECHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEECCCCCEEEEEC
IKAQGAWVPVDALQSGEGSVWTLMLVVEDRLQPAAVEILHIEDQRAYVRGTFEQGSVFVT
CCCCCCEEEHHHHCCCCCCEEEEEEEEECCCCCCEEEEEEEECCCEEEEEEECCCCEEEE
TGAHRVVPGQSVSVLTQEG
ECCEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA