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The map label for this gene is gbd [H]

Identifier: 110679445

GI number: 110679445

Start: 2067645

End: 2068790

Strand: Reverse

Name: gbd [H]

Synonym: RD1_2171

Alternate gene names: 110679445

Gene position: 2068790-2067645 (Counterclockwise)

Preceding gene: 110679446

Following gene: 110679443

Centisome position: 50.05

GC content: 60.3

Gene sequence:

>1146_bases
ATGACCCTTTCAGCAAACTGGTCCTATCCCACCGCCATCCGTTTCGGTGCCGGCCGTATTTCAGAGATCGGGGAAGCCTG
CGCGGCTGCCGGGATCAAAAAACCCCTGTTGATCACCGACCGTGGGCTTGCAGGGATGGATATCACCACCCGCACGCTTG
ACCTGATGGCAGCGGCGGGCCTTGGCCGTGCGATCTTTGCCGATGTGGACCCGAACCCCAACGAAAAGAACGCCGCCGCT
GGTGTTCAGGCCTTCAAAGCGGGCGGATATGACGGTGTGATTGCCTTTGGCGGCGGCTCCGGCCTTGATCTGGGCAAGCT
GGTGGCCTTTCTGGCAGGCCAGACCCGACCGCTGTGGGATTTCGAGGACATCGGCGATTACTGGACGCGCGCGGATGCCG
ATGCCATCGCGCCAATCGTGGCCGTGCCCACCACCGCCGGGACCGGTTCAGAGGTCGGTCGCGCCTCCGTCATCACCAAT
TCTGAGACCGAAGAGAAAAAGATCATATTCCATCCGAAATTCCTGCCCAGCGTCGTGATCTGCGATCCCGAACTGACAGT
CGGCATGCCAAAATTCATCACGGCAGGCACCGGGCTTGATGCCTTTGCCCATTGTGTCGAGGCATTCTGCTCACCGCATT
ACCACCCCATGTCGCAGGGCATTGCGCTTGAGGGCATGCGACTGGTCAAGGACTACCTGCCACGCGCCTATGCCGACGGC
AGCGATCTGGAGGCGCGCGCGCATATGATGTCCGCAGCTGCCATGGGGGCAACGGCGTTCCAAAAAGGGCTTGGGGCGAT
CCATGCCTTGTCCCACCCGATTGGCGCGATCCATCATACGCACCACGGCACCACCAATGCCGTCTGCATGCCGGCGGTCT
TGCAGTTCAACAAATCCGCCATTGCCGCCCCCCTTGGCAACGCCGCGGCTTATCTGGGCATCGAGGGTGGTTTTGACGGC
TTCTGTGCCTTCGTGGATGATCTGAATGCAACACTGGGCATCCCCAAGACACTGACAGAGCTTGGCGTCACTTCACCTGA
TATCGACCGGATCGTCGCAGGAGCACTCAATGATCCAAGCACGGGCGGGAACCCGGTTGAGATGACCAAATCCAACACCA
CCGCGCTGCTGGAAGGACTGTTTTAA

Upstream 100 bases:

>100_bases
ACCGGATGCAAAGACACCGGGCGCGGAGGTGGTCTGTCGCTGATCGGCTATCACAACCTGACGCGCCCCAAATCCTACCA
CTTCAAGAAGGCCTGAGCCC

Downstream 100 bases:

>100_bases
AGCGTCATGCGAAAATCTTGCATCACGTAACGCTGCCTGAAGTCAAAGGTTTCAACGCGTTGCGTGACACTTGATGTTTC
AGATGTTTCGTTGGACGCTC

Product: NAD-dependent 4-hydroxybutyrate dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTLSANWSYPTAIRFGAGRISEIGEACAAAGIKKPLLITDRGLAGMDITTRTLDLMAAAGLGRAIFADVDPNPNEKNAAA
GVQAFKAGGYDGVIAFGGGSGLDLGKLVAFLAGQTRPLWDFEDIGDYWTRADADAIAPIVAVPTTAGTGSEVGRASVITN
SETEEKKIIFHPKFLPSVVICDPELTVGMPKFITAGTGLDAFAHCVEAFCSPHYHPMSQGIALEGMRLVKDYLPRAYADG
SDLEARAHMMSAAAMGATAFQKGLGAIHALSHPIGAIHHTHHGTTNAVCMPAVLQFNKSAIAAPLGNAAAYLGIEGGFDG
FCAFVDDLNATLGIPKTLTELGVTSPDIDRIVAGALNDPSTGGNPVEMTKSNTTALLEGLF

Sequences:

>Translated_381_residues
MTLSANWSYPTAIRFGAGRISEIGEACAAAGIKKPLLITDRGLAGMDITTRTLDLMAAAGLGRAIFADVDPNPNEKNAAA
GVQAFKAGGYDGVIAFGGGSGLDLGKLVAFLAGQTRPLWDFEDIGDYWTRADADAIAPIVAVPTTAGTGSEVGRASVITN
SETEEKKIIFHPKFLPSVVICDPELTVGMPKFITAGTGLDAFAHCVEAFCSPHYHPMSQGIALEGMRLVKDYLPRAYADG
SDLEARAHMMSAAAMGATAFQKGLGAIHALSHPIGAIHHTHHGTTNAVCMPAVLQFNKSAIAAPLGNAAAYLGIEGGFDG
FCAFVDDLNATLGIPKTLTELGVTSPDIDRIVAGALNDPSTGGNPVEMTKSNTTALLEGLF
>Mature_380_residues
TLSANWSYPTAIRFGAGRISEIGEACAAAGIKKPLLITDRGLAGMDITTRTLDLMAAAGLGRAIFADVDPNPNEKNAAAG
VQAFKAGGYDGVIAFGGGSGLDLGKLVAFLAGQTRPLWDFEDIGDYWTRADADAIAPIVAVPTTAGTGSEVGRASVITNS
ETEEKKIIFHPKFLPSVVICDPELTVGMPKFITAGTGLDAFAHCVEAFCSPHYHPMSQGIALEGMRLVKDYLPRAYADGS
DLEARAHMMSAAAMGATAFQKGLGAIHALSHPIGAIHHTHHGTTNAVCMPAVLQFNKSAIAAPLGNAAAYLGIEGGFDGF
CAFVDDLNATLGIPKTLTELGVTSPDIDRIVAGALNDPSTGGNPVEMTKSNTTALLEGLF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=417, Percent_Identity=26.1390887290168, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=29.9212598425197, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1789163, Length=371, Percent_Identity=30.9973045822102, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87082107, Length=365, Percent_Identity=31.7808219178082, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1787493, Length=392, Percent_Identity=30.1020408163265, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789386, Length=361, Percent_Identity=27.4238227146814, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=289, Percent_Identity=29.0657439446367, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=371, Percent_Identity=33.9622641509434, Blast_Score=215, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24657991, Length=413, Percent_Identity=25.6658595641646, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 39500; Mature: 39369

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSANWSYPTAIRFGAGRISEIGEACAAAGIKKPLLITDRGLAGMDITTRTLDLMAAAG
CEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHC
LGRAIFADVDPNPNEKNAAAGVQAFKAGGYDGVIAFGGGSGLDLGKLVAFLAGQTRPLWD
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
FEDIGDYWTRADADAIAPIVAVPTTAGTGSEVGRASVITNSETEEKKIIFHPKFLPSVVI
HHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCEEEE
CDPELTVGMPKFITAGTGLDAFAHCVEAFCSPHYHPMSQGIALEGMRLVKDYLPRAYADG
ECCCCCCCCCHHEECCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCHHCCCC
SDLEARAHMMSAAAMGATAFQKGLGAIHALSHPIGAIHHTHHGTTNAVCMPAVLQFNKSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHCCHH
IAAPLGNAAAYLGIEGGFDGFCAFVDDLNATLGIPKTLTELGVTSPDIDRIVAGALNDPS
HHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCC
TGGNPVEMTKSNTTALLEGLF
CCCCCEEEECCCHHHHHHCCC
>Mature Secondary Structure 
TLSANWSYPTAIRFGAGRISEIGEACAAAGIKKPLLITDRGLAGMDITTRTLDLMAAAG
EECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHC
LGRAIFADVDPNPNEKNAAAGVQAFKAGGYDGVIAFGGGSGLDLGKLVAFLAGQTRPLWD
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
FEDIGDYWTRADADAIAPIVAVPTTAGTGSEVGRASVITNSETEEKKIIFHPKFLPSVVI
HHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCEEEE
CDPELTVGMPKFITAGTGLDAFAHCVEAFCSPHYHPMSQGIALEGMRLVKDYLPRAYADG
ECCCCCCCCCHHEECCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCHHCCCC
SDLEARAHMMSAAAMGATAFQKGLGAIHALSHPIGAIHHTHHGTTNAVCMPAVLQFNKSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHCCHH
IAAPLGNAAAYLGIEGGFDGFCAFVDDLNATLGIPKTLTELGVTSPDIDRIVAGALNDPS
HHCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCC
TGGNPVEMTKSNTTALLEGLF
CCCCCEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]