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The map label for this gene is thrC [H]

Identifier: 110679416

GI number: 110679416

Start: 2038965

End: 2040347

Strand: Direct

Name: thrC [H]

Synonym: RD1_2141

Alternate gene names: 110679416

Gene position: 2038965-2040347 (Clockwise)

Preceding gene: 110679415

Following gene: 110679417

Centisome position: 49.33

GC content: 60.59

Gene sequence:

>1383_bases
ATGCAGTATATCTCGACCCGTGGCACGGCCCCTGTGCTGAATTTCGAAGAGGCGATGTTGAGCGGCCTTGCCCGTGACGG
CGGCCTCTATGTGCCCCAGACGATCCCGCAGCTGTCGGCCGAAGCCATCAGCGCGATGGAGGGTCAGCCTTATGAGGAGA
TCGCCTACAGGGTGATGCGCCCCTTTGTCGGGGAGGTGTTCACGGACACGGAGTTCCGCGAGATCATCGCGCGCGCTTAT
GCGGTCTTTGGCCATGATGCACGCGCGCCCTTGAAACAGCTGGATCAGGGTCATTTCCTGCTGGAGCTGTTTCACGGGCC
GACGCTGGCCTTCAAGGATTTTGCGATGCAGTTGATCGGTCAGATGTTCCAGACCGCATTGGGGCGCAAGAACGAACGCG
TGACGATTGTGGGGGCCACATCCGGTGACACCGGCTCCGCTGCAATCGAGGCCTTCCGGGGTCTGAGCAACGTGGATGTG
TTCATCATGTATCCCCATGGCCGCATTTCAGAGGTCCAGCGCCGCCAGATGACTACACCGGGCGAAAGCAATGTGCATGC
GCTCGCCGTGGATGGTGATTTTGACGACTGTCAGGCGCGTCTGAAGGACATGTTCAATGATTTCGAATTCCGCGATACCG
TGCGCCTTGCCGGGGTGAATTCGATCAACTGGGGCCGGGTGCTTGCGCAGGTGGTCTATTACTTTTCAGCCGCCGTTGCG
CTTGGCGCGCCGCACCGCCAGATCAGCTTTACCGTGCCCACCGGAAATTTCGGGGACGTCTTTGCCGGCTATATCGCCAA
GCGGATGGGCTTGCCGATTGACAAGCTGGTGGTGGCCACCAATCAGAACGATATTCTGCACCGGTGCTTGAGCGGGCAGG
GCTATCACAAGGGCGAAACCGTGCCCTCGATCAGCCCGTCGATGGACATTCAGGTCAGTTCAAACTTTGAACGCGCGCTC
TTTGACGCCTATGACCGTGAGGCACCCGCCATCGTCCAGCTGATGGATGAGTTGAAGGCCGGCGGCTTTGACGTCAGCCA
GGGAGCGATGCAGGTCCTGCAATCGCATTATGCGTCCGGTCGCGCCTCCGAAGAGGAAACGTCGGCGACCATCACGCGCG
CGCTGAAACACAGCGGAGAGTTGCTGTGCCCGCATTCTGCCATTGGCGTCAAGGTCGCCGAAGAGCAGCGCGTAATCGGC
ACGCCCATGGTCACGCTGGCAACCGCCCATCCGGCCAAATTCCCCGCAGCCGTCGAGGCGGCATCCGGCGTACACCCGCC
CTTGCCTGCGCGCATGGCGGACCTGTATGACCGCACCGAAAGGGTGACTCGCGTGCCAAACGATCTGGCCGCCCTCAAAG
ACCACATAAAAGGGCACATCTGA

Upstream 100 bases:

>100_bases
TGCAATATGCGGTAACGTGGTTTTCCCTTGCGGCAATCTGGTCCCTGATGACTTTCTTCTTTCTCCGCCGGAAATCCGGC
GCAATCAAAAGCTGAACGAT

Downstream 100 bases:

>100_bases
GCGTGACATTGAACCAACACCGCCTGCCGAATGGCTTTCGCATTGTAACGGAACATATGCCGGGGCTTGCCTCTGCCTCG
ATCGGCGTCTGGGTCACGGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MQYISTRGTAPVLNFEEAMLSGLARDGGLYVPQTIPQLSAEAISAMEGQPYEEIAYRVMRPFVGEVFTDTEFREIIARAY
AVFGHDARAPLKQLDQGHFLLELFHGPTLAFKDFAMQLIGQMFQTALGRKNERVTIVGATSGDTGSAAIEAFRGLSNVDV
FIMYPHGRISEVQRRQMTTPGESNVHALAVDGDFDDCQARLKDMFNDFEFRDTVRLAGVNSINWGRVLAQVVYYFSAAVA
LGAPHRQISFTVPTGNFGDVFAGYIAKRMGLPIDKLVVATNQNDILHRCLSGQGYHKGETVPSISPSMDIQVSSNFERAL
FDAYDREAPAIVQLMDELKAGGFDVSQGAMQVLQSHYASGRASEEETSATITRALKHSGELLCPHSAIGVKVAEEQRVIG
TPMVTLATAHPAKFPAAVEAASGVHPPLPARMADLYDRTERVTRVPNDLAALKDHIKGHI

Sequences:

>Translated_460_residues
MQYISTRGTAPVLNFEEAMLSGLARDGGLYVPQTIPQLSAEAISAMEGQPYEEIAYRVMRPFVGEVFTDTEFREIIARAY
AVFGHDARAPLKQLDQGHFLLELFHGPTLAFKDFAMQLIGQMFQTALGRKNERVTIVGATSGDTGSAAIEAFRGLSNVDV
FIMYPHGRISEVQRRQMTTPGESNVHALAVDGDFDDCQARLKDMFNDFEFRDTVRLAGVNSINWGRVLAQVVYYFSAAVA
LGAPHRQISFTVPTGNFGDVFAGYIAKRMGLPIDKLVVATNQNDILHRCLSGQGYHKGETVPSISPSMDIQVSSNFERAL
FDAYDREAPAIVQLMDELKAGGFDVSQGAMQVLQSHYASGRASEEETSATITRALKHSGELLCPHSAIGVKVAEEQRVIG
TPMVTLATAHPAKFPAAVEAASGVHPPLPARMADLYDRTERVTRVPNDLAALKDHIKGHI
>Mature_460_residues
MQYISTRGTAPVLNFEEAMLSGLARDGGLYVPQTIPQLSAEAISAMEGQPYEEIAYRVMRPFVGEVFTDTEFREIIARAY
AVFGHDARAPLKQLDQGHFLLELFHGPTLAFKDFAMQLIGQMFQTALGRKNERVTIVGATSGDTGSAAIEAFRGLSNVDV
FIMYPHGRISEVQRRQMTTPGESNVHALAVDGDFDDCQARLKDMFNDFEFRDTVRLAGVNSINWGRVLAQVVYYFSAAVA
LGAPHRQISFTVPTGNFGDVFAGYIAKRMGLPIDKLVVATNQNDILHRCLSGQGYHKGETVPSISPSMDIQVSSNFERAL
FDAYDREAPAIVQLMDELKAGGFDVSQGAMQVLQSHYASGRASEEETSATITRALKHSGELLCPHSAIGVKVAEEQRVIG
TPMVTLATAHPAKFPAAVEAASGVHPPLPARMADLYDRTERVTRVPNDLAALKDHIKGHI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=471, Percent_Identity=36.9426751592357, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI153792148, Length=509, Percent_Identity=32.6129666011788, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1786185, Length=448, Percent_Identity=35.7142857142857, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=43.1072210065646, Blast_Score=347, Evalue=2e-96,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50275; Mature: 50275

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYISTRGTAPVLNFEEAMLSGLARDGGLYVPQTIPQLSAEAISAMEGQPYEEIAYRVMR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
PFVGEVFTDTEFREIIARAYAVFGHDARAPLKQLDQGHFLLELFHGPTLAFKDFAMQLIG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
QMFQTALGRKNERVTIVGATSGDTGSAAIEAFRGLSNVDVFIMYPHGRISEVQRRQMTTP
HHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCC
GESNVHALAVDGDFDDCQARLKDMFNDFEFRDTVRLAGVNSINWGRVLAQVVYYFSAAVA
CCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
LGAPHRQISFTVPTGNFGDVFAGYIAKRMGLPIDKLVVATNQNDILHRCLSGQGYHKGET
HCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCHHHHHHHHCCCCCCCCCC
VPSISPSMDIQVSSNFERALFDAYDREAPAIVQLMDELKAGGFDVSQGAMQVLQSHYASG
CCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
RASEEETSATITRALKHSGELLCPHSAIGVKVAEEQRVIGTPMVTLATAHPAKFPAAVEA
CCCCHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCHHCCCCEEEEECCCCCCCCHHHHH
ASGVHPPLPARMADLYDRTERVTRVPNDLAALKDHIKGHI
HCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MQYISTRGTAPVLNFEEAMLSGLARDGGLYVPQTIPQLSAEAISAMEGQPYEEIAYRVMR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
PFVGEVFTDTEFREIIARAYAVFGHDARAPLKQLDQGHFLLELFHGPTLAFKDFAMQLIG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
QMFQTALGRKNERVTIVGATSGDTGSAAIEAFRGLSNVDVFIMYPHGRISEVQRRQMTTP
HHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCC
GESNVHALAVDGDFDDCQARLKDMFNDFEFRDTVRLAGVNSINWGRVLAQVVYYFSAAVA
CCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
LGAPHRQISFTVPTGNFGDVFAGYIAKRMGLPIDKLVVATNQNDILHRCLSGQGYHKGET
HCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCHHHHHHHHCCCCCCCCCC
VPSISPSMDIQVSSNFERALFDAYDREAPAIVQLMDELKAGGFDVSQGAMQVLQSHYASG
CCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
RASEEETSATITRALKHSGELLCPHSAIGVKVAEEQRVIGTPMVTLATAHPAKFPAAVEA
CCCCHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCHHCCCCEEEEECCCCCCCCHHHHH
ASGVHPPLPARMADLYDRTERVTRVPNDLAALKDHIKGHI
HCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]