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The map label for this gene is parE [H]

Identifier: 110679338

GI number: 110679338

Start: 1962765

End: 1964813

Strand: Reverse

Name: parE [H]

Synonym: RD1_2057

Alternate gene names: 110679338

Gene position: 1964813-1962765 (Counterclockwise)

Preceding gene: 110679339

Following gene: 110679337

Centisome position: 47.54

GC content: 60.66

Gene sequence:

>2049_bases
GTGACGGCATGCGCGCGGCGACACGGTCTTTTCCCCAAGCGGCGCCTCTGCCATACTCATGGTCAAACCAACACAAAAAA
GAGCAGCGGTATGAATGACCTTCTTTCCTCGGGGACCGAGGCCACAGATTATGATGCGTCTTCCATTGAGGTGCTCGAGG
GTCTCGAACCCGTACGCAAGCGCCCCGGCATGTATATCGGCGGCACGGATGAACGCGCGTTGCACCATCTGGTGGCCGAA
GTGCTCGACAACTCGATGGATGAGGCCGTCGCCGGTCACGCCACAAGGATCGAGGTCGAGTTGCACGAGGATTACGCCAT
CACCATCCGCGACAATGGCCGTGGCATCCCCATCGACCCGCACCCGAAATTCCCCGACAAATCCGCACTTGAGGTGATCC
TTTGCACGCTGCATGCGGGGGGTAAATTTTCCGGCAAGGCTTACGAGACATCGGGCGGTTTGCACGGCGTCGGGGCTTCG
GTGGTGAATGCGCTCAGCGACAGTATGGTGGTGCAGGTCGCGCGCAACAAACAACTCTTTGAGCAACGGTTTTCGCGCGG
CGTGCCGCTTGGCCCCGTGCAGGAACTGGGCCCGACGCAGAACCGGCGCGGCACGACGGTGACCTTCCATGCGGATGCCG
AAATCTTCGGCGCACACCGCTTCAAACCTGCGCGGCTGTTCAATTCCATCCGCTCCAAGGCCTATCTGTTTTCCGGCGTC
GAAATCCGCTGGAAATCTGCCATCGCGGATGGCGACACCCCGCAGGAGGCGACGTTCCACTTCCCCGGGGGCCTGTCGGA
TTATCTGCGCGAAACCCTCGGGACTGCTACCACCTATGCCGACAACCCCTTTGCCGGGTCCGTTGATTTCAAAGAGAAAT
TCGGCGAACCGGGCAAGGTTGAATGGGCCATCAACTGGACACCCTCACGCGATGGGTTCATCCAGTCCTACTGCAACACC
GTCCCCACGCCCGAAGGGGGCACCCATGTGGCCGGGTTCTGGGCTGCGATCCTCAAGGGTATCAAGGCCTATGGTGAGTT
GTCCAACACCAAGAAGGCCGCGCAGATCACGCGTGAAGACCTGACATCCGGCGGCTGCGCGCTGGTGTCCTGCTTCATTG
CCGAACCCGCCTTTGTCGGGCAGACCAAGGACCGTTTGTCCACTGAAGCCGCCGCGAAAATGACCGAAGGGGCCGTGCGC
GATCATTTTGATAACTGGTTGGCGGCGGATACGAAATCCGCCGGGGCGATCCTCGATTTTCTGGTGCTGCGCGCCGAAGA
ACGCCTGCGTCGCCGTCAGGAAAAGGAAACCGCGCGCAAATCGGCCACCAAGAAACTGCGCCTGCCCGGCAAGCTGACCG
ACTGCACTTCAAAGGATCGCGCCGGCACGGAACTGTTCATCGTGGAGGGCGACAGCGCCGGCGGCTCCGGCAAGGGTGCG
CGCAACCGCAACACGCAGGCGCTCCTGCCGCTCAAGGGCAAGATCCTGAACGTGCTGGGGGCGGCGTCGTCAAAACTGGG
CACCAACGCCGAAATCTCGGACCTGTGCGAAGCGCTTGGCTGTGGCATGGGCACCAAATTCAACCTCGATGATCTGCGCT
ATGAAAAGATCATCATCATGACCGACGCGGATGTGGATGGCGCCCATATCGCGGCCCTGCTGATGACGTTCTTCTACACC
CAGATGCGGCCGCTGATCGACGCGGGCCACCTCTATCTGGCCTGCCCGCCCCTGTTCCGGCTGACTCAAGGGGCCAAACG
CGTCTACTGCCTGACGGAGGAGGAAAAGAACGACTGGCTGGAAAAAGGTCTGGGCGGCAAGGGCAAGATCGACGTCTCGC
GCTTCAAGGGCCTGGGCGAAATGGACGCCAAGGACCTCAAGGAAACCACTATGGACCCCACGACCCGCAAACTCATCCGC
GTGTCAATCGACGAGGACGTACCGGGCGAGACGGGCGATCTGGTGGAGCGTTTGATGGGCAAGAAACCCGAACTGCGCTT
CCAGTATATTCAGGAAAACGCGAAGTTTGTGGAGGAGTTGGATGTTTGA

Upstream 100 bases:

>100_bases
TGACGGATCACCTTGATCCTGCGCGATGGCCGCACACACCGCGGCGCTGTGTGCACAGCGCGAAGGGGCAGACCCGCCGC
CTGCGACAGCTTTTTGCGCT

Downstream 100 bases:

>100_bases
AGCCAGAAAAATTAGAAGATCCCGAGCTATGTCGGCGCGTCAAACGCTTAGATAAAGTTGTCGGGCAGCTTGAAAAGCGC
TTTTCGTCAGCACTTTATGA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 682; Mature: 681

Protein sequence:

>682_residues
MTACARRHGLFPKRRLCHTHGQTNTKKSSGMNDLLSSGTEATDYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAE
VLDNSMDEAVAGHATRIEVELHEDYAITIRDNGRGIPIDPHPKFPDKSALEVILCTLHAGGKFSGKAYETSGGLHGVGAS
VVNALSDSMVVQVARNKQLFEQRFSRGVPLGPVQELGPTQNRRGTTVTFHADAEIFGAHRFKPARLFNSIRSKAYLFSGV
EIRWKSAIADGDTPQEATFHFPGGLSDYLRETLGTATTYADNPFAGSVDFKEKFGEPGKVEWAINWTPSRDGFIQSYCNT
VPTPEGGTHVAGFWAAILKGIKAYGELSNTKKAAQITREDLTSGGCALVSCFIAEPAFVGQTKDRLSTEAAAKMTEGAVR
DHFDNWLAADTKSAGAILDFLVLRAEERLRRRQEKETARKSATKKLRLPGKLTDCTSKDRAGTELFIVEGDSAGGSGKGA
RNRNTQALLPLKGKILNVLGAASSKLGTNAEISDLCEALGCGMGTKFNLDDLRYEKIIIMTDADVDGAHIAALLMTFFYT
QMRPLIDAGHLYLACPPLFRLTQGAKRVYCLTEEEKNDWLEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPTTRKLIR
VSIDEDVPGETGDLVERLMGKKPELRFQYIQENAKFVEELDV

Sequences:

>Translated_682_residues
MTACARRHGLFPKRRLCHTHGQTNTKKSSGMNDLLSSGTEATDYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAE
VLDNSMDEAVAGHATRIEVELHEDYAITIRDNGRGIPIDPHPKFPDKSALEVILCTLHAGGKFSGKAYETSGGLHGVGAS
VVNALSDSMVVQVARNKQLFEQRFSRGVPLGPVQELGPTQNRRGTTVTFHADAEIFGAHRFKPARLFNSIRSKAYLFSGV
EIRWKSAIADGDTPQEATFHFPGGLSDYLRETLGTATTYADNPFAGSVDFKEKFGEPGKVEWAINWTPSRDGFIQSYCNT
VPTPEGGTHVAGFWAAILKGIKAYGELSNTKKAAQITREDLTSGGCALVSCFIAEPAFVGQTKDRLSTEAAAKMTEGAVR
DHFDNWLAADTKSAGAILDFLVLRAEERLRRRQEKETARKSATKKLRLPGKLTDCTSKDRAGTELFIVEGDSAGGSGKGA
RNRNTQALLPLKGKILNVLGAASSKLGTNAEISDLCEALGCGMGTKFNLDDLRYEKIIIMTDADVDGAHIAALLMTFFYT
QMRPLIDAGHLYLACPPLFRLTQGAKRVYCLTEEEKNDWLEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPTTRKLIR
VSIDEDVPGETGDLVERLMGKKPELRFQYIQENAKFVEELDV
>Mature_681_residues
TACARRHGLFPKRRLCHTHGQTNTKKSSGMNDLLSSGTEATDYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEV
LDNSMDEAVAGHATRIEVELHEDYAITIRDNGRGIPIDPHPKFPDKSALEVILCTLHAGGKFSGKAYETSGGLHGVGASV
VNALSDSMVVQVARNKQLFEQRFSRGVPLGPVQELGPTQNRRGTTVTFHADAEIFGAHRFKPARLFNSIRSKAYLFSGVE
IRWKSAIADGDTPQEATFHFPGGLSDYLRETLGTATTYADNPFAGSVDFKEKFGEPGKVEWAINWTPSRDGFIQSYCNTV
PTPEGGTHVAGFWAAILKGIKAYGELSNTKKAAQITREDLTSGGCALVSCFIAEPAFVGQTKDRLSTEAAAKMTEGAVRD
HFDNWLAADTKSAGAILDFLVLRAEERLRRRQEKETARKSATKKLRLPGKLTDCTSKDRAGTELFIVEGDSAGGSGKGAR
NRNTQALLPLKGKILNVLGAASSKLGTNAEISDLCEALGCGMGTKFNLDDLRYEKIIIMTDADVDGAHIAALLMTFFYTQ
MRPLIDAGHLYLACPPLFRLTQGAKRVYCLTEEEKNDWLEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPTTRKLIRV
SIDEDVPGETGDLVERLMGKKPELRFQYIQENAKFVEELDV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=577, Percent_Identity=25.4766031195841, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI19913408, Length=588, Percent_Identity=24.6598639455782, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1789408, Length=639, Percent_Identity=42.7230046948357, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI48994957, Length=568, Percent_Identity=41.9014084507042, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI212645845, Length=604, Percent_Identity=25, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17535065, Length=594, Percent_Identity=24.2424242424242, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212645657, Length=203, Percent_Identity=27.0935960591133, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=626, Percent_Identity=24.9201277955272, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17136538, Length=581, Percent_Identity=24.4406196213425, Blast_Score=141, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.3

Molecular weight: Translated: 74554; Mature: 74423

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTACARRHGLFPKRRLCHTHGQTNTKKSSGMNDLLSSGTEATDYDASSIEVLEGLEPVRK
CCCCHHHHCCCHHHHHHHHCCCCCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHCCHHHHH
RPGMYIGGTDERALHHLVAEVLDNSMDEAVAGHATRIEVELHEDYAITIRDNGRGIPIDP
CCCEEECCCHHHHHHHHHHHHHHCHHHHHHCCCCEEEEEEEECCEEEEEEECCCCCCCCC
HPKFPDKSALEVILCTLHAGGKFSGKAYETSGGLHGVGASVVNALSDSMVVQVARNKQLF
CCCCCCHHHHEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQRFSRGVPLGPVQELGPTQNRRGTTVTFHADAEIFGAHRFKPARLFNSIRSKAYLFSGV
HHHHHCCCCCCCHHHCCCCCCCCCCEEEEECCCHHHCCCCCCHHHHHHHHHHHHEEECCC
EIRWKSAIADGDTPQEATFHFPGGLSDYLRETLGTATTYADNPFAGSVDFKEKFGEPGKV
EEEEEHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHCCCCCEE
EWAINWTPSRDGFIQSYCNTVPTPEGGTHVAGFWAAILKGIKAYGELSNTKKAAQITRED
EEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LTSGGCALVSCFIAEPAFVGQTKDRLSTEAAAKMTEGAVRDHFDNWLAADTKSAGAILDF
HCCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVLRAEERLRRRQEKETARKSATKKLRLPGKLTDCTSKDRAGTELFIVEGDSAGGSGKGA
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
RNRNTQALLPLKGKILNVLGAASSKLGTNAEISDLCEALGCGMGTKFNLDDLRYEKIIIM
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
TDADVDGAHIAALLMTFFYTQMRPLIDAGHLYLACPPLFRLTQGAKRVYCLTEEEKNDWL
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEECCHHHHHH
EKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPTTRKLIRVSIDEDVPGETGDLVERLMG
HHCCCCCCCEEHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHC
KKPELRFQYIQENAKFVEELDV
CCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TACARRHGLFPKRRLCHTHGQTNTKKSSGMNDLLSSGTEATDYDASSIEVLEGLEPVRK
CCCHHHHCCCHHHHHHHHCCCCCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHCCHHHHH
RPGMYIGGTDERALHHLVAEVLDNSMDEAVAGHATRIEVELHEDYAITIRDNGRGIPIDP
CCCEEECCCHHHHHHHHHHHHHHCHHHHHHCCCCEEEEEEEECCEEEEEEECCCCCCCCC
HPKFPDKSALEVILCTLHAGGKFSGKAYETSGGLHGVGASVVNALSDSMVVQVARNKQLF
CCCCCCHHHHEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EQRFSRGVPLGPVQELGPTQNRRGTTVTFHADAEIFGAHRFKPARLFNSIRSKAYLFSGV
HHHHHCCCCCCCHHHCCCCCCCCCCEEEEECCCHHHCCCCCCHHHHHHHHHHHHEEECCC
EIRWKSAIADGDTPQEATFHFPGGLSDYLRETLGTATTYADNPFAGSVDFKEKFGEPGKV
EEEEEHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHCCCCCEE
EWAINWTPSRDGFIQSYCNTVPTPEGGTHVAGFWAAILKGIKAYGELSNTKKAAQITRED
EEEEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LTSGGCALVSCFIAEPAFVGQTKDRLSTEAAAKMTEGAVRDHFDNWLAADTKSAGAILDF
HCCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LVLRAEERLRRRQEKETARKSATKKLRLPGKLTDCTSKDRAGTELFIVEGDSAGGSGKGA
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
RNRNTQALLPLKGKILNVLGAASSKLGTNAEISDLCEALGCGMGTKFNLDDLRYEKIIIM
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEE
TDADVDGAHIAALLMTFFYTQMRPLIDAGHLYLACPPLFRLTQGAKRVYCLTEEEKNDWL
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEECCHHHHHH
EKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPTTRKLIRVSIDEDVPGETGDLVERLMG
HHCCCCCCCEEHHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHC
KKPELRFQYIQENAKFVEELDV
CCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647; 9426128 [H]