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The map label for this gene is mutA [H]

Identifier: 110679317

GI number: 110679317

Start: 1943692

End: 1945821

Strand: Direct

Name: mutA [H]

Synonym: RD1_2035

Alternate gene names: 110679317

Gene position: 1943692-1945821 (Clockwise)

Preceding gene: 110679316

Following gene: 110679318

Centisome position: 47.03

GC content: 58.73

Gene sequence:

>2130_bases
ATGAGCTCGACAAAAGACAAATGGCGCGCCCTCGCTGAAGCTGAATTGCGCGGCCGTCCGATTGAGGACCTGACGTGGCG
CACGCTTGAAGGGATCGACGTACAACCGTTCTATACCGAAGAAGACCTGAAAGACGTCAAACACCTCGGCTCAACCCCCG
GTGCGGCGCCCTATACGCGCGGCGTCAAGGCCACGATGTACGCAGGCCGCCCCTGGACCATTCGCCAGTACGCCGGGTTT
TCGACGGCTGAGGAATCCAACGCCTTTTACCGCCAAGCACTGGCCAATGGGCAACAAGGTGTTTCGGTGGCCTTTGATCT
GGCGACACACCGGGGTTATGACAGCGACCACGAACGCGTTGAAGGCGATGTGGGCAAGGCGGGCGTGGCCATCGACAGTA
TTGAGGATATGAAAATCCTCTTTGACGGCATCCCGCTGGATAAAGTGTCCGTTTCCATGACGATGAATGGTGCGGTTATT
CCGATCCTTGCGAATTTCATCGTCGCGGGGGAAGAGCAGGGGCATGACCGCGCGGTACTTTCGGGGACAATCCAGAACGA
TATTCTCAAGGAATTCATGGTGCGCAACACCTATGTTTATCCGCCCGAACCCTCGATGCGGATCATCGCGGATATCATCG
AATATACCTCCGCCGAGATGCCGAAATTCAATTCGATTTCCATCTCCGGCTATCACATGCAGGAGGCGGGCGCGAACCTC
GTGCAGGAGCTTGCCTTTACCCTTGCTGACGGGCGCGAATACGTGCGCGCCGCGATTGCGCGGGGCATGGATGTGGATAA
ATTCGCCGGACGGCTGAGCTTCTTTTTCGCCATCGGGATGAACTTTTTCATGGAAGCGGCCAAGCTGCGTGCCGCGCGTT
TGCTCTGGTCGCGGATTATGGAGGAGTTCGAACCGAAGAACCCCAAATCCTCGATGTTGCGGACCCATTGCCAGACCTCC
GGTGTGAGCCTTCAGGAACAAGACCCTTATAACAACGTGATCCGCACGGCCTATGAAGCGATGAGCGCGGTGTTGGGGGG
CACACAATCGCTGCACACAAATGCGCTGGATGAGGCGATTGCGTTGCCCACGGAAAACTCAAGCCGGATTGCACGCAATA
CCCAGTTGATTTTGCAGGAAGAAACGGGTGTGACCAATGTGGTTGACCCTCTGGCCGGGTCCTACTATGTCGAAAAACTG
ACCCATGATCTGGCCGAGGCGGCGTGGCAGTTGATCGAAGAGGTTGAGGAAATGGGCGGCATGACCAAGGCCGTGGCCAG
CGGCATGCCCAAGTTGCGCATCGAAGAGGCCGCCGCCACCCGTCAGGCCAACATCGACCGGGGCACCGAAGTGATTGTCG
GTGTCAACAAGTACCGCCGCGACAAAGAGGACCTGATCGACATTCTGGACATCGACAACGCCGCCGTGCGCCAAAGTCAG
ATTGCGCGCCTGGAACAGGTACGTGCCGGTCGTGACGGCGCGGCCTGCGACGCCGCCCTTGAAGAACTCAGCCGGCGCGC
GGCGGAAGGTGGCAACCTTTTGGAAGCGGCCGTTGAGGCGGCACGCGCCCGCGCAACAGTAGGAGAGATCAGCATGGCGA
TGGAAAAGATTTTTGGCCGCCACAGAGCCGAAGTAAAAACCCTCGCCGGTGTTTATGGCGCGGCTTACGAAGGGGATGCG
GGTTTTGCCGCCATTCAGAAATCGGTCGAAGCCTTTGCCGAGACCGAAGGGCGCAGACCGCGTATGCTGGTCGTGAAAAT
GGGGCAGGACGGGCATGACCGGGGGGCCAAGGTGATCGCGACCGCTTTTGCGGATATCGGGTTTGATGTGGACGTCGGAC
CGCTCTTTCAGACGCCCGCCGAGGCCGCACAGGATGCGGTTGACAACGATGTGCATGTGATCGGCATCAGCAGCCAGGCG
GCGGGCCACAAGACACTGGCACCGCAATTGGTCACGGCCCTCAAGGAAGCGGGAGCGGAGGATATTCTGGTGATCTGCGG
TGGCGTAATCCCACAGCAGGACTATCAGTTCCTTTACGATTCAGGGGTTAAGGCCATTTTCGGACCGGGCACCAATATCC
CCGAAGCGGCGCAGGATATCCTCAAACTGATTGCCGAGGCGCGCGGTTGA

Upstream 100 bases:

>100_bases
ACAGCGGGCGCTGATGGCCGTGCCACACTGAGAGAGGATCGCCGCCCGGAAAGAGCAGGGCCAACCCTGCCGCGGATGGC
ACAAAACAAAGGACAAGAAG

Downstream 100 bases:

>100_bases
TCGCGTTTGACCATATTGCAATCGCCGGTGAAACGCTGTCGGCCGCGCGCGCTTATGTCGAAGATGCGCTTGGCGTCGCC
CTGCAAGACGGTGGCGCGCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MSSTKDKWRALAEAELRGRPIEDLTWRTLEGIDVQPFYTEEDLKDVKHLGSTPGAAPYTRGVKATMYAGRPWTIRQYAGF
STAEESNAFYRQALANGQQGVSVAFDLATHRGYDSDHERVEGDVGKAGVAIDSIEDMKILFDGIPLDKVSVSMTMNGAVI
PILANFIVAGEEQGHDRAVLSGTIQNDILKEFMVRNTYVYPPEPSMRIIADIIEYTSAEMPKFNSISISGYHMQEAGANL
VQELAFTLADGREYVRAAIARGMDVDKFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFEPKNPKSSMLRTHCQTS
GVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTENSSRIARNTQLILQEETGVTNVVDPLAGSYYVEKL
THDLAEAAWQLIEEVEEMGGMTKAVASGMPKLRIEEAAATRQANIDRGTEVIVGVNKYRRDKEDLIDILDIDNAAVRQSQ
IARLEQVRAGRDGAACDAALEELSRRAAEGGNLLEAAVEAARARATVGEISMAMEKIFGRHRAEVKTLAGVYGAAYEGDA
GFAAIQKSVEAFAETEGRRPRMLVVKMGQDGHDRGAKVIATAFADIGFDVDVGPLFQTPAEAAQDAVDNDVHVIGISSQA
AGHKTLAPQLVTALKEAGAEDILVICGGVIPQQDYQFLYDSGVKAIFGPGTNIPEAAQDILKLIAEARG

Sequences:

>Translated_709_residues
MSSTKDKWRALAEAELRGRPIEDLTWRTLEGIDVQPFYTEEDLKDVKHLGSTPGAAPYTRGVKATMYAGRPWTIRQYAGF
STAEESNAFYRQALANGQQGVSVAFDLATHRGYDSDHERVEGDVGKAGVAIDSIEDMKILFDGIPLDKVSVSMTMNGAVI
PILANFIVAGEEQGHDRAVLSGTIQNDILKEFMVRNTYVYPPEPSMRIIADIIEYTSAEMPKFNSISISGYHMQEAGANL
VQELAFTLADGREYVRAAIARGMDVDKFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFEPKNPKSSMLRTHCQTS
GVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTENSSRIARNTQLILQEETGVTNVVDPLAGSYYVEKL
THDLAEAAWQLIEEVEEMGGMTKAVASGMPKLRIEEAAATRQANIDRGTEVIVGVNKYRRDKEDLIDILDIDNAAVRQSQ
IARLEQVRAGRDGAACDAALEELSRRAAEGGNLLEAAVEAARARATVGEISMAMEKIFGRHRAEVKTLAGVYGAAYEGDA
GFAAIQKSVEAFAETEGRRPRMLVVKMGQDGHDRGAKVIATAFADIGFDVDVGPLFQTPAEAAQDAVDNDVHVIGISSQA
AGHKTLAPQLVTALKEAGAEDILVICGGVIPQQDYQFLYDSGVKAIFGPGTNIPEAAQDILKLIAEARG
>Mature_708_residues
SSTKDKWRALAEAELRGRPIEDLTWRTLEGIDVQPFYTEEDLKDVKHLGSTPGAAPYTRGVKATMYAGRPWTIRQYAGFS
TAEESNAFYRQALANGQQGVSVAFDLATHRGYDSDHERVEGDVGKAGVAIDSIEDMKILFDGIPLDKVSVSMTMNGAVIP
ILANFIVAGEEQGHDRAVLSGTIQNDILKEFMVRNTYVYPPEPSMRIIADIIEYTSAEMPKFNSISISGYHMQEAGANLV
QELAFTLADGREYVRAAIARGMDVDKFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIMEEFEPKNPKSSMLRTHCQTSG
VSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTENSSRIARNTQLILQEETGVTNVVDPLAGSYYVEKLT
HDLAEAAWQLIEEVEEMGGMTKAVASGMPKLRIEEAAATRQANIDRGTEVIVGVNKYRRDKEDLIDILDIDNAAVRQSQI
ARLEQVRAGRDGAACDAALEELSRRAAEGGNLLEAAVEAARARATVGEISMAMEKIFGRHRAEVKTLAGVYGAAYEGDAG
FAAIQKSVEAFAETEGRRPRMLVVKMGQDGHDRGAKVIATAFADIGFDVDVGPLFQTPAEAAQDAVDNDVHVIGISSQAA
GHKTLAPQLVTALKEAGAEDILVICGGVIPQQDYQFLYDSGVKAIFGPGTNIPEAAQDILKLIAEARG

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=697, Percent_Identity=63.4146341463415, Blast_Score=931, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=710, Percent_Identity=61.1267605633803, Blast_Score=864, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=703, Percent_Identity=62.0199146514936, Blast_Score=902, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77068; Mature: 76937

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTKDKWRALAEAELRGRPIEDLTWRTLEGIDVQPFYTEEDLKDVKHLGSTPGAAPYTR
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GVKATMYAGRPWTIRQYAGFSTAEESNAFYRQALANGQQGVSVAFDLATHRGYDSDHERV
CCEEEEECCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCHHHH
EGDVGKAGVAIDSIEDMKILFDGIPLDKVSVSMTMNGAVIPILANFIVAGEEQGHDRAVL
CCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
SGTIQNDILKEFMVRNTYVYPPEPSMRIIADIIEYTSAEMPKFNSISISGYHMQEAGANL
HHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHH
VQELAFTLADGREYVRAAIARGMDVDKFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEFEPKNPKSSMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAI
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALPTENSSRIARNTQLILQEETGVTNVVDPLAGSYYVEKLTHDLAEAAWQLIEEVEEMGG
CCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MTKAVASGMPKLRIEEAAATRQANIDRGTEVIVGVNKYRRDKEDLIDILDIDNAAVRQSQ
HHHHHHCCCCCEEEHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHCCCHHHHHHHH
IARLEQVRAGRDGAACDAALEELSRRAAEGGNLLEAAVEAARARATVGEISMAMEKIFGR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRAEVKTLAGVYGAAYEGDAGFAAIQKSVEAFAETEGRRPRMLVVKMGQDGHDRGAKVIA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHH
TAFADIGFDVDVGPLFQTPAEAAQDAVDNDVHVIGISSQAAGHKTLAPQLVTALKEAGAE
HHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
DILVICGGVIPQQDYQFLYDSGVKAIFGPGTNIPEAAQDILKLIAEARG
CEEEEECCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTKDKWRALAEAELRGRPIEDLTWRTLEGIDVQPFYTEEDLKDVKHLGSTPGAAPYTR
CCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GVKATMYAGRPWTIRQYAGFSTAEESNAFYRQALANGQQGVSVAFDLATHRGYDSDHERV
CCEEEEECCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCHHHH
EGDVGKAGVAIDSIEDMKILFDGIPLDKVSVSMTMNGAVIPILANFIVAGEEQGHDRAVL
CCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
SGTIQNDILKEFMVRNTYVYPPEPSMRIIADIIEYTSAEMPKFNSISISGYHMQEAGANL
HHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHH
VQELAFTLADGREYVRAAIARGMDVDKFAGRLSFFFAIGMNFFMEAAKLRAARLLWSRIM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEFEPKNPKSSMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAI
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALPTENSSRIARNTQLILQEETGVTNVVDPLAGSYYVEKLTHDLAEAAWQLIEEVEEMGG
CCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MTKAVASGMPKLRIEEAAATRQANIDRGTEVIVGVNKYRRDKEDLIDILDIDNAAVRQSQ
HHHHHHCCCCCEEEHHHHHHHHCCCCCCCEEEEECHHHHCCHHHHHHHHCCCHHHHHHHH
IARLEQVRAGRDGAACDAALEELSRRAAEGGNLLEAAVEAARARATVGEISMAMEKIFGR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRAEVKTLAGVYGAAYEGDAGFAAIQKSVEAFAETEGRRPRMLVVKMGQDGHDRGAKVIA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHH
TAFADIGFDVDVGPLFQTPAEAAQDAVDNDVHVIGISSQAAGHKTLAPQLVTALKEAGAE
HHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
DILVICGGVIPQQDYQFLYDSGVKAIFGPGTNIPEAAQDILKLIAEARG
CEEEEECCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]