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The map label for this gene is betA [H]

Identifier: 110679306

GI number: 110679306

Start: 1931387

End: 1933045

Strand: Direct

Name: betA [H]

Synonym: RD1_2024

Alternate gene names: 110679306

Gene position: 1931387-1933045 (Clockwise)

Preceding gene: 110679305

Following gene: 110679307

Centisome position: 46.73

GC content: 61.36

Gene sequence:

>1659_bases
ATGCAAGCAGATTTCGTTATCGTGGGGGCGGGCAGCGCAGGCTGCGCGATGGCATACCGCCTGTCCGAGGCGGGAGCATC
CGTCATCGTCATTGAACATGGGGGGACAGATGCCGGGCCGCTCATCCAGATGCCCGCAGCACTTTCCTATCCGATGAACA
TGAAACGCTATGATTGGGGCTATAGCTCGGAGCCTGAGCCGCATCTGGGCGGGCGCAGGCTCGCTTGCCCACGCGGCAAG
GTCATCGGCGGCTCATCCAGTATCAACGGCATGGTCTATGTCCGCGGCCATGCGATGGATTTTGACCATTGGGCAGAGCA
GGGCGCGGAGGGCTGGTCCTATGCGGATGTGCTGCCCTATTACAAACGGATGGAGAATTGGCACGATGGCGGTCATGGCG
GTGACCCTGCGTGGCGCGGCACCGACGGGCCGCTGCATGTCAGCCGGGGGGCACGGCAAAATCCGCTCTTCAAAGCCTTT
GTGCAGGCCGGGATCGAGGCAGGCTATCAGGCGACCGATGACTACAACGGTCACAAGCAGGAAGGTTTCGGCCCGATGGA
GCAAACGGTCTGGCGCGGGCGGCGCTGGTCTGCGGCAAACGCCTATCTGCGCCCCGCGCTGAAGCGCGACAATTGCACGC
TTGTGAATGGCCTCGCGCAGCGGGTGATATTCGAAGGGCGCCGGGCGCGCGGCGTCGAAATCCTGCAAGGCGGCAAGACA
AAGGTGATCCACGCGGCGCGCGAGGTCGTGCTTGCGGCCTCATCCATCAATTCGCCCAAATTGCTGATGCTCTCGGGTGT
CGGCCCGGCTGGGCATCTGGCGGAACAGGGCGTTGACGTGATCGCGGACCGCCCCGGCGTGGGGCAGAACCTGCAGGATC
ATCTGGAACTTTACCTGCAGATGGCCTCGAAACAGCCCATCACGCTCTATCGCTATTGGAACCTGTTTTCCAAGGCCGTG
ATCGGCGCGCAGTGGCTGTTTACAAAAACCGGCATGGGATCGTCCAACCAATTCGAAAGTGCAGCGTTCATCCGGTCCAA
GGCGGGCGTGCCCTATCCTGATGTGCAGTACCATTTCCTGCCAATCGCCGTGCGCTACGATGGTAAAGTCGCGGCGGAAG
GTCACGGGTTTCAGGCCCATGTGGGGCCGATGCGGTCAAAATCACGCGGGTCGGTTACGCTGGCCTCGCCTGATCCGGCT
GAAGCGCCGAAAATAACCTTTAACTACATGTCGCACGCGGATGACTGGGAGGATTTCAGGCGTTGCATCCGCCTGACCCG
CGAGATTTTCGCGCAGGACGCGTTCAAACCCTTCGTCAAACATGAGATCCAGCCGGGTGCTGCCGTGCAATCCGATGACG
CCTTGAATGACTTCATCTCGGAACATGTGGAAAGCGCCTATCACCCCTGCGGCACCTGCCGGATGGGGCGTGCCGATGAT
CCGCAGGCGGTTGTGGACCCGCAGGCCCGTGTGATCGGTGTCGAGGGGCTGCGCGTCGCGGACAGCAGCATTTTTCCCCG
GATTACCAACGGTAACCTGAACGCGCCCTCCATCATGGTGGGGGAAAAAGTCTCTGACCACCTGCTGGGCAAAGACACAT
TGGCGCGCAGCAATGACCGGGCGTGGATACATCCGGACTGGCAAACTGCACAGCGGTAA

Upstream 100 bases:

>100_bases
GCGGTTGGCGTGATGTGGAAAGACAAGGCGATCATGGTCGTCCATATCGGCGCGTTTCTCTCCTTGTTCATTGGCTACAT
GAACGCCTGAGGATCATGTG

Downstream 100 bases:

>100_bases
GCTTTGGTTAGTCTAGATTGAGGCCAGCGCTTGTTTTGGCGGCGTGAGATGCACATCTCATGCACATGGTGAGGTGGGTC
TTGAGCATGTTGACTGCAAT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MQADFVIVGAGSAGCAMAYRLSEAGASVIVIEHGGTDAGPLIQMPAALSYPMNMKRYDWGYSSEPEPHLGGRRLACPRGK
VIGGSSSINGMVYVRGHAMDFDHWAEQGAEGWSYADVLPYYKRMENWHDGGHGGDPAWRGTDGPLHVSRGARQNPLFKAF
VQAGIEAGYQATDDYNGHKQEGFGPMEQTVWRGRRWSAANAYLRPALKRDNCTLVNGLAQRVIFEGRRARGVEILQGGKT
KVIHAAREVVLAASSINSPKLLMLSGVGPAGHLAEQGVDVIADRPGVGQNLQDHLELYLQMASKQPITLYRYWNLFSKAV
IGAQWLFTKTGMGSSNQFESAAFIRSKAGVPYPDVQYHFLPIAVRYDGKVAAEGHGFQAHVGPMRSKSRGSVTLASPDPA
EAPKITFNYMSHADDWEDFRRCIRLTREIFAQDAFKPFVKHEIQPGAAVQSDDALNDFISEHVESAYHPCGTCRMGRADD
PQAVVDPQARVIGVEGLRVADSSIFPRITNGNLNAPSIMVGEKVSDHLLGKDTLARSNDRAWIHPDWQTAQR

Sequences:

>Translated_552_residues
MQADFVIVGAGSAGCAMAYRLSEAGASVIVIEHGGTDAGPLIQMPAALSYPMNMKRYDWGYSSEPEPHLGGRRLACPRGK
VIGGSSSINGMVYVRGHAMDFDHWAEQGAEGWSYADVLPYYKRMENWHDGGHGGDPAWRGTDGPLHVSRGARQNPLFKAF
VQAGIEAGYQATDDYNGHKQEGFGPMEQTVWRGRRWSAANAYLRPALKRDNCTLVNGLAQRVIFEGRRARGVEILQGGKT
KVIHAAREVVLAASSINSPKLLMLSGVGPAGHLAEQGVDVIADRPGVGQNLQDHLELYLQMASKQPITLYRYWNLFSKAV
IGAQWLFTKTGMGSSNQFESAAFIRSKAGVPYPDVQYHFLPIAVRYDGKVAAEGHGFQAHVGPMRSKSRGSVTLASPDPA
EAPKITFNYMSHADDWEDFRRCIRLTREIFAQDAFKPFVKHEIQPGAAVQSDDALNDFISEHVESAYHPCGTCRMGRADD
PQAVVDPQARVIGVEGLRVADSSIFPRITNGNLNAPSIMVGEKVSDHLLGKDTLARSNDRAWIHPDWQTAQR
>Mature_552_residues
MQADFVIVGAGSAGCAMAYRLSEAGASVIVIEHGGTDAGPLIQMPAALSYPMNMKRYDWGYSSEPEPHLGGRRLACPRGK
VIGGSSSINGMVYVRGHAMDFDHWAEQGAEGWSYADVLPYYKRMENWHDGGHGGDPAWRGTDGPLHVSRGARQNPLFKAF
VQAGIEAGYQATDDYNGHKQEGFGPMEQTVWRGRRWSAANAYLRPALKRDNCTLVNGLAQRVIFEGRRARGVEILQGGKT
KVIHAAREVVLAASSINSPKLLMLSGVGPAGHLAEQGVDVIADRPGVGQNLQDHLELYLQMASKQPITLYRYWNLFSKAV
IGAQWLFTKTGMGSSNQFESAAFIRSKAGVPYPDVQYHFLPIAVRYDGKVAAEGHGFQAHVGPMRSKSRGSVTLASPDPA
EAPKITFNYMSHADDWEDFRRCIRLTREIFAQDAFKPFVKHEIQPGAAVQSDDALNDFISEHVESAYHPCGTCRMGRADD
PQAVVDPQARVIGVEGLRVADSSIFPRITNGNLNAPSIMVGEKVSDHLLGKDTLARSNDRAWIHPDWQTAQR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=539, Percent_Identity=50.0927643784787, Blast_Score=524, Evalue=1e-148,
Organism=Escherichia coli, GI1786503, Length=547, Percent_Identity=49.7257769652651, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17532301, Length=559, Percent_Identity=44.7227191413238, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45549471, Length=568, Percent_Identity=38.9084507042254, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI45551458, Length=568, Percent_Identity=38.9084507042254, Blast_Score=345, Evalue=6e-95,
Organism=Drosophila melanogaster, GI24642042, Length=571, Percent_Identity=36.4273204903678, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24642048, Length=564, Percent_Identity=35.6382978723404, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24642059, Length=563, Percent_Identity=33.7477797513321, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24650267, Length=574, Percent_Identity=34.6689895470383, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI17137792, Length=547, Percent_Identity=34.0036563071298, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24642055, Length=571, Percent_Identity=34.3257443082312, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI18859995, Length=563, Percent_Identity=32.6820603907638, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24642037, Length=571, Percent_Identity=33.0998248686515, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24642039, Length=566, Percent_Identity=32.6855123674912, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24642035, Length=566, Percent_Identity=31.095406360424, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=29.9651567944251, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI18859993, Length=562, Percent_Identity=29.3594306049822, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24642057, Length=590, Percent_Identity=28.3050847457627, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645930, Length=569, Percent_Identity=26.713532513181, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60469; Mature: 60469

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQADFVIVGAGSAGCAMAYRLSEAGASVIVIEHGGTDAGPLIQMPAALSYPMNMKRYDWG
CCCCEEEEECCCCCHHEEEEHHCCCCEEEEEECCCCCCCCEEECCCHHCCCCCCCEECCC
YSSEPEPHLGGRRLACPRGKVIGGSSSINGMVYVRGHAMDFDHWAEQGAEGWSYADVLPY
CCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHH
YKRMENWHDGGHGGDPAWRGTDGPLHVSRGARQNPLFKAFVQAGIEAGYQATDDYNGHKQ
HHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
EGFGPMEQTVWRGRRWSAANAYLRPALKRDNCTLVNGLAQRVIFEGRRARGVEILQGGKT
CCCCHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCH
KVIHAAREVVLAASSINSPKLLMLSGVGPAGHLAEQGVDVIADRPGVGQNLQDHLELYLQ
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCEEECCCCCCCCHHHHHHHHHH
MASKQPITLYRYWNLFSKAVIGAQWLFTKTGMGSSNQFESAAFIRSKAGVPYPDVQYHFL
HHCCCCEEEHHHHHHHHHHHHCHHEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
PIAVRYDGKVAAEGHGFQAHVGPMRSKSRGSVTLASPDPAEAPKITFNYMSHADDWEDFR
EEEEEECCEEEECCCCCEEECCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHH
RCIRLTREIFAQDAFKPFVKHEIQPGAAVQSDDALNDFISEHVESAYHPCGTCRMGRADD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PQAVVDPQARVIGVEGLRVADSSIFPRITNGNLNAPSIMVGEKVSDHLLGKDTLARSNDR
CCCEECCCEEEEECCCEEEECCCCCCEECCCCCCCCEEEECCCHHHHHCCCHHHCCCCCC
AWIHPDWQTAQR
EEECCCHHHCCC
>Mature Secondary Structure
MQADFVIVGAGSAGCAMAYRLSEAGASVIVIEHGGTDAGPLIQMPAALSYPMNMKRYDWG
CCCCEEEEECCCCCHHEEEEHHCCCCEEEEEECCCCCCCCEEECCCHHCCCCCCCEECCC
YSSEPEPHLGGRRLACPRGKVIGGSSSINGMVYVRGHAMDFDHWAEQGAEGWSYADVLPY
CCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHH
YKRMENWHDGGHGGDPAWRGTDGPLHVSRGARQNPLFKAFVQAGIEAGYQATDDYNGHKQ
HHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
EGFGPMEQTVWRGRRWSAANAYLRPALKRDNCTLVNGLAQRVIFEGRRARGVEILQGGKT
CCCCHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCH
KVIHAAREVVLAASSINSPKLLMLSGVGPAGHLAEQGVDVIADRPGVGQNLQDHLELYLQ
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCEEECCCCCCCCHHHHHHHHHH
MASKQPITLYRYWNLFSKAVIGAQWLFTKTGMGSSNQFESAAFIRSKAGVPYPDVQYHFL
HHCCCCEEEHHHHHHHHHHHHCHHEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
PIAVRYDGKVAAEGHGFQAHVGPMRSKSRGSVTLASPDPAEAPKITFNYMSHADDWEDFR
EEEEEECCEEEECCCCCEEECCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHH
RCIRLTREIFAQDAFKPFVKHEIQPGAAVQSDDALNDFISEHVESAYHPCGTCRMGRADD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PQAVVDPQARVIGVEGLRVADSSIFPRITNGNLNAPSIMVGEKVSDHLLGKDTLARSNDR
CCCEECCCEEEEECCCEEEECCCCCCEECCCCCCCCEEEECCCHHHHHCCCHHHCCCCCC
AWIHPDWQTAQR
EEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA