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The map label for this gene is pyrG

Identifier: 110679195

GI number: 110679195

Start: 1818752

End: 1820395

Strand: Reverse

Name: pyrG

Synonym: RD1_1906

Alternate gene names: 110679195

Gene position: 1820395-1818752 (Counterclockwise)

Preceding gene: 110679196

Following gene: 110679194

Centisome position: 44.04

GC content: 56.87

Gene sequence:

>1644_bases
ATGGCACGATATATTTTCATCACCGGTGGCGTGGTTTCGTCGCTTGGAAAAGGGCTGGCCTCGGCGGCTCTGGGTGCCTT
GCTGCAGGCGCGTGGTTTCTCGGTCAGATTACGCAAGCTCGACCCCTATCTGAATGTTGACCCCGGCACGATGTCACCCT
TTGAACACGGTGAGGTTTTTGTTACGGATGATGGCGCGGAAACCGACCTTGATCTGGGACACTATGAGCGTTTCACCGGT
GTCGCGGCGCGCAGCACTGATTCCGTATCTTCCGGGCGGATTTATTCCACGGTTCTGGAAAAGGAACGGCGCGGTGATTA
CCTGGGCAAAACCATACAGGTGATCCCCCATGTGACGAATGAGATCAAGGATTTCATCGCCATCGGCGACGATGAGGTTG
ATTTCATGCTGTGTGAAATCGGCGGGACGGTCGGTGATATCGAAGGCTTACCATTCTTTGAAGCGATCCGGCAGTTCACC
CATGACAAGCCGCGCGGGCAATGCATCTTTATGCACCTGACCTTGCTGCCCTATCTTGCCGCCTCAGGCGAGTTGAAAAC
CAAACCGACGCAGCATTCGGTCAAAGAACTGCAATCCATCGGCATTGCGCCCGATATCCTTGTCTGCCGCTCCGAACACC
CGATTCCGGAAAAGGAACGGGAAAAAATCGCGCTGTTCTGCAACGTGCGCAAGGAAGCCGTTGTGGCGGCCTATGATCTG
AAAACCATCTACGACGCGCCGCTTGCCTATCACGAACAGGGGCTTGATCAGGCTGTTCTGGATGCGTTTGACATCTCACC
CGCGCCCAAACCCGACCTGACGGTATGGCGGGATGTGTCGGACCGGGTGCATAATCCCGAAGGCGAAGTCAAAGTGGCCA
TCGTCGGCAAATACACGCAGCTTGAGGATGCGTATAAATCCATTGCCGAGGCGCTGACCCACGGCGGAATGGCGAACCGC
GTCAAGGTGATCGTGGAATGGGTCGACGCCGAAGTCTTCGACACGCAGGATGTCGCGCCGCACCTTGAAGGGTTCCACGC
GATCCTTGTCCCCGGCGGGTTTGGAGAACGCGGCACCGAAGGCAAGATTAAGGCCGCTCAATATGCACGCGAGCACAATG
TACCCTACCTTGGCATTTGCCTCGGCATGCAGATGGCCGTGATTGAAGCGGCCCGCAATGTGGCCAACATCAAGGCCGCA
GGGTCCGAGGAATTCGACCATGAAGCGGGCAAGAAACGGTTTGAACCGGTTGTCTATCACCTCAAGGAATGGGTGCAGGG
CAACGCCAAAGTGTCGCGCAGGGTTGGCGATGACAAGGGCGGAACCATGCGTCTGGGTGCTTATGATGCCGCCCTGACCC
CGGGCACGCGGGTGGCAGATATCTATCACACCTCCGCCATTGATGAACGGCACCGCCACCGCTACGAGGTCGACATCAAG
TACCGCGCGCAACTCGAAGATGCGGGCCTGGTGTTTTCCGGCATGTCCCCTGATGGCAAACTGCCAGAAATCATCGAATG
GCCGAATCATCCATGGTTCATCGGCGTGCAATTTCACCCGGAATTGAAGTCGAAACCCTTTGATCCGCACCCCCTGTTCG
CCGATTTCATCCGTGCCGCCAAAGAAAACAGCCGCCTCGTTTGA

Upstream 100 bases:

>100_bases
ATCCTGATAAACTTTACTCCCGTGGTGCTGCGACTTTTCGCAGTCGAAATTTCGCGAAACGGACTTTAATTCGCGGCGAC
GCACGGGAGCAGCTCAAGCA

Downstream 100 bases:

>100_bases
TTAAGAGTGGTTTTATTGCGGGTAATTCCCGTGTTGCGTGCGCGAATTACTACCTAGAGTCGCACTTTTTATACCCACGC
AATCAAGGCGATAGAAAAAG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MARYIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTG
VAARSTDSVSSGRIYSTVLEKERRGDYLGKTIQVIPHVTNEIKDFIAIGDDEVDFMLCEIGGTVGDIEGLPFFEAIRQFT
HDKPRGQCIFMHLTLLPYLAASGELKTKPTQHSVKELQSIGIAPDILVCRSEHPIPEKEREKIALFCNVRKEAVVAAYDL
KTIYDAPLAYHEQGLDQAVLDAFDISPAPKPDLTVWRDVSDRVHNPEGEVKVAIVGKYTQLEDAYKSIAEALTHGGMANR
VKVIVEWVDAEVFDTQDVAPHLEGFHAILVPGGFGERGTEGKIKAAQYAREHNVPYLGICLGMQMAVIEAARNVANIKAA
GSEEFDHEAGKKRFEPVVYHLKEWVQGNAKVSRRVGDDKGGTMRLGAYDAALTPGTRVADIYHTSAIDERHRHRYEVDIK
YRAQLEDAGLVFSGMSPDGKLPEIIEWPNHPWFIGVQFHPELKSKPFDPHPLFADFIRAAKENSRLV

Sequences:

>Translated_547_residues
MARYIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTG
VAARSTDSVSSGRIYSTVLEKERRGDYLGKTIQVIPHVTNEIKDFIAIGDDEVDFMLCEIGGTVGDIEGLPFFEAIRQFT
HDKPRGQCIFMHLTLLPYLAASGELKTKPTQHSVKELQSIGIAPDILVCRSEHPIPEKEREKIALFCNVRKEAVVAAYDL
KTIYDAPLAYHEQGLDQAVLDAFDISPAPKPDLTVWRDVSDRVHNPEGEVKVAIVGKYTQLEDAYKSIAEALTHGGMANR
VKVIVEWVDAEVFDTQDVAPHLEGFHAILVPGGFGERGTEGKIKAAQYAREHNVPYLGICLGMQMAVIEAARNVANIKAA
GSEEFDHEAGKKRFEPVVYHLKEWVQGNAKVSRRVGDDKGGTMRLGAYDAALTPGTRVADIYHTSAIDERHRHRYEVDIK
YRAQLEDAGLVFSGMSPDGKLPEIIEWPNHPWFIGVQFHPELKSKPFDPHPLFADFIRAAKENSRLV
>Mature_546_residues
ARYIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTGV
AARSTDSVSSGRIYSTVLEKERRGDYLGKTIQVIPHVTNEIKDFIAIGDDEVDFMLCEIGGTVGDIEGLPFFEAIRQFTH
DKPRGQCIFMHLTLLPYLAASGELKTKPTQHSVKELQSIGIAPDILVCRSEHPIPEKEREKIALFCNVRKEAVVAAYDLK
TIYDAPLAYHEQGLDQAVLDAFDISPAPKPDLTVWRDVSDRVHNPEGEVKVAIVGKYTQLEDAYKSIAEALTHGGMANRV
KVIVEWVDAEVFDTQDVAPHLEGFHAILVPGGFGERGTEGKIKAAQYAREHNVPYLGICLGMQMAVIEAARNVANIKAAG
SEEFDHEAGKKRFEPVVYHLKEWVQGNAKVSRRVGDDKGGTMRLGAYDAALTPGTRVADIYHTSAIDERHRHRYEVDIKY
RAQLEDAGLVFSGMSPDGKLPEIIEWPNHPWFIGVQFHPELKSKPFDPHPLFADFIRAAKENSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=563, Percent_Identity=41.563055062167, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI28559083, Length=563, Percent_Identity=41.563055062167, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI221316689, Length=563, Percent_Identity=41.563055062167, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI148491070, Length=560, Percent_Identity=41.0714285714286, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=56.2730627306273, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI25148299, Length=617, Percent_Identity=36.6288492706645, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=39.7188049209139, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=40.0702987697715, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24664469, Length=561, Percent_Identity=42.0677361853832, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21357815, Length=506, Percent_Identity=41.1067193675889, Blast_Score=380, Evalue=1e-105,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_ROSDO (Q168S7)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682202.1
- ProteinModelPortal:   Q168S7
- SMR:   Q168S7
- STRING:   Q168S7
- GeneID:   4196808
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1906
- NMPDR:   fig|375451.6.peg.1782
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   TEWLRGN
- PhylomeDB:   Q168S7
- ProtClustDB:   PRK05380
- BioCyc:   RDEN375451:RD1_1906-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60555; Mature: 60424

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 380-380 ACT_SITE 519-519 ACT_SITE 521-521

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVF
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVAARSTDSVSSGRIYSTVLEKERRGDYLGKTIQVIPHVTN
EECCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIKDFIAIGDDEVDFMLCEIGGTVGDIEGLPFFEAIRQFTHDKPRGQCIFMHLTLLPYLA
HHHHHHCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHH
ASGELKTKPTQHSVKELQSIGIAPDILVCRSEHPIPEKEREKIALFCNVRKEAVVAAYDL
CCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCEEEEEEECCCHHEEEEEHH
KTIYDAPLAYHEQGLDQAVLDAFDISPAPKPDLTVWRDVSDRVHNPEGEVKVAIVGKYTQ
HHHHCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEECCCHHHCCCCCCCEEEEEEECCHH
LEDAYKSIAEALTHGGMANRVKVIVEWVDAEVFDTQDVAPHLEGFHAILVPGGFGERGTE
HHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHCCCCCCCHHHCCCEEEEECCCCCCCCCC
GKIKAAQYAREHNVPYLGICLGMQMAVIEAARNVANIKAAGSEEFDHEAGKKRFEPVVYH
CCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
LKEWVQGNAKVSRRVGDDKGGTMRLGAYDAALTPGTRVADIYHTSAIDERHRHRYEVDIK
HHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCEEEEEEE
YRAQLEDAGLVFSGMSPDGKLPEIIEWPNHPWFIGVQFHPELKSKPFDPHPLFADFIRAA
EEEEECCCCEEEECCCCCCCCCHHHCCCCCCEEEEEEECCHHCCCCCCCCCHHHHHHHHH
KENSRLV
HCCCCCC
>Mature Secondary Structure 
ARYIFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVF
CEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVAARSTDSVSSGRIYSTVLEKERRGDYLGKTIQVIPHVTN
EECCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIKDFIAIGDDEVDFMLCEIGGTVGDIEGLPFFEAIRQFTHDKPRGQCIFMHLTLLPYLA
HHHHHHCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHH
ASGELKTKPTQHSVKELQSIGIAPDILVCRSEHPIPEKEREKIALFCNVRKEAVVAAYDL
CCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCEEEEEEECCCHHEEEEEHH
KTIYDAPLAYHEQGLDQAVLDAFDISPAPKPDLTVWRDVSDRVHNPEGEVKVAIVGKYTQ
HHHHCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEECCCHHHCCCCCCCEEEEEEECCHH
LEDAYKSIAEALTHGGMANRVKVIVEWVDAEVFDTQDVAPHLEGFHAILVPGGFGERGTE
HHHHHHHHHHHHHCCCCHHHHEEEEEECCCHHCCCCCCCHHHCCCEEEEECCCCCCCCCC
GKIKAAQYAREHNVPYLGICLGMQMAVIEAARNVANIKAAGSEEFDHEAGKKRFEPVVYH
CCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
LKEWVQGNAKVSRRVGDDKGGTMRLGAYDAALTPGTRVADIYHTSAIDERHRHRYEVDIK
HHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHCCEEEEEEE
YRAQLEDAGLVFSGMSPDGKLPEIIEWPNHPWFIGVQFHPELKSKPFDPHPLFADFIRAA
EEEEECCCCEEEECCCCCCCCCHHHCCCCCCEEEEEEECCHHCCCCCCCCCHHHHHHHHH
KENSRLV
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA