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The map label for this gene is kefC [H]

Identifier: 110679123

GI number: 110679123

Start: 1752488

End: 1754371

Strand: Reverse

Name: kefC [H]

Synonym: RD1_1828

Alternate gene names: 110679123

Gene position: 1754371-1752488 (Counterclockwise)

Preceding gene: 110679124

Following gene: 110679121

Centisome position: 42.45

GC content: 59.24

Gene sequence:

>1884_bases
ATGGAAGGCTTCCTTTATCAGGCGTCCATCTATCTGGCCGCCGCCGTGATTGCCGTTCCAATTGCGGCCCGCCTGGGCCT
GGGTTCGGTGCTGGGGTACATTGCGGCAGGCATCATCATCGGCCCGGTGCTCGGGCTGGTGGGCGCCGAAACGCAGGACT
TGCAGCATTTTGCCGAGTTCGGCGTCGTCGTCATGCTGTTTCTGATCGGTCTCGAACTTGAACCGCGCGCCCTGTGGGAC
ATGCGCAACCGGTTGCTTGGCCTTGGGGGATTGCAAGTGGCGCTGAGTACGCTCGCACTCATGGGCATCGCCATGGCCTA
CGACCAGCCGTGGGGCGTGGCACTGGCCATCGGGCTGAGCCTGTCGCTGAGTTCAACCGCGATTGTGCTTCAAACACTGT
CCGAAAAAGGGCTGATGCAGACGAATGGGGGCCGCAACGTGTTCTCCGTGCTGTTGGCACAGGATATCGCGGTCATTCCC
ATGCTGGCCTTTTTGCCCCTGCTCGTCGTCACGATCCCCCTGCAGATCGCGCAGGATGGCTCGATCATAGTGACCGCAAC
CAGCCATGCCGGCGGGGATGCACATCATTCCCTGTCTCTGGTTGACGGCTTGCCCGCCTGGGGTGTCACGCTGGTGACGA
TCGGCGCCATTGCCGCCGTCATCTTTGCGGGTGTCTACCTGACGCGGCCCCTCTTTCGCTTTATCCACGCCGCGCGCCTG
CGCGAGATGTATACAGCGCTCGCGCTCCTGATTGTCGTGGGGATTTCATTTCTGATGACGCTTGTGGGCCTGTCCCCTGC
ACTTGGTGCCTTTCTGGCGGGTGTGGTTCTGGCGAATTCCGAATTCCGCCATGAGCTTGAGAGCGATCTTGAACCCTTCA
AAGGTCTGCTGCTGGGGCTGTTTTTCATCACGGTTGGCGCGGGGATCAACTTCCCGCTGCTTTTTGACAACACGCCAGCC
ATCCTTTCCATGGCGCTGCTGGTCATTATCGTCAAAGGTCTGATCCTGTTTGTTCTCGGCTGGGCGTTCAAGCTGAAGGG
GCGCGACCAGTGGCTCTTTGCCCTTGGCCTCGCACAGGCGGGCGAATTCGGCTTTGTTCTGACTTCTTTTTCGGTGCAGC
AAAACGTCATCCCGCTTGAGATTGCCGAAACGCTGTTGCTGGTCATCGCACTGTCGATGCTGATCACGCCGCTGCTCTTT
ATCATCTATGATGTCCTGTCGCGCCGCATGGAAGAACAGGTCGAGCAGCATCCCGACGATGAAATCGATGAACAAGGCCC
CGTCATCATCGCGGGTGTCGGGCGCTTTGGGCAGATCGTCAACCGATTGGTGCAGGCGAACGGATTCAAAACCGTCGTCC
TCGATCAGGATATGGAAACCATCGCCGTCATGCGCCGCTTTGGATACAAAGGGTTTCTGGGGGACCCCAACCGGCCCGAT
ATTCTGCGCGCTGCCGGGATCGACAGTGCCAAGGTGCTGGTTGTGGCGCTGGATGATCCTGAGGCGTCAATAAAACTGGT
GAAATACGCCCGCAGTATCCGGCCGGATTTGCACATCATCGCGCGCGCCCGGGACCGCACATTCGTCTATCGCCTGTTTC
AGGCCGGGGCCAGCGACATTGTGCGTGAAATGTTCGACAGCTCCCTGCGCGCAGGCCGGTATGTGCTTGAAAACGTGGGC
TTGAGCGAGTTCGAAGCCGCCGAAGCAGAGCGTGTATTCTACCATCACGACCGCAAAACGATACGGCAGCTGGCCGATCT
TTGGGACCCGTCGCGGCCCGCCAGTCAGAACCCCGCCTATGTCGCGCGGGCCAAAGAGCTGCAAAAGGAGTTGGAAACTG
CCATTTTAAGCCGCTCAATCTCCGCAAAAAACACCGACGGTTGA

Upstream 100 bases:

>100_bases
TTTCACCCTACAATTGCACGCGTGCACAGCCAAATCGTAATGGATCAGTTGAAGACCGACGGTCCGCTGCCCATGTGACC
GGACGGGAGACGTAAACGCA

Downstream 100 bases:

>100_bases
GCCCTCAGCCCGGCTCATCCGTCGGCAACGCCTGCTTCGGCAAAGGTTGCCATGCCGCTGAGGCAGGCAACGGCCCCTTG
CAGCACCGCCAGGGACAAAG

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MEGFLYQASIYLAAAVIAVPIAARLGLGSVLGYIAAGIIIGPVLGLVGAETQDLQHFAEFGVVVMLFLIGLELEPRALWD
MRNRLLGLGGLQVALSTLALMGIAMAYDQPWGVALAIGLSLSLSSTAIVLQTLSEKGLMQTNGGRNVFSVLLAQDIAVIP
MLAFLPLLVVTIPLQIAQDGSIIVTATSHAGGDAHHSLSLVDGLPAWGVTLVTIGAIAAVIFAGVYLTRPLFRFIHAARL
REMYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINFPLLFDNTPA
ILSMALLVIIVKGLILFVLGWAFKLKGRDQWLFALGLAQAGEFGFVLTSFSVQQNVIPLEIAETLLLVIALSMLITPLLF
IIYDVLSRRMEEQVEQHPDDEIDEQGPVIIAGVGRFGQIVNRLVQANGFKTVVLDQDMETIAVMRRFGYKGFLGDPNRPD
ILRAAGIDSAKVLVVALDDPEASIKLVKYARSIRPDLHIIARARDRTFVYRLFQAGASDIVREMFDSSLRAGRYVLENVG
LSEFEAAEAERVFYHHDRKTIRQLADLWDPSRPASQNPAYVARAKELQKELETAILSRSISAKNTDG

Sequences:

>Translated_627_residues
MEGFLYQASIYLAAAVIAVPIAARLGLGSVLGYIAAGIIIGPVLGLVGAETQDLQHFAEFGVVVMLFLIGLELEPRALWD
MRNRLLGLGGLQVALSTLALMGIAMAYDQPWGVALAIGLSLSLSSTAIVLQTLSEKGLMQTNGGRNVFSVLLAQDIAVIP
MLAFLPLLVVTIPLQIAQDGSIIVTATSHAGGDAHHSLSLVDGLPAWGVTLVTIGAIAAVIFAGVYLTRPLFRFIHAARL
REMYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINFPLLFDNTPA
ILSMALLVIIVKGLILFVLGWAFKLKGRDQWLFALGLAQAGEFGFVLTSFSVQQNVIPLEIAETLLLVIALSMLITPLLF
IIYDVLSRRMEEQVEQHPDDEIDEQGPVIIAGVGRFGQIVNRLVQANGFKTVVLDQDMETIAVMRRFGYKGFLGDPNRPD
ILRAAGIDSAKVLVVALDDPEASIKLVKYARSIRPDLHIIARARDRTFVYRLFQAGASDIVREMFDSSLRAGRYVLENVG
LSEFEAAEAERVFYHHDRKTIRQLADLWDPSRPASQNPAYVARAKELQKELETAILSRSISAKNTDG
>Mature_627_residues
MEGFLYQASIYLAAAVIAVPIAARLGLGSVLGYIAAGIIIGPVLGLVGAETQDLQHFAEFGVVVMLFLIGLELEPRALWD
MRNRLLGLGGLQVALSTLALMGIAMAYDQPWGVALAIGLSLSLSSTAIVLQTLSEKGLMQTNGGRNVFSVLLAQDIAVIP
MLAFLPLLVVTIPLQIAQDGSIIVTATSHAGGDAHHSLSLVDGLPAWGVTLVTIGAIAAVIFAGVYLTRPLFRFIHAARL
REMYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGLFFITVGAGINFPLLFDNTPA
ILSMALLVIIVKGLILFVLGWAFKLKGRDQWLFALGLAQAGEFGFVLTSFSVQQNVIPLEIAETLLLVIALSMLITPLLF
IIYDVLSRRMEEQVEQHPDDEIDEQGPVIIAGVGRFGQIVNRLVQANGFKTVVLDQDMETIAVMRRFGYKGFLGDPNRPD
ILRAAGIDSAKVLVVALDDPEASIKLVKYARSIRPDLHIIARARDRTFVYRLFQAGASDIVREMFDSSLRAGRYVLENVG
LSEFEAAEAERVFYHHDRKTIRQLADLWDPSRPASQNPAYVARAKELQKELETAILSRSISAKNTDG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=402, Percent_Identity=27.8606965174129, Blast_Score=83, Evalue=9e-16,
Organism=Escherichia coli, GI1786232, Length=589, Percent_Identity=43.2937181663837, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1789749, Length=629, Percent_Identity=39.1096979332273, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1786685, Length=538, Percent_Identity=27.3234200743494, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67949; Mature: 67949

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGFLYQASIYLAAAVIAVPIAARLGLGSVLGYIAAGIIIGPVLGLVGAETQDLQHFAEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVVMLFLIGLELEPRALWDMRNRLLGLGGLQVALSTLALMGIAMAYDQPWGVALAIGLS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHH
LSLSSTAIVLQTLSEKGLMQTNGGRNVFSVLLAQDIAVIPMLAFLPLLVVTIPLQIAQDG
HCCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
SIIVTATSHAGGDAHHSLSLVDGLPAWGVTLVTIGAIAAVIFAGVYLTRPLFRFIHAARL
CEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REMYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FFITVGAGINFPLLFDNTPAILSMALLVIIVKGLILFVLGWAFKLKGRDQWLFALGLAQA
HHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHEEHHHCC
GEFGFVLTSFSVQQNVIPLEIAETLLLVIALSMLITPLLFIIYDVLSRRMEEQVEQHPDD
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EIDEQGPVIIAGVGRFGQIVNRLVQANGFKTVVLDQDMETIAVMRRFGYKGFLGDPNRPD
CCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCC
ILRAAGIDSAKVLVVALDDPEASIKLVKYARSIRPDLHIIARARDRTFVYRLFQAGASDI
HHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHCHHHH
VREMFDSSLRAGRYVLENVGLSEFEAAEAERVFYHHDRKTIRQLADLWDPSRPASQNPAY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VARAKELQKELETAILSRSISAKNTDG
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEGFLYQASIYLAAAVIAVPIAARLGLGSVLGYIAAGIIIGPVLGLVGAETQDLQHFAEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVVMLFLIGLELEPRALWDMRNRLLGLGGLQVALSTLALMGIAMAYDQPWGVALAIGLS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHH
LSLSSTAIVLQTLSEKGLMQTNGGRNVFSVLLAQDIAVIPMLAFLPLLVVTIPLQIAQDG
HCCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
SIIVTATSHAGGDAHHSLSLVDGLPAWGVTLVTIGAIAAVIFAGVYLTRPLFRFIHAARL
CEEEEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REMYTALALLIVVGISFLMTLVGLSPALGAFLAGVVLANSEFRHELESDLEPFKGLLLGL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FFITVGAGINFPLLFDNTPAILSMALLVIIVKGLILFVLGWAFKLKGRDQWLFALGLAQA
HHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHEEHHHCC
GEFGFVLTSFSVQQNVIPLEIAETLLLVIALSMLITPLLFIIYDVLSRRMEEQVEQHPDD
CCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EIDEQGPVIIAGVGRFGQIVNRLVQANGFKTVVLDQDMETIAVMRRFGYKGFLGDPNRPD
CCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCC
ILRAAGIDSAKVLVVALDDPEASIKLVKYARSIRPDLHIIARARDRTFVYRLFQAGASDI
HHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHHHHCHHHH
VREMFDSSLRAGRYVLENVGLSEFEAAEAERVFYHHDRKTIRQLADLWDPSRPASQNPAY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VARAKELQKELETAILSRSISAKNTDG
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA