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The map label for this gene is hemN [H]

Identifier: 110678999

GI number: 110678999

Start: 1627549

End: 1628898

Strand: Direct

Name: hemN [H]

Synonym: RD1_1696

Alternate gene names: 110678999

Gene position: 1627549-1628898 (Clockwise)

Preceding gene: 110678998

Following gene: 110679000

Centisome position: 39.38

GC content: 60.52

Gene sequence:

>1350_bases
ATGACCAACACGCTTAAAACCTACATGAACCGCAACGTGCCGCGCTACACCAGCTATCCCACGGCGCCGCATTTTTCCGA
TGCCATCGGTTCTGAGGACTATGCGGCGTGGTTGTCGACGCTTCCTCCCGAAAAACCAGTCTCTCTCTACCTGCATGTGC
CCTTTTGTCGTGAGCTGTGCTGGTATTGCGGGTGCAATATGAAACTGGCGAAAAAGGATGCGCCTGTCGCGCAATACGCA
AAGACGCTCAACCGCGAGATCGGCTTGTTGGCGCAACATCTGCCGCAGCGGATGCAGGTTTCGCATCTGCATTGGGGCGG
TGGAACACCCACAGCCCTTGTGCCGGACGATCTGGAGCGTGCGATGGACGCTGTGCAGGCCAGCTTCGATTTCACCCCTG
ACGCCGAACTGGCGATCGAGAGTGACCCGCGCACGCTCACCGATGAGATGACCCTGCGGATCGGGCAAATGGGTTTCACC
CGTGCCAGCTTTGGGGTGCAGGAATTTGACCCCAAGGTGCAAAAAGCCATCAACCGGATACAGCCGCCCGACATGGTGCG
CCATTCAGTCGAGGGCCTGCGTGCGGCGGGTGTCACGGGCATCAACTTTGATCTGATTTACGGGCTGCCGCATCAGACCG
TCGATACGCTGTTGGAGACAATTCGCCTCTGCGTGGAAATGCAGCCGGATCGCATTGCGCTGTTTGGATATGCGCATGTG
CCCTGGATGGCCAAGAAACAAAGGCTTATTGATGAGGCTGCCCTGCCCGATGGGGATGCTCGCTTGCAGCAATCACAGGC
GGCGGCCCTCGCCCTGGTCGCGGCGGGATATGTGGCCATTGGCCTTGATCATTTCGCGCTGCCCTCTGACCCGATGGCTA
AAGCTGCCCGAGAAGGCAGCCTGCGCCGCAATTTCCAAGGATACACAACCGACCGCGCGGAAACCATGCTGGGCGTGGGG
TCAACGTCCATCGGGCGCACGCCGTCAGGATACGTTCAAAACCTCGCGGAAACGGGTGCCTGGGCGCGCGCTGTTGAAGC
AGGTGTGCTGCCCATCGCCAAGGGCGTCGGCCTGAGCAAGGATGACAACCTGCGCGGTCATGTCATAGAGCGGCTGATGT
GCAATGGGGAGGTGGACCTCGACGCGGCTGCCCTGCAGTTTGGCACGCCGCGCGATTGGTATCACCCCCACGAAGCAGAA
CTGGCCATTCTTGAAGCCGATGGTCTGATCACGCGCCGGGGTGGAAAAATCACGGTCACGGATCACGGCGCACCGGTCGT
GCGCGTCGCGGCAGCTGTCTTTGACGCCTATTTCGCGGCGCAGCGGGCACGCCATGCGGTTGCTGTCTAG

Upstream 100 bases:

>100_bases
TGACCGAAACCGGGCTGTCTTCAAGGCCCTGACGACCGAATGGCTTGGGACGGTTTCCAGGCCCGCAGCCACAACGCTGA
AAAAACAGACTGGGACTTCG

Downstream 100 bases:

>100_bases
GGGCTTTTAGCCCCGCTGCACCCCATGCGCCTTTTGACGGGCGATGCTCCGTTGCCTACCACTTGCCCCGCACCCAACTG
CGCCGGACTGGCGTGCGGAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTNTLKTYMNRNVPRYTSYPTAPHFSDAIGSEDYAAWLSTLPPEKPVSLYLHVPFCRELCWYCGCNMKLAKKDAPVAQYA
KTLNREIGLLAQHLPQRMQVSHLHWGGGTPTALVPDDLERAMDAVQASFDFTPDAELAIESDPRTLTDEMTLRIGQMGFT
RASFGVQEFDPKVQKAINRIQPPDMVRHSVEGLRAAGVTGINFDLIYGLPHQTVDTLLETIRLCVEMQPDRIALFGYAHV
PWMAKKQRLIDEAALPDGDARLQQSQAAALALVAAGYVAIGLDHFALPSDPMAKAAREGSLRRNFQGYTTDRAETMLGVG
STSIGRTPSGYVQNLAETGAWARAVEAGVLPIAKGVGLSKDDNLRGHVIERLMCNGEVDLDAAALQFGTPRDWYHPHEAE
LAILEADGLITRRGGKITVTDHGAPVVRVAAAVFDAYFAAQRARHAVAV

Sequences:

>Translated_449_residues
MTNTLKTYMNRNVPRYTSYPTAPHFSDAIGSEDYAAWLSTLPPEKPVSLYLHVPFCRELCWYCGCNMKLAKKDAPVAQYA
KTLNREIGLLAQHLPQRMQVSHLHWGGGTPTALVPDDLERAMDAVQASFDFTPDAELAIESDPRTLTDEMTLRIGQMGFT
RASFGVQEFDPKVQKAINRIQPPDMVRHSVEGLRAAGVTGINFDLIYGLPHQTVDTLLETIRLCVEMQPDRIALFGYAHV
PWMAKKQRLIDEAALPDGDARLQQSQAAALALVAAGYVAIGLDHFALPSDPMAKAAREGSLRRNFQGYTTDRAETMLGVG
STSIGRTPSGYVQNLAETGAWARAVEAGVLPIAKGVGLSKDDNLRGHVIERLMCNGEVDLDAAALQFGTPRDWYHPHEAE
LAILEADGLITRRGGKITVTDHGAPVVRVAAAVFDAYFAAQRARHAVAV
>Mature_448_residues
TNTLKTYMNRNVPRYTSYPTAPHFSDAIGSEDYAAWLSTLPPEKPVSLYLHVPFCRELCWYCGCNMKLAKKDAPVAQYAK
TLNREIGLLAQHLPQRMQVSHLHWGGGTPTALVPDDLERAMDAVQASFDFTPDAELAIESDPRTLTDEMTLRIGQMGFTR
ASFGVQEFDPKVQKAINRIQPPDMVRHSVEGLRAAGVTGINFDLIYGLPHQTVDTLLETIRLCVEMQPDRIALFGYAHVP
WMAKKQRLIDEAALPDGDARLQQSQAAALALVAAGYVAIGLDHFALPSDPMAKAAREGSLRRNFQGYTTDRAETMLGVGS
TSIGRTPSGYVQNLAETGAWARAVEAGVLPIAKGVGLSKDDNLRGHVIERLMCNGEVDLDAAALQFGTPRDWYHPHEAEL
AILEADGLITRRGGKITVTDHGAPVVRVAAAVFDAYFAAQRARHAVAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=291, Percent_Identity=25.4295532646048, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI87082341, Length=436, Percent_Identity=38.5321100917431, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=28.3950617283951, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49116; Mature: 48984

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTLKTYMNRNVPRYTSYPTAPHFSDAIGSEDYAAWLSTLPPEKPVSLYLHVPFCRELC
CCCHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHH
WYCGCNMKLAKKDAPVAQYAKTLNREIGLLAQHLPQRMQVSHLHWGGGTPTALVPDDLER
HHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCEEECCCCCCCCCCCHHHHH
AMDAVQASFDFTPDAELAIESDPRTLTDEMTLRIGQMGFTRASFGVQEFDPKVQKAINRI
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHCCHHHCCHHHHHHHHHC
QPPDMVRHSVEGLRAAGVTGINFDLIYGLPHQTVDTLLETIRLCVEMQPDRIALFGYAHV
CCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
PWMAKKQRLIDEAALPDGDARLQQSQAAALALVAAGYVAIGLDHFALPSDPMAKAAREGS
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHCCC
LRRNFQGYTTDRAETMLGVGSTSIGRTPSGYVQNLAETGAWARAVEAGVLPIAKGVGLSK
HHHCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHCCHHHHHCCCCCC
DDNLRGHVIERLMCNGEVDLDAAALQFGTPRDWYHPHEAELAILEADGLITRRGGKITVT
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCEEEECCCEEEEE
DHGAPVVRVAAAVFDAYFAAQRARHAVAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNTLKTYMNRNVPRYTSYPTAPHFSDAIGSEDYAAWLSTLPPEKPVSLYLHVPFCRELC
CCHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHH
WYCGCNMKLAKKDAPVAQYAKTLNREIGLLAQHLPQRMQVSHLHWGGGTPTALVPDDLER
HHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCEEECCCCCCCCCCCHHHHH
AMDAVQASFDFTPDAELAIESDPRTLTDEMTLRIGQMGFTRASFGVQEFDPKVQKAINRI
HHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHCCHHHCCHHHHHHHHHC
QPPDMVRHSVEGLRAAGVTGINFDLIYGLPHQTVDTLLETIRLCVEMQPDRIALFGYAHV
CCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
PWMAKKQRLIDEAALPDGDARLQQSQAAALALVAAGYVAIGLDHFALPSDPMAKAAREGS
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHCCC
LRRNFQGYTTDRAETMLGVGSTSIGRTPSGYVQNLAETGAWARAVEAGVLPIAKGVGLSK
HHHCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHCCHHHHHCCCCCC
DDNLRGHVIERLMCNGEVDLDAAALQFGTPRDWYHPHEAELAILEADGLITRRGGKITVT
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCEEEECCCEEEEE
DHGAPVVRVAAAVFDAYFAAQRARHAVAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]