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The map label for this gene is kdsA [H]

Identifier: 110678965

GI number: 110678965

Start: 1597171

End: 1598004

Strand: Reverse

Name: kdsA [H]

Synonym: RD1_1661

Alternate gene names: 110678965

Gene position: 1598004-1597171 (Counterclockwise)

Preceding gene: 110678966

Following gene: 110678963

Centisome position: 38.66

GC content: 60.43

Gene sequence:

>834_bases
ATGACACATGTTCCCGTCGGCGATCTTGTGATCGGTAACGACCGCCCCCTGACCGTGATCGCAGGCCCTTGCCAGTTGGA
AAGCGCGGATCACGCCCAGATGATCGCAGGCCGCATGAAAGAGGCCTGCGACAAGGCCGGCGCGCAATATGTGTTCAAGG
CCTCATACGACAAGGCAAACCGGACGTCACTGTCCGGCATTCGCGGCCCCGGCATGGATGAGGGCCTCAAGATCTTGCAA
TCGGTGGGACAGGCAATTGATGTGCCCGTCCTGACCGATGTGCACAATGAGGGACAATGCGCGCCAGCCGCCCAAGCCGT
CGATATCTTGCAAATCCCGGCGTTTTTGTGCCGCCAGACCGATATGCTGCTGGCGGCGGGTCAAACCGGGGCTGCGGTCA
ACGTCAAAAAGGGACAGTTTCTGGCCCCCTGGGAGATGTCGAACATCACGACCAAGATCGAAAGCACCGGCAACACCCGT
ATCTTGCTGACCGAGCGTGGGACGTCCTTTGGCTATAACACGCTGGTGGCTGACATGCGCGCCCTGCCCCAGATGGCGCA
AACCGGCTATCCGGTGGTGATGGATGCGACACATTCGGTGCAGCAACCGGGCGGCAAGGGTGGATCATCGGGCGGTCAGC
GCGAATTTGCACCCGTGATGGCGCGGGCGGCGGTCGCCATTGGTGTTGCCGCCGTCTTCATTGAAACGCATGAAAACCCG
GACGCCTCGCCCTCGGACGGGCCCAATATGATATACCTCGACCAGATGCCGGACCTGATCGAGACGTTGATGCAATTTGA
TGCGCTGGCCAAGGCCAGACCGGTCGTGATCTAA

Upstream 100 bases:

>100_bases
AGCTTTGGCAACACGACGCGCGCCTTCTTGATCTTTACCGGAAACTGCCTGATGGTCTTTCTGACAGCATCAATTCTCAC
AGAACAGGTAACTTCTTGAC

Downstream 100 bases:

>100_bases
AGCGGCATGCCCAAAACATGGATCACGCAACGCTGCCTGAAATCAGGGATTCCAACGCGTTACGTGATTTTCAAGTATGT
CGCCAGACGCTCTAGTCGAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTHVPVGDLVIGNDRPLTVIAGPCQLESADHAQMIAGRMKEACDKAGAQYVFKASYDKANRTSLSGIRGPGMDEGLKILQ
SVGQAIDVPVLTDVHNEGQCAPAAQAVDILQIPAFLCRQTDMLLAAGQTGAAVNVKKGQFLAPWEMSNITTKIESTGNTR
ILLTERGTSFGYNTLVADMRALPQMAQTGYPVVMDATHSVQQPGGKGGSSGGQREFAPVMARAAVAIGVAAVFIETHENP
DASPSDGPNMIYLDQMPDLIETLMQFDALAKARPVVI

Sequences:

>Translated_277_residues
MTHVPVGDLVIGNDRPLTVIAGPCQLESADHAQMIAGRMKEACDKAGAQYVFKASYDKANRTSLSGIRGPGMDEGLKILQ
SVGQAIDVPVLTDVHNEGQCAPAAQAVDILQIPAFLCRQTDMLLAAGQTGAAVNVKKGQFLAPWEMSNITTKIESTGNTR
ILLTERGTSFGYNTLVADMRALPQMAQTGYPVVMDATHSVQQPGGKGGSSGGQREFAPVMARAAVAIGVAAVFIETHENP
DASPSDGPNMIYLDQMPDLIETLMQFDALAKARPVVI
>Mature_276_residues
THVPVGDLVIGNDRPLTVIAGPCQLESADHAQMIAGRMKEACDKAGAQYVFKASYDKANRTSLSGIRGPGMDEGLKILQS
VGQAIDVPVLTDVHNEGQCAPAAQAVDILQIPAFLCRQTDMLLAAGQTGAAVNVKKGQFLAPWEMSNITTKIESTGNTRI
LLTERGTSFGYNTLVADMRALPQMAQTGYPVVMDATHSVQQPGGKGGSSGGQREFAPVMARAAVAIGVAAVFIETHENPD
ASPSDGPNMIYLDQMPDLIETLMQFDALAKARPVVI

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=270, Percent_Identity=41.8518518518518, Blast_Score=230, Evalue=7e-62,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29292; Mature: 29161

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVPVGDLVIGNDRPLTVIAGPCQLESADHAQMIAGRMKEACDKAGAQYVFKASYDKAN
CCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
RTSLSGIRGPGMDEGLKILQSVGQAIDVPVLTDVHNEGQCAPAAQAVDILQIPAFLCRQT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
DMLLAAGQTGAAVNVKKGQFLAPWEMSNITTKIESTGNTRILLTERGTSFGYNTLVADMR
CCEEECCCCCCEEEECCCCEECCCCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHH
ALPQMAQTGYPVVMDATHSVQQPGGKGGSSGGQREFAPVMARAAVAIGVAAVFIETHENP
HHHHHHHCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCC
DASPSDGPNMIYLDQMPDLIETLMQFDALAKARPVVI
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THVPVGDLVIGNDRPLTVIAGPCQLESADHAQMIAGRMKEACDKAGAQYVFKASYDKAN
CCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
RTSLSGIRGPGMDEGLKILQSVGQAIDVPVLTDVHNEGQCAPAAQAVDILQIPAFLCRQT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCC
DMLLAAGQTGAAVNVKKGQFLAPWEMSNITTKIESTGNTRILLTERGTSFGYNTLVADMR
CCEEECCCCCCEEEECCCCEECCCCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHH
ALPQMAQTGYPVVMDATHSVQQPGGKGGSSGGQREFAPVMARAAVAIGVAAVFIETHENP
HHHHHHHCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCC
DASPSDGPNMIYLDQMPDLIETLMQFDALAKARPVVI
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA