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The map label for this gene is hemA [H]

Identifier: 110678883

GI number: 110678883

Start: 1497792

End: 1499006

Strand: Direct

Name: hemA [H]

Synonym: RD1_1576

Alternate gene names: 110678883

Gene position: 1497792-1499006 (Clockwise)

Preceding gene: 110678882

Following gene: 110678884

Centisome position: 36.24

GC content: 62.06

Gene sequence:

>1215_bases
ATGAACTACGACGCCTTTTTCGCTGAACAACTGGACCAACTGCGCGCCGAAGGGAACTACCGCGTTTTTGCGGAACTTGA
ACGAGACGCCACTGATGCGCCCCACGCTACGATGCACGGGGCTGACAAGGCGCGCCCCGTGACGGTCTGGTGTTCCAACG
ATTATCTTGGGATGGGCAAATCGGCATTCGTGCGGCAAGCCGTTGCCGACGCGGCCCTGAAGGATGGGGCCGGTGCCGGG
GGCACGCGCAACATTTCAGGCACGGCCACGCAGCACGTCGCGCTTGAGGCCGAACTGGCGGATTTGCACGGCAAGGAAGC
CGCATTGCTGTTCACGTCGGGCTATGTGTCCAACTGGGCGAGCCTCAGCACATTGGGTGCGCATCTGCCCGGTTGCACCA
TTCTTTCGGATGAAATGAACCATGCCAGCATGATCGAAGGCATCCGCCACAGCCGGGCAGGCAAGGTCATCTGGAAACAC
AACGACCCCGAAGACCTCAATCGCAAGCTTGAGGCGCTGCCGAAAGGGGGCGCGCGTCTGATCGCCTTTGAATCGGTCTA
TTCCATGGATGGAGACATCGCGCCAATCGCGGAAATCCTCGATGTGGCCGAGGCGCATGGGGCCATGACCTATCTCGATG
AGGTGCATGCCGTCGGGCTTTATGGCCCGCAGGGCGGCGGCATTGCCGAACGCGAGGGGCTGGCGCACCGCGTGTCCCTG
ATCGAGGGCACATTGGGCAAGGCCTTTGGCGTCATGGGGGGCTATATCGCGGGATCAGCCGTGATGTGCGATTTCGTGCG
CTCTTTTGCCAGCGGGTTCATCTTTACCACCGCCTTGCCCCCCGCGCTGGCCGCGGGCGCGCTGACGTCCATCCGGCATC
TGCGGCGCAGTGATCTGGAACGCCGCCGCCAACAGGCCAATGTGGCCAAGCTGCGCGCGCGCCTTGATGCGATGCGTCTG
CCCCATCTGGACAACCCAAGCCATATCGTGCCGGTGATGGTCGGTGATCCGTTCAAAGCCAAATTCCTCAGCGACACCCT
GCTGGAGCAGCATGGCATCTACGTGCAGCCGATCAATTACCCGACCGTGCCCAAAGGAACGGAGCGGTTGCGCATCACGC
CCTCACCCCTGCATACGGATGAAGATACCGACCGTCTGGTTGCGGCACTGTCCGATCTGTGGTCGCAATGCGCGCTGAAC
CGGGCAGTTGCCTGA

Upstream 100 bases:

>100_bases
GTCATTTAATGGATGAGGCAGACGAGGGCACTTGACCAATGTCAAGGCCATGGGCGCGCACCCCCGGTTTTATGGGTGAA
ACCCCGGGGGAGAGACCTGC

Downstream 100 bases:

>100_bases
AACCTCTGCGGGAAAAACCGTTTTCGGGGCGGCCTGATGCCGCTGTTCTGCATGGAATCGCCGGGGCTTGCCCGACAAAA
GCCCTTCAGCCAGCCAAGGT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNYDAFFAEQLDQLRAEGNYRVFAELERDATDAPHATMHGADKARPVTVWCSNDYLGMGKSAFVRQAVADAALKDGAGAG
GTRNISGTATQHVALEAELADLHGKEAALLFTSGYVSNWASLSTLGAHLPGCTILSDEMNHASMIEGIRHSRAGKVIWKH
NDPEDLNRKLEALPKGGARLIAFESVYSMDGDIAPIAEILDVAEAHGAMTYLDEVHAVGLYGPQGGGIAEREGLAHRVSL
IEGTLGKAFGVMGGYIAGSAVMCDFVRSFASGFIFTTALPPALAAGALTSIRHLRRSDLERRRQQANVAKLRARLDAMRL
PHLDNPSHIVPVMVGDPFKAKFLSDTLLEQHGIYVQPINYPTVPKGTERLRITPSPLHTDEDTDRLVAALSDLWSQCALN
RAVA

Sequences:

>Translated_404_residues
MNYDAFFAEQLDQLRAEGNYRVFAELERDATDAPHATMHGADKARPVTVWCSNDYLGMGKSAFVRQAVADAALKDGAGAG
GTRNISGTATQHVALEAELADLHGKEAALLFTSGYVSNWASLSTLGAHLPGCTILSDEMNHASMIEGIRHSRAGKVIWKH
NDPEDLNRKLEALPKGGARLIAFESVYSMDGDIAPIAEILDVAEAHGAMTYLDEVHAVGLYGPQGGGIAEREGLAHRVSL
IEGTLGKAFGVMGGYIAGSAVMCDFVRSFASGFIFTTALPPALAAGALTSIRHLRRSDLERRRQQANVAKLRARLDAMRL
PHLDNPSHIVPVMVGDPFKAKFLSDTLLEQHGIYVQPINYPTVPKGTERLRITPSPLHTDEDTDRLVAALSDLWSQCALN
RAVA
>Mature_404_residues
MNYDAFFAEQLDQLRAEGNYRVFAELERDATDAPHATMHGADKARPVTVWCSNDYLGMGKSAFVRQAVADAALKDGAGAG
GTRNISGTATQHVALEAELADLHGKEAALLFTSGYVSNWASLSTLGAHLPGCTILSDEMNHASMIEGIRHSRAGKVIWKH
NDPEDLNRKLEALPKGGARLIAFESVYSMDGDIAPIAEILDVAEAHGAMTYLDEVHAVGLYGPQGGGIAEREGLAHRVSL
IEGTLGKAFGVMGGYIAGSAVMCDFVRSFASGFIFTTALPPALAAGALTSIRHLRRSDLERRRQQANVAKLRARLDAMRL
PHLDNPSHIVPVMVGDPFKAKFLSDTLLEQHGIYVQPINYPTVPKGTERLRITPSPLHTDEDTDRLVAALSDLWSQCALN
RAVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=48.8833746898263, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=48.8833746898263, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=48.8833746898263, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.8759305210918, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.8759305210918, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=36.2694300518135, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=38.4393063583815, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI119220554, Length=390, Percent_Identity=31.025641025641, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4758668, Length=386, Percent_Identity=31.3471502590674, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=26.3374485596708, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790046, Length=391, Percent_Identity=35.0383631713555, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=36.0703812316716, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=360, Percent_Identity=35.8333333333333, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=31.9444444444444, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=404, Percent_Identity=27.2277227722772, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=404, Percent_Identity=27.2277227722772, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=256, Percent_Identity=27.734375, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=256, Percent_Identity=27.734375, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=47.0449172576832, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=29.3010752688172, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=24.4186046511628, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137420, Length=405, Percent_Identity=49.1358024691358, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24662918, Length=385, Percent_Identity=33.5064935064935, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=30.6849315068493, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24653280, Length=261, Percent_Identity=27.5862068965517, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653276, Length=261, Percent_Identity=27.5862068965517, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653278, Length=261, Percent_Identity=27.5862068965517, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 43545; Mature: 43545

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDAFFAEQLDQLRAEGNYRVFAELERDATDAPHATMHGADKARPVTVWCSNDYLGMGK
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCH
SAFVRQAVADAALKDGAGAGGTRNISGTATQHVALEAELADLHGKEAALLFTSGYVSNWA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEHHHHHCCCCCEEEEEECCHHHHHH
SLSTLGAHLPGCTILSDEMNHASMIEGIRHSRAGKVIWKHNDPEDLNRKLEALPKGGARL
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCEE
IAFESVYSMDGDIAPIAEILDVAEAHGAMTYLDEVHAVGLYGPQGGGIAEREGLAHRVSL
EEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHH
IEGTLGKAFGVMGGYIAGSAVMCDFVRSFASGFIFTTALPPALAAGALTSIRHLRRSDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RRRQQANVAKLRARLDAMRLPHLDNPSHIVPVMVGDPFKAKFLSDTLLEQHGIYVQPINY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PTVPKGTERLRITPSPLHTDEDTDRLVAALSDLWSQCALNRAVA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYDAFFAEQLDQLRAEGNYRVFAELERDATDAPHATMHGADKARPVTVWCSNDYLGMGK
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCH
SAFVRQAVADAALKDGAGAGGTRNISGTATQHVALEAELADLHGKEAALLFTSGYVSNWA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEHHHHHCCCCCEEEEEECCHHHHHH
SLSTLGAHLPGCTILSDEMNHASMIEGIRHSRAGKVIWKHNDPEDLNRKLEALPKGGARL
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCEE
IAFESVYSMDGDIAPIAEILDVAEAHGAMTYLDEVHAVGLYGPQGGGIAEREGLAHRVSL
EEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHH
IEGTLGKAFGVMGGYIAGSAVMCDFVRSFASGFIFTTALPPALAAGALTSIRHLRRSDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RRRQQANVAKLRARLDAMRLPHLDNPSHIVPVMVGDPFKAKFLSDTLLEQHGIYVQPINY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
PTVPKGTERLRITPSPLHTDEDTDRLVAALSDLWSQCALNRAVA
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]