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The map label for this gene is regM [H]

Identifier: 110678779

GI number: 110678779

Start: 1389304

End: 1390710

Strand: Direct

Name: regM [H]

Synonym: RD1_1465

Alternate gene names: 110678779

Gene position: 1389304-1390710 (Clockwise)

Preceding gene: 110678778

Following gene: 110678780

Centisome position: 33.61

GC content: 58.21

Gene sequence:

>1407_bases
ATGTTCAATTCGCTTTCAGGTCGTCTCATCATTCTGACAACCATCTTTGTGATGATTGCAGAGGTCCTGATTTTTGTGCC
CTCGATCGCGCGGTTCCGCGAGGATTATCTCAACAACAAGCTGGAGCGGGCGCAGATCGCGTCGCTGGCCTTGCTGGCGG
ATGATATGCTTGACGGCGAGCTGGAAAAGGAGCTGCTGGAAAACGCGGGCGTTTTCAATGTGGTGCTGCGTCGCGATCAG
GTGCGCCAACTCGTGCTGTCCTCCGATATGCCGCAAGCTATCGCGGCCACATATGACATGCGAGACAACTCCGCTGTGGT
CTTGATCCGCGATGCGCTGGCGCGTTTTGTCTCACCGCAAAACGAGGTGATCCGCGTGATCGGGGCGCCTGTGCGGGATG
CGGGCCTGCTGATCGAAATCACGATGGAGACTGATCCATTGCGGATGACGATGATAGATTATGGCATCCGTATTCTGATC
CTCTCGGCTGTGATTTCGGTTATCACCGCCTCTTTGCTGTTCGTGGCGATGCGGGCCCTGTTGCTCAAGCCGATCAAACG
GGTGGTGGGGGACATGCAGAATTACGCCGCGGCCCCCGAGGATGCGCGCCGCATTATTGTGCCCTCTGCCAGTGTGACCG
AGTTGCGCGAAGCCGAAGAAGCGTTGCAAAAGCTGGAAACCGACCTGACGCAGGCCTTGCGCCAAAAGGAGCGGTTGGCG
CAGCTGGGTAGTGCTGTGAGCAAGATCAGCCACGATCTGCGCAATATTCTGACCTCGGCTCAGCTATTCACGGACCGGAT
CGAGATGAGCGAGGATCCGACCGTCAAGCGGATGGCCCCCAAGCTTGTCGGGTCGATCACGCGGGCAGTTCATCTGTGCG
AAAGTACGCTGGCGTTTGGTAAGGCCGAAGAACCAAGCCCGACGCTCACGCGGCTTGCGCTGCGCGATCTTGTCGATGAA
GTGATCGATGGGGAGGTGCTGGCGATCGGTGATCATGATGTAGAGATCGTCTGTAAAGTCCCCGCAATGATGATGGTGCG
TGCAGACCCGGAGCAGCTTTACCGTGTCATTGCAAACCTGATGCGAAACGCACGTCAGGCCATCACTGCGACCAGTCAGC
CTGGACAGATCAACATCGAGGGCAGGGAGGACGCAGGTGCCTGGTATCTCGATGTCGCAGACACAGGTCCGGGTTTGCCC
CCAAAAGCGCAGGAGTTCCTGTTTGCCCCTTTCCAAGGCGGCGCGCGCAAAGGAGGATCAGGCCTTGGGCTCGCGATTTC
CGCCGAGCTCGTCAAAGGTCACGGCGGTATCCTTGATTTGGCGTGGACCGGACCGGACGGCACGTGTTTCACCATTACGC
TGCCCAAAGGGGACGGCACATTGCCCGATCGGCAGCTGGATACATAA

Upstream 100 bases:

>100_bases
GCGCCGCAGGGGCCTATTACAGTCCGCGACTTTTCGACAATCCCAAGGTCAAAAAGATCGTGGGGCTTGTTCAACGCTAC
ATCCCGTGAAAATCTGACAT

Downstream 100 bases:

>100_bases
ACTGCGCGGAGTCCGCCGAGGCCGCACATACAGGCCGAAAACGGGGGTGAAAAAATGACAGCAATTTTGATGCCTTTGGG
CTTGCATAAATCATAAGGCA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MFNSLSGRLIILTTIFVMIAEVLIFVPSIARFREDYLNNKLERAQIASLALLADDMLDGELEKELLENAGVFNVVLRRDQ
VRQLVLSSDMPQAIAATYDMRDNSAVVLIRDALARFVSPQNEVIRVIGAPVRDAGLLIEITMETDPLRMTMIDYGIRILI
LSAVISVITASLLFVAMRALLLKPIKRVVGDMQNYAAAPEDARRIIVPSASVTELREAEEALQKLETDLTQALRQKERLA
QLGSAVSKISHDLRNILTSAQLFTDRIEMSEDPTVKRMAPKLVGSITRAVHLCESTLAFGKAEEPSPTLTRLALRDLVDE
VIDGEVLAIGDHDVEIVCKVPAMMMVRADPEQLYRVIANLMRNARQAITATSQPGQINIEGREDAGAWYLDVADTGPGLP
PKAQEFLFAPFQGGARKGGSGLGLAISAELVKGHGGILDLAWTGPDGTCFTITLPKGDGTLPDRQLDT

Sequences:

>Translated_468_residues
MFNSLSGRLIILTTIFVMIAEVLIFVPSIARFREDYLNNKLERAQIASLALLADDMLDGELEKELLENAGVFNVVLRRDQ
VRQLVLSSDMPQAIAATYDMRDNSAVVLIRDALARFVSPQNEVIRVIGAPVRDAGLLIEITMETDPLRMTMIDYGIRILI
LSAVISVITASLLFVAMRALLLKPIKRVVGDMQNYAAAPEDARRIIVPSASVTELREAEEALQKLETDLTQALRQKERLA
QLGSAVSKISHDLRNILTSAQLFTDRIEMSEDPTVKRMAPKLVGSITRAVHLCESTLAFGKAEEPSPTLTRLALRDLVDE
VIDGEVLAIGDHDVEIVCKVPAMMMVRADPEQLYRVIANLMRNARQAITATSQPGQINIEGREDAGAWYLDVADTGPGLP
PKAQEFLFAPFQGGARKGGSGLGLAISAELVKGHGGILDLAWTGPDGTCFTITLPKGDGTLPDRQLDT
>Mature_468_residues
MFNSLSGRLIILTTIFVMIAEVLIFVPSIARFREDYLNNKLERAQIASLALLADDMLDGELEKELLENAGVFNVVLRRDQ
VRQLVLSSDMPQAIAATYDMRDNSAVVLIRDALARFVSPQNEVIRVIGAPVRDAGLLIEITMETDPLRMTMIDYGIRILI
LSAVISVITASLLFVAMRALLLKPIKRVVGDMQNYAAAPEDARRIIVPSASVTELREAEEALQKLETDLTQALRQKERLA
QLGSAVSKISHDLRNILTSAQLFTDRIEMSEDPTVKRMAPKLVGSITRAVHLCESTLAFGKAEEPSPTLTRLALRDLVDE
VIDGEVLAIGDHDVEIVCKVPAMMMVRADPEQLYRVIANLMRNARQAITATSQPGQINIEGREDAGAWYLDVADTGPGLP
PKAQEFLFAPFQGGARKGGSGLGLAISAELVKGHGGILDLAWTGPDGTCFTITLPKGDGTLPDRQLDT

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790300, Length=188, Percent_Identity=32.4468085106383, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=272, Percent_Identity=28.3088235294118, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=27.4261603375527, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=28.6919831223629, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=318, Percent_Identity=26.1006289308176, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=28.5123966942149, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51117; Mature: 51117

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNSLSGRLIILTTIFVMIAEVLIFVPSIARFREDYLNNKLERAQIASLALLADDMLDGE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHH
LEKELLENAGVFNVVLRRDQVRQLVLSSDMPQAIAATYDMRDNSAVVLIRDALARFVSPQ
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCH
NEVIRVIGAPVRDAGLLIEITMETDPLRMTMIDYGIRILILSAVISVITASLLFVAMRAL
HHHHHHHCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKPIKRVVGDMQNYAAAPEDARRIIVPSASVTELREAEEALQKLETDLTQALRQKERLA
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGSAVSKISHDLRNILTSAQLFTDRIEMSEDPTVKRMAPKLVGSITRAVHLCESTLAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KAEEPSPTLTRLALRDLVDEVIDGEVLAIGDHDVEIVCKVPAMMMVRADPEQLYRVIANL
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCHHHEEECCHHHHHHHHHHH
MRNARQAITATSQPGQINIEGREDAGAWYLDVADTGPGLPPKAQEFLFAPFQGGARKGGS
HHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCHHHEECCCCCCCCCCCC
GLGLAISAELVKGHGGILDLAWTGPDGTCFTITLPKGDGTLPDRQLDT
CCEEEEEHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MFNSLSGRLIILTTIFVMIAEVLIFVPSIARFREDYLNNKLERAQIASLALLADDMLDGE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHH
LEKELLENAGVFNVVLRRDQVRQLVLSSDMPQAIAATYDMRDNSAVVLIRDALARFVSPQ
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCH
NEVIRVIGAPVRDAGLLIEITMETDPLRMTMIDYGIRILILSAVISVITASLLFVAMRAL
HHHHHHHCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKPIKRVVGDMQNYAAAPEDARRIIVPSASVTELREAEEALQKLETDLTQALRQKERLA
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGSAVSKISHDLRNILTSAQLFTDRIEMSEDPTVKRMAPKLVGSITRAVHLCESTLAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KAEEPSPTLTRLALRDLVDEVIDGEVLAIGDHDVEIVCKVPAMMMVRADPEQLYRVIANL
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCHHHEEECCHHHHHHHHHHH
MRNARQAITATSQPGQINIEGREDAGAWYLDVADTGPGLPPKAQEFLFAPFQGGARKGGS
HHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCHHHEECCCCCCCCCCCC
GLGLAISAELVKGHGGILDLAWTGPDGTCFTITLPKGDGTLPDRQLDT
CCEEEEEHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]