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The map label for this gene is gcvT [H]

Identifier: 110678666

GI number: 110678666

Start: 1296217

End: 1298619

Strand: Reverse

Name: gcvT [H]

Synonym: RD1_1345

Alternate gene names: 110678666

Gene position: 1298619-1296217 (Counterclockwise)

Preceding gene: 110678668

Following gene: 110678665

Centisome position: 31.42

GC content: 62.13

Gene sequence:

>2403_bases
ATGAAGTCACATTACCGCGTTGTCGTGATCGGCGGGGGTGTCGTGGGCACGTCCATCCTCTACCATCTGGCCAAGATGGG
GTGGAGCGACGTGTGCCTCATCGAACGTTCCCTGCTGACAGCCGGGTCAAGCTGGCATGCGGCGGGCGGGTTTCATGCCC
TGAATGCGGACCCGAACATCGCACAGCTTCAGTCCTATACGATTGACCTCTTTGACGACATTCAGGAGGAAAGCGGGCAG
GACATCGGCCTGCACCGCACCGGCGGGTTGACCATGGCGGGCACGCCGGACCGTTGGGAATGGCTGCAATCGGCGTATCG
CACGTTTCAGTCCATCGGCATCCACGACTGCCGCCTTGTGACGGTGGAAGAGGCAGTGGCCCTCAATCCGATCATGTCCG
GTGACGGGCTGCTTGGCGGCATGTGGGCCGACCGCGAAGGGTACATCGACACAACCGGCACGGTGCACGCCTATGCAGGC
GCGGCCAAGAAACGCGGCGCCACCGTGATCGAACACAACCGTGTGCTGGAACTGAACCAGACTCTGCAAGGGTGGGACGT
TGTTACCGAAAAAGGGACGGTGAGCTGCGAACATGTGGTCAATGCGGCGGGCCTCTGGGCCAAGCAGGTGGGGCGTATGG
CCGGGATCGAATTGCCTGTCTCCCCGCTCAACCACCACTATCTGATCTCGGACACGATCCCGCAGCTTGAAGGCCTTGAT
TTCGAGGTCCCCATGACCGTGGATCTCGAAGGATTCACCTATCTGCGGCAGGATCAGAAGGGCGTGCTGCTGGGCATCTA
CGAGGTCAATCACCAGCACTGGATGATGGACGGCGCACCGTGGGAATACGGGTTTGAATTGCAGCAGGAAGACCCCGACC
GCATCGAAAATGAACTGATCATGGGCTTTGAGCGCTACCCCTGCCTGCAGGAGGTCGGCGTCAAGACATGGGTGAACGGC
GCGTTCACCTTCTCGCCCGATGGCAACCCGCTGGTGGGGCCTGTGCCGGGCAAGCGCGGGTACTGGTCGGCCTGCGCGGT
GATGGCCGGGTTCCTGCAGGGCGGCGGCGTCGGCAAATCGCTGGCCGAATGGATGATCAACGGCACACCTGATGCGGATG
TCTACGGGATGGATGTGGCCCGCTATGGCGTCTGGGCCGAAAACAAGCAGTACATCAAGGAAACAACCGGCCAGTTCTAT
ACCCGCCGCTTTGTGATGACCTATCCGAATGAACAGCTGCCCGCGGGCCGCCCGTTGAAAACCGCCGGGGCCTATGCGGA
TATGAGTGCTGCGGGCTGTCAGTGGGGGCAAAGCTGGGATTTGGAAGTGCCGCTTTATTTTGCCGAACCGGGCTTTGTCG
AAGCGCCCTCGCTGAAACGCTCGAACGCGCATGGAATCGTGGCGGATGAATGTCAGGCGGTGCGCAATGGCGTCGGCCTG
CTGGATATCACCGGCTTTTCCCGCTTCGAGGTGTCAGGGCCCAACGCCGAGCAGTGGCTTGACCAGATCATGGCAAGCAA
GCTGCCCAAACCGGGCCGCGCGCGGCTCGCCCCCATGCTGGCCGAGGATGGGCGGCTCAAGGGTGATCTGACCGTCTTCA
ACTGGGGCGATGGCATCTGGTGGATCATGGGCAGCTACTACCTGCGCCGGTGGCACATGCGCTGGTTTGTCGATCACATG
ATGGAGGGCGTCACCCTGCGCGATCTGGGCGACGAGGTGTCCGGGTTCTCTCTGGCGGGTCCTGCATCGCTCGGTGTGAT
CGAGAAACTGACCGACGGCCCGATTGCGGATCTGAATTTCATGGGCTGTGGTCATTTTGACATCGGGCTGTTGCGCTGCA
AGGTCGGGCGTCTGTCGGTCGCGGGTGAGCGCGGGTATGAAATCCACTGCCGCGCGGGGGATCACGCGGTGCTGCGCCGT
ATCCTGCTGGAGGCGGGCGCGGATGCGGGGATCCGCGAATACGGGTTCAATGCGCTGCTGAGCCTGCGGCTGGAAAAGAG
CTTTGGCATCTGGAATGCGGAATTCACCCAAGGCTACACCCCCGGCATGACCGGAATGGACCGCTGGATCGACTGGGACA
AGGAGTTCATTGGCAAATCCGCAGCCATGGCGGAACGCGATGGCAATGGCCCGGCACAAACACTTGTCACGATGGAAATC
GACGCCGATGGTGCGGACGCCAGCGGGTTCGAACCGATTTGGGTCAACGGCGCTCAGGTCGGTTTTGTCACCTCCGGCGG
ATATGGCCACACGGTCGGCAAATCGCTCGCCATGGCGCTGGTGGACCCGACCCACAGCAGCGCAGGCACAGAGGTCAGCG
TGCATGTGGTCGGCGTCAAGCGGGCCGCACGCATCATCGCCGCATCGCCCTATGATCCGGACGGCAAGGCCATGCGCGGA
TGA

Upstream 100 bases:

>100_bases
AAAAATCTTGACCGATGAATGCTATTGAACCTAGCGTTCTGAGCAGAACTGTACACAAATGTACAGTAGTCGCGTCTGAT
ACGAATCGAAAGGCCACAGC

Downstream 100 bases:

>100_bases
GCTTGCGCGAAAACACCGGGCGCAGACGGACCCGCCGCGATGGCGGGCCCAAGGCCGCACCAGAGCGCAACGTGAACTAT
CGCAACCTGCGCAACCCCTT

Product: dimethylglycine dehydrogenase, putative

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 800; Mature: 800

Protein sequence:

>800_residues
MKSHYRVVVIGGGVVGTSILYHLAKMGWSDVCLIERSLLTAGSSWHAAGGFHALNADPNIAQLQSYTIDLFDDIQEESGQ
DIGLHRTGGLTMAGTPDRWEWLQSAYRTFQSIGIHDCRLVTVEEAVALNPIMSGDGLLGGMWADREGYIDTTGTVHAYAG
AAKKRGATVIEHNRVLELNQTLQGWDVVTEKGTVSCEHVVNAAGLWAKQVGRMAGIELPVSPLNHHYLISDTIPQLEGLD
FEVPMTVDLEGFTYLRQDQKGVLLGIYEVNHQHWMMDGAPWEYGFELQQEDPDRIENELIMGFERYPCLQEVGVKTWVNG
AFTFSPDGNPLVGPVPGKRGYWSACAVMAGFLQGGGVGKSLAEWMINGTPDADVYGMDVARYGVWAENKQYIKETTGQFY
TRRFVMTYPNEQLPAGRPLKTAGAYADMSAAGCQWGQSWDLEVPLYFAEPGFVEAPSLKRSNAHGIVADECQAVRNGVGL
LDITGFSRFEVSGPNAEQWLDQIMASKLPKPGRARLAPMLAEDGRLKGDLTVFNWGDGIWWIMGSYYLRRWHMRWFVDHM
MEGVTLRDLGDEVSGFSLAGPASLGVIEKLTDGPIADLNFMGCGHFDIGLLRCKVGRLSVAGERGYEIHCRAGDHAVLRR
ILLEAGADAGIREYGFNALLSLRLEKSFGIWNAEFTQGYTPGMTGMDRWIDWDKEFIGKSAAMAERDGNGPAQTLVTMEI
DADGADASGFEPIWVNGAQVGFVTSGGYGHTVGKSLAMALVDPTHSSAGTEVSVHVVGVKRAARIIAASPYDPDGKAMRG

Sequences:

>Translated_800_residues
MKSHYRVVVIGGGVVGTSILYHLAKMGWSDVCLIERSLLTAGSSWHAAGGFHALNADPNIAQLQSYTIDLFDDIQEESGQ
DIGLHRTGGLTMAGTPDRWEWLQSAYRTFQSIGIHDCRLVTVEEAVALNPIMSGDGLLGGMWADREGYIDTTGTVHAYAG
AAKKRGATVIEHNRVLELNQTLQGWDVVTEKGTVSCEHVVNAAGLWAKQVGRMAGIELPVSPLNHHYLISDTIPQLEGLD
FEVPMTVDLEGFTYLRQDQKGVLLGIYEVNHQHWMMDGAPWEYGFELQQEDPDRIENELIMGFERYPCLQEVGVKTWVNG
AFTFSPDGNPLVGPVPGKRGYWSACAVMAGFLQGGGVGKSLAEWMINGTPDADVYGMDVARYGVWAENKQYIKETTGQFY
TRRFVMTYPNEQLPAGRPLKTAGAYADMSAAGCQWGQSWDLEVPLYFAEPGFVEAPSLKRSNAHGIVADECQAVRNGVGL
LDITGFSRFEVSGPNAEQWLDQIMASKLPKPGRARLAPMLAEDGRLKGDLTVFNWGDGIWWIMGSYYLRRWHMRWFVDHM
MEGVTLRDLGDEVSGFSLAGPASLGVIEKLTDGPIADLNFMGCGHFDIGLLRCKVGRLSVAGERGYEIHCRAGDHAVLRR
ILLEAGADAGIREYGFNALLSLRLEKSFGIWNAEFTQGYTPGMTGMDRWIDWDKEFIGKSAAMAERDGNGPAQTLVTMEI
DADGADASGFEPIWVNGAQVGFVTSGGYGHTVGKSLAMALVDPTHSSAGTEVSVHVVGVKRAARIIAASPYDPDGKAMRG
>Mature_800_residues
MKSHYRVVVIGGGVVGTSILYHLAKMGWSDVCLIERSLLTAGSSWHAAGGFHALNADPNIAQLQSYTIDLFDDIQEESGQ
DIGLHRTGGLTMAGTPDRWEWLQSAYRTFQSIGIHDCRLVTVEEAVALNPIMSGDGLLGGMWADREGYIDTTGTVHAYAG
AAKKRGATVIEHNRVLELNQTLQGWDVVTEKGTVSCEHVVNAAGLWAKQVGRMAGIELPVSPLNHHYLISDTIPQLEGLD
FEVPMTVDLEGFTYLRQDQKGVLLGIYEVNHQHWMMDGAPWEYGFELQQEDPDRIENELIMGFERYPCLQEVGVKTWVNG
AFTFSPDGNPLVGPVPGKRGYWSACAVMAGFLQGGGVGKSLAEWMINGTPDADVYGMDVARYGVWAENKQYIKETTGQFY
TRRFVMTYPNEQLPAGRPLKTAGAYADMSAAGCQWGQSWDLEVPLYFAEPGFVEAPSLKRSNAHGIVADECQAVRNGVGL
LDITGFSRFEVSGPNAEQWLDQIMASKLPKPGRARLAPMLAEDGRLKGDLTVFNWGDGIWWIMGSYYLRRWHMRWFVDHM
MEGVTLRDLGDEVSGFSLAGPASLGVIEKLTDGPIADLNFMGCGHFDIGLLRCKVGRLSVAGERGYEIHCRAGDHAVLRR
ILLEAGADAGIREYGFNALLSLRLEKSFGIWNAEFTQGYTPGMTGMDRWIDWDKEFIGKSAAMAERDGNGPAQTLVTMEI
DADGADASGFEPIWVNGAQVGFVTSGGYGHTVGKSLAMALVDPTHSSAGTEVSVHVVGVKRAARIIAASPYDPDGKAMRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=803, Percent_Identity=33.6239103362391, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI197927446, Length=871, Percent_Identity=27.8989667049369, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI21361378, Length=871, Percent_Identity=27.8989667049369, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI194306651, Length=823, Percent_Identity=26.9744835965978, Blast_Score=292, Evalue=8e-79,
Organism=Escherichia coli, GI1789272, Length=308, Percent_Identity=24.6753246753247, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994045, Length=831, Percent_Identity=27.0758122743682, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71994052, Length=838, Percent_Identity=26.7303102625298, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI32563613, Length=833, Percent_Identity=24.3697478991597, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20130091, Length=860, Percent_Identity=28.0232558139535, Blast_Score=291, Evalue=2e-78,
Organism=Drosophila melanogaster, GI28571104, Length=833, Percent_Identity=24.609843937575, Blast_Score=235, Evalue=1e-61,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 87438; Mature: 87438

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHYRVVVIGGGVVGTSILYHLAKMGWSDVCLIERSLLTAGSSWHAAGGFHALNADPNI
CCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCH
AQLQSYTIDLFDDIQEESGQDIGLHRTGGLTMAGTPDRWEWLQSAYRTFQSIGIHDCRLV
HHHHHEEEHHHHHHHHHCCCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
TVEEAVALNPIMSGDGLLGGMWADREGYIDTTGTVHAYAGAAKKRGATVIEHNRVLELNQ
EEHHHHHCCCCCCCCCCEECEECCCCCCEECCCCEEEECCCHHHCCCEEEECCEEEEECC
TLQGWDVVTEKGTVSCEHVVNAAGLWAKQVGRMAGIELPVSPLNHHYLISDTIPQLEGLD
CCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
FEVPMTVDLEGFTYLRQDQKGVLLGIYEVNHQHWMMDGAPWEYGFELQQEDPDRIENELI
EECCEEEECCCCEEEECCCCCEEEEEEEECCCEEEECCCCCCCCCEECCCCHHHHHHHHH
MGFERYPCLQEVGVKTWVNGAFTFSPDGNPLVGPVPGKRGYWSACAVMAGFLQGGGVGKS
CCCHHCCCHHHCCHHHEECCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHH
LAEWMINGTPDADVYGMDVARYGVWAENKQYIKETTGQFYTRRFVMTYPNEQLPAGRPLK
HHHHHCCCCCCCCEEECCHHHHCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCH
TAGAYADMSAAGCQWGQSWDLEVPLYFAEPGFVEAPSLKRSNAHGIVADECQAVRNGVGL
HCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCE
LDITGFSRFEVSGPNAEQWLDQIMASKLPKPGRARLAPMLAEDGRLKGDLTVFNWGDGIW
EEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHCHHHHCCCCCCCCEEEEECCCCHH
WIMGSYYLRRWHMRWFVDHMMEGVTLRDLGDEVSGFSLAGPASLGVIEKLTDGPIADLNF
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEE
MGCGHFDIGLLRCKVGRLSVAGERGYEIHCRAGDHAVLRRILLEAGADAGIREYGFNALL
EECCCCCEEEEEEECCCEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCEEE
SLRLEKSFGIWNAEFTQGYTPGMTGMDRWIDWDKEFIGKSAAMAERDGNGPAQTLVTMEI
EEEEECCCCCCCCHHCCCCCCCCCCHHHHHCCCHHHHCCHHHHHCCCCCCCCCEEEEEEE
DADGADASGFEPIWVNGAQVGFVTSGGYGHTVGKSLAMALVDPTHSSAGTEVSVHVVGVK
CCCCCCCCCCCCEEECCEEEEEEECCCCCHHHHHHHEEEEECCCCCCCCCEEEEEEEEEC
RAARIIAASPYDPDGKAMRG
CEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKSHYRVVVIGGGVVGTSILYHLAKMGWSDVCLIERSLLTAGSSWHAAGGFHALNADPNI
CCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCH
AQLQSYTIDLFDDIQEESGQDIGLHRTGGLTMAGTPDRWEWLQSAYRTFQSIGIHDCRLV
HHHHHEEEHHHHHHHHHCCCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
TVEEAVALNPIMSGDGLLGGMWADREGYIDTTGTVHAYAGAAKKRGATVIEHNRVLELNQ
EEHHHHHCCCCCCCCCCEECEECCCCCCEECCCCEEEECCCHHHCCCEEEECCEEEEECC
TLQGWDVVTEKGTVSCEHVVNAAGLWAKQVGRMAGIELPVSPLNHHYLISDTIPQLEGLD
CCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCC
FEVPMTVDLEGFTYLRQDQKGVLLGIYEVNHQHWMMDGAPWEYGFELQQEDPDRIENELI
EECCEEEECCCCEEEECCCCCEEEEEEEECCCEEEECCCCCCCCCEECCCCHHHHHHHHH
MGFERYPCLQEVGVKTWVNGAFTFSPDGNPLVGPVPGKRGYWSACAVMAGFLQGGGVGKS
CCCHHCCCHHHCCHHHEECCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHH
LAEWMINGTPDADVYGMDVARYGVWAENKQYIKETTGQFYTRRFVMTYPNEQLPAGRPLK
HHHHHCCCCCCCCEEECCHHHHCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCH
TAGAYADMSAAGCQWGQSWDLEVPLYFAEPGFVEAPSLKRSNAHGIVADECQAVRNGVGL
HCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCE
LDITGFSRFEVSGPNAEQWLDQIMASKLPKPGRARLAPMLAEDGRLKGDLTVFNWGDGIW
EEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHCHHHHCCCCCCCCEEEEECCCCHH
WIMGSYYLRRWHMRWFVDHMMEGVTLRDLGDEVSGFSLAGPASLGVIEKLTDGPIADLNF
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEE
MGCGHFDIGLLRCKVGRLSVAGERGYEIHCRAGDHAVLRRILLEAGADAGIREYGFNALL
EECCCCCEEEEEEECCCEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHCCCEEE
SLRLEKSFGIWNAEFTQGYTPGMTGMDRWIDWDKEFIGKSAAMAERDGNGPAQTLVTMEI
EEEEECCCCCCCCHHCCCCCCCCCCHHHHHCCCHHHHCCHHHHHCCCCCCCCCEEEEEEE
DADGADASGFEPIWVNGAQVGFVTSGGYGHTVGKSLAMALVDPTHSSAGTEVSVHVVGVK
CCCCCCCCCCCCEEECCEEEEEEECCCCCHHHHHHHEEEEECCCCCCCCCEEEEEEEEEC
RAARIIAASPYDPDGKAMRG
CEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA