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The map label for this gene is cobD [H]

Identifier: 110678652

GI number: 110678652

Start: 1282095

End: 1283003

Strand: Reverse

Name: cobD [H]

Synonym: RD1_1330

Alternate gene names: 110678652

Gene position: 1283003-1282095 (Counterclockwise)

Preceding gene: 110678653

Following gene: 110678651

Centisome position: 31.04

GC content: 63.59

Gene sequence:

>909_bases
ATGACGCTCGCCCTGGTTCTGCTCTGTGCGTTGATGCTGGACGCTGTGCTTGGAGAACCCAAGTGGCTCTGGTCCCGCCT
GCCCCATCCGGCCGTGCTCATGGGCAGGCTGATCGGCTGGCTGGACAGAACCTTCAACACCGGCCCGGCAAAGCGCGCAA
AAGGAACGCTCTGCCTGATTTTTGCGGTTGGCTGCGCTGTGATCACGGGCTTGGTCCTGTCTGCCCTCGGCCCCCTTGCC
GAAGTTATCATCGCCGCCATTCTGCTCGCGCAGCGCTCTTTGAGCGATCACGTCGCGGCAGTTGCCAAGGGCCTGCGGCG
CTCTCTGCCCGAGGGTCGCGCGGCGGTTGCGATGATCGTCAGCCGCGATACATCCGACATGGACCCGTCACAGACCGCGC
GGGCCGCCATAGAAAGCGCTGCGGAAAACATGTCGGATGGCGTGATCGCGCCTGCCTTCTGGTTTCTCATCGGCGGGCTG
CCCGCAATGCTCGCCTACAAGATGATCAATACCGCCGACAGCATGATCGGCTATCGCACCCCGCGCCATCACGCCTTCGG
ATGGGCCGCCGCGCGCATGGACGATCTGGTCAACATCCTGCCCGCGCGGCTCACCGCTCTGCTGATCGCGAACGCCGCTT
GGCAATGGGACGGGGCCGCGATCCGTGCCGATGCCAGATTGCACAAATCGCCGAACGCCGGCTGGCCGGAGGCCGCAATG
GCCCGCGCCCTTGGCATCGCGCTGGCCGGTCCGCGCGCCTATGACGGCACGCTACAGGACTTCCCATGGGTGAACGAAGC
AGGGCGCAAAGTGCTGAGCGCAGATGATATCGACGCGAGTCTTTCTATTTTATGGAAAGCGTGGGGCATGATGTTTACCC
TTTGCGTGGTACTTGCCATCCTGTCCTAG

Upstream 100 bases:

>100_bases
AGCATCACATCTGGACCCGTATTTTTCCCTATGACAAGGAATGGCTGCGTCTGGGTTTACCGCATCCCGTCCAATGGGAA
CGCCTCGAAAACGCACTGGC

Downstream 100 bases:

>100_bases
AACAGACCGGAGTTTCCGATGCGCTTAAAAACACTCGCCTTCGTCCTTTGCTTTGCCTTCTCCCCCTTACCGCTTCTCGC
AGCCTGCGGGGGCAGCTTTA

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTLALVLLCALMLDAVLGEPKWLWSRLPHPAVLMGRLIGWLDRTFNTGPAKRAKGTLCLIFAVGCAVITGLVLSALGPLA
EVIIAAILLAQRSLSDHVAAVAKGLRRSLPEGRAAVAMIVSRDTSDMDPSQTARAAIESAAENMSDGVIAPAFWFLIGGL
PAMLAYKMINTADSMIGYRTPRHHAFGWAAARMDDLVNILPARLTALLIANAAWQWDGAAIRADARLHKSPNAGWPEAAM
ARALGIALAGPRAYDGTLQDFPWVNEAGRKVLSADDIDASLSILWKAWGMMFTLCVVLAILS

Sequences:

>Translated_302_residues
MTLALVLLCALMLDAVLGEPKWLWSRLPHPAVLMGRLIGWLDRTFNTGPAKRAKGTLCLIFAVGCAVITGLVLSALGPLA
EVIIAAILLAQRSLSDHVAAVAKGLRRSLPEGRAAVAMIVSRDTSDMDPSQTARAAIESAAENMSDGVIAPAFWFLIGGL
PAMLAYKMINTADSMIGYRTPRHHAFGWAAARMDDLVNILPARLTALLIANAAWQWDGAAIRADARLHKSPNAGWPEAAM
ARALGIALAGPRAYDGTLQDFPWVNEAGRKVLSADDIDASLSILWKAWGMMFTLCVVLAILS
>Mature_301_residues
TLALVLLCALMLDAVLGEPKWLWSRLPHPAVLMGRLIGWLDRTFNTGPAKRAKGTLCLIFAVGCAVITGLVLSALGPLAE
VIIAAILLAQRSLSDHVAAVAKGLRRSLPEGRAAVAMIVSRDTSDMDPSQTARAAIESAAENMSDGVIAPAFWFLIGGLP
AMLAYKMINTADSMIGYRTPRHHAFGWAAARMDDLVNILPARLTALLIANAAWQWDGAAIRADARLHKSPNAGWPEAAMA
RALGIALAGPRAYDGTLQDFPWVNEAGRKVLSADDIDASLSILWKAWGMMFTLCVVLAILS

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 32257; Mature: 32126

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLALVLLCALMLDAVLGEPKWLWSRLPHPAVLMGRLIGWLDRTFNTGPAKRAKGTLCLI
CHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHH
FAVGCAVITGLVLSALGPLAEVIIAAILLAQRSLSDHVAAVAKGLRRSLPEGRAAVAMIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHE
SRDTSDMDPSQTARAAIESAAENMSDGVIAPAFWFLIGGLPAMLAYKMINTADSMIGYRT
ECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PRHHAFGWAAARMDDLVNILPARLTALLIANAAWQWDGAAIRADARLHKSPNAGWPEAAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCHHHH
ARALGIALAGPRAYDGTLQDFPWVNEAGRKVLSADDIDASLSILWKAWGMMFTLCVVLAI
HHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LS
HC
>Mature Secondary Structure 
TLALVLLCALMLDAVLGEPKWLWSRLPHPAVLMGRLIGWLDRTFNTGPAKRAKGTLCLI
HHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHH
FAVGCAVITGLVLSALGPLAEVIIAAILLAQRSLSDHVAAVAKGLRRSLPEGRAAVAMIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHE
SRDTSDMDPSQTARAAIESAAENMSDGVIAPAFWFLIGGLPAMLAYKMINTADSMIGYRT
ECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PRHHAFGWAAARMDDLVNILPARLTALLIANAAWQWDGAAIRADARLHKSPNAGWPEAAM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCCCCCCHHHH
ARALGIALAGPRAYDGTLQDFPWVNEAGRKVLSADDIDASLSILWKAWGMMFTLCVVLAI
HHHHHHHHCCCCCCCCCCCCCCCCCHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LS
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA