Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 110678644

GI number: 110678644

Start: 1273556

End: 1274302

Strand: Direct

Name: atpB

Synonym: RD1_1322

Alternate gene names: 110678644

Gene position: 1273556-1274302 (Clockwise)

Preceding gene: 110678643

Following gene: 110678645

Centisome position: 30.81

GC content: 56.89

Gene sequence:

>747_bases
ATGGCGGACAAGGCAGAAGGCGGCGGGTTGGTTTTCAAACCGATGGAGCAGTTTGAGATCACTGCGCTGTTTGGGGGTGA
TGTGACCTGGTACACGCCGACGAATACGGCGCTGTGGATGGGTTTTTCGATCATTGCCGTGGTGCTGCTGCTGGTCGTGG
GAAGCTCCAAACGTGCGGTGGTGCCATCGCGTGCGCAGTCGGTTGCCGAACTGGCCTACGGGTTCATCTACAAGATGGTT
GAGGACATCTGCGGCAAAGAGGGTCTGAAGTTTTTCCCCTACATCATGACGTTGTTCATGTTCATTGTCTGCGCGAACTT
TCTGGGTCTGATCCCGTCGTCCTTTACCCCGACCTCGCATTTTGCGGTCACCGTCGTGCTGGCGCTGGCGGTATTTGTGA
CGGTGACCATTCTGGGGTTTGTCAAGAACGGGACGGCTTTCCTGAGCCTGTTCTGGGTTTCGTCGGCACCTTTGGCGCTG
CGCCCGGTGCTGGCCATCATCGAAATCATTTCCTATTTCGTGCGCCCGGTGAGCCACTCCATTCGTCTGGCGGGCAACGT
CATGGCGGGCCACGCGGTGATCAAGGTTTTCGCAGGTTTTGCAGCGCTGACCCTCGTCAGCCCGGTCGCAATCCTCGGCA
TCACGGCGATGTATGGTCTGGAGGTCCTCGTGTCCTTCATCCAGGCCTATGTTTTCACAATTCTGACGTGCGTTTATCTG
AAAGACGCGCTTCACCCGCATCACTAA

Upstream 100 bases:

>100_bases
GGTCTGGCGGCCGGGGTGAAGACGATGCTCCGCTCCGCGCAGGAAATCCAGGAAAAGAAGTTGGCCGAAGAGGCCGCAGA
TCGAGACGAGGGAGCCTGAC

Downstream 100 bases:

>100_bases
TTCGGGCGGCTACACCCGTTCAAATACTCAACTTCCAATCGTAAGGAGAATTCACATGGAAGGCGAACTCGCACACATCG
GCGCAGGTCTGGCGGCAATC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MADKAEGGGLVFKPMEQFEITALFGGDVTWYTPTNTALWMGFSIIAVVLLLVVGSSKRAVVPSRAQSVAELAYGFIYKMV
EDICGKEGLKFFPYIMTLFMFIVCANFLGLIPSSFTPTSHFAVTVVLALAVFVTVTILGFVKNGTAFLSLFWVSSAPLAL
RPVLAIIEIISYFVRPVSHSIRLAGNVMAGHAVIKVFAGFAALTLVSPVAILGITAMYGLEVLVSFIQAYVFTILTCVYL
KDALHPHH

Sequences:

>Translated_248_residues
MADKAEGGGLVFKPMEQFEITALFGGDVTWYTPTNTALWMGFSIIAVVLLLVVGSSKRAVVPSRAQSVAELAYGFIYKMV
EDICGKEGLKFFPYIMTLFMFIVCANFLGLIPSSFTPTSHFAVTVVLALAVFVTVTILGFVKNGTAFLSLFWVSSAPLAL
RPVLAIIEIISYFVRPVSHSIRLAGNVMAGHAVIKVFAGFAALTLVSPVAILGITAMYGLEVLVSFIQAYVFTILTCVYL
KDALHPHH
>Mature_247_residues
ADKAEGGGLVFKPMEQFEITALFGGDVTWYTPTNTALWMGFSIIAVVLLLVVGSSKRAVVPSRAQSVAELAYGFIYKMVE
DICGKEGLKFFPYIMTLFMFIVCANFLGLIPSSFTPTSHFAVTVVLALAVFVTVTILGFVKNGTAFLSLFWVSSAPLALR
PVLAIIEIISYFVRPVSHSIRLAGNVMAGHAVIKVFAGFAALTLVSPVAILGITAMYGLEVLVSFIQAYVFTILTCVYLK
DALHPHH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=197, Percent_Identity=29.9492385786802, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790176, Length=222, Percent_Identity=27.9279279279279, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6226527, Length=252, Percent_Identity=36.9047619047619, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ROSDO (Q16AM8)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_681651.1
- ProteinModelPortal:   Q16AM8
- SMR:   Q16AM8
- STRING:   Q16AM8
- GeneID:   4197375
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1322
- NMPDR:   fig|375451.6.peg.1237
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   YIFTILT
- PhylomeDB:   Q16AM8
- ProtClustDB:   PRK05815
- BioCyc:   RDEN375451:RD1_1322-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26840; Mature: 26709

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d1b58c0)-; HASH(0x1da20330)-; HASH(0x1d5e0fec)-; HASH(0x14db995c)-; HASH(0x1da0fc44)-; HASH(0x1d480d80)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKAEGGGLVFKPMEQFEITALFGGDVTWYTPTNTALWMGFSIIAVVLLLVVGSSKRAV
CCCCCCCCCEEECCHHHHEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VPSRAQSVAELAYGFIYKMVEDICGKEGLKFFPYIMTLFMFIVCANFLGLIPSSFTPTSH
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FAVTVVLALAVFVTVTILGFVKNGTAFLSLFWVSSAPLALRPVLAIIEIISYFVRPVSHS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLAGNVMAGHAVIKVFAGFAALTLVSPVAILGITAMYGLEVLVSFIQAYVFTILTCVYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDALHPHH
HHHCCCCH
>Mature Secondary Structure 
ADKAEGGGLVFKPMEQFEITALFGGDVTWYTPTNTALWMGFSIIAVVLLLVVGSSKRAV
CCCCCCCCEEECCHHHHEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
VPSRAQSVAELAYGFIYKMVEDICGKEGLKFFPYIMTLFMFIVCANFLGLIPSSFTPTSH
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FAVTVVLALAVFVTVTILGFVKNGTAFLSLFWVSSAPLALRPVLAIIEIISYFVRPVSHS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLAGNVMAGHAVIKVFAGFAALTLVSPVAILGITAMYGLEVLVSFIQAYVFTILTCVYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDALHPHH
HHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA