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The map label for this gene is pbpA [H]

Identifier: 110678534

GI number: 110678534

Start: 1169319

End: 1171262

Strand: Reverse

Name: pbpA [H]

Synonym: RD1_1206

Alternate gene names: 110678534

Gene position: 1171262-1169319 (Counterclockwise)

Preceding gene: 110678535

Following gene: 110678533

Centisome position: 28.34

GC content: 60.29

Gene sequence:

>1944_bases
GTGAAACGGACACGGGCAGAAACGGATTTCAGCCATCGGCACCTGTCACGACGCGCCGCACTTCTTGGCGGGGCGCAATT
GCTGTTCATTGGCGGGTTGGCCGCGCGCATGCGGTACCTGCAGGTCGAACAGGCCGATGAATTCCGACTGCTGGCCGAAG
AAAACCGCATAAACGTGCGCCTGATCCCACCGTCGCGCGGGGAGGTTTTTGACAGGAACGGGGTTCGGCTCGCACAAAAC
GCGCCCTCTTATCGCATTGTGATCATCAAGGAAGACGCCGGCGATGTGGATGCCTCTCTGAAACAGCTGTCCAGGATCAT
TGCGCTTGACGACAATGCGATTGCCCGCGTCAAGGAGGAGATGCGCAGGTCAGCCCCGTTTCTGCCCGTCACCGTCGCGT
CGGACGTCACTTGGGATGAAATCAGCCGTGTTTCGGTGAATGCGCCCGCCTTGCCGGGCATCACACCCGAGGTGGGGCTC
AGCCGTGTCTATCCGCAAGGCTCTGACTTTGCGCATGTTTTGGGGTATGTGGGCCCGGTGTCGGATTATGACCTTTCAAA
GATCACTGACCCGGAACCGGTCCTGATGATACCCCGGTTTCAGATCGGGAAGGTGGGCGTGGAAACCAAGCTCGAACCGC
TTTTGCGCGGGAAAGCCGGGGCCAAACGGGTCGAGGTCAACGCCACGGGACGCGTGATGCGTGAACTCGACCGTCAGGAG
GGCACTGCCGGATCGGATGTCCAGCTTACCGTTGATGCGGCCTTGCAGGGGTATGTGCAGGCGCGTCTGACCGGCGAAAG
TGCGAGCGCGGTGATCATCGACTGTGACAACGGCGATCTTGTCGCCTGCGCCTCGGCCCCGACATTTGATCCCAATTTGT
TTGTGCGCGGCATCTCGCAAAAAGACTACGGGGCGCTGACCAGCAACAAGTACCGCCCGCTGGCCAGCAAGACCGTTCAG
GGGCTGTACCCGCCGGGGTCCACCTTCAAGATGATCACCGCCATGGCCGCCCTTGAGGCCGGGCTGATCGGGCCGGATGA
AACTGCCTATTGCCCCGGCCACCTCGAAGTGTCCGGTCGCCGGTTTCACTGCTGGAAACGCGCAGGCCACGGGTGGGTGG
ATTTGCAGGATTCGCTCAAGAAATCCTGCGATGTCTATTACTATGATCTGGCCATCAAGGTCGGTATTGAAAAGATTACC
GCAATGGCCAATCGTTTTGGCCTTGGCGTGAAACACGATGTGCCCATGTCAGCCGTCGCCTCCGGCCTGATGCCGACGAT
GGAATGGAAACAGATCAATCAAGGCCAATCCTGGCGGGTCGGTGACACGGTCAATGCCTCCATCGGGCAAGGGTTTTTGC
TGGCCTCTCCCCTGCAGCTTGCGGTCATGACCGCGCGACTTGCCACCGGGCGCGCGGTATCCCCGCGGCTGATCAAATCA
ATCGACGGTGTTGAACAACCCGATCGCGGTGGCGAAAACATGGGTATGAATGAGAACAACCTGCGCAAGATGCGCAGGGC
CATGTTTGCCGTCGTCAATGACCGGCGGGGCACTGCCTATGGGTCACGCGTGATCGAAGAAGAGATGCGCATGGCCGGTA
AAACCGGCACAAGTCAGGTGCGCAACATCACCGCCGCAGAACGCCGCGCAGGTGTCATCCGCAACGAGGATCTGCCGTGG
GAACGCCGCGATCATGCCTTGTTTGTGAATTTCGCACCATATGACCGCCCAAAATACGCCGTGGCCGTTATCGTCGAACA
CGGCGGCGGCGGGTCGAAAGCCGCCGCCCCGATTGCCCGCGATATCACCCTGCAGGCGCTTTATGGCGGCACACCACCGC
TTGAGGCATACCCGGCCAAGGACCGCGAACGCATCGGCACGCTGCAAAAAGAATTGCAAAAGATGCAGCCACAGGCCGCT
ATCAGCGGGCGGGATCAGGCATGA

Upstream 100 bases:

>100_bases
ACTCACAGCGTGCTCGGTGTGCAAAAAACGGCACCGGGTGAACTTGATGCGCGGGGGCGGCGCGGGTGATGAGCAAAGGG
CATAGACCGGGGGGGCTGCT

Downstream 100 bases:

>100_bases
GTTATCTCGAGCATAACGTCAAATCCACGCCCGTGGGCTTGCGCAAGATCCTGCACCTCAACTGGCCCGTTGCGATCCTG
CTGGCCGCAGTTGCGGGCGT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MKRTRAETDFSHRHLSRRAALLGGAQLLFIGGLAARMRYLQVEQADEFRLLAEENRINVRLIPPSRGEVFDRNGVRLAQN
APSYRIVIIKEDAGDVDASLKQLSRIIALDDNAIARVKEEMRRSAPFLPVTVASDVTWDEISRVSVNAPALPGITPEVGL
SRVYPQGSDFAHVLGYVGPVSDYDLSKITDPEPVLMIPRFQIGKVGVETKLEPLLRGKAGAKRVEVNATGRVMRELDRQE
GTAGSDVQLTVDAALQGYVQARLTGESASAVIIDCDNGDLVACASAPTFDPNLFVRGISQKDYGALTSNKYRPLASKTVQ
GLYPPGSTFKMITAMAALEAGLIGPDETAYCPGHLEVSGRRFHCWKRAGHGWVDLQDSLKKSCDVYYYDLAIKVGIEKIT
AMANRFGLGVKHDVPMSAVASGLMPTMEWKQINQGQSWRVGDTVNASIGQGFLLASPLQLAVMTARLATGRAVSPRLIKS
IDGVEQPDRGGENMGMNENNLRKMRRAMFAVVNDRRGTAYGSRVIEEEMRMAGKTGTSQVRNITAAERRAGVIRNEDLPW
ERRDHALFVNFAPYDRPKYAVAVIVEHGGGGSKAAAPIARDITLQALYGGTPPLEAYPAKDRERIGTLQKELQKMQPQAA
ISGRDQA

Sequences:

>Translated_647_residues
MKRTRAETDFSHRHLSRRAALLGGAQLLFIGGLAARMRYLQVEQADEFRLLAEENRINVRLIPPSRGEVFDRNGVRLAQN
APSYRIVIIKEDAGDVDASLKQLSRIIALDDNAIARVKEEMRRSAPFLPVTVASDVTWDEISRVSVNAPALPGITPEVGL
SRVYPQGSDFAHVLGYVGPVSDYDLSKITDPEPVLMIPRFQIGKVGVETKLEPLLRGKAGAKRVEVNATGRVMRELDRQE
GTAGSDVQLTVDAALQGYVQARLTGESASAVIIDCDNGDLVACASAPTFDPNLFVRGISQKDYGALTSNKYRPLASKTVQ
GLYPPGSTFKMITAMAALEAGLIGPDETAYCPGHLEVSGRRFHCWKRAGHGWVDLQDSLKKSCDVYYYDLAIKVGIEKIT
AMANRFGLGVKHDVPMSAVASGLMPTMEWKQINQGQSWRVGDTVNASIGQGFLLASPLQLAVMTARLATGRAVSPRLIKS
IDGVEQPDRGGENMGMNENNLRKMRRAMFAVVNDRRGTAYGSRVIEEEMRMAGKTGTSQVRNITAAERRAGVIRNEDLPW
ERRDHALFVNFAPYDRPKYAVAVIVEHGGGGSKAAAPIARDITLQALYGGTPPLEAYPAKDRERIGTLQKELQKMQPQAA
ISGRDQA
>Mature_647_residues
MKRTRAETDFSHRHLSRRAALLGGAQLLFIGGLAARMRYLQVEQADEFRLLAEENRINVRLIPPSRGEVFDRNGVRLAQN
APSYRIVIIKEDAGDVDASLKQLSRIIALDDNAIARVKEEMRRSAPFLPVTVASDVTWDEISRVSVNAPALPGITPEVGL
SRVYPQGSDFAHVLGYVGPVSDYDLSKITDPEPVLMIPRFQIGKVGVETKLEPLLRGKAGAKRVEVNATGRVMRELDRQE
GTAGSDVQLTVDAALQGYVQARLTGESASAVIIDCDNGDLVACASAPTFDPNLFVRGISQKDYGALTSNKYRPLASKTVQ
GLYPPGSTFKMITAMAALEAGLIGPDETAYCPGHLEVSGRRFHCWKRAGHGWVDLQDSLKKSCDVYYYDLAIKVGIEKIT
AMANRFGLGVKHDVPMSAVASGLMPTMEWKQINQGQSWRVGDTVNASIGQGFLLASPLQLAVMTARLATGRAVSPRLIKS
IDGVEQPDRGGENMGMNENNLRKMRRAMFAVVNDRRGTAYGSRVIEEEMRMAGKTGTSQVRNITAAERRAGVIRNEDLPW
ERRDHALFVNFAPYDRPKYAVAVIVEHGGGGSKAAAPIARDITLQALYGGTPPLEAYPAKDRERIGTLQKELQKMQPQAA
ISGRDQA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=606, Percent_Identity=35.3135313531353, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1786272, Length=598, Percent_Identity=25.2508361204013, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70693; Mature: 70693

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTRAETDFSHRHLSRRAALLGGAQLLFIGGLAARMRYLQVEQADEFRLLAEENRINVR
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
LIPPSRGEVFDRNGVRLAQNAPSYRIVIIKEDAGDVDASLKQLSRIIALDDNAIARVKEE
EECCCCCCEECCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHEEECCHHHHHHHHH
MRRSAPFLPVTVASDVTWDEISRVSVNAPALPGITPEVGLSRVYPQGSDFAHVLGYVGPV
HHHCCCCEEEEEECCCCHHHHCEEEECCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCC
SDYDLSKITDPEPVLMIPRFQIGKVGVETKLEPLLRGKAGAKRVEVNATGRVMRELDRQE
CCCCHHHCCCCCCEEEECCEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHC
GTAGSDVQLTVDAALQGYVQARLTGESASAVIIDCDNGDLVACASAPTFDPNLFVRGISQ
CCCCCCEEEEEHHHHHCEEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCEEEECCC
KDYGALTSNKYRPLASKTVQGLYPPGSTFKMITAMAALEAGLIGPDETAYCPGHLEVSGR
CCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
RFHCWKRAGHGWVDLQDSLKKSCDVYYYDLAIKVGIEKITAMANRFGLGVKHDVPMSAVA
EEEEEHHCCCCEEECHHHHHCCCCEEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLMPTMEWKQINQGQSWRVGDTVNASIGQGFLLASPLQLAVMTARLATGRAVSPRLIKS
HCCCCCHHHHHCCCCCCEECCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHH
IDGVEQPDRGGENMGMNENNLRKMRRAMFAVVNDRRGTAYGSRVIEEEMRMAGKTGTSQV
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RNITAAERRAGVIRNEDLPWERRDHALFVNFAPYDRPKYAVAVIVEHGGGGSKAAAPIAR
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCHHH
DITLQALYGGTPPLEAYPAKDRERIGTLQKELQKMQPQAAISGRDQA
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure
MKRTRAETDFSHRHLSRRAALLGGAQLLFIGGLAARMRYLQVEQADEFRLLAEENRINVR
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
LIPPSRGEVFDRNGVRLAQNAPSYRIVIIKEDAGDVDASLKQLSRIIALDDNAIARVKEE
EECCCCCCEECCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHEEECCHHHHHHHHH
MRRSAPFLPVTVASDVTWDEISRVSVNAPALPGITPEVGLSRVYPQGSDFAHVLGYVGPV
HHHCCCCEEEEEECCCCHHHHCEEEECCCCCCCCCCCCCCHHCCCCCCCHHHHHHCCCCC
SDYDLSKITDPEPVLMIPRFQIGKVGVETKLEPLLRGKAGAKRVEVNATGRVMRELDRQE
CCCCHHHCCCCCCEEEECCEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHC
GTAGSDVQLTVDAALQGYVQARLTGESASAVIIDCDNGDLVACASAPTFDPNLFVRGISQ
CCCCCCEEEEEHHHHHCEEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCEEEECCC
KDYGALTSNKYRPLASKTVQGLYPPGSTFKMITAMAALEAGLIGPDETAYCPGHLEVSGR
CCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
RFHCWKRAGHGWVDLQDSLKKSCDVYYYDLAIKVGIEKITAMANRFGLGVKHDVPMSAVA
EEEEEHHCCCCEEECHHHHHCCCCEEEEEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLMPTMEWKQINQGQSWRVGDTVNASIGQGFLLASPLQLAVMTARLATGRAVSPRLIKS
HCCCCCHHHHHCCCCCCEECCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHH
IDGVEQPDRGGENMGMNENNLRKMRRAMFAVVNDRRGTAYGSRVIEEEMRMAGKTGTSQV
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RNITAAERRAGVIRNEDLPWERRDHALFVNFAPYDRPKYAVAVIVEHGGGGSKAAAPIAR
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCHHH
DITLQALYGGTPPLEAYPAKDRERIGTLQKELQKMQPQAAISGRDQA
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]