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The map label for this gene is hisD [H]

Identifier: 110678407

GI number: 110678407

Start: 1026911

End: 1028224

Strand: Direct

Name: hisD [H]

Synonym: RD1_1068

Alternate gene names: 110678407

Gene position: 1026911-1028224 (Clockwise)

Preceding gene: 110678406

Following gene: 110678408

Centisome position: 24.85

GC content: 63.62

Gene sequence:

>1314_bases
ATGCCCGTATTCCTGAATGCTGCCGACCCGGATTTTGAAAACCGTTTCAACGCCTTGCTGAGTGCCAAGCGCGAAGACAG
CCCCGATGTGGACGCCACCGTCGCGCAGATTATCGCAGATGTACGTGCGCGCGGCGACGCGGCCCTGATCGAACTGACAA
AAAAGTTCGATCGGGTGACGCTGACGCCCGACAGCCTCGCCATCACGCCTGACGAGGTGGACGCGGCGGTGGCGGATGCG
CCCGCCGATCAGGTGGCCGCACTGGAACTGGCGGCGCAACGTATCCGTGTCTATCATGAACGTCAGCGCCCTGAAGATGC
GGAATGGGTGGATGACAGTGGCGCAATGCTGGGCTGGCGCTGGACGGCGGTGGCGGCGGCGGGGCTTTATGTGCCCGGGG
GTCTTGCGTCCTACCCGTCCTCGGTTCTGATGAACGCCATCCCTGCCAAAGTCGCGGGGGTTTCCCGTCTTGCCATGGTG
GTGCCGGCACCTGATGGCGTGCTGAACCCGCTCGTGCTGGCGGCGGCGCGTCTGTCGGGGGTGGATGAAATCTACCGCAT
CGGGGGGGCACAGGCCGTAGCGGCGCTTGCCTATGGGACGGCCACAATCGCACCGGTGGATAAGATCACGGGTCCGGGCA
ATGCCTTTGTCGCGGCGGCCAAGCGGCGTGTGTTTGGCAAAGTCGGCATTGATATGATAGCGGGCCCGTCCGAAATACTG
GTGATCGCAGATGCGCAGAATGACCCCGATTGGATCGCGCTTGATCTGCTGAGCCAGGCAGAACATGACGAAAGCGCGCA
ATCCATATTGATCACGACCGATGCGGCCTTCGGGCAGGCGGTTGCGGCCGCTGTAGAAAAGCGGTTGGAAACCCTCGAGC
GGCGCGCGATCGCGGGTGCATCCTGGCGCGATTTTGGCGCGGTTGTGACGGTCCCTGATCTGGCGACGGCGGCGGCCTTG
TCGGATCGGATTGCCCCGGAACACCTTGAACTCTGTGTGGCGGATCCCGATGCCCTGAGCGCGCAGATCACCCATGCCGG
GGCGATTTTCCTCGGGCAATGGACGCCGGAGGCGATTGGCGATTATGTCGGCGGGCCGAACCACGTGCTTCCGACCGCGC
GGTCTGCGCGCTTTTCATCGGGGCTGTCGGTCCTTGATTTCATGAAACGTACGACGCTGGCGCGCATGACCCCGGCGGCC
TTGCGCGCGGTGGGTCCTGCTGCCGAGACGCTGGCCAAATCGGAAAGCCTTGAGGCGCATGGCCTTTCCGTAACGGCCCG
CCTGCGCAAACTAAACGATACGCAGATGCCCTAA

Upstream 100 bases:

>100_bases
TGTCACAAAACCCTATGTTGCACCGTCCAGGACGACGCCTTCGCATCCTGAATGACCGATCCCCGACACAGCCCTTTCCC
AGACGAGACATAGACCGCCC

Downstream 100 bases:

>100_bases
AAGGTTGCCCCGTGCGGGGTTTCCGGGCTACTCAGGCGCGGCTAAGTTCCATCGGCAAGAAGTATTCCTATGTCCCGCAT
CTCGCATATCACCCTTGATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 3 [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPVFLNAADPDFENRFNALLSAKREDSPDVDATVAQIIADVRARGDAALIELTKKFDRVTLTPDSLAITPDEVDAAVADA
PADQVAALELAAQRIRVYHERQRPEDAEWVDDSGAMLGWRWTAVAAAGLYVPGGLASYPSSVLMNAIPAKVAGVSRLAMV
VPAPDGVLNPLVLAAARLSGVDEIYRIGGAQAVAALAYGTATIAPVDKITGPGNAFVAAAKRRVFGKVGIDMIAGPSEIL
VIADAQNDPDWIALDLLSQAEHDESAQSILITTDAAFGQAVAAAVEKRLETLERRAIAGASWRDFGAVVTVPDLATAAAL
SDRIAPEHLELCVADPDALSAQITHAGAIFLGQWTPEAIGDYVGGPNHVLPTARSARFSSGLSVLDFMKRTTLARMTPAA
LRAVGPAAETLAKSESLEAHGLSVTARLRKLNDTQMP

Sequences:

>Translated_437_residues
MPVFLNAADPDFENRFNALLSAKREDSPDVDATVAQIIADVRARGDAALIELTKKFDRVTLTPDSLAITPDEVDAAVADA
PADQVAALELAAQRIRVYHERQRPEDAEWVDDSGAMLGWRWTAVAAAGLYVPGGLASYPSSVLMNAIPAKVAGVSRLAMV
VPAPDGVLNPLVLAAARLSGVDEIYRIGGAQAVAALAYGTATIAPVDKITGPGNAFVAAAKRRVFGKVGIDMIAGPSEIL
VIADAQNDPDWIALDLLSQAEHDESAQSILITTDAAFGQAVAAAVEKRLETLERRAIAGASWRDFGAVVTVPDLATAAAL
SDRIAPEHLELCVADPDALSAQITHAGAIFLGQWTPEAIGDYVGGPNHVLPTARSARFSSGLSVLDFMKRTTLARMTPAA
LRAVGPAAETLAKSESLEAHGLSVTARLRKLNDTQMP
>Mature_436_residues
PVFLNAADPDFENRFNALLSAKREDSPDVDATVAQIIADVRARGDAALIELTKKFDRVTLTPDSLAITPDEVDAAVADAP
ADQVAALELAAQRIRVYHERQRPEDAEWVDDSGAMLGWRWTAVAAAGLYVPGGLASYPSSVLMNAIPAKVAGVSRLAMVV
PAPDGVLNPLVLAAARLSGVDEIYRIGGAQAVAALAYGTATIAPVDKITGPGNAFVAAAKRRVFGKVGIDMIAGPSEILV
IADAQNDPDWIALDLLSQAEHDESAQSILITTDAAFGQAVAAAVEKRLETLERRAIAGASWRDFGAVVTVPDLATAAALS
DRIAPEHLELCVADPDALSAQITHAGAIFLGQWTPEAIGDYVGGPNHVLPTARSARFSSGLSVLDFMKRTTLARMTPAAL
RAVGPAAETLAKSESLEAHGLSVTARLRKLNDTQMP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=412, Percent_Identity=41.504854368932, Blast_Score=281, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=38.1516587677725, Blast_Score=248, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45856; Mature: 45725

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFLNAADPDFENRFNALLSAKREDSPDVDATVAQIIADVRARGDAALIELTKKFDRVT
CCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEE
LTPDSLAITPDEVDAAVADAPADQVAALELAAQRIRVYHERQRPEDAEWVDDSGAMLGWR
ECCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
WTAVAAAGLYVPGGLASYPSSVLMNAIPAKVAGVSRLAMVVPAPDGVLNPLVLAAARLSG
HHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCHHHEEEEEECCCCHHHHHHHHHHHHCC
VDEIYRIGGAQAVAALAYGTATIAPVDKITGPGNAFVAAAKRRVFGKVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCEEECCHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEE
VIADAQNDPDWIALDLLSQAEHDESAQSILITTDAAFGQAVAAAVEKRLETLERRAIAGA
EEEECCCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
SWRDFGAVVTVPDLATAAALSDRIAPEHLELCVADPDALSAQITHAGAIFLGQWTPEAIG
CCHHCCCEEECCCHHHHHHHHHCCCCCHHEEEECCCCHHHEEHEECCEEEEECCCHHHHH
DYVGGPNHVLPTARSARFSSGLSVLDFMKRTTLARMTPAALRAVGPAAETLAKSESLEAH
HHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCC
GLSVTARLRKLNDTQMP
CCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PVFLNAADPDFENRFNALLSAKREDSPDVDATVAQIIADVRARGDAALIELTKKFDRVT
CEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEE
LTPDSLAITPDEVDAAVADAPADQVAALELAAQRIRVYHERQRPEDAEWVDDSGAMLGWR
ECCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
WTAVAAAGLYVPGGLASYPSSVLMNAIPAKVAGVSRLAMVVPAPDGVLNPLVLAAARLSG
HHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCHHHEEEEEECCCCHHHHHHHHHHHHCC
VDEIYRIGGAQAVAALAYGTATIAPVDKITGPGNAFVAAAKRRVFGKVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCEEECCHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCEEE
VIADAQNDPDWIALDLLSQAEHDESAQSILITTDAAFGQAVAAAVEKRLETLERRAIAGA
EEEECCCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
SWRDFGAVVTVPDLATAAALSDRIAPEHLELCVADPDALSAQITHAGAIFLGQWTPEAIG
CCHHCCCEEECCCHHHHHHHHHCCCCCHHEEEECCCCHHHEEHEECCEEEEECCCHHHHH
DYVGGPNHVLPTARSARFSSGLSVLDFMKRTTLARMTPAALRAVGPAAETLAKSESLEAH
HHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCC
GLSVTARLRKLNDTQMP
CCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA