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The map label for this gene is lrp [H]

Identifier: 110678344

GI number: 110678344

Start: 963208

End: 963660

Strand: Direct

Name: lrp [H]

Synonym: RD1_1000

Alternate gene names: 110678344

Gene position: 963208-963660 (Clockwise)

Preceding gene: 110678341

Following gene: 110678346

Centisome position: 23.3

GC content: 60.71

Gene sequence:

>453_bases
ATGACCAGCCTTGACCAGAAAACCGAACATATATTGCGTGAACTGACCGCCAACGGACGCATCAGCAATATCGAACTCGC
CGACCGTGTGGGGCTGTCACCCTCTGCCTGTCTGCGTCGCGTGCAGGAACTGGAGCGCGCGGGTCTGATCAAAGGGTATC
GCGCCGTGCTTGACCGGACCGCATTGGGGCGCGGGTTTGTCGCCTATATCGGTGTCGGCCTGCGAGAACATTCCAAGGCC
AGCCAGGAAGCGTTCGAGCGCGCCATCGCACGCGCGCCCGAAGTGCGCGAATGTCACAACACCACCGGCACGATCGAGTA
TCTGCTGCGGGTGGAATGCGCCGACCTGCCGGAATACAAATCGTTCCACACCGATACTTTGGGCGCCATTCCGCAGGTGA
GCGCCATCACCTCTTATGTTGTGATGGGCTCCCCCAAGGACGAACGCGCCTGA

Upstream 100 bases:

>100_bases
CGAGGGCGGAGAGTGTTTCATAAGGCATGCGCAAAGAATGGCGCATTCGAAATATATGTGGATTGCAAAATTTTCGGATT
TTGCGGAATAATCACAATTA

Downstream 100 bases:

>100_bases
GGGTGATCGCCCCGCTCAGGAGGCGATCATCTCCGACTGGCGCACGATCACTTCGGCCTGTTTGATCGAGGCGATATCAA
CCAGCCGCCCCTTGTAAACG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTSLDQKTEHILRELTANGRISNIELADRVGLSPSACLRRVQELERAGLIKGYRAVLDRTALGRGFVAYIGVGLREHSKA
SQEAFERAIARAPEVRECHNTTGTIEYLLRVECADLPEYKSFHTDTLGAIPQVSAITSYVVMGSPKDERA

Sequences:

>Translated_150_residues
MTSLDQKTEHILRELTANGRISNIELADRVGLSPSACLRRVQELERAGLIKGYRAVLDRTALGRGFVAYIGVGLREHSKA
SQEAFERAIARAPEVRECHNTTGTIEYLLRVECADLPEYKSFHTDTLGAIPQVSAITSYVVMGSPKDERA
>Mature_149_residues
TSLDQKTEHILRELTANGRISNIELADRVGLSPSACLRRVQELERAGLIKGYRAVLDRTALGRGFVAYIGVGLREHSKAS
QEAFERAIARAPEVRECHNTTGTIEYLLRVECADLPEYKSFHTDTLGAIPQVSAITSYVVMGSPKDERA

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=39.2857142857143, Blast_Score=113, Evalue=6e-27,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=29.3706293706294, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16572; Mature: 16441

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLDQKTEHILRELTANGRISNIELADRVGLSPSACLRRVQELERAGLIKGYRAVLDRT
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGRGFVAYIGVGLREHSKASQEAFERAIARAPEVRECHNTTGTIEYLLRVECADLPEYK
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCHH
SFHTDTLGAIPQVSAITSYVVMGSPKDERA
HHCCHHHCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TSLDQKTEHILRELTANGRISNIELADRVGLSPSACLRRVQELERAGLIKGYRAVLDRT
CCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGRGFVAYIGVGLREHSKASQEAFERAIARAPEVRECHNTTGTIEYLLRVECADLPEYK
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCHH
SFHTDTLGAIPQVSAITSYVVMGSPKDERA
HHCCHHHCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]