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The map label for this gene is tyrB [H]

Identifier: 110678282

GI number: 110678282

Start: 903707

End: 904891

Strand: Direct

Name: tyrB [H]

Synonym: RD1_0935

Alternate gene names: 110678282

Gene position: 903707-904891 (Clockwise)

Preceding gene: 110678281

Following gene: 110678285

Centisome position: 21.87

GC content: 61.52

Gene sequence:

>1185_bases
ATGTTCGAGACCCTCAAGGCGCGCCCTGCCGACGGAATCCTCGCATTGATGCAGATGTTCAAAGACGATCCGCGCGACAA
CAAGATCGACCTTGGCGTCGGTGTCTACAAAGACGCGACGGGCCTCACGCCGATCATGCGCGCGGTCAAGGCTGCCGAAC
ACACCCTTTGGGAAACGCAGGACAGCAAGGTTTACACGGGCCTCGCGGGCGATCCGGCGTTTTCGGATGCAATGGTCGCC
CTCGTGCTGGGCAGTGCCGTGCCGCGTGACGCTGTGGCATCCGTGGCGACACCGGGCGGGACCGGGGCGGTGCGACAGGC
CTTTGAGCTTATCCGCATGGCGCGCCCGGATGCGCGGGTGTTTGTGTCAGATCCGACATGGCCCAACCATGTTTCGATCC
TGAACTATCTCGGGATGGAGGTGGTGCGCTATCGGTATTTCGACAGTGAGACCCGCGGTGTCGATTTCGATGGTATGATG
GCCGACCTCAAGACGGCGCGCGCGGGGGATGTGATCTTGCTGCATGGATGCTGTCACAATCCGACCGGCGCCAACCTGAA
CCTGACCGAATGGCAGGCCGTGGTTGAAACGCTGCTTGAAACGGGCGCGGTGCCGATGATCGACATCGCCTATCAGGGCT
TTGGTGACGGGCTTGAAGAAGACGCGGCCGGTACTCGGCTTGTCGCCTCGTCTGTACCGGAATGTCTGATCGCGGCGAGT
TGTTCCAAGAATTTCGGCATTTACCGGGAGCGGACGGGGATATTGATGGCGGTCAGTGCGAATAAGGGCGCACGCAAACT
GCATCAGGACACGCTGGCGTTCCTGAACCGGCAGAACTACAGCTTTCCGCCCGATCACGGCGCGCGGTTGGTCACGATGA
TCCTGACGGACGAGTCCCTGCGCGCCGACTGGCAGGCGGAACTGGAAGACGTGCGGCTGAGCATGTTGACCCTGCGCCAG
CACCTGGCGGATGAGTTGCAGCAACTCTCTGGTTCGGACCGGTTCGGGTTCCTGGCGCAGCACCGTGGCATGTTTTCCCT
GCTCGGTACAACGCCGGACAGAGTGCAGGCCCTGCGCGAGCAAAACGGGATTTATATGGTGGGGGACAGCCGGATGAACA
TTGCCGGTTTGAACGCGCAAACGGTTCCGATCCTGGCGCGCGCGATCGTGGATGTAGGGGTCTGA

Upstream 100 bases:

>100_bases
CGCTGGAACGCATGGGACACCGCCATTGGTCCTTGTACGATGGGTCCTGGGCCGAATGGGGGATGTTTCCCACCGTGCCC
GTCGCGACAGGAGACGCATG

Downstream 100 bases:

>100_bases
CCTCGGCAAAACCCGGACCAGACCCCTTTGTTAGTGGCGTTTTGCGGCCCGTGGCACAGGGTGCCCGGTCTGCATCACGC
GGGTGGCCCCACTGTGTCTC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MFETLKARPADGILALMQMFKDDPRDNKIDLGVGVYKDATGLTPIMRAVKAAEHTLWETQDSKVYTGLAGDPAFSDAMVA
LVLGSAVPRDAVASVATPGGTGAVRQAFELIRMARPDARVFVSDPTWPNHVSILNYLGMEVVRYRYFDSETRGVDFDGMM
ADLKTARAGDVILLHGCCHNPTGANLNLTEWQAVVETLLETGAVPMIDIAYQGFGDGLEEDAAGTRLVASSVPECLIAAS
CSKNFGIYRERTGILMAVSANKGARKLHQDTLAFLNRQNYSFPPDHGARLVTMILTDESLRADWQAELEDVRLSMLTLRQ
HLADELQQLSGSDRFGFLAQHRGMFSLLGTTPDRVQALREQNGIYMVGDSRMNIAGLNAQTVPILARAIVDVGV

Sequences:

>Translated_394_residues
MFETLKARPADGILALMQMFKDDPRDNKIDLGVGVYKDATGLTPIMRAVKAAEHTLWETQDSKVYTGLAGDPAFSDAMVA
LVLGSAVPRDAVASVATPGGTGAVRQAFELIRMARPDARVFVSDPTWPNHVSILNYLGMEVVRYRYFDSETRGVDFDGMM
ADLKTARAGDVILLHGCCHNPTGANLNLTEWQAVVETLLETGAVPMIDIAYQGFGDGLEEDAAGTRLVASSVPECLIAAS
CSKNFGIYRERTGILMAVSANKGARKLHQDTLAFLNRQNYSFPPDHGARLVTMILTDESLRADWQAELEDVRLSMLTLRQ
HLADELQQLSGSDRFGFLAQHRGMFSLLGTTPDRVQALREQNGIYMVGDSRMNIAGLNAQTVPILARAIVDVGV
>Mature_394_residues
MFETLKARPADGILALMQMFKDDPRDNKIDLGVGVYKDATGLTPIMRAVKAAEHTLWETQDSKVYTGLAGDPAFSDAMVA
LVLGSAVPRDAVASVATPGGTGAVRQAFELIRMARPDARVFVSDPTWPNHVSILNYLGMEVVRYRYFDSETRGVDFDGMM
ADLKTARAGDVILLHGCCHNPTGANLNLTEWQAVVETLLETGAVPMIDIAYQGFGDGLEEDAAGTRLVASSVPECLIAAS
CSKNFGIYRERTGILMAVSANKGARKLHQDTLAFLNRQNYSFPPDHGARLVTMILTDESLRADWQAELEDVRLSMLTLRQ
HLADELQQLSGSDRFGFLAQHRGMFSLLGTTPDRVQALREQNGIYMVGDSRMNIAGLNAQTVPILARAIVDVGV

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=390, Percent_Identity=32.8205128205128, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4504067, Length=400, Percent_Identity=31, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI117414139, Length=386, Percent_Identity=25.1295336787565, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=44.5843828715365, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=40.4522613065327, Blast_Score=299, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71981858, Length=400, Percent_Identity=34.75, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=32.3076923076923, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17569539, Length=395, Percent_Identity=30.6329113924051, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17569537, Length=379, Percent_Identity=25.8575197889182, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25147136, Length=189, Percent_Identity=34.9206349206349, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17550384, Length=250, Percent_Identity=28.8, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323055, Length=404, Percent_Identity=31.4356435643564, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322743, Length=422, Percent_Identity=30.3317535545024, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24580970, Length=402, Percent_Identity=34.0796019900498, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24580972, Length=402, Percent_Identity=34.0796019900498, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI19920542, Length=395, Percent_Identity=34.4303797468354, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=34.8837209302326, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=34.8837209302326, Blast_Score=231, Evalue=9e-61,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 42935; Mature: 42935

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETLKARPADGILALMQMFKDDPRDNKIDLGVGVYKDATGLTPIMRAVKAAEHTLWETQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCC
DSKVYTGLAGDPAFSDAMVALVLGSAVPRDAVASVATPGGTGAVRQAFELIRMARPDARV
CCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
FVSDPTWPNHVSILNYLGMEVVRYRYFDSETRGVDFDGMMADLKTARAGDVILLHGCCHN
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCC
PTGANLNLTEWQAVVETLLETGAVPMIDIAYQGFGDGLEEDAAGTRLVASSVPECLIAAS
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCCCHHHHHCCHHHHHHH
CSKNFGIYRERTGILMAVSANKGARKLHQDTLAFLNRQNYSFPPDHGARLVTMILTDESL
CCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHH
RADWQAELEDVRLSMLTLRQHLADELQQLSGSDRFGFLAQHRGMFSLLGTTPDRVQALRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHCCCHHHHHHHHH
QNGIYMVGDSRMNIAGLNAQTVPILARAIVDVGV
CCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFETLKARPADGILALMQMFKDDPRDNKIDLGVGVYKDATGLTPIMRAVKAAEHTLWETQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHCCC
DSKVYTGLAGDPAFSDAMVALVLGSAVPRDAVASVATPGGTGAVRQAFELIRMARPDARV
CCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
FVSDPTWPNHVSILNYLGMEVVRYRYFDSETRGVDFDGMMADLKTARAGDVILLHGCCHN
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCC
PTGANLNLTEWQAVVETLLETGAVPMIDIAYQGFGDGLEEDAAGTRLVASSVPECLIAAS
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCCCHHHHHCCHHHHHHH
CSKNFGIYRERTGILMAVSANKGARKLHQDTLAFLNRQNYSFPPDHGARLVTMILTDESL
CCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHH
RADWQAELEDVRLSMLTLRQHLADELQQLSGSDRFGFLAQHRGMFSLLGTTPDRVQALRE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHCCCHHHHHHHHH
QNGIYMVGDSRMNIAGLNAQTVPILARAIVDVGV
CCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]