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The map label for this gene is gabT [H]

Identifier: 110678191

GI number: 110678191

Start: 816875

End: 818170

Strand: Direct

Name: gabT [H]

Synonym: RD1_0839

Alternate gene names: 110678191

Gene position: 816875-818170 (Clockwise)

Preceding gene: 110678189

Following gene: 110678192

Centisome position: 19.76

GC content: 58.1

Gene sequence:

>1296_bases
ATGTCGTACACTGCAGACCTTAAAACCCGTCGTGAAAACGCTGTTGCTACCGGTGTCGGCACGCGGGGAATCTATGCCGA
ACGCGCGCAGAATTCTGAGCTTTGGGACGTGGATGGCAAGCGGTTTATTGATTTTGCAGCGGGCATAGCCGTGAATAATG
CAGGTCACCGCCACCCGAAATTGATGGAGGCCGTGGCCAAGCAATGCGAAGTCTTTACGCATACCTGTTTCCACGTCGCC
CCATATGAAAGCTACATCCGCCTGGCCGAACGGCTGAACAGTCTGACCCCCGGTGATTTCAAGAAAAAGACGATGCTGGT
TACGACCGGCGCCGAAGCCGTCGAGAACGCCATCAAAATGGCCCGCGCGTTTACCGGTCGGTCGGGCGTCATCGCGTTTT
CCGGTGCGTTTCATGGCCGGACCCTTTTGGGGATGGCATTGTGCGGCAAGGTCGCCCCTTACAAGAAATCCTTCGGTGCA
ATGCCGCCCGAAATCTACCATGCCGCTTTCCCGAATGAATATCACGGCATCACGCCCGAAATGAGCCTTGCCCAGTTGGA
CCTGCTGTTCAAGTCGAGCATTGATCCCGAGCGCGTGGCCGCGATTGTTATCGAGGCGGTACAGGGTGAGGGTGGTTTCA
ACATCGCTGATTTCGACTTCCTGCGCAAACTGCGCCAGATCGCGGATGATCACGGTATCCTGCTGATCGCGGATGAGGTG
CAGGCCGGTATGGCGCGGACAGGCAAGATGTTTGCCTTTGAACATGCAGGTGTTGCGGCAGACCTCGTGACGATGGCCAA
GGGTCTCGCGGGGGGGTTCCCACTTTCGGCCGTGACCGGTCGTGCCGAGGTGGTGGACGCGCCGCCCGTTGGCGGGATCG
GCGGCACCTATGCCGGTAATCCGCTCGCCGTTGCGGCGGCGAATGCCATGCTGGACATCATCGAAGACGAGGGTCTGTGT
GCCAATGCGGCAAAGATCGGCGCGACCATCAAGGATCGGCTGACGGCAATTGCCAAACGTCAGGGCATGGAGCCGATTGG
CGATGTGCGCGGCTTGGGTGCTATGATCGCCTTCGAACTAGTCAAAAACCGCGAAACCCGTGAACCGGATACCGCTTTAA
CCGCTGCGATTGTAACACAGGCCGAACACCGTGGGCTTATCATTTTGCCATGCGGGACCCGTGGCAATGTCATTCGCCTG
CTGCCGCCGCTGAATACGTCGGATGCCATCGTGCACGAAGCACTCGATGTTCTGGAGACATCCATCGAAGCCGCGATGAC
ACAGATACAAATCTGA

Upstream 100 bases:

>100_bases
CGAGTTTAGCTTGAACCATGCCTTTCGCTCAACAGGAAAGAAATACTTGCTCGATATATTGAGCAATGATACCGCTGAAT
CATGAGCCAAGGAGAGAATC

Downstream 100 bases:

>100_bases
TTGCAGGCTGTCGGACAGCCGACTGATGCCCTGAAAACTCTACGGGAGAAACCCATGTCACAACATAAGAACCTGATTGC
TGGAGCGTGGGTTTCCGGCA

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSYTADLKTRRENAVATGVGTRGIYAERAQNSELWDVDGKRFIDFAAGIAVNNAGHRHPKLMEAVAKQCEVFTHTCFHVA
PYESYIRLAERLNSLTPGDFKKKTMLVTTGAEAVENAIKMARAFTGRSGVIAFSGAFHGRTLLGMALCGKVAPYKKSFGA
MPPEIYHAAFPNEYHGITPEMSLAQLDLLFKSSIDPERVAAIVIEAVQGEGGFNIADFDFLRKLRQIADDHGILLIADEV
QAGMARTGKMFAFEHAGVAADLVTMAKGLAGGFPLSAVTGRAEVVDAPPVGGIGGTYAGNPLAVAAANAMLDIIEDEGLC
ANAAKIGATIKDRLTAIAKRQGMEPIGDVRGLGAMIAFELVKNRETREPDTALTAAIVTQAEHRGLIILPCGTRGNVIRL
LPPLNTSDAIVHEALDVLETSIEAAMTQIQI

Sequences:

>Translated_431_residues
MSYTADLKTRRENAVATGVGTRGIYAERAQNSELWDVDGKRFIDFAAGIAVNNAGHRHPKLMEAVAKQCEVFTHTCFHVA
PYESYIRLAERLNSLTPGDFKKKTMLVTTGAEAVENAIKMARAFTGRSGVIAFSGAFHGRTLLGMALCGKVAPYKKSFGA
MPPEIYHAAFPNEYHGITPEMSLAQLDLLFKSSIDPERVAAIVIEAVQGEGGFNIADFDFLRKLRQIADDHGILLIADEV
QAGMARTGKMFAFEHAGVAADLVTMAKGLAGGFPLSAVTGRAEVVDAPPVGGIGGTYAGNPLAVAAANAMLDIIEDEGLC
ANAAKIGATIKDRLTAIAKRQGMEPIGDVRGLGAMIAFELVKNRETREPDTALTAAIVTQAEHRGLIILPCGTRGNVIRL
LPPLNTSDAIVHEALDVLETSIEAAMTQIQI
>Mature_430_residues
SYTADLKTRRENAVATGVGTRGIYAERAQNSELWDVDGKRFIDFAAGIAVNNAGHRHPKLMEAVAKQCEVFTHTCFHVAP
YESYIRLAERLNSLTPGDFKKKTMLVTTGAEAVENAIKMARAFTGRSGVIAFSGAFHGRTLLGMALCGKVAPYKKSFGAM
PPEIYHAAFPNEYHGITPEMSLAQLDLLFKSSIDPERVAAIVIEAVQGEGGFNIADFDFLRKLRQIADDHGILLIADEVQ
AGMARTGKMFAFEHAGVAADLVTMAKGLAGGFPLSAVTGRAEVVDAPPVGGIGGTYAGNPLAVAAANAMLDIIEDEGLCA
NAAKIGATIKDRLTAIAKRQGMEPIGDVRGLGAMIAFELVKNRETREPDTALTAAIVTQAEHRGLIILPCGTRGNVIRLL
PPLNTSDAIVHEALDVLETSIEAAMTQIQI

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=30.2439024390244, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=30.7142857142857, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI13994255, Length=457, Percent_Identity=28.4463894967177, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=30.2380952380952, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=31.0432569974555, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI24119277, Length=395, Percent_Identity=27.0886075949367, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=30.4615384615385, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI188536080, Length=439, Percent_Identity=28.4738041002278, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38679950, Length=439, Percent_Identity=28.4738041002278, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38679946, Length=439, Percent_Identity=28.4738041002278, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=51.8779342723005, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=52.1531100478469, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788044, Length=403, Percent_Identity=37.7171215880893, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=36.0406091370558, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI145693181, Length=386, Percent_Identity=34.1968911917098, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786991, Length=390, Percent_Identity=32.3076923076923, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=332, Percent_Identity=31.3253012048193, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=33.4894613583138, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=31.4285714285714, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144271, Length=403, Percent_Identity=29.2803970223325, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=233, Percent_Identity=32.1888412017167, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=443, Percent_Identity=26.1851015801354, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=31.2348668280872, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=30.5825242718447, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=301, Percent_Identity=25.5813953488372, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=247, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161085790, Length=457, Percent_Identity=32.3851203501094, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574759, Length=457, Percent_Identity=32.3851203501094, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21357415, Length=453, Percent_Identity=27.5938189845475, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21356575, Length=397, Percent_Identity=31.2342569269521, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI281366494, Length=395, Percent_Identity=25.3164556962025, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24667139, Length=395, Percent_Identity=25.3164556962025, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24667143, Length=395, Percent_Identity=25.3164556962025, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45928; Mature: 45797

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTADLKTRRENAVATGVGTRGIYAERAQNSELWDVDGKRFIDFAAGIAVNNAGHRHPK
CCCCCCHHHHHCCCEEECCCCCCEEHHHCCCCCEECCCCCHHHHHHHCEEECCCCCCCHH
LMEAVAKQCEVFTHTCFHVAPYESYIRLAERLNSLTPGDFKKKTMLVTTGAEAVENAIKM
HHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHH
ARAFTGRSGVIAFSGAFHGRTLLGMALCGKVAPYKKSFGAMPPEIYHAAFPNEYHGITPE
HHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCCCCCCCCCCC
MSLAQLDLLFKSSIDPERVAAIVIEAVQGEGGFNIADFDFLRKLRQIADDHGILLIADEV
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCH
QAGMARTGKMFAFEHAGVAADLVTMAKGLAGGFPLSAVTGRAEVVDAPPVGGIGGTYAGN
HHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHCCCCEEECCCCCCCCCCCCCCC
PLAVAAANAMLDIIEDEGLCANAAKIGATIKDRLTAIAKRQGMEPIGDVRGLGAMIAFEL
CCEEHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VKNRETREPDTALTAAIVTQAEHRGLIILPCGTRGNVIRLLPPLNTSDAIVHEALDVLET
HHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHH
SIEAAMTQIQI
HHHHHHHHHCC
>Mature Secondary Structure 
SYTADLKTRRENAVATGVGTRGIYAERAQNSELWDVDGKRFIDFAAGIAVNNAGHRHPK
CCCCCHHHHHCCCEEECCCCCCEEHHHCCCCCEECCCCCHHHHHHHCEEECCCCCCCHH
LMEAVAKQCEVFTHTCFHVAPYESYIRLAERLNSLTPGDFKKKTMLVTTGAEAVENAIKM
HHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHH
ARAFTGRSGVIAFSGAFHGRTLLGMALCGKVAPYKKSFGAMPPEIYHAAFPNEYHGITPE
HHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCCCCCCCCCCC
MSLAQLDLLFKSSIDPERVAAIVIEAVQGEGGFNIADFDFLRKLRQIADDHGILLIADEV
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCH
QAGMARTGKMFAFEHAGVAADLVTMAKGLAGGFPLSAVTGRAEVVDAPPVGGIGGTYAGN
HHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHCCCCEEECCCCCCCCCCCCCCC
PLAVAAANAMLDIIEDEGLCANAAKIGATIKDRLTAIAKRQGMEPIGDVRGLGAMIAFEL
CCEEHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VKNRETREPDTALTAAIVTQAEHRGLIILPCGTRGNVIRLLPPLNTSDAIVHEALDVLET
HHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHH
SIEAAMTQIQI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]