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The map label for this gene is rad50 [H]

Identifier: 110678163

GI number: 110678163

Start: 788135

End: 790186

Strand: Direct

Name: rad50 [H]

Synonym: RD1_0806

Alternate gene names: 110678163

Gene position: 788135-790186 (Clockwise)

Preceding gene: 110678162

Following gene: 110678164

Centisome position: 19.07

GC content: 49.27

Gene sequence:

>2052_bases
GTGAGAATACTTCGCCTCAAGATAAAGAACTTCCGCCAGTTTTATGGTGATTGTGAGTTAGAGTTCCTCTCAGACGATAC
ATCGAGAATTACCGTCATTCATGGTGAAAACGGATCTGGTAAAACTTCTCTTTTAAACGCATTCAAATGGGTTCTATACG
GTAAGACAGATTTCGATACTGGCGAGCAGACAATCCTCAACGAACTTGCTTTGTCTGAAATCTCTCCTGGAGCGGTGACT
GAGCTAAGCCTAGAACTTGAGTTTGAGCACGAAGGCTCCACCTACACTGTGCACCGAAAGCAGGAGTTCAAGCGTACAGG
AGAAGCGCTGGAAGCCGAACCAATTGGGAAATCTGTTCCAACCCTGTCCTGGATCGATGAACGGGGGAAGTATGAGACAG
CAAAGAACCCTGCCAACCGGATCAACCAATTGATACCTGAGCAGATGCACTCGTATTTCTTCTTCAACGGCGAGCGCATC
GAAAAACTGGCTAACGTGTCTGCTTCTGGCGAAATCCGAGATGCTATCAAGACCTTGATGGGCTTGGAGATCATAGACCG
GGCAAGCGATCATCTTGGTCGTTTGGTGATCAAGGATCTTCGGAAGGAAGCAAGTGAGACGGCTTCAGCTGACTATCGCG
ATCTACTTGAAAAAGAGTCGAGGATTAGCTCAGAGATAGATCAACGGAAACTAGAGCGGGATACGGCGGCAAAATCCAGC
AAGGGCTTCCAAACAGAACTAGACGCCATCAATGCCTCTTATGAGCGAATAGCCGATGTAAAGGCAAAGGCCGAGCAAAG
GCGAAGTCTGGAAGCCGAGAGAGGTAGAATCGAAGGCGTCCTTGAAAAGCTGAGCCAAGAGAGGATGGATCTGGTATCGC
AATCGGGCGCACTGGCCTTTCTGAGCGATACTGTAGCATCTGTCTCAACTGTTCTAGAAGACTGTCGCAAGAGGGGTGAG
TTGCCTTATAAGATTAGGCGGACGTTCATTGACGACCTATTACACGACGCGAAGTGCATTTGTGGAACTGAACTTCAAGA
GGGCACGAAAGCACGAGCCGCGATTGAAGGATACCGTGACCAAGCGACTGGAGAGGATCTTGAGGCCGCGTTCACAGACG
TCGTGAGCAACCTAAGAGCAATGCCTCGTGAGAGGACCAGACTGTATGCACAGCTGTCAACTTGGTCGGCAGAAGAGAGC
GACTACAACAAGCGACTAAAAGCGATCACTGAAGAGCTCGACGAGATCAGCAGCAGTTTAGGGTCTTCTGACATTGAAGA
CGTTAAACGTCTGGAAGAGCGCCGGAATGAGCTGACAAAACTCCAAGCGGAAGAACGCCTTAAAATCGCCAAAGCAAAAG
ATGCGATTGAACTTCTGAATGACGACCTAGCCAAGGTTAAAAAAGAGATTGAGAAGGTCCAATCGAAGTCCCAAAAAGAA
GACTTGGCAAGGCAGAAACTTGAGTTCGCCGAAGCTTGTAAGAGTCTGGTGGACAACCTGCATGAGGCCTTGGCCGAGGA
GACACGCCATCATTTGTCTACAAAGGTAAATGACACTTTCCAGAGCATCCTCCGTAAAGATTTCTACGCAGAGATTGATC
GCGACTACACCTTGAGAATCTTCAAAGACGTCCCGGGGGTCGGAAAGCAACCCGTTTCTGAGAAGTCGACGGGGGAGAAC
CAGGTTATCAGCCTGAGCTTCATTGCGAGTTTGGTTAATCTCGCAAAGGAACGCAACAAGGCAAAAACAACCTTTTTCAA
GGGCGGTGTTTATCCCTTGATTATGGACTCGCCGTTCGGCGCTTTGGACCGCGAATATCGGGAAAAGATTGCGCAGCACA
TTCCTGATCTCGCAGACCAAGTGATTGTCTTTGCTTCAAACTCTCAGTGGAGCAAGGAAGTCGATGAAAAGTGTCGACCG
TTCATCGGCAAGGAGTATAGCTTGGTCTACCACGCGCCGAAGTCCAAAGGGCGCGAAGAAGACACCGACTACGTGAAACG
CACTGATGGTCCTGAGTTCACAAAAATCGAGGAGGGCTATCTTGGCCACTAG

Upstream 100 bases:

>100_bases
AGCATGAGTATCAGAGTTATCGAAACCTTGGGGCCGTCAGCAGTGTTGAGAAAGAGATTGCTGCGCGGATCAAGCAACTC
ATCGAGCGTGAGGTAAAACG

Downstream 100 bases:

>100_bases
AGTAAGACGCCCCGCCGAGTTCGAAGAAATGCTCAGCGAGCTTCGGGACGAAGGCATTTTTCCGACCTTCAAGGACACTC
TTGTTTTTGCGGCTGCATTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MRILRLKIKNFRQFYGDCELEFLSDDTSRITVIHGENGSGKTSLLNAFKWVLYGKTDFDTGEQTILNELALSEISPGAVT
ELSLELEFEHEGSTYTVHRKQEFKRTGEALEAEPIGKSVPTLSWIDERGKYETAKNPANRINQLIPEQMHSYFFFNGERI
EKLANVSASGEIRDAIKTLMGLEIIDRASDHLGRLVIKDLRKEASETASADYRDLLEKESRISSEIDQRKLERDTAAKSS
KGFQTELDAINASYERIADVKAKAEQRRSLEAERGRIEGVLEKLSQERMDLVSQSGALAFLSDTVASVSTVLEDCRKRGE
LPYKIRRTFIDDLLHDAKCICGTELQEGTKARAAIEGYRDQATGEDLEAAFTDVVSNLRAMPRERTRLYAQLSTWSAEES
DYNKRLKAITEELDEISSSLGSSDIEDVKRLEERRNELTKLQAEERLKIAKAKDAIELLNDDLAKVKKEIEKVQSKSQKE
DLARQKLEFAEACKSLVDNLHEALAEETRHHLSTKVNDTFQSILRKDFYAEIDRDYTLRIFKDVPGVGKQPVSEKSTGEN
QVISLSFIASLVNLAKERNKAKTTFFKGGVYPLIMDSPFGALDREYREKIAQHIPDLADQVIVFASNSQWSKEVDEKCRP
FIGKEYSLVYHAPKSKGREEDTDYVKRTDGPEFTKIEEGYLGH

Sequences:

>Translated_683_residues
MRILRLKIKNFRQFYGDCELEFLSDDTSRITVIHGENGSGKTSLLNAFKWVLYGKTDFDTGEQTILNELALSEISPGAVT
ELSLELEFEHEGSTYTVHRKQEFKRTGEALEAEPIGKSVPTLSWIDERGKYETAKNPANRINQLIPEQMHSYFFFNGERI
EKLANVSASGEIRDAIKTLMGLEIIDRASDHLGRLVIKDLRKEASETASADYRDLLEKESRISSEIDQRKLERDTAAKSS
KGFQTELDAINASYERIADVKAKAEQRRSLEAERGRIEGVLEKLSQERMDLVSQSGALAFLSDTVASVSTVLEDCRKRGE
LPYKIRRTFIDDLLHDAKCICGTELQEGTKARAAIEGYRDQATGEDLEAAFTDVVSNLRAMPRERTRLYAQLSTWSAEES
DYNKRLKAITEELDEISSSLGSSDIEDVKRLEERRNELTKLQAEERLKIAKAKDAIELLNDDLAKVKKEIEKVQSKSQKE
DLARQKLEFAEACKSLVDNLHEALAEETRHHLSTKVNDTFQSILRKDFYAEIDRDYTLRIFKDVPGVGKQPVSEKSTGEN
QVISLSFIASLVNLAKERNKAKTTFFKGGVYPLIMDSPFGALDREYREKIAQHIPDLADQVIVFASNSQWSKEVDEKCRP
FIGKEYSLVYHAPKSKGREEDTDYVKRTDGPEFTKIEEGYLGH
>Mature_683_residues
MRILRLKIKNFRQFYGDCELEFLSDDTSRITVIHGENGSGKTSLLNAFKWVLYGKTDFDTGEQTILNELALSEISPGAVT
ELSLELEFEHEGSTYTVHRKQEFKRTGEALEAEPIGKSVPTLSWIDERGKYETAKNPANRINQLIPEQMHSYFFFNGERI
EKLANVSASGEIRDAIKTLMGLEIIDRASDHLGRLVIKDLRKEASETASADYRDLLEKESRISSEIDQRKLERDTAAKSS
KGFQTELDAINASYERIADVKAKAEQRRSLEAERGRIEGVLEKLSQERMDLVSQSGALAFLSDTVASVSTVLEDCRKRGE
LPYKIRRTFIDDLLHDAKCICGTELQEGTKARAAIEGYRDQATGEDLEAAFTDVVSNLRAMPRERTRLYAQLSTWSAEES
DYNKRLKAITEELDEISSSLGSSDIEDVKRLEERRNELTKLQAEERLKIAKAKDAIELLNDDLAKVKKEIEKVQSKSQKE
DLARQKLEFAEACKSLVDNLHEALAEETRHHLSTKVNDTFQSILRKDFYAEIDRDYTLRIFKDVPGVGKQPVSEKSTGEN
QVISLSFIASLVNLAKERNKAKTTFFKGGVYPLIMDSPFGALDREYREKIAQHIPDLADQVIVFASNSQWSKEVDEKCRP
FIGKEYSLVYHAPKSKGREEDTDYVKRTDGPEFTKIEEGYLGH

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022982
- InterPro:   IPR003395
- InterPro:   IPR013134 [H]

Pfam domain/function: PF02463 SMC_N [H]

EC number: NA

Molecular weight: Translated: 77534; Mature: 77534

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILRLKIKNFRQFYGDCELEFLSDDTSRITVIHGENGSGKTSLLNAFKWVLYGKTDFDT
CCEEHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
GEQTILNELALSEISPGAVTELSLELEFEHEGSTYTVHRKQEFKRTGEALEAEPIGKSVP
CHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHCCHHCCCCCCCCCC
TLSWIDERGKYETAKNPANRINQLIPEQMHSYFFFNGERIEKLANVSASGEIRDAIKTLM
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEECHHHHHHHHCCCCCCHHHHHHHHHH
GLEIIDRASDHLGRLVIKDLRKEASETASADYRDLLEKESRISSEIDQRKLERDTAAKSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGFQTELDAINASYERIADVKAKAEQRRSLEAERGRIEGVLEKLSQERMDLVSQSGALAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LSDTVASVSTVLEDCRKRGELPYKIRRTFIDDLLHDAKCICGTELQEGTKARAAIEGYRD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHC
QATGEDLEAAFTDVVSNLRAMPRERTRLYAQLSTWSAEESDYNKRLKAITEELDEISSSL
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
GSSDIEDVKRLEERRNELTKLQAEERLKIAKAKDAIELLNDDLAKVKKEIEKVQSKSQKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARQKLEFAEACKSLVDNLHEALAEETRHHLSTKVNDTFQSILRKDFYAEIDRDYTLRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
FKDVPGVGKQPVSEKSTGENQVISLSFIASLVNLAKERNKAKTTFFKGGVYPLIMDSPFG
HHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHHEECCCCEEEEECCCCC
ALDREYREKIAQHIPDLADQVIVFASNSQWSKEVDEKCRPFIGKEYSLVYHAPKSKGREE
CCCHHHHHHHHHHCCHHHHCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
DTDYVKRTDGPEFTKIEEGYLGH
CHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRILRLKIKNFRQFYGDCELEFLSDDTSRITVIHGENGSGKTSLLNAFKWVLYGKTDFDT
CCEEHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
GEQTILNELALSEISPGAVTELSLELEFEHEGSTYTVHRKQEFKRTGEALEAEPIGKSVP
CHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHCCHHCCCCCCCCCC
TLSWIDERGKYETAKNPANRINQLIPEQMHSYFFFNGERIEKLANVSASGEIRDAIKTLM
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEECHHHHHHHHCCCCCCHHHHHHHHHH
GLEIIDRASDHLGRLVIKDLRKEASETASADYRDLLEKESRISSEIDQRKLERDTAAKSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGFQTELDAINASYERIADVKAKAEQRRSLEAERGRIEGVLEKLSQERMDLVSQSGALAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LSDTVASVSTVLEDCRKRGELPYKIRRTFIDDLLHDAKCICGTELQEGTKARAAIEGYRD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHC
QATGEDLEAAFTDVVSNLRAMPRERTRLYAQLSTWSAEESDYNKRLKAITEELDEISSSL
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
GSSDIEDVKRLEERRNELTKLQAEERLKIAKAKDAIELLNDDLAKVKKEIEKVQSKSQKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARQKLEFAEACKSLVDNLHEALAEETRHHLSTKVNDTFQSILRKDFYAEIDRDYTLRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
FKDVPGVGKQPVSEKSTGENQVISLSFIASLVNLAKERNKAKTTFFKGGVYPLIMDSPFG
HHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHHEECCCCEEEEECCCCC
ALDREYREKIAQHIPDLADQVIVFASNSQWSKEVDEKCRPFIGKEYSLVYHAPKSKGREE
CCCHHHHHHHHHHCCHHHHCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
DTDYVKRTDGPEFTKIEEGYLGH
CHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]