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The map label for this gene is mutL [H]

Identifier: 110678039

GI number: 110678039

Start: 643354

End: 645186

Strand: Direct

Name: mutL [H]

Synonym: RD1_0662

Alternate gene names: 110678039

Gene position: 643354-645186 (Clockwise)

Preceding gene: 110678036

Following gene: 110678040

Centisome position: 15.57

GC content: 61.59

Gene sequence:

>1833_bases
ATGAACGTAGCGAACCCCAATATAGGCGCAAGTCGGCCCGTAATCCGCCAGTTGGACGAGGGGGCCGTGAACCGCATTGC
GGCAGGTGAGGTGGTGGAACGCCCTGCCTCTGCCATCAAGGAACTCGTCGAAAATGCACTCGATGCAAGCGCGCGCAAGA
TCGCGATTGATTACGGGGATGGTGGCAAGACACTGATCCGGGTTCAGGATGATGGCTGCGGGATGACGGCCACTGATTTG
CCGCTGGCCTTGTCGCGTCATGCGACGTCCAAGATTGACGGCAGTGATTTGCTGAACATCCAGACATTCGGGTTTCGTGG
GGAGGCGTTGCCGTCTCTGGCTGCCGTTGGCCGGCTGACGATTGTCACGCGCGCCGGTGGCGATGACGGGGTCGAGGCGA
GCGTTTCAGGCGGGGATGAAAAGCCACTCAAGCCAGCGGCCTGCAACCCGGGAACGACGGTCACGATCCGCGATCTGTTT
TACGCCACGCCAGCGCGGCTGAAATTCCTGCGCAGTGATCGGGCGGAGGCGCAGGCGATTATCGACGTGGTCAAACGCCT
CGCCATGGCGGAGCCTTTCGTGCAGTTTGTGCTGCGCGATGTCTCCGGCGATGGACCGGGCCGTGAAGTGTTTCGCGCCG
ACGCGCAGCAGGGCGATCTGTTTGGCGCGTTGCATGGGCGGCTTGCGCGCGTTCTGGGCCGTGAGTTTGCAGAAAATGCG
CTGGCAATTGATGCGGAACGTGAAGGGTTGCATCTGACGGGCTTTGCGGCCCTGCCGACCTATTCGCGCGGCTCCGCTGT
GGCGCAGTATTTTTTCGTCAACGGACGCCCGGTCAAGGACAAGCTGCTGGTTGGGGCGCTCCGGGGTGCCTATTCCGATT
TCCTGAGCAGGGACCGCCACCCGGCCGCGGCGCTGTTTCTGGATTGTGATCCCAAACTGGTCGATGTGAATGTCCACCCG
GCCAAATCAGAGGTGCGGTTTCGCGACCCCGGTATCGCGCGCGGCCTGATCGTTTCAGCGCTGCGCCACGCGCTGGCCGA
GGCAGGCCATCGTGCATCAACGACTGTCAGCACAGCGACCCTTGGGGCGATGCAGCCTGAACCCATCGGCGCGCGCGTCT
ACCAGATGGATCAAGCCTCAAGGCCGGTGTCCGCGCCGCCGCCGCAAACACCGGCTTTTCAGGAGGTTGCCGCGCCTTGG
GGGCGTGTGGCAGAAACAGACCCTGACGAGCAAACGGCAGGTGATCCCGGTGACTATCCGCTTGGTGCGGCGCGCGGTCA
GGTGCATGAGAACTACATCATTGCGCAGACCGCGACCGGCATGGTCATCGTCGATCAGCACGCCGCGCACGAACGTCTCG
TCTATGAAAAGCTGAAACGCCAGATGGCGGAGAATGGGGTCGCTTCGCAAGCCTTGCTGATCCCTGAGATTGTTGAACTG
TCCGCCGCTGATTGCGCGTCTTTGATGCAGATTTCCGATGACCTGGCCCGGTTGGGTTTTGTTGTGGAGCCTTTTGGCGG
GGATGCGATCGCGGTGCGTGAGACACCGGCCATTCTCGGGGTGGTGGATGCACGCGCGCTGATACTGGATATTCTGGATG
AGCTTGCGGATCAGAACGCGTCTGAAAACATACGCATGCGTATAGATGCGATCCTGAGCCGGGTGGCCTGCCATGGGTCG
ATCCGCTCGGGGCGCTGGATGAAAACCGAAGAGATGAATGCCCTGCTGCGCGAGATGGAGGCGACGCCGCATTCCGGGCA
ATGCAACCATGGGCGGCCCACATATGTGGAACTCAAACTGTCCGACATCGAACGCTTGTTTGGCCGCACATGA

Upstream 100 bases:

>100_bases
AGTCGCATGACCCATGTATCTTGGCAAGCGGTCTGACATGTCCGAGGCTCCGCGTGTTACGGGTTTCAGAATCGTGCCAA
AGCATGCTAAGTGTAGTATC

Downstream 100 bases:

>100_bases
TCGAGTTTGCGGGACATACGATTGATCTCACGGACCCCGTTGTTCTGGCGGCAATGGGCGGCGGTGCTGTGGTTCTGCTG
ATCCTTGTGCTGCTTGTGAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MNVANPNIGASRPVIRQLDEGAVNRIAAGEVVERPASAIKELVENALDASARKIAIDYGDGGKTLIRVQDDGCGMTATDL
PLALSRHATSKIDGSDLLNIQTFGFRGEALPSLAAVGRLTIVTRAGGDDGVEASVSGGDEKPLKPAACNPGTTVTIRDLF
YATPARLKFLRSDRAEAQAIIDVVKRLAMAEPFVQFVLRDVSGDGPGREVFRADAQQGDLFGALHGRLARVLGREFAENA
LAIDAEREGLHLTGFAALPTYSRGSAVAQYFFVNGRPVKDKLLVGALRGAYSDFLSRDRHPAAALFLDCDPKLVDVNVHP
AKSEVRFRDPGIARGLIVSALRHALAEAGHRASTTVSTATLGAMQPEPIGARVYQMDQASRPVSAPPPQTPAFQEVAAPW
GRVAETDPDEQTAGDPGDYPLGAARGQVHENYIIAQTATGMVIVDQHAAHERLVYEKLKRQMAENGVASQALLIPEIVEL
SAADCASLMQISDDLARLGFVVEPFGGDAIAVRETPAILGVVDARALILDILDELADQNASENIRMRIDAILSRVACHGS
IRSGRWMKTEEMNALLREMEATPHSGQCNHGRPTYVELKLSDIERLFGRT

Sequences:

>Translated_610_residues
MNVANPNIGASRPVIRQLDEGAVNRIAAGEVVERPASAIKELVENALDASARKIAIDYGDGGKTLIRVQDDGCGMTATDL
PLALSRHATSKIDGSDLLNIQTFGFRGEALPSLAAVGRLTIVTRAGGDDGVEASVSGGDEKPLKPAACNPGTTVTIRDLF
YATPARLKFLRSDRAEAQAIIDVVKRLAMAEPFVQFVLRDVSGDGPGREVFRADAQQGDLFGALHGRLARVLGREFAENA
LAIDAEREGLHLTGFAALPTYSRGSAVAQYFFVNGRPVKDKLLVGALRGAYSDFLSRDRHPAAALFLDCDPKLVDVNVHP
AKSEVRFRDPGIARGLIVSALRHALAEAGHRASTTVSTATLGAMQPEPIGARVYQMDQASRPVSAPPPQTPAFQEVAAPW
GRVAETDPDEQTAGDPGDYPLGAARGQVHENYIIAQTATGMVIVDQHAAHERLVYEKLKRQMAENGVASQALLIPEIVEL
SAADCASLMQISDDLARLGFVVEPFGGDAIAVRETPAILGVVDARALILDILDELADQNASENIRMRIDAILSRVACHGS
IRSGRWMKTEEMNALLREMEATPHSGQCNHGRPTYVELKLSDIERLFGRT
>Mature_610_residues
MNVANPNIGASRPVIRQLDEGAVNRIAAGEVVERPASAIKELVENALDASARKIAIDYGDGGKTLIRVQDDGCGMTATDL
PLALSRHATSKIDGSDLLNIQTFGFRGEALPSLAAVGRLTIVTRAGGDDGVEASVSGGDEKPLKPAACNPGTTVTIRDLF
YATPARLKFLRSDRAEAQAIIDVVKRLAMAEPFVQFVLRDVSGDGPGREVFRADAQQGDLFGALHGRLARVLGREFAENA
LAIDAEREGLHLTGFAALPTYSRGSAVAQYFFVNGRPVKDKLLVGALRGAYSDFLSRDRHPAAALFLDCDPKLVDVNVHP
AKSEVRFRDPGIARGLIVSALRHALAEAGHRASTTVSTATLGAMQPEPIGARVYQMDQASRPVSAPPPQTPAFQEVAAPW
GRVAETDPDEQTAGDPGDYPLGAARGQVHENYIIAQTATGMVIVDQHAAHERLVYEKLKRQMAENGVASQALLIPEIVEL
SAADCASLMQISDDLARLGFVVEPFGGDAIAVRETPAILGVVDARALILDILDELADQNASENIRMRIDAILSRVACHGS
IRSGRWMKTEEMNALLREMEATPHSGQCNHGRPTYVELKLSDIERLFGRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=317, Percent_Identity=37.8548895899054, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=29.5977011494253, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=29.5977011494253, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI4505911, Length=331, Percent_Identity=28.7009063444109, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=28.7009063444109, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI189458896, Length=324, Percent_Identity=27.7777777777778, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=31.5315315315315, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI310128480, Length=303, Percent_Identity=27.7227722772277, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI91992162, Length=338, Percent_Identity=23.9644970414201, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI91992160, Length=338, Percent_Identity=23.9644970414201, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790612, Length=564, Percent_Identity=35.2836879432624, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71991825, Length=408, Percent_Identity=33.578431372549, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=25.9365994236311, Blast_Score=116, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=365, Percent_Identity=33.972602739726, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=334, Percent_Identity=28.4431137724551, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=26.7955801104972, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325093, Length=375, Percent_Identity=24, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136968, Length=317, Percent_Identity=37.2239747634069, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17136970, Length=440, Percent_Identity=26.5909090909091, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65371; Mature: 65371

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVANPNIGASRPVIRQLDEGAVNRIAAGEVVERPASAIKELVENALDASARKIAIDYGD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGKTLIRVQDDGCGMTATDLPLALSRHATSKIDGSDLLNIQTFGFRGEALPSLAAVGRLT
CCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHCCEEE
IVTRAGGDDGVEASVSGGDEKPLKPAACNPGTTVTIRDLFYATPARLKFLRSDRAEAQAI
EEEECCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHH
IDVVKRLAMAEPFVQFVLRDVSGDGPGREVFRADAQQGDLFGALHGRLARVLGREFAENA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LAIDAEREGLHLTGFAALPTYSRGSAVAQYFFVNGRPVKDKLLVGALRGAYSDFLSRDRH
EEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PAAALFLDCDPKLVDVNVHPAKSEVRFRDPGIARGLIVSALRHALAEAGHRASTTVSTAT
CCEEEEEECCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
LGAMQPEPIGARVYQMDQASRPVSAPPPQTPAFQEVAAPWGRVAETDPDEQTAGDPGDYP
HCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
LGAARGQVHENYIIAQTATGMVIVDQHAAHERLVYEKLKRQMAENGVASQALLIPEIVEL
CCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SAADCASLMQISDDLARLGFVVEPFGGDAIAVRETPAILGVVDARALILDILDELADQNA
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCC
SENIRMRIDAILSRVACHGSIRSGRWMKTEEMNALLREMEATPHSGQCNHGRPTYVELKL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
SDIERLFGRT
HHHHHHHCCC
>Mature Secondary Structure
MNVANPNIGASRPVIRQLDEGAVNRIAAGEVVERPASAIKELVENALDASARKIAIDYGD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GGKTLIRVQDDGCGMTATDLPLALSRHATSKIDGSDLLNIQTFGFRGEALPSLAAVGRLT
CCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHCCEEE
IVTRAGGDDGVEASVSGGDEKPLKPAACNPGTTVTIRDLFYATPARLKFLRSDRAEAQAI
EEEECCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHH
IDVVKRLAMAEPFVQFVLRDVSGDGPGREVFRADAQQGDLFGALHGRLARVLGREFAENA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LAIDAEREGLHLTGFAALPTYSRGSAVAQYFFVNGRPVKDKLLVGALRGAYSDFLSRDRH
EEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PAAALFLDCDPKLVDVNVHPAKSEVRFRDPGIARGLIVSALRHALAEAGHRASTTVSTAT
CCEEEEEECCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
LGAMQPEPIGARVYQMDQASRPVSAPPPQTPAFQEVAAPWGRVAETDPDEQTAGDPGDYP
HCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
LGAARGQVHENYIIAQTATGMVIVDQHAAHERLVYEKLKRQMAENGVASQALLIPEIVEL
CCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SAADCASLMQISDDLARLGFVVEPFGGDAIAVRETPAILGVVDARALILDILDELADQNA
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCC
SENIRMRIDAILSRVACHGSIRSGRWMKTEEMNALLREMEATPHSGQCNHGRPTYVELKL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
SDIERLFGRT
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA