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The map label for this gene is pqqE [C]

Identifier: 110678035

GI number: 110678035

Start: 637158

End: 638489

Strand: Direct

Name: pqqE [C]

Synonym: RD1_0658

Alternate gene names: 110678035

Gene position: 637158-638489 (Clockwise)

Preceding gene: 110678034

Following gene: 110678036

Centisome position: 15.42

GC content: 57.81

Gene sequence:

>1332_bases
TTGCGATGTACTGCGTTTGCGGCGCTTTTGAGCCTGATACCCGTCACCCTGAGTGCCGGCGAAGAGGCGGTGACGACCTT
CGAGCTCGAAAATGGCATGCAAGTGGTCGTTGTCGAAGACCACCGCGCCCCCGTGGTTCAGCACATGCTCTGGTATCGCG
CCGGATCAGCGGATGAGCCCAAAGGGTCTTCAGGTGTTGCACATTTCCTTGAGCATTTGCTGTTCAAGGCGACCGACACT
TTGGCCGAGGGCGAACTGTCCGCTACAGTTGCGCGAAACGGGGGGCGCGATAATGCGTTCACCTCCTATGACTACACGGC
CTACTTCCAGCGCGTCGCGTCAGACCGCCTTGGGTTGATGATGAAAATGGAAGCGGACAGGATGAAAAACATTCGCCTGA
CGGAGGAAAACATCGCGACCGAGCGCAACGTGATCATTGAAGAGCGTAACCAACGCACCGAAAACAATCCCGGTGCCCTT
TTCGGGGAGCAGATCAACGCGGCACAGTTTCTCAACCACCGCTACGGTGTGCCGATCATCGGCTGGATGCACGAGATGGA
AACGCTTGATATGGAGGACGCGCTTGGGTTTTACGAGATCTATTATTCGCCCAACAATGCCGTTCTGGTCGTGTCTGGTG
ACGTGACGCCCGAAGAGGTGCGCGCCTTGGCCGAAGAACACTACGGCGCAATTCCCAGCAATCCCGACCTGCCCACCCGG
ATGCGCACACAGGAGCCGCCGCAAACGGCGGAGCGGCGTTTGATCTATCGCGATGCGCGTGTCGCACAGCCCTATGTGCG
CCGTTCGTATCTTGCGCCGGAACGCGACCCCGGCGCGCAGGAAACTGCAGCGGCACTTGTGTTCCTGAGCGAGATTTTGG
GCGGTGGCACGACTTCATTCCTTGCTGAAGAGTTGCAGTTCAACAATCAGTTAGCGACCTATGCGGCCAGTTTTTACCGC
CCGGTTTCGCTCGATGATACCACGTTCAATCTGATCGTGGTGCCGCGGCCTGACGTTTCGCTGCAGGAAGCCGAAGATGC
GATGGATGCCGCTCTTGCCAAATTCATGGAAACCGGTGTCGATCCTGAACAGCTTGAGCGGATCAAGTTCCAGATCCGCG
CTGATCAGATTTATGCCCGCGACGATGTGGACCGGATCGCCAACCGATACGGTCAAGCCCTGACATCCGGTCTTACGGTT
GAGGACGTGCAGGTCTGGCCCGACGTCCTGCAGGCTGTGACAGAAGAAGATATCATGGCCGCGGCGCGTGAGGTTTTTGA
CCGCCGCGCATCGGTAACAGGCTGGATTATGCGCGAAGAGGTGACACAATGA

Upstream 100 bases:

>100_bases
GCCGCTCACATTCGTGACAGCGTGCCTTGAACCATGGCTTTTGCAACGTACCTAACTGCGCAGACCTATGTGTTTTTACT
TTGCGAAAGGATTGCACATG

Downstream 100 bases:

>100_bases
TGCGATTGATGATGACAATTGCTGCGGTTCTTTGTCTGGCGCTCCCGGCGTCTGCGACCGTGGATATCAAGGAAGTCAAC
ACGCCCGGCGGGCTGACGGC

Product: M16 family peptidase putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRCTAFAALLSLIPVTLSAGEEAVTTFELENGMQVVVVEDHRAPVVQHMLWYRAGSADEPKGSSGVAHFLEHLLFKATDT
LAEGELSATVARNGGRDNAFTSYDYTAYFQRVASDRLGLMMKMEADRMKNIRLTEENIATERNVIIEERNQRTENNPGAL
FGEQINAAQFLNHRYGVPIIGWMHEMETLDMEDALGFYEIYYSPNNAVLVVSGDVTPEEVRALAEEHYGAIPSNPDLPTR
MRTQEPPQTAERRLIYRDARVAQPYVRRSYLAPERDPGAQETAAALVFLSEILGGGTTSFLAEELQFNNQLATYAASFYR
PVSLDDTTFNLIVVPRPDVSLQEAEDAMDAALAKFMETGVDPEQLERIKFQIRADQIYARDDVDRIANRYGQALTSGLTV
EDVQVWPDVLQAVTEEDIMAAAREVFDRRASVTGWIMREEVTQ

Sequences:

>Translated_443_residues
MRCTAFAALLSLIPVTLSAGEEAVTTFELENGMQVVVVEDHRAPVVQHMLWYRAGSADEPKGSSGVAHFLEHLLFKATDT
LAEGELSATVARNGGRDNAFTSYDYTAYFQRVASDRLGLMMKMEADRMKNIRLTEENIATERNVIIEERNQRTENNPGAL
FGEQINAAQFLNHRYGVPIIGWMHEMETLDMEDALGFYEIYYSPNNAVLVVSGDVTPEEVRALAEEHYGAIPSNPDLPTR
MRTQEPPQTAERRLIYRDARVAQPYVRRSYLAPERDPGAQETAAALVFLSEILGGGTTSFLAEELQFNNQLATYAASFYR
PVSLDDTTFNLIVVPRPDVSLQEAEDAMDAALAKFMETGVDPEQLERIKFQIRADQIYARDDVDRIANRYGQALTSGLTV
EDVQVWPDVLQAVTEEDIMAAAREVFDRRASVTGWIMREEVTQ
>Mature_443_residues
MRCTAFAALLSLIPVTLSAGEEAVTTFELENGMQVVVVEDHRAPVVQHMLWYRAGSADEPKGSSGVAHFLEHLLFKATDT
LAEGELSATVARNGGRDNAFTSYDYTAYFQRVASDRLGLMMKMEADRMKNIRLTEENIATERNVIIEERNQRTENNPGAL
FGEQINAAQFLNHRYGVPIIGWMHEMETLDMEDALGFYEIYYSPNNAVLVVSGDVTPEEVRALAEEHYGAIPSNPDLPTR
MRTQEPPQTAERRLIYRDARVAQPYVRRSYLAPERDPGAQETAAALVFLSEILGGGTTSFLAEELQFNNQLATYAASFYR
PVSLDDTTFNLIVVPRPDVSLQEAEDAMDAALAKFMETGVDPEQLERIKFQIRADQIYARDDVDRIANRYGQALTSGLTV
EDVQVWPDVLQAVTEEDIMAAAREVFDRRASVTGWIMREEVTQ

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=215, Percent_Identity=31.1627906976744, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI46593007, Length=233, Percent_Identity=27.4678111587983, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1787770, Length=396, Percent_Identity=26.010101010101, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=218, Percent_Identity=27.9816513761468, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17553678, Length=289, Percent_Identity=26.643598615917, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323192, Length=219, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323421, Length=200, Percent_Identity=23.5, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357875, Length=209, Percent_Identity=29.6650717703349, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646943, Length=209, Percent_Identity=29.6650717703349, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49663; Mature: 49663

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCTAFAALLSLIPVTLSAGEEAVTTFELENGMQVVVVEDHRAPVVQHMLWYRAGSADEP
CCHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
KGSSGVAHFLEHLLFKATDTLAEGELSATVARNGGRDNAFTSYDYTAYFQRVASDRLGLM
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCEE
MKMEADRMKNIRLTEENIATERNVIIEERNQRTENNPGALFGEQINAAQFLNHRYGVPII
EEECHHHHCCCEECHHHHCCCCHHHEECCCCCCCCCCCCEECCCCCHHHHHHCCCCCCHH
GWMHEMETLDMEDALGFYEIYYSPNNAVLVVSGDVTPEEVRALAEEHYGAIPSNPDLPTR
HHHHHHHHCCHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
MRTQEPPQTAERRLIYRDARVAQPYVRRSYLAPERDPGAQETAAALVFLSEILGGGTTSF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
LAEELQFNNQLATYAASFYRPVSLDDTTFNLIVVPRPDVSLQEAEDAMDAALAKFMETGV
HHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
DPEQLERIKFQIRADQIYARDDVDRIANRYGQALTSGLTVEDVQVWPDVLQAVTEEDIMA
CHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AAREVFDRRASVTGWIMREEVTQ
HHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MRCTAFAALLSLIPVTLSAGEEAVTTFELENGMQVVVVEDHRAPVVQHMLWYRAGSADEP
CCHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCCCC
KGSSGVAHFLEHLLFKATDTLAEGELSATVARNGGRDNAFTSYDYTAYFQRVASDRLGLM
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCEE
MKMEADRMKNIRLTEENIATERNVIIEERNQRTENNPGALFGEQINAAQFLNHRYGVPII
EEECHHHHCCCEECHHHHCCCCHHHEECCCCCCCCCCCCEECCCCCHHHHHHCCCCCCHH
GWMHEMETLDMEDALGFYEIYYSPNNAVLVVSGDVTPEEVRALAEEHYGAIPSNPDLPTR
HHHHHHHHCCHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
MRTQEPPQTAERRLIYRDARVAQPYVRRSYLAPERDPGAQETAAALVFLSEILGGGTTSF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
LAEELQFNNQLATYAASFYRPVSLDDTTFNLIVVPRPDVSLQEAEDAMDAALAKFMETGV
HHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
DPEQLERIKFQIRADQIYARDDVDRIANRYGQALTSGLTVEDVQVWPDVLQAVTEEDIMA
CHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AAREVFDRRASVTGWIMREEVTQ
HHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]