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The map label for this gene is acdA [H]

Identifier: 110677990

GI number: 110677990

Start: 592957

End: 594120

Strand: Direct

Name: acdA [H]

Synonym: RD1_0611

Alternate gene names: 110677990

Gene position: 592957-594120 (Clockwise)

Preceding gene: 110677989

Following gene: 110677991

Centisome position: 14.35

GC content: 57.73

Gene sequence:

>1164_bases
ATGACAACTTACGGCTTAACCGAAGAACATACGATGATTGCGGAGTCCGTCCGCAGCTTTGTTGAAAAAGAGATCTACCC
CCACGAGGAACTGGTCGAGCGGACAGGCGAAGTGCCTGCAGAGATTGCGGATGAGATCAAACGCAAAACCATTGATCTGG
GCTTTTACGCCTGCAATTTTCCGGAAAGTGTGGGTTGTGCCGGGCTGAACCATCTTGAATTTGCGCTTGTCGAGCGTGAA
TTGGGGCGCGGCTCCATGGCGCTGACGCATTTCTTTGGCCGTCCGCAGAATATCCTGATGGCCTGTGAAGGGGATCAGAT
CGAACGCTATCTCATGCCCGCCGTGCGCGGTGAGCGGATGGACGCGCTGGCCATGACCGAACCGGGTGCGGGATCGGATG
TGCGCGGCATGAAATGTGCTGCGGTGCGGAAAGGTGGTGACTGGGTCGTGAATGGCACCAAGCATTTCATCTCGGGCGCG
GATCATGCGGATTTCATCATCGTATTCATCGCAACTGGCGAAGATCAGACGCCCAAGGGTCCCAAAAAGCGGATCACAGC
GTTTCTGGTGGATCGCGGCACGCCGGGTTTCACCATCCGCGACGGGTATAAATCCGTCAGCCACAGGGGGTACAAAAACA
TGATCCTCGACTTCGATGATTGCCGCCTTTCGGATGCGCAGGTTCTGGGCGAAGTTGATGGCGGTTTCGAGGTCATGAAC
ACCTGGCTTTACGCGACCCGTATTACGGTGGCCACAATGTCGGTGGGGCGGGCGCGGCGTGTCTTTGATTATGCGCTGAA
CTATGCGGCGGAACGGGAACAGTTCGGACAAAAGATCGGTAAATTTCAGGGCGTGAGTTTCCAACTGGCCGATATGGTGA
CCGAGATTGATGCGGCAGACCTGCTGACGCTGGCCGCTGCGGATCGGCTGGACAAGGACCTGCCTGCAAACCGCGAGATC
GCGTCGGCCAAGCTATATGCTTCGGAGATGCTGGCGCGGGTCACCGATGCGGCGGTCCAGATTCATGGGGGCATGGGCCT
GATGGATGACTACCCGCTGGAACGGTTCTGGCGGGATGCCCGGGTTGAACGGATCTGGGACGGGACGTCTGAAATCCAGC
GCCACATTATCAGCCGTGATCTGCTGCGCGCTTTGGGGGCCTAG

Upstream 100 bases:

>100_bases
CCGGTATTTTACGAGGACTTGAAACGCTGGACCAGCACACGCCGGTTGGGAAGAAGGGCAAGCTGTCGCCCGTTCCTTTC
CCAATCAAAAGACACATATC

Downstream 100 bases:

>100_bases
CGGCGATGTCGCCCCTTGAAAGCAGCAGGGTCAAAAAAGGCGCAACGCGCGATCTGTCGCGCTTGCTGCGACCCCGGTCC
ATCGCGGTTGTCGGCGGTGG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTTYGLTEEHTMIAESVRSFVEKEIYPHEELVERTGEVPAEIADEIKRKTIDLGFYACNFPESVGCAGLNHLEFALVERE
LGRGSMALTHFFGRPQNILMACEGDQIERYLMPAVRGERMDALAMTEPGAGSDVRGMKCAAVRKGGDWVVNGTKHFISGA
DHADFIIVFIATGEDQTPKGPKKRITAFLVDRGTPGFTIRDGYKSVSHRGYKNMILDFDDCRLSDAQVLGEVDGGFEVMN
TWLYATRITVATMSVGRARRVFDYALNYAAEREQFGQKIGKFQGVSFQLADMVTEIDAADLLTLAAADRLDKDLPANREI
ASAKLYASEMLARVTDAAVQIHGGMGLMDDYPLERFWRDARVERIWDGTSEIQRHIISRDLLRALGA

Sequences:

>Translated_387_residues
MTTYGLTEEHTMIAESVRSFVEKEIYPHEELVERTGEVPAEIADEIKRKTIDLGFYACNFPESVGCAGLNHLEFALVERE
LGRGSMALTHFFGRPQNILMACEGDQIERYLMPAVRGERMDALAMTEPGAGSDVRGMKCAAVRKGGDWVVNGTKHFISGA
DHADFIIVFIATGEDQTPKGPKKRITAFLVDRGTPGFTIRDGYKSVSHRGYKNMILDFDDCRLSDAQVLGEVDGGFEVMN
TWLYATRITVATMSVGRARRVFDYALNYAAEREQFGQKIGKFQGVSFQLADMVTEIDAADLLTLAAADRLDKDLPANREI
ASAKLYASEMLARVTDAAVQIHGGMGLMDDYPLERFWRDARVERIWDGTSEIQRHIISRDLLRALGA
>Mature_386_residues
TTYGLTEEHTMIAESVRSFVEKEIYPHEELVERTGEVPAEIADEIKRKTIDLGFYACNFPESVGCAGLNHLEFALVEREL
GRGSMALTHFFGRPQNILMACEGDQIERYLMPAVRGERMDALAMTEPGAGSDVRGMKCAAVRKGGDWVVNGTKHFISGAD
HADFIIVFIATGEDQTPKGPKKRITAFLVDRGTPGFTIRDGYKSVSHRGYKNMILDFDDCRLSDAQVLGEVDGGFEVMNT
WLYATRITVATMSVGRARRVFDYALNYAAEREQFGQKIGKFQGVSFQLADMVTEIDAADLLTLAAADRLDKDLPANREIA
SAKLYASEMLARVTDAAVQIHGGMGLMDDYPLERFWRDARVERIWDGTSEIQRHIISRDLLRALGA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=385, Percent_Identity=37.4025974025974, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=33.1578947368421, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=34.6041055718475, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=31.9371727748691, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=32.1148825065274, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=32.1148825065274, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4501857, Length=387, Percent_Identity=31.266149870801, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=29.4871794871795, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=30.3571428571429, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=30.3571428571429, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI21361497, Length=363, Percent_Identity=28.3746556473829, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI38505218, Length=402, Percent_Identity=27.1144278606965, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI211971008, Length=399, Percent_Identity=26.0651629072682, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI48976061, Length=399, Percent_Identity=26.0651629072682, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=24.4791666666667, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=24.7222222222222, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=30.5483028720627, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=27.0833333333333, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17538396, Length=388, Percent_Identity=33.2474226804124, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=32.987012987013, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=34.1902313624679, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=32.9015544041451, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=32.1052631578947, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=383, Percent_Identity=30.8093994778068, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=29.1005291005291, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71990804, Length=326, Percent_Identity=32.2085889570552, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=27.154046997389, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=382, Percent_Identity=25.6544502617801, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=385, Percent_Identity=26.2337662337662, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=360, Percent_Identity=28.0555555555556, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17534353, Length=384, Percent_Identity=22.1354166666667, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71985192, Length=318, Percent_Identity=24.2138364779874, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=27.3127753303965, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=283, Percent_Identity=25.7950530035336, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=27.1604938271605, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17531913, Length=101, Percent_Identity=36.6336633663366, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356377, Length=383, Percent_Identity=33.9425587467363, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24660351, Length=388, Percent_Identity=33.7628865979381, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24646207, Length=385, Percent_Identity=32.987012987013, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=31.3984168865435, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=31.0704960835509, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281363737, Length=351, Percent_Identity=31.9088319088319, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=27.319587628866, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43081; Mature: 42949

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYGLTEEHTMIAESVRSFVEKEIYPHEELVERTGEVPAEIADEIKRKTIDLGFYACNF
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEECC
PESVGCAGLNHLEFALVERELGRGSMALTHFFGRPQNILMACEGDQIERYLMPAVRGERM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCC
DALAMTEPGAGSDVRGMKCAAVRKGGDWVVNGTKHFISGADHADFIIVFIATGEDQTPKG
CEEEECCCCCCCCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCEEEEEEEECCCCCCCC
PKKRITAFLVDRGTPGFTIRDGYKSVSHRGYKNMILDFDDCRLSDAQVLGEVDGGFEVMN
HHHHEEEEEEECCCCCCEEECCHHHHHCCCCHHCEEECCCCCCCHHHHHHCCCCCHHHHH
TWLYATRITVATMSVGRARRVFDYALNYAAEREQFGQKIGKFQGVSFQLADMVTEIDAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
LLTLAAADRLDKDLPANREIASAKLYASEMLARVTDAAVQIHGGMGLMDDYPLERFWRDA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHH
RVERIWDGTSEIQRHIISRDLLRALGA
HHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTYGLTEEHTMIAESVRSFVEKEIYPHEELVERTGEVPAEIADEIKRKTIDLGFYACNF
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEECC
PESVGCAGLNHLEFALVERELGRGSMALTHFFGRPQNILMACEGDQIERYLMPAVRGERM
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCC
DALAMTEPGAGSDVRGMKCAAVRKGGDWVVNGTKHFISGADHADFIIVFIATGEDQTPKG
CEEEECCCCCCCCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCEEEEEEEECCCCCCCC
PKKRITAFLVDRGTPGFTIRDGYKSVSHRGYKNMILDFDDCRLSDAQVLGEVDGGFEVMN
HHHHEEEEEEECCCCCCEEECCHHHHHCCCCHHCEEECCCCCCCHHHHHHCCCCCHHHHH
TWLYATRITVATMSVGRARRVFDYALNYAAEREQFGQKIGKFQGVSFQLADMVTEIDAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
LLTLAAADRLDKDLPANREIASAKLYASEMLARVTDAAVQIHGGMGLMDDYPLERFWRDA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHH
RVERIWDGTSEIQRHIISRDLLRALGA
HHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]