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The map label for this gene is fghA [H]

Identifier: 110677723

GI number: 110677723

Start: 308437

End: 309267

Strand: Direct

Name: fghA [H]

Synonym: RD1_0320

Alternate gene names: 110677723

Gene position: 308437-309267 (Clockwise)

Preceding gene: 110677722

Following gene: 110677724

Centisome position: 7.46

GC content: 58.72

Gene sequence:

>831_bases
ATGGAAACGATTTCTGAAAACGCCTGTTTCGGCGGCACACAGGGTGTCTATTCTCACACATCGGCCAGCTGCAATTGTGA
CATGACGTTCGGTCTGTTTCTGCCGGAGGAAGCACAGGACGGCCCTGTGCCGCTGTTGTGGTTTCTGTCGGGCCTGACCT
GCACGCATGAAAACGCGATGATCAAGGCCGGTGCGCAGTCCTGGGCGGCAGAGCACGGAATCGCGCTGGTCTTTCCCGAC
ACCTCACCACGCGGTGAGGGTGTGGCCGATGATGACGCCTATGATCTGGGACAGGGTGCGGGGTTTTACGTGAACGCCAC
GCAAGCCCCTTGGTCGTCGCATTTCAAGATGTGGGATTATGTGACCGAGGAACTGCCAAATTTGCTGGAGCAGAATTTTG
CGCTCGACATGAAGCGGCAGGCGATCACGGGCCATTCCATGGGCGGGCATGGCGCTTTGACCATCGCGATGTCCTTGCCG
GGGCGATTCCGCTCCGTCTCTGCCTTTGCGCCGATCTCTCACCCGACCGCCAGTGACTGGGGCCGCAAACAGCTGAGCGC
CTACCTTGGCGATGATCAAAGCACATGGGCCCCACATGATTCGACGCTTTTGATGCGCGAAAAAGGCTTTGACGGGCCTA
TGCTGGTGGATACCGGCACCAAGGACCAGTTCATTGACCTGCTCCAGCCCGAAGCGCTGGCCGAAGCGGTCAATACACGC
CGTCAACAGGCGGTGCTGCGGCTGCAACCGGGCTATGACCACAGCTATTTCTTTATCGCCACCTTCATGGAGGAACACAT
CGCCTTTCACGCCGACGCGCTTTACGCATGA

Upstream 100 bases:

>100_bases
CTTTGTCATTGGCCTTGTGGCACCGCTCTGAGTGCTGAAGGGCTTGCCGACAGACCGATCACGCGATAGCCAATGAGCGA
ACACAAAAGGGAGACCCGCA

Downstream 100 bases:

>100_bases
CGGCGCTTTACATCGACGCGGATGCCTGCCCGGTCAAATCCGAAGCCGAGCGCGTTGCCACAAGGCACCGGGTCAAGATG
TATATCGTGTCCAACGGCGG

Product: S-formylglutathione hydrolase, putative

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
METISENACFGGTQGVYSHTSASCNCDMTFGLFLPEEAQDGPVPLLWFLSGLTCTHENAMIKAGAQSWAAEHGIALVFPD
TSPRGEGVADDDAYDLGQGAGFYVNATQAPWSSHFKMWDYVTEELPNLLEQNFALDMKRQAITGHSMGGHGALTIAMSLP
GRFRSVSAFAPISHPTASDWGRKQLSAYLGDDQSTWAPHDSTLLMREKGFDGPMLVDTGTKDQFIDLLQPEALAEAVNTR
RQQAVLRLQPGYDHSYFFIATFMEEHIAFHADALYA

Sequences:

>Translated_276_residues
METISENACFGGTQGVYSHTSASCNCDMTFGLFLPEEAQDGPVPLLWFLSGLTCTHENAMIKAGAQSWAAEHGIALVFPD
TSPRGEGVADDDAYDLGQGAGFYVNATQAPWSSHFKMWDYVTEELPNLLEQNFALDMKRQAITGHSMGGHGALTIAMSLP
GRFRSVSAFAPISHPTASDWGRKQLSAYLGDDQSTWAPHDSTLLMREKGFDGPMLVDTGTKDQFIDLLQPEALAEAVNTR
RQQAVLRLQPGYDHSYFFIATFMEEHIAFHADALYA
>Mature_276_residues
METISENACFGGTQGVYSHTSASCNCDMTFGLFLPEEAQDGPVPLLWFLSGLTCTHENAMIKAGAQSWAAEHGIALVFPD
TSPRGEGVADDDAYDLGQGAGFYVNATQAPWSSHFKMWDYVTEELPNLLEQNFALDMKRQAITGHSMGGHGALTIAMSLP
GRFRSVSAFAPISHPTASDWGRKQLSAYLGDDQSTWAPHDSTLLMREKGFDGPMLVDTGTKDQFIDLLQPEALAEAVNTR
RQQAVLRLQPGYDHSYFFIATFMEEHIAFHADALYA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=48.5714285714286, Blast_Score=287, Evalue=6e-78,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=54.1516245487365, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=45.4545454545455, Blast_Score=266, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17510185, Length=277, Percent_Identity=45.8483754512635, Blast_Score=257, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6322393, Length=298, Percent_Identity=42.6174496644295, Blast_Score=218, Evalue=8e-58,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=49.645390070922, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=49.645390070922, Blast_Score=273, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30236; Mature: 30236

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METISENACFGGTQGVYSHTSASCNCDMTFGLFLPEEAQDGPVPLLWFLSGLTCTHENAM
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEHHHHHCCCEEECCCCE
IKAGAQSWAAEHGIALVFPDTSPRGEGVADDDAYDLGQGAGFYVNATQAPWSSHFKMWDY
EECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEECCCCCCHHHHHHHHH
VTEELPNLLEQNFALDMKRQAITGHSMGGHGALTIAMSLPGRFRSVSAFAPISHPTASDW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCHH
GRKQLSAYLGDDQSTWAPHDSTLLMREKGFDGPMLVDTGTKDQFIDLLQPEALAEAVNTR
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHH
RQQAVLRLQPGYDHSYFFIATFMEEHIAFHADALYA
HHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
METISENACFGGTQGVYSHTSASCNCDMTFGLFLPEEAQDGPVPLLWFLSGLTCTHENAM
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEHHHHHCCCEEECCCCE
IKAGAQSWAAEHGIALVFPDTSPRGEGVADDDAYDLGQGAGFYVNATQAPWSSHFKMWDY
EECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEECCCCCCHHHHHHHHH
VTEELPNLLEQNFALDMKRQAITGHSMGGHGALTIAMSLPGRFRSVSAFAPISHPTASDW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCHH
GRKQLSAYLGDDQSTWAPHDSTLLMREKGFDGPMLVDTGTKDQFIDLLQPEALAEAVNTR
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHH
RQQAVLRLQPGYDHSYFFIATFMEEHIAFHADALYA
HHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]