Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 110677422

GI number: 110677422

Start: 1723

End: 2871

Strand: Direct

Name: gcvT [H]

Synonym: RD1_0003

Alternate gene names: 110677422

Gene position: 1723-2871 (Clockwise)

Preceding gene: NA

Following gene: 110677423

Centisome position: 0.04

GC content: 59.18

Gene sequence:

>1149_bases
ATGGCGATCATTTACAGAACGTCGGCACTGGCGCAGCGCCATGCTGAAATCGGCGGTGAACTGGAAGACTGGAATGGCAT
GGGAACCGCATGGTTCTACGACCATTCCGATGAGCGTGCGAAAGCGGACTACGAGGCTGTGCGCACCAAGGCCGGCCTTA
TGGATGTGTCGGGCCTCAAGAAGATTCACCTGAGCGGTCCGCACGCAGCAGCGGTAATCGACCGGGCCACCACGCGCAAC
GTGGACAAGCTGATGCCGGGTCGCGCGGTCTATGCCGCGATGCTGGACGATCGCGGTCTCTTTATCGACGACTGCGTGAT
CTACCGTTTGTCGGTGAACAACTGGCTTTTGGTCCACGGCACGGGAACAGGCCACGAAAGCCTTGCGATGGCCGCCTATG
GCAAGAATGTGTCGATGATCTTTGACGACGATCTACACGATATGTCGCTGCAGGGTCCCGTTGCGGTGGATTTCCTCGCC
AAACATGTGCCGGGCATTCGTGATCTCGCGTATTTCGGCATCATCCAGACCAAACTGTTCGGCATGCCCGTCATGATTTC
GCGCACCGGCTATACCGGCGAGCGCGGCTACGAGATTTTCTGCGAAGGCCGTCACGCCATCGCCCTGTGGGACGCGATCC
TCGAAGATGGCAAGGACATGGGCATTCGCCCGGTGCAGTTCTCCACCCTCGACCTGCTGCGGACCGAAAGCTACCTGCTG
TTCTATCCCGGCGACAATTCCGAGACCTACCCCTTCGAGAATGGCGCCGCCTGTGGCGACTCGCTGTGGGAGCTGGGGCT
GGAATTCACCGTCTCACCGGGCAAGACCGGTTTCCGCGGTGCGGAAAACCACTATGCGCTTGAGGGCAAGGAACGCTTCA
AGATCTACGGCGTGCGGCTTGAAGGTACAACCGCCGCGGATGAGGGGGCAGATTTGCTCAAGGATGGCGAAAAGGTCGGT
GTCGTGACGTATGGCATGCGCTCTGATCTGTTTGATCACACCGTAGGCATTGCCCGGATGCCCGTCGAATGTGCAACCCC
GGGAACCAAGATGACGGTGCGCAATGGCGATGGCACGGAAATCCCATGTGTCGCCGAGGAAATGCCATTCTATGACAAGG
ACAAGGCCATCCGCACAGCCAAGGGCTGA

Upstream 100 bases:

>100_bases
TATAAAGTTTCCCATCAGGAAAAAATTCTGATCACAGGTATTGCTTTTTCAACGCACTTGGGTCTCAATATCGCGGAACA
GAAGATCAGGGAGACAGGAA

Downstream 100 bases:

>100_bases
TCTGGATGTACATTGAAAGGCGCCTTCCAAGCGGGCGCCTTTTTCGCCACCGTAGATCGAAAGGAGAGACGGCAGCATGT
CGAAATTTCAGTTTCCGAAA

Product: aminomethyltransferase, putative

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAIIYRTSALAQRHAEIGGELEDWNGMGTAWFYDHSDERAKADYEAVRTKAGLMDVSGLKKIHLSGPHAAAVIDRATTRN
VDKLMPGRAVYAAMLDDRGLFIDDCVIYRLSVNNWLLVHGTGTGHESLAMAAYGKNVSMIFDDDLHDMSLQGPVAVDFLA
KHVPGIRDLAYFGIIQTKLFGMPVMISRTGYTGERGYEIFCEGRHAIALWDAILEDGKDMGIRPVQFSTLDLLRTESYLL
FYPGDNSETYPFENGAACGDSLWELGLEFTVSPGKTGFRGAENHYALEGKERFKIYGVRLEGTTAADEGADLLKDGEKVG
VVTYGMRSDLFDHTVGIARMPVECATPGTKMTVRNGDGTEIPCVAEEMPFYDKDKAIRTAKG

Sequences:

>Translated_382_residues
MAIIYRTSALAQRHAEIGGELEDWNGMGTAWFYDHSDERAKADYEAVRTKAGLMDVSGLKKIHLSGPHAAAVIDRATTRN
VDKLMPGRAVYAAMLDDRGLFIDDCVIYRLSVNNWLLVHGTGTGHESLAMAAYGKNVSMIFDDDLHDMSLQGPVAVDFLA
KHVPGIRDLAYFGIIQTKLFGMPVMISRTGYTGERGYEIFCEGRHAIALWDAILEDGKDMGIRPVQFSTLDLLRTESYLL
FYPGDNSETYPFENGAACGDSLWELGLEFTVSPGKTGFRGAENHYALEGKERFKIYGVRLEGTTAADEGADLLKDGEKVG
VVTYGMRSDLFDHTVGIARMPVECATPGTKMTVRNGDGTEIPCVAEEMPFYDKDKAIRTAKG
>Mature_381_residues
AIIYRTSALAQRHAEIGGELEDWNGMGTAWFYDHSDERAKADYEAVRTKAGLMDVSGLKKIHLSGPHAAAVIDRATTRNV
DKLMPGRAVYAAMLDDRGLFIDDCVIYRLSVNNWLLVHGTGTGHESLAMAAYGKNVSMIFDDDLHDMSLQGPVAVDFLAK
HVPGIRDLAYFGIIQTKLFGMPVMISRTGYTGERGYEIFCEGRHAIALWDAILEDGKDMGIRPVQFSTLDLLRTESYLLF
YPGDNSETYPFENGAACGDSLWELGLEFTVSPGKTGFRGAENHYALEGKERFKIYGVRLEGTTAADEGADLLKDGEKVGV
VTYGMRSDLFDHTVGIARMPVECATPGTKMTVRNGDGTEIPCVAEEMPFYDKDKAIRTAKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=386, Percent_Identity=25.1295336787565, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI257796258, Length=375, Percent_Identity=25.6, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI257796256, Length=308, Percent_Identity=26.6233766233766, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI24797151, Length=356, Percent_Identity=23.876404494382, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI257796254, Length=246, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789272, Length=391, Percent_Identity=26.3427109974425, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32563613, Length=240, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560118, Length=384, Percent_Identity=24.7395833333333, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=261, Percent_Identity=25.6704980842912, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129441, Length=394, Percent_Identity=25.1269035532995, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42024; Mature: 41893

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIYRTSALAQRHAEIGGELEDWNGMGTAWFYDHSDERAKADYEAVRTKAGLMDVSGLK
CEEEEECHHHHHHHHHHCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEECCCCE
KIHLSGPHAAAVIDRATTRNVDKLMPGRAVYAAMLDDRGLFIDDCVIYRLSVNNWLLVHG
EEEECCCCCEEEEECHHHCCHHHHCCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEEEE
TGTGHESLAMAAYGKNVSMIFDDDLHDMSLQGPVAVDFLAKHVPGIRDLAYFGIIQTKLF
CCCCCHHEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
GMPVMISRTGYTGERGYEIFCEGRHAIALWDAILEDGKDMGIRPVQFSTLDLLRTESYLL
CCCEEEEECCCCCCCCCEEEECCCCEEHHHHHHHHCCCCCCCCEEEEHHHHHEECCCEEE
FYPGDNSETYPFENGAACGDSLWELGLEFTVSPGKTGFRGAENHYALEGKERFKIYGVRL
EEECCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCEEECCCCEEEEEEEEE
EGTTAADEGADLLKDGEKVGVVTYGMRSDLFDHTVGIARMPVECATPGTKMTVRNGDGTE
ECCCCCCCCHHHHHCCCEEEEEEECCHHHHHHHHCCCEECCEECCCCCCEEEEECCCCCC
IPCVAEEMPFYDKDKAIRTAKG
CCEEHHCCCCCCCCCCEECCCC
>Mature Secondary Structure 
AIIYRTSALAQRHAEIGGELEDWNGMGTAWFYDHSDERAKADYEAVRTKAGLMDVSGLK
EEEEECHHHHHHHHHHCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEECCCCE
KIHLSGPHAAAVIDRATTRNVDKLMPGRAVYAAMLDDRGLFIDDCVIYRLSVNNWLLVHG
EEEECCCCCEEEEECHHHCCHHHHCCCCEEEEEEECCCCCEEEEEEEEEEECCCEEEEEE
TGTGHESLAMAAYGKNVSMIFDDDLHDMSLQGPVAVDFLAKHVPGIRDLAYFGIIQTKLF
CCCCCHHEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
GMPVMISRTGYTGERGYEIFCEGRHAIALWDAILEDGKDMGIRPVQFSTLDLLRTESYLL
CCCEEEEECCCCCCCCCEEEECCCCEEHHHHHHHHCCCCCCCCEEEEHHHHHEECCCEEE
FYPGDNSETYPFENGAACGDSLWELGLEFTVSPGKTGFRGAENHYALEGKERFKIYGVRL
EEECCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCEEECCCCEEEEEEEEE
EGTTAADEGADLLKDGEKVGVVTYGMRSDLFDHTVGIARMPVECATPGTKMTVRNGDGTE
ECCCCCCCCHHHHHCCCEEEEEEECCHHHHHHHHCCCEECCEECCCCCCEEEEECCCCCC
IPCVAEEMPFYDKDKAIRTAKG
CCEEHHCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]