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The map label for this gene is folE [H]

Identifier: 108812635

GI number: 108812635

Start: 2774360

End: 2775064

Strand: Reverse

Name: folE [H]

Synonym: YPN_2474

Alternate gene names: 108812635

Gene position: 2775064-2774360 (Counterclockwise)

Preceding gene: 108812636

Following gene: 108812634

Centisome position: 61.2

GC content: 45.25

Gene sequence:

>705_bases
ATGCTTGTCTTATCTGGATGCGTAAGCCTGTTGGAGAAAAGAATGTCATCGCTAAGTAAAGAAGCTGAGTTGGTTCATCA
AGCGCTGCTGGCCCGTGGTCTTGAAACCCCTTTACGTAAACCAGAATTAGATGCCGAGACGCGCAAAACTCGGATTCAGG
CCCATATGACAGAAGTCATGCATTTGCTGAATCTTGATTTAACCGACGATAGTCTGGCTGATACACCAAGACGCATTGCG
AAGATGTATGTTGATGAGATTTTCTCCGGATTGGATTACGAAAATTTCCCTAAAATCACACTGATTCAAAATAAAATGAA
AGTTGATGAAATGGTAACGGTACGGGATATCACTCTGACCAGCACCTGCGAACATCATTTTGTGACGATTGATGGGAAAG
CCACCGTCGCTTATATTCCGAAAGACAGTGTCATTGGTTTGTCGAAAATCAACCGTATCGTGCAGTTTTTTGCGCAGCGT
CCGCAAGTGCAGGAACGATTAACACAGCAGATCTTGCTCGCATTACAAACCCTGTTGGGTACCAATAATGTCGCAGTTTC
TATTGATGCAGTTCATTATTGCGTTAAAGCACGTGGTATCCGTGATGCGACCAGCGCGACGACCACCACATCATTAGGCG
GGTTATTTAAATCCAGTCAGAATACGCGTCAGGAATTTCTGCGTGCGGTTCGTCACCACGGCTGA

Upstream 100 bases:

>100_bases
ATTGTTCGCAATGAATAACCGGTCGAAATGAAGAACAATCACTGGATAATCATTTCGCTCTCAATTAGAGTGAGAGCGAA
ATTCGGGTGTGACCCGCATC

Downstream 100 bases:

>100_bases
TTGGCTTTTTGCCAGAGGGAGGGCCTGTAGGCCCTCGAATACAGGATGTCGAGTATGCGTCAACGCATCGCAACGTTAGA
CAGTGCGCGGGGGCTGGCCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIA
KMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQR
PQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Sequences:

>Translated_234_residues
MLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIA
KMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQR
PQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
>Mature_234_residues
MLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIA
KMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQR
PQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4503949, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI66932970, Length=82, Percent_Identity=48.780487804878, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI66932972, Length=82, Percent_Identity=48.780487804878, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1788476, Length=222, Percent_Identity=89.1891891891892, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17560486, Length=189, Percent_Identity=37.5661375661376, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=40.1098901098901, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656796, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656782, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656791, Length=122, Percent_Identity=45.0819672131148, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26245; Mature: 26245

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVM
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEE
STCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLG
CCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
TNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
CCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVLSGCVSLLEKRMSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVM
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLT
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEE
STCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLG
CCCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
TNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
CCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA