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The map label for this gene is tibA [H]

Identifier: 108811520

GI number: 108811520

Start: 1541185

End: 1543395

Strand: Reverse

Name: tibA [H]

Synonym: YPN_1357

Alternate gene names: 108811520

Gene position: 1543395-1541185 (Counterclockwise)

Preceding gene: 108811521

Following gene: 108811518

Centisome position: 34.04

GC content: 44.6

Gene sequence:

>2211_bases
ATGAACGCAAACGCCGATTCATGTATTGATTATACTGTCACTGATATTTGTGAGCAGAGTAAATATGCTGCGGGTGAATT
TCATAATATTAAGCTGGGTGATGGTGTCACTGCTGGTAGCGAAGATCACCATTTTGTCTTTAATGGTGAAGGATATGAAT
TATACAATTCTAACGCGAATTTCTCTGCTCAAATTGCCTCAGGTACCATTCGCTATACCGAAGTGAACAACAGTTACTTT
ACTGTAAACGCTCACCATTTTCCGGATGATACCATCTATGCCGGCCGTGCAGAAAATACCACATTGAATGATAGCCTGAT
GTGGGTGGCAACATCGGCTGATCAGACACTGGCTAAAGGTAATTCAATGGTCGTTGTTTCCACCCAAATGGCCATGGTTG
ATCAAATTTTTGTTACGACGTTGAATGATGGTAGCCTTCCATTTGATCCCGTCATTACCAATAGCCGCTATGAAGATACG
TCATATGAAATGTTATGGGGTATGAAAAACGAGGCAAAAGGGTGGGATACCAAAGCCACATCGCATGACTCCGTATTTGT
TGATGCCAGCAAGCAGTCTATCGAAGCCAATGGTCACAGCATTGGTGCCACATTTTATGGTAGGGCCACTCAGGTGGTCA
AAGCTGGCGGTGAGTCACAGGATACCCACTTATTTGATCACAGTTATTCCTGGGTATATGCCGAGGCTAAATTAACCGGT
CTGACGGAGGTTAATGACGCTGCCACTGTCTATCTGAATGCCGCAGCAACTCAAGGTGCTTACGCTGAGAATGTCGTTCT
CAACGGCGAAGATACAACATTGATGGTGCGCGCGAGTCTGGATAACAATGCCTATGCCACGGTGGATAACCTAATATTGA
ATGGCGGTGAAGTGGTTTTCCAGCAGAGCTCTGGCGACCAATATGCTTCATTAAACATCGGCACACTTTCCGGCTCGGGC
TCCTTCCTATTCAATACCTCTATTGCTGAGGGGAAAGGAAACTTCGTGACTATCGCCAATGCCAGTGGGGAACATAAGGT
GATAGTTAACGACTCTGGCCATGAGATCACCTCACCTGATATGACCACATTGGACTTGATTCACGATCTCAGTGGTGATG
CAACATTCACACTGGCCTCTATTTCTGGAGCTAACATCATTGAAGTCGATGGCGGCACTTACGTATATAGCTTGAATACC
TGGGATAATTCCGCACGAGCTGGCGGAAATCTGTGGTATTTAGGCTCAGGTTTGAATACAGGCACTGAGCTTGAACCCGA
ACCTGAAGAGAAAACAACCCCGTCAACGGATGCGGTGTTGAGTATGGCCTCATCCAACCAGTTTATTTTCGATGGTGAAA
TGCAAAATCTGCGTTTTCGTAAAGGGGATTTAAATAATAATAAAGGTGATGGCGCCAGTGTTTGGGGGCGTTATTTAACC
AACAATACTCGGGTCAATGCTGCTCATGATGCCGCTTACCGTTTGCAGCAAGATGGCTTTGAAATTGGTGCTGATAAAGT
GCTGGAAATGTCTTCAGGTCAATTAGTCTTGGGTGGTTTTACCTCTTATAGCAATAACCGAGTGAAACATGCTCGTGGTG
GAAACAGTACGGTTGATAGTTATAGCTTGGGTGCCTACGGCACTTATTTCGATAACAGTGGTTATTATGTCGATGCCGTC
GTTAAAGCCAACCGTTTTAAAAACTCACTGAATGCCCATATGACCAACGGCGGTTCGGTACAAAGTGATTATAACCAGAA
TGCAATCGGTGGCTCACTGGAAGCCGGTTATCACTACAGCCTGTCGAATAATTGGTTCGTAGAGCCTTATGTTCGTACCA
GCTATTACACGGCACAGGATAAAGATATTGCGCTGAATAATGGCATGACAGCGAATATTGATAATAACCGCTCAGCTAAA
GGTGAAATAGGTACACATCTGGGAACGAAGATTGACCTGAATAATGGGGCTATCATCCGCCCTTATGCCAAAGTCGCTAT
TGAACGAGAGTTCATCAAATCAAATACCGTGACGATCAATCAGGTTAACGACTTTAATAATGATTTATCAGGACATACCG
CGAAGTATGGTTTAGGCATGGATATCAACCTGATGAAACAGACTTCCGTTTATGCCGAAGCCAATTACCGCAACGGGACT
CATGTGGAGTCACCTATCATGGCTAATATCGGTTTCCGGATTAATTTCTAA

Upstream 100 bases:

>100_bases
AAATTAAAAAATAAATTGGAGTATTGTTACATTGAACACCAATAGTAAAAAAACCTACCTTAACATTGCTATTTCATTCA
TTCTTTACGCCTCAACAGCA

Downstream 100 bases:

>100_bases
AGAACATACCAGATGAGTGGTTTCCCGCGATAATGCGGGAGACCATTTTTTTGCTCAATAGATTAAACATGTCTACCCAC
GTTACTTCGAGCTACATCTT

Product: autotransporter

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSYF
TVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRYEDT
SYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGGESQDTHLFDHSYSWVYAEAKLTG
LTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSG
SFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYSLNT
WDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNLRFRKGDLNNNKGDGASVWGRYLT
NNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNSTVDSYSLGAYGTYFDNSGYYVDAV
VKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNRSAK
GEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYGLGMDINLMKQTSVYAEANYRNGT
HVESPIMANIGFRINF

Sequences:

>Translated_736_residues
MNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSYF
TVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRYEDT
SYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGGESQDTHLFDHSYSWVYAEAKLTG
LTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSG
SFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYSLNT
WDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNLRFRKGDLNNNKGDGASVWGRYLT
NNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNSTVDSYSLGAYGTYFDNSGYYVDAV
VKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNRSAK
GEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYGLGMDINLMKQTSVYAEANYRNGT
HVESPIMANIGFRINF
>Mature_736_residues
MNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSYF
TVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRYEDT
SYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGGESQDTHLFDHSYSWVYAEAKLTG
LTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSG
SFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYSLNT
WDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNLRFRKGDLNNNKGDGASVWGRYLT
NNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNSTVDSYSLGAYGTYFDNSGYYVDAV
VKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNRSAK
GEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYGLGMDINLMKQTSVYAEANYRNGT
HVESPIMANIGFRINF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=556, Percent_Identity=31.8345323741007, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787452, Length=483, Percent_Identity=25.4658385093168, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 79745; Mature: 79745

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNSNAN
CCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEECCCCC
FSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKG
EEEEEECCEEEEEEECCCEEEEEECCCCCCCEEECCCCCCEECCCEEEEEECCCHHHHCC
NSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRYEDTSYEMLWGMKNEAKGWDTKAT
CCEEEEEEHHHEEEEEEEEEECCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCC
SHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGGESQDTHLFDHSYSWVYAEAKLTG
CCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCCCCCCCEEEECCCEEEEEEEEEEC
LTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGEVVF
CEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEHEEECCCEEEE
QQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPD
EECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCEEEEECCCCCEECCCC
MTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNT
CCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEECCCCC
GTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNLRFRKGDLNNNKGDGASVWGRYLT
CCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHC
NNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNSTVDS
CCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCC
YSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYS
CCCCCEEEEECCCCEEEEEEEECHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEE
LSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIR
CCCCEEECCEEEEEEEECCCCCEEECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCEEC
PYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYGLGMDINLMKQTSVYAEANYRNGT
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEEECEEEEEECCCCCC
HVESPIMANIGFRINF
CCCCCEEEECCEEEEC
>Mature Secondary Structure
MNANADSCIDYTVTDICEQSKYAAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNSNAN
CCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEEEECCCCC
FSAQIASGTIRYTEVNNSYFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKG
EEEEEECCEEEEEEECCCEEEEEECCCCCCCEEECCCCCCEECCCEEEEEECCCHHHHCC
NSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVITNSRYEDTSYEMLWGMKNEAKGWDTKAT
CCEEEEEEHHHEEEEEEEEEECCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCC
SHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGGESQDTHLFDHSYSWVYAEAKLTG
CCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCCCCCCCEEEECCCEEEEEEEEEEC
LTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGEVVF
CEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEEEECCCCCEEEEEHEEECCCEEEE
QQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPD
EECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCEEEEECCCCCEECCCC
MTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNT
CCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCEEEEECCCCC
GTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNLRFRKGDLNNNKGDGASVWGRYLT
CCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHC
NNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARGGNSTVDS
CCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCC
YSLGAYGTYFDNSGYYVDAVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYS
CCCCCEEEEECCCCEEEEEEEECHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEE
LSNNWFVEPYVRTSYYTAQDKDIALNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIR
CCCCEEECCEEEEEEEECCCCCEEECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCEEC
PYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYGLGMDINLMKQTSVYAEANYRNGT
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEEECEEEEEECCCCCC
HVESPIMANIGFRINF
CCCCCEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]