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The map label for this gene is accD5 [H]

Identifier: 108801972

GI number: 108801972

Start: 5302735

End: 5304285

Strand: Reverse

Name: accD5 [H]

Synonym: Mmcs_5009

Alternate gene names: 108801972

Gene position: 5304285-5302735 (Counterclockwise)

Preceding gene: 108801973

Following gene: 108801970

Centisome position: 92.97

GC content: 67.7

Gene sequence:

>1551_bases
TTGACCGGACGGACCACCGCACAACAGCTCGCCGAGCTCCGCGAGAAGCTGGAGCTCGCCAAGGAACCCGGCGGTGAGAA
GGCCGCCGCCAAGCGTGACGCCAAGGGCATCCCGAGCCCGCGGGCGCGGATCCACGCGCTGCTCGATCCGGGCAGCTTCC
TCGAGATCGGCGCCCTGGCGCGCACGCCGGGCGACCCGAACGCGCTCTTCGGCGACGGTGTGGTGACCGGCCACGGCACC
ATCGACGGTCGGCCGGTCGGCGTGTTCAGCCACGACCAGACGGTGTTCGGCGGTTCGGTCGGGGAGATGTTCGGCCGCAA
GGTGTCCCGGCTGATGGAGTGGGTGGCCATGGTCGGCTGCCCGATCATCGGCATCAACGACTCGGGCGGGGCCCGCATCC
AGGACCTGGCGACGTCGCTGGCCTGGTACGCCGAACTCGGCCGCCGCCACGAACTGCTGTCCGGTCTGGTCCCGCAGATC
TCGATCATCCTCGGCAAGTGCGCGGGTGGTGCGGTCTACTCGCCGATCCAGACCGACCTCATCCTCGCGGTGCGCGATCA
GGGCTACATGTTCGTCACCGGCCCCGACGTGATCAAGGACGTCACCGGTGAGGACGTCACCCTCGACGAACTCGGCGGCG
CCGACGCCCAGGCCAAGTACGGCAACATCCACACGGTCGTCGACACCGAGAAGGACGCGTTCCAGTACGTCCGCGATTAC
CTGGGCTTCCTGCCGTCGAACACCTTCGACGACCCGCCGATCGTCAACCCCGGCCTGGAGCCGGAGGTCACCCCGCACGA
TCTGGAACTGGACTCGATCGTTCCGGACAGCGACAACACCGCCTACGACATGCACGAGATCCTGCTGCGGATCTTCGATG
ACGGTGACTTCCTCGAGGTGGCGGGGCAGGCCGGGCAGGCGATCATCACCGGGTACGCGCGGGTCGACGGCCGTCCGGTC
GGCGTGATCGCCAACCAGCCGATGCACATGTCCGGGGCGATCGACAACGAGGCCTCCGACAAGGCGGCGCGGTTCGTGCG
GTTCTGCGACTCGTTCAACGTCCCGCTGGTTTTCGTCGTCGACACCCCCGGCTTCCTGCCGGGTGTCGAGCAGGAGAAGA
ACGGCATCATCAAGCGCGGCGGCCGGTTCCTGTACTCCGTCGTCGAGGCCGACGTGCCGAAGGTGACGATCACGGTGCGC
AAGTCCTACGGCGGCGCGTACGCGGTGATGGGCTCCAAGCAGCTGACGTCCGACTTCAACTTCCTGTGGCCGACGGCGCG
CATCGCGGTGATCGGCGCCGAGGGTGCCGCGCAGCTCATCGTCAAACGGTTCCCGGACCCGAACGCACCCGAGGTGCAGG
AGATCCGGCGGCAGTTCATCGAGGGCTACAACCGCGATATGGCGACGCCGTACGTGGCGGCCGAGCGGGGCTACGTCGAC
GCGGTCATCGAACCGCACGAGACCCGGCTCAAGCTGCGCAGCGCGATGCGCCTGTTGCGGGACAAGCAGATTCAGCGAGT
CCAGCGCAAGCACGGCTTGATCCCGATCTGA

Upstream 100 bases:

>100_bases
TGAGCACATCCAGGCGATCGACGAGCCGTACATCGCGAAGGTGGGTGCCCACATGAGCGAGGCGATCAACCGTATCGAGG
CCCAGGGAAAGTAGAGCAAG

Downstream 100 bases:

>100_bases
CCTTCCCGAATGTGATCACCCGCGACGTGGCGCCGAGCGCGGTGGCCGACCTGGCGTCGGCCCCGCCGCGTACCGCCCTG
GCCGCCGTCGTCGACGGCCA

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTGRTTAQQLAELREKLELAKEPGGEKAAAKRDAKGIPSPRARIHALLDPGSFLEIGALARTPGDPNALFGDGVVTGHGT
IDGRPVGVFSHDQTVFGGSVGEMFGRKVSRLMEWVAMVGCPIIGINDSGGARIQDLATSLAWYAELGRRHELLSGLVPQI
SIILGKCAGGAVYSPIQTDLILAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQAKYGNIHTVVDTEKDAFQYVRDY
LGFLPSNTFDDPPIVNPGLEPEVTPHDLELDSIVPDSDNTAYDMHEILLRIFDDGDFLEVAGQAGQAIITGYARVDGRPV
GVIANQPMHMSGAIDNEASDKAARFVRFCDSFNVPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYSVVEADVPKVTITVR
KSYGGAYAVMGSKQLTSDFNFLWPTARIAVIGAEGAAQLIVKRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVD
AVIEPHETRLKLRSAMRLLRDKQIQRVQRKHGLIPI

Sequences:

>Translated_516_residues
MTGRTTAQQLAELREKLELAKEPGGEKAAAKRDAKGIPSPRARIHALLDPGSFLEIGALARTPGDPNALFGDGVVTGHGT
IDGRPVGVFSHDQTVFGGSVGEMFGRKVSRLMEWVAMVGCPIIGINDSGGARIQDLATSLAWYAELGRRHELLSGLVPQI
SIILGKCAGGAVYSPIQTDLILAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQAKYGNIHTVVDTEKDAFQYVRDY
LGFLPSNTFDDPPIVNPGLEPEVTPHDLELDSIVPDSDNTAYDMHEILLRIFDDGDFLEVAGQAGQAIITGYARVDGRPV
GVIANQPMHMSGAIDNEASDKAARFVRFCDSFNVPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYSVVEADVPKVTITVR
KSYGGAYAVMGSKQLTSDFNFLWPTARIAVIGAEGAAQLIVKRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVD
AVIEPHETRLKLRSAMRLLRDKQIQRVQRKHGLIPI
>Mature_515_residues
TGRTTAQQLAELREKLELAKEPGGEKAAAKRDAKGIPSPRARIHALLDPGSFLEIGALARTPGDPNALFGDGVVTGHGTI
DGRPVGVFSHDQTVFGGSVGEMFGRKVSRLMEWVAMVGCPIIGINDSGGARIQDLATSLAWYAELGRRHELLSGLVPQIS
IILGKCAGGAVYSPIQTDLILAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQAKYGNIHTVVDTEKDAFQYVRDYL
GFLPSNTFDDPPIVNPGLEPEVTPHDLELDSIVPDSDNTAYDMHEILLRIFDDGDFLEVAGQAGQAIITGYARVDGRPVG
VIANQPMHMSGAIDNEASDKAARFVRFCDSFNVPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYSVVEADVPKVTITVRK
SYGGAYAVMGSKQLTSDFNFLWPTARIAVIGAEGAAQLIVKRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVDA
VIEPHETRLKLRSAMRLLRDKQIQRVQRKHGLIPI

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=527, Percent_Identity=43.8330170777989, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI295821216, Length=547, Percent_Identity=42.0475319926874, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI11545863, Length=497, Percent_Identity=32.5955734406439, Blast_Score=221, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25147362, Length=519, Percent_Identity=42.7745664739884, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25147359, Length=519, Percent_Identity=42.7745664739884, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17552936, Length=509, Percent_Identity=30.0589390962672, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=375, Percent_Identity=22.9333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586065, Length=532, Percent_Identity=29.6992481203008, Blast_Score=225, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56036; Mature: 55905

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRTTAQQLAELREKLELAKEPGGEKAAAKRDAKGIPSPRARIHALLDPGSFLEIGALA
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHEEEEECCCCCEEHHHHC
RTPGDPNALFGDGVVTGHGTIDGRPVGVFSHDQTVFGGSVGEMFGRKVSRLMEWVAMVGC
CCCCCCCCEECCCEEECCCCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCC
PIIGINDSGGARIQDLATSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQAKYGNIHTVVDTEKDAFQYVRDY
EEEEECCCEEEEECHHHHHHCCCCCEEHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHH
LGFLPSNTFDDPPIVNPGLEPEVTPHDLELDSIVPDSDNTAYDMHEILLRIFDDGDFLEV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEH
AGQAGQAIITGYARVDGRPVGVIANQPMHMSGAIDNEASDKAARFVRFCDSFNVPLVFVV
HCCCCCEEEEEEEEECCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
DTPGFLPGVEQEKNGIIKRGGRFLYSVVEADVPKVTITVRKSYGGAYAVMGSKQLTSDFN
ECCCCCCCCCHHHCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCHHHHCCCC
FLWPTARIAVIGAEGAAQLIVKRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVD
EECCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEE
AVIEPHETRLKLRSAMRLLRDKQIQRVQRKHGLIPI
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TGRTTAQQLAELREKLELAKEPGGEKAAAKRDAKGIPSPRARIHALLDPGSFLEIGALA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHEEEEECCCCCEEHHHHC
RTPGDPNALFGDGVVTGHGTIDGRPVGVFSHDQTVFGGSVGEMFGRKVSRLMEWVAMVGC
CCCCCCCCEECCCEEECCCCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHCC
PIIGINDSGGARIQDLATSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILAVRDQGYMFVTGPDVIKDVTGEDVTLDELGGADAQAKYGNIHTVVDTEKDAFQYVRDY
EEEEECCCEEEEECHHHHHHCCCCCEEHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHH
LGFLPSNTFDDPPIVNPGLEPEVTPHDLELDSIVPDSDNTAYDMHEILLRIFDDGDFLEV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEH
AGQAGQAIITGYARVDGRPVGVIANQPMHMSGAIDNEASDKAARFVRFCDSFNVPLVFVV
HCCCCCEEEEEEEEECCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
DTPGFLPGVEQEKNGIIKRGGRFLYSVVEADVPKVTITVRKSYGGAYAVMGSKQLTSDFN
ECCCCCCCCCHHHCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCHHHHCCCC
FLWPTARIAVIGAEGAAQLIVKRFPDPNAPEVQEIRRQFIEGYNRDMATPYVAAERGYVD
EECCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEE
AVIEPHETRLKLRSAMRLLRDKQIQRVQRKHGLIPI
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]