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The map label for this gene is dnaX [H]

Identifier: 108801872

GI number: 108801872

Start: 5197817

End: 5199667

Strand: Reverse

Name: dnaX [H]

Synonym: Mmcs_4909

Alternate gene names: 108801872

Gene position: 5199667-5197817 (Counterclockwise)

Preceding gene: 108801873

Following gene: 108801869

Centisome position: 91.14

GC content: 71.53

Gene sequence:

>1851_bases
GTGGCGCTCTACCGCAAGTACCGACCGGCGACCTTCGCGGAGGTGGTCGGGCAGGAGCATGTCACCGAGCCGCTGTCGAC
CGCGCTGTCGGCGGGCCGCATCAACCACGCATATTTGTTCTCCGGCCCACGTGGTTGTGGGAAGACGTCGTCGGCACGCA
TCCTGGCCCGCTCGCTCAACTGCGAGCAGGGGCCGACCCCGACGCCCTGTGGAACGTGCGACTCGTGTGTGGCGCTGGCT
CCCAACGGCCCGGGCAACATGGACGTCACCGAACTCGACGCGGCCAGCCACGGCGGTGTCGACGACACTCGTGAACTGCG
GGACCGGGCGTTCTACGCGCCCGCGCAGTCGCGCTATCGCATCTTCATCGTCGACGAAGCCCACATGGTCACCACCGCGG
GCTTCAACGCGCTGCTCAAGATCGTCGAGGAGCCGCCGGAGCATCTGATCTTCGTGTTCGCCACCACCGAACCGGAGAAG
GTGCTGCCGACGATCCGGTCGCGCACCCACCACTACCCGTTCCGGCTGTTGGCGCCCAAGACGATGCGCACGCTGCTGGA
ACGGATCTGCGCCGACGAGGGCGTCAGCGTCGACGACGCGGTGTACCCGCTGGTGATCCGCGCCGGCGGCGGTTCGCCCC
GCGACACGCTGTCGGTGCTCGACCAGCTGCTGGCCGGCGCGGCGGGCAACCGGGTGGAGTACGGCCGCGCACTGGCGCTG
CTGGGGGCCACCGACGTCGCGCTGATCGACGATGCGGTCGACGCGCTGGCCGCCGGGGATGCCGCCGCGCTGTTCGGCGC
GGTCGAATCGGTGATCGACGCCGGACACGATCCGCGACGGTTCGCGGTCGACCTGCTCGAGAGGTTCCGCGATCTGATCG
TGCTGCAGGCGGTGCCGGACGCCGCCGCGCGCGGTGTGGTCGACGCGCCCGGTGACGTGCTGGAGCGGATGCGGGATCAG
GCCGCCCGGCTGGGGTCCGCGACACTGACCCGCTATGCCGAGGTCGTCCACGCCGGGCTGGGGGAGATGCGCGGGGCCAC
CGCACCGCGACTGCTGCTCGAGGTGGTGTGCGCCCGGCTGTTGCTGCCGTCGGCCAGCGACACGGAATCGGCTCTGCTGC
AACGCGTCGAGCGCATCGAGACCCGCCTCGAGATGTCGATACCCGCGTCCGACATGCCCGCGGCCGCTCGCCCCGTCGAA
CCGGCGAAGACGTTCACCCGCAGGAGTCAGGTGGCCGATGCGCCGGCCCCGGCCCCTGCTCCCGTTGAGATCCGTCCGGA
ACCGCCCGCGCCACCCGTGGCGCCACCGCCTGCGCCTGCGCCGCCGCCCTCTCCGCCCCCGGTGCGCCCACCCGCCGAAC
CGGTGGTCGAAGCGCCCGCGGCGGCACCGCCGCCGGCCGCCGGTGCGCCCAATGCGGCTGCGGTGCGCAGCATGTGGACG
ACGGTGCGGGAGAAGGTCCGGCAGCGCAGCCGCACGATCGATGTGATGCTGGCCGGTGCGATCGTCCGCACGGTCGAGGG
TGACACACTGGTGTTGAGCCACGAATCGGCACCGCTGGCGAAACGGCTTGTCGAGCAACGGAACTCCGACGTGATCCGCG
AAGCGCTCAAGGATGCGCTCGGTGTGGACTGGAAGATCCGATGCGAGGCGGGCGGTGGTCCCGCGCCGGCTGTGGTCGCC
GAGCCGGCACGTCCCGCCCCCGTCGCCGATCCGCCGCCCCCGGAGGACGACGAGGAGAGCATGCTGGCCGAAGCGGTGCG
CGAGGAGGCAGGGCCCCGTCGTGACCCCGAGGAAGCCGCGCTCGAACTACTGCAGAACGAACTCGGCGCTCGCCGGATCG
ACGGGAGCTAG

Upstream 100 bases:

>100_bases
CGGTCGGCCATCGACGGTCTGGCGACGTGTGCGCTGCTGGCCGCCACCGAGTCACTGCTCGGTTGACCATCCGTCGTAGT
CCGTCGGTAGCCTGCTGACC

Downstream 100 bases:

>100_bases
CGAGCAGCTACGCCGACCACCACGGCCGCAGCGGCAGCCCGCCGTCATTGCCGCGCTCGTCCAGCTTGACCGCCAGAACC
TGGTGCAGCTGAACGATGTT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MALYRKYRPATFAEVVGQEHVTEPLSTALSAGRINHAYLFSGPRGCGKTSSARILARSLNCEQGPTPTPCGTCDSCVALA
PNGPGNMDVTELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEK
VLPTIRSRTHHYPFRLLAPKTMRTLLERICADEGVSVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAAGNRVEYGRALAL
LGATDVALIDDAVDALAAGDAAALFGAVESVIDAGHDPRRFAVDLLERFRDLIVLQAVPDAAARGVVDAPGDVLERMRDQ
AARLGSATLTRYAEVVHAGLGEMRGATAPRLLLEVVCARLLLPSASDTESALLQRVERIETRLEMSIPASDMPAAARPVE
PAKTFTRRSQVADAPAPAPAPVEIRPEPPAPPVAPPPAPAPPPSPPPVRPPAEPVVEAPAAAPPPAAGAPNAAAVRSMWT
TVREKVRQRSRTIDVMLAGAIVRTVEGDTLVLSHESAPLAKRLVEQRNSDVIREALKDALGVDWKIRCEAGGGPAPAVVA
EPARPAPVADPPPPEDDEESMLAEAVREEAGPRRDPEEAALELLQNELGARRIDGS

Sequences:

>Translated_616_residues
MALYRKYRPATFAEVVGQEHVTEPLSTALSAGRINHAYLFSGPRGCGKTSSARILARSLNCEQGPTPTPCGTCDSCVALA
PNGPGNMDVTELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEK
VLPTIRSRTHHYPFRLLAPKTMRTLLERICADEGVSVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAAGNRVEYGRALAL
LGATDVALIDDAVDALAAGDAAALFGAVESVIDAGHDPRRFAVDLLERFRDLIVLQAVPDAAARGVVDAPGDVLERMRDQ
AARLGSATLTRYAEVVHAGLGEMRGATAPRLLLEVVCARLLLPSASDTESALLQRVERIETRLEMSIPASDMPAAARPVE
PAKTFTRRSQVADAPAPAPAPVEIRPEPPAPPVAPPPAPAPPPSPPPVRPPAEPVVEAPAAAPPPAAGAPNAAAVRSMWT
TVREKVRQRSRTIDVMLAGAIVRTVEGDTLVLSHESAPLAKRLVEQRNSDVIREALKDALGVDWKIRCEAGGGPAPAVVA
EPARPAPVADPPPPEDDEESMLAEAVREEAGPRRDPEEAALELLQNELGARRIDGS
>Mature_615_residues
ALYRKYRPATFAEVVGQEHVTEPLSTALSAGRINHAYLFSGPRGCGKTSSARILARSLNCEQGPTPTPCGTCDSCVALAP
NGPGNMDVTELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEKV
LPTIRSRTHHYPFRLLAPKTMRTLLERICADEGVSVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAAGNRVEYGRALALL
GATDVALIDDAVDALAAGDAAALFGAVESVIDAGHDPRRFAVDLLERFRDLIVLQAVPDAAARGVVDAPGDVLERMRDQA
ARLGSATLTRYAEVVHAGLGEMRGATAPRLLLEVVCARLLLPSASDTESALLQRVERIETRLEMSIPASDMPAAARPVEP
AKTFTRRSQVADAPAPAPAPVEIRPEPPAPPVAPPPAPAPPPSPPPVRPPAEPVVEAPAAAPPPAAGAPNAAAVRSMWTT
VREKVRQRSRTIDVMLAGAIVRTVEGDTLVLSHESAPLAKRLVEQRNSDVIREALKDALGVDWKIRCEAGGGPAPAVVAE
PARPAPVADPPPPEDDEESMLAEAVREEAGPRRDPEEAALELLQNELGARRIDGS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=331, Percent_Identity=24.773413897281, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI31881687, Length=331, Percent_Identity=24.773413897281, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI6677723, Length=217, Percent_Identity=24.8847926267281, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786676, Length=359, Percent_Identity=38.4401114206128, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=27.6497695852535, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65373; Mature: 65242

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYRKYRPATFAEVVGQEHVTEPLSTALSAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CEQGPTPTPCGTCDSCVALAPNGPGNMDVTELDAASHGGVDDTRELRDRAFYAPAQSRYR
CCCCCCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
IFIVDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEKVLPTIRSRTHHYPFRLLAPK
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEECHH
TMRTLLERICADEGVSVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAAGNRVEYGRALAL
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEEE
LGATDVALIDDAVDALAAGDAAALFGAVESVIDAGHDPRRFAVDLLERFRDLIVLQAVPD
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEHHCCCC
AAARGVVDAPGDVLERMRDQAARLGSATLTRYAEVVHAGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSASDTESALLQRVERIETRLEMSIPASDMPAAARPVEPAKTFTRRSQVADAPAPAPA
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PVEIRPEPPAPPVAPPPAPAPPPSPPPVRPPAEPVVEAPAAAPPPAAGAPNAAAVRSMWT
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
TVREKVRQRSRTIDVMLAGAIVRTVEGDTLVLSHESAPLAKRLVEQRNSDVIREALKDAL
HHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHH
GVDWKIRCEAGGGPAPAVVAEPARPAPVADPPPPEDDEESMLAEAVREEAGPRRDPEEAA
CCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
LELLQNELGARRIDGS
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALYRKYRPATFAEVVGQEHVTEPLSTALSAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CEQGPTPTPCGTCDSCVALAPNGPGNMDVTELDAASHGGVDDTRELRDRAFYAPAQSRYR
CCCCCCCCCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
IFIVDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEKVLPTIRSRTHHYPFRLLAPK
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEECHH
TMRTLLERICADEGVSVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAAGNRVEYGRALAL
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHEEE
LGATDVALIDDAVDALAAGDAAALFGAVESVIDAGHDPRRFAVDLLERFRDLIVLQAVPD
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEHHCCCC
AAARGVVDAPGDVLERMRDQAARLGSATLTRYAEVVHAGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSASDTESALLQRVERIETRLEMSIPASDMPAAARPVEPAKTFTRRSQVADAPAPAPA
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
PVEIRPEPPAPPVAPPPAPAPPPSPPPVRPPAEPVVEAPAAAPPPAAGAPNAAAVRSMWT
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
TVREKVRQRSRTIDVMLAGAIVRTVEGDTLVLSHESAPLAKRLVEQRNSDVIREALKDAL
HHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHH
GVDWKIRCEAGGGPAPAVVAEPARPAPVADPPPPEDDEESMLAEAVREEAGPRRDPEEAA
CCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
LELLQNELGARRIDGS
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]