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The map label for this gene is fgd1 [H]

Identifier: 108801818

GI number: 108801818

Start: 5140709

End: 5141734

Strand: Reverse

Name: fgd1 [H]

Synonym: Mmcs_4855

Alternate gene names: 108801818

Gene position: 5141734-5140709 (Counterclockwise)

Preceding gene: 108801819

Following gene: 108801817

Centisome position: 90.12

GC content: 70.47

Gene sequence:

>1026_bases
TTGCGTCGGTACGCCACGGGTTACCCGGACGCCATGACGCTGACGCGCTTCGGATACGCGCTGATGACCGAGCAGAGCGG
ACCCAAGGATCTCGTCCGCTACGCCGCCGCCGCGGAGAACGTCGGATTCGACTTCGAGGTGTCCAGCGACCACTACTCAC
CGTGGCTCGCGGCGCAGGGCCACGCGCCCAGCGCCTGGACCACCCTGGGCGCCGTCGCGCACGTCACCGAACGCGTCGAA
CTGTTCACCTACGTGACCTGCCCGACCATGCGCTACCACCCCGCGATCGTCGCGCAGCAGGCCGCGACACTGCAGATCCT
CGCCGACGGTCGCTTCACCCTCGGCCTGGGCACCGGCGAGAACCTCAACGAACACGTCGTCGGCAAGGGGTGGCCGACGG
TCGCCCGTCGCCAGGACATGCTGCGCGAAGCCATTCAGATCATCCGCGAGCTGTTCACCGGTGAGGTCGTCGACTGGCGC
GGTGAGTACTTCGAGATCGACTCCGCGCGGCTGTGGGATCTGCCCGAGACGCCGGTGGACATCGCCGCGGCGGTGTCCGG
TGACCGTTCGGTCGAAGCCTTCGCCCAGCTCGCCGACCATCTCATCGCCGTCGAGCCGAACAAGGACCTCGTCCACGCGT
GGCACGACGCGCGGCGGGCGACCGGTCTGCCCGGCCACGTGCGGGTGATCGGCCAGATCCCGATCTGCTGGGACCCCGAC
CGGGAGGCGGCGGTCGCGCGGGCCCACGAGCAGTTCCGATGGTTCGCCGGCGGGTGGGCCGTCAACGCGGACCTGCCCAC
CACGGCGGGGTTTGCCGGCGCGACGCAGTTCGTGCGTCCGGAGGACACCGCCGGATCGATCCCGTGCGGACCCGACCTCG
ACGCGATCGTCGAGGCGGTCAGCGAGTACTGGAAGGCCGGGTTCACCGACATCGCGCTGGTCCAGGTGGGCGACGAGGGT
CAGGACCGGTTCCTGGACGAGGCGGCCGGCCCGCTCCTGGAGAAGCTGCGCGCCGCGGCGGGGTGA

Upstream 100 bases:

>100_bases
CCGCTGGTAAGGCCGACGGCTCGCGGCTGTCCGCCGCAGTCAAGGCACGCCTGTAGTTGCGTGTAAAGCGCGCCCGCTCA
CCGTATTCCGGGGCCGTCGT

Downstream 100 bases:

>100_bases
CGCGTCAGCTGTGGGCGAGATCGGGTTGAGTCCGGGGCCGGACGGGTAGTCCGGCCGTGACGAGAGGAGGGCGACCGTGC
CCCGTGGAGAAGGCATCTAC

Product: luciferase-like protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRRYATGYPDAMTLTRFGYALMTEQSGPKDLVRYAAAAENVGFDFEVSSDHYSPWLAAQGHAPSAWTTLGAVAHVTERVE
LFTYVTCPTMRYHPAIVAQQAATLQILADGRFTLGLGTGENLNEHVVGKGWPTVARRQDMLREAIQIIRELFTGEVVDWR
GEYFEIDSARLWDLPETPVDIAAAVSGDRSVEAFAQLADHLIAVEPNKDLVHAWHDARRATGLPGHVRVIGQIPICWDPD
REAAVARAHEQFRWFAGGWAVNADLPTTAGFAGATQFVRPEDTAGSIPCGPDLDAIVEAVSEYWKAGFTDIALVQVGDEG
QDRFLDEAAGPLLEKLRAAAG

Sequences:

>Translated_341_residues
MRRYATGYPDAMTLTRFGYALMTEQSGPKDLVRYAAAAENVGFDFEVSSDHYSPWLAAQGHAPSAWTTLGAVAHVTERVE
LFTYVTCPTMRYHPAIVAQQAATLQILADGRFTLGLGTGENLNEHVVGKGWPTVARRQDMLREAIQIIRELFTGEVVDWR
GEYFEIDSARLWDLPETPVDIAAAVSGDRSVEAFAQLADHLIAVEPNKDLVHAWHDARRATGLPGHVRVIGQIPICWDPD
REAAVARAHEQFRWFAGGWAVNADLPTTAGFAGATQFVRPEDTAGSIPCGPDLDAIVEAVSEYWKAGFTDIALVQVGDEG
QDRFLDEAAGPLLEKLRAAAG
>Mature_341_residues
MRRYATGYPDAMTLTRFGYALMTEQSGPKDLVRYAAAAENVGFDFEVSSDHYSPWLAAQGHAPSAWTTLGAVAHVTERVE
LFTYVTCPTMRYHPAIVAQQAATLQILADGRFTLGLGTGENLNEHVVGKGWPTVARRQDMLREAIQIIRELFTGEVVDWR
GEYFEIDSARLWDLPETPVDIAAAVSGDRSVEAFAQLADHLIAVEPNKDLVHAWHDARRATGLPGHVRVIGQIPICWDPD
REAAVARAHEQFRWFAGGWAVNADLPTTAGFAGATQFVRPEDTAGSIPCGPDLDAIVEAVSEYWKAGFTDIALVQVGDEG
QDRFLDEAAGPLLEKLRAAAG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787247, Length=168, Percent_Identity=30.3571428571429, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 37273; Mature: 37273

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRYATGYPDAMTLTRFGYALMTEQSGPKDLVRYAAAAENVGFDFEVSSDHYSPWLAAQG
CCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECC
HAPSAWTTLGAVAHVTERVELFTYVTCPTMRYHPAIVAQQAATLQILADGRFTLGLGTGE
CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHCCCEEEEEECCEEEEEECCCC
NLNEHVVGKGWPTVARRQDMLREAIQIIRELFTGEVVDWRGEYFEIDSARLWDLPETPVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCEECCCCCCCHH
IAAAVSGDRSVEAFAQLADHLIAVEPNKDLVHAWHDARRATGLPGHVRVIGQIPICWDPD
HHEECCCCCHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCC
REAAVARAHEQFRWFAGGWAVNADLPTTAGFAGATQFVRPEDTAGSIPCGPDLDAIVEAV
HHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SEYWKAGFTDIALVQVGDEGQDRFLDEAAGPLLEKLRAAAG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRYATGYPDAMTLTRFGYALMTEQSGPKDLVRYAAAAENVGFDFEVSSDHYSPWLAAQG
CCCCCCCCCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECC
HAPSAWTTLGAVAHVTERVELFTYVTCPTMRYHPAIVAQQAATLQILADGRFTLGLGTGE
CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHCCCEEEEEECCEEEEEECCCC
NLNEHVVGKGWPTVARRQDMLREAIQIIRELFTGEVVDWRGEYFEIDSARLWDLPETPVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCEECCCCCCCHH
IAAAVSGDRSVEAFAQLADHLIAVEPNKDLVHAWHDARRATGLPGHVRVIGQIPICWDPD
HHEECCCCCHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCEEECCC
REAAVARAHEQFRWFAGGWAVNADLPTTAGFAGATQFVRPEDTAGSIPCGPDLDAIVEAV
HHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SEYWKAGFTDIALVQVGDEGQDRFLDEAAGPLLEKLRAAAG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]