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The map label for this gene is hpt [H]

Identifier: 108801738

GI number: 108801738

Start: 5051862

End: 5052497

Strand: Reverse

Name: hpt [H]

Synonym: Mmcs_4775

Alternate gene names: 108801738

Gene position: 5052497-5051862 (Counterclockwise)

Preceding gene: 108801739

Following gene: 108801733

Centisome position: 88.56

GC content: 66.51

Gene sequence:

>636_bases
GTGAGAGCGGCCGCGTTGGTTCCGGTCCCGACGGCATGGCACGCTGTGGGCGTGCCTGCGCATACACCCGACCTGTACGA
GGGCGACATCAAGTCGGTGCTGCTGTCGGAGGAACAGATCCAATCCCGGACGGCCGAATTGGCCGCGCAGATCGCGGACA
CCTACCGCGCGGCGATCGGGGATAGCGGGCAGGACCTGCTGCTGGTCACGGTGCTCAAGGGCGCCGTCATGTTCGTCACC
GACCTGGCCCGTTCGATCCCGCTGCCCACCCAGCTCGAGTTCATGGCCGTCAGCTCCTACGGCTCGTCCACGTCGTCGTC
GGGGGTGGTGCGCATCCTCAAGGACCTCGACCGCGACATCAACGACCGCGACGTGCTGATCGTCGAGGACATCGTCGACT
CGGGTCTGACGCTGTCGTGGCTGCTGCGCAACCTGGCCACCCGGCAGCCACGGTCGCTGCGGGTGTGCACGCTGCTGCGC
AAACCTGACGCCGTGCGCGCCGACGTCGACATCGAGTACGTCGGTTTCGACATCCCCAACGAGTTCGTCGTCGGCTACGG
GCTGGACTACGCCGAGCGCTACCGCGACCTGCCCTACATCGGCACGCTGGAACCGAAGGTCTATACGCACGACTGA

Upstream 100 bases:

>100_bases
GGCACGGACAGGGCGGCGTGGCGGTCCCGTCCGCGTCGGTGCGTCAGCGGCTGATCGCGGGACGCCGCGACGGGCTGCTG
ACCCTGCATCACGAGCCGGT

Downstream 100 bases:

>100_bases
TCGGCGATCAGCCGCTCAGGCGAGCTCCCAGATCACAGTCACGCTGAACCCGACGGTCTGCCGGCCCGGCTCCAGCGGCA
CCGCCATGGCGGCCTCCCCA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRAAALVPVPTAWHAVGVPAHTPDLYEGDIKSVLLSEEQIQSRTAELAAQIADTYRAAIGDSGQDLLLVTVLKGAVMFVT
DLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDINDRDVLIVEDIVDSGLTLSWLLRNLATRQPRSLRVCTLLR
KPDAVRADVDIEYVGFDIPNEFVVGYGLDYAERYRDLPYIGTLEPKVYTHD

Sequences:

>Translated_211_residues
MRAAALVPVPTAWHAVGVPAHTPDLYEGDIKSVLLSEEQIQSRTAELAAQIADTYRAAIGDSGQDLLLVTVLKGAVMFVT
DLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDINDRDVLIVEDIVDSGLTLSWLLRNLATRQPRSLRVCTLLR
KPDAVRADVDIEYVGFDIPNEFVVGYGLDYAERYRDLPYIGTLEPKVYTHD
>Mature_211_residues
MRAAALVPVPTAWHAVGVPAHTPDLYEGDIKSVLLSEEQIQSRTAELAAQIADTYRAAIGDSGQDLLLVTVLKGAVMFVT
DLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDINDRDVLIVEDIVDSGLTLSWLLRNLATRQPRSLRVCTLLR
KPDAVRADVDIEYVGFDIPNEFVVGYGLDYAERYRDLPYIGTLEPKVYTHD

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=195, Percent_Identity=34.3589743589744, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI4504483, Length=189, Percent_Identity=32.2751322751323, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI87081689, Length=171, Percent_Identity=52.046783625731, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17510817, Length=192, Percent_Identity=35.4166666666667, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 23249; Mature: 23249

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAALVPVPTAWHAVGVPAHTPDLYEGDIKSVLLSEEQIQSRTAELAAQIADTYRAAIG
CCCCEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DSGQDLLLVTVLKGAVMFVTDLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDI
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCC
NDRDVLIVEDIVDSGLTLSWLLRNLATRQPRSLRVCTLLRKPDAVRADVDIEYVGFDIPN
CCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCCCEEECCEEEEEECCCCC
EFVVGYGLDYAERYRDLPYIGTLEPKVYTHD
CEEEECCCCHHHHHCCCCCEECCCCEEEECC
>Mature Secondary Structure
MRAAALVPVPTAWHAVGVPAHTPDLYEGDIKSVLLSEEQIQSRTAELAAQIADTYRAAIG
CCCCEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DSGQDLLLVTVLKGAVMFVTDLARSIPLPTQLEFMAVSSYGSSTSSSGVVRILKDLDRDI
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCC
NDRDVLIVEDIVDSGLTLSWLLRNLATRQPRSLRVCTLLRKPDAVRADVDIEYVGFDIPN
CCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHCCCCCEEECCEEEEEECCCCC
EFVVGYGLDYAERYRDLPYIGTLEPKVYTHD
CEEEECCCCHHHHHCCCCCEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA