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The map label for this gene is purR [H]

Identifier: 108801679

GI number: 108801679

Start: 4996581

End: 4997681

Strand: Reverse

Name: purR [H]

Synonym: Mmcs_4716

Alternate gene names: 108801679

Gene position: 4997681-4996581 (Counterclockwise)

Preceding gene: 108801680

Following gene: 108801675

Centisome position: 87.59

GC content: 69.48

Gene sequence:

>1101_bases
ATGTCCAGGAGTCCGGAGCCGCGGCGCCATGCGACCCTGGCCTCGCTCGCCGCGGAACTGAAGGTCAGCCGCACCACGAT
ATCCAATGCGTACAACCGGCCGGACCAGTTGTCGGCCGAACTGCGCGAGCGAATCTTCAGCGCCGCCAAACGCCTCGGCT
ACCCCGGCCCCGATCCGGTGGCCAGATCGCTGCGCACCCGCAGGGCCGGTGCCGTCGGGCTGATGATCACCGAACCGCTC
AACTACTCCTTCAGCGATCCGGCCGCACTGGATTTCGTTGCCGGCCTTGCGGAATCGTGTGAGGAGGCCGGCCAGGGGCT
GCTCCTGGTCGCCATCGGACCGAACCGCAGCGTGGCGGACGGTTCGGCCGCCGTCCTGGCCGCCGGCGTCGACGGTTTCG
TCATCTACTCCGCGAGCGACGACGATCCGTACCTTCCGGTCGTGCAGCAGCGGCACCTGCCGGTGGTGGTGGTCGACCAA
CCCAAAGACGTCCCCGGCACCTCCCGCGTGGGTATCGACGACCGCGCGGCGATGCGTGAGCTGACCGAATACGTTCTGGG
CCTTGGCCACCGCGACATCGGACTACTCACGATGCGGCTCGGCCTGGACCGGCCCGACGGCGATCCCCGCCCAGCCGTCG
CCCATCCGGACCGGCTGCGGACACCGCACTTCCACGTTCAGCGTGAGCGCATCGGAGGTGTGTTCGACGCGATCGCCGCG
GCCGGACTCGATCAGCGCGCGGTGACGGTCGTCGAGAGCTACGAGCACCTGCCCACCTCGGGCGGCGCGGCCGCCGAGGT
CGCACTGGCCACCAATCCGCGGCTGACAGCGCTGATGTGCACCGCCGACGTGCTCGCATTGTCGGCGATGGACCATCTGC
GTTCGCGCGGCATCTACGTCCCGGGACAGATGACGGTCACGGGGTTCGACGGCATCCCCGATGCGGTGCGCCGCGGACTG
ACCACGGTCGTCCAACCGAGTATGGAGAAGGGGCGTCGCGCGGGAAGACTGCTGCACCAGCCACCCCGTAACGGTCTGCC
CGTCGTCGACATCCTCGACACCCGCATGGTGCGCGGCCGCACCGCCGGTCCGCCCGCCTGA

Upstream 100 bases:

>100_bases
GGTGTGGGCGGTGGTGTGGGCGGTCGAACGCGGCCTGCGGTCGTCGGCCGACCGCGTGCTGGTCACCTGACGTCGCCCGC
ATCGGCTAACGTGGCAGAGC

Downstream 100 bases:

>100_bases
CCGCTACCCGCTGCGGGCGCGCCACAGGTCGACCGTCGGGGCGAGCGCATCGACGAGCATCGGCAACTGCGGTGCCATCG
CCAGGCAGGCGACCGCGGCG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSRSPEPRRHATLASLAAELKVSRTTISNAYNRPDQLSAELRERIFSAAKRLGYPGPDPVARSLRTRRAGAVGLMITEPL
NYSFSDPAALDFVAGLAESCEEAGQGLLLVAIGPNRSVADGSAAVLAAGVDGFVIYSASDDDPYLPVVQQRHLPVVVVDQ
PKDVPGTSRVGIDDRAAMRELTEYVLGLGHRDIGLLTMRLGLDRPDGDPRPAVAHPDRLRTPHFHVQRERIGGVFDAIAA
AGLDQRAVTVVESYEHLPTSGGAAAEVALATNPRLTALMCTADVLALSAMDHLRSRGIYVPGQMTVTGFDGIPDAVRRGL
TTVVQPSMEKGRRAGRLLHQPPRNGLPVVDILDTRMVRGRTAGPPA

Sequences:

>Translated_366_residues
MSRSPEPRRHATLASLAAELKVSRTTISNAYNRPDQLSAELRERIFSAAKRLGYPGPDPVARSLRTRRAGAVGLMITEPL
NYSFSDPAALDFVAGLAESCEEAGQGLLLVAIGPNRSVADGSAAVLAAGVDGFVIYSASDDDPYLPVVQQRHLPVVVVDQ
PKDVPGTSRVGIDDRAAMRELTEYVLGLGHRDIGLLTMRLGLDRPDGDPRPAVAHPDRLRTPHFHVQRERIGGVFDAIAA
AGLDQRAVTVVESYEHLPTSGGAAAEVALATNPRLTALMCTADVLALSAMDHLRSRGIYVPGQMTVTGFDGIPDAVRRGL
TTVVQPSMEKGRRAGRLLHQPPRNGLPVVDILDTRMVRGRTAGPPA
>Mature_365_residues
SRSPEPRRHATLASLAAELKVSRTTISNAYNRPDQLSAELRERIFSAAKRLGYPGPDPVARSLRTRRAGAVGLMITEPLN
YSFSDPAALDFVAGLAESCEEAGQGLLLVAIGPNRSVADGSAAVLAAGVDGFVIYSASDDDPYLPVVQQRHLPVVVVDQP
KDVPGTSRVGIDDRAAMRELTEYVLGLGHRDIGLLTMRLGLDRPDGDPRPAVAHPDRLRTPHFHVQRERIGGVFDAIAAA
GLDQRAVTVVESYEHLPTSGGAAAEVALATNPRLTALMCTADVLALSAMDHLRSRGIYVPGQMTVTGFDGIPDAVRRGLT
TVVQPSMEKGRRAGRLLHQPPRNGLPVVDILDTRMVRGRTAGPPA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=24.9249249249249, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790369, Length=344, Percent_Identity=25.2906976744186, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=26.2820512820513, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI48994940, Length=306, Percent_Identity=25.1633986928105, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=26.9461077844311, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789202, Length=328, Percent_Identity=25.9146341463415, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 39095; Mature: 38964

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSPEPRRHATLASLAAELKVSRTTISNAYNRPDQLSAELRERIFSAAKRLGYPGPDPV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
ARSLRTRRAGAVGLMITEPLNYSFSDPAALDFVAGLAESCEEAGQGLLLVAIGPNRSVAD
HHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
GSAAVLAAGVDGFVIYSASDDDPYLPVVQQRHLPVVVVDQPKDVPGTSRVGIDDRAAMRE
CCCEEEEECCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
LTEYVLGLGHRDIGLLTMRLGLDRPDGDPRPAVAHPDRLRTPHFHVQRERIGGVFDAIAA
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHH
AGLDQRAVTVVESYEHLPTSGGAAAEVALATNPRLTALMCTADVLALSAMDHLRSRGIYV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEC
PGQMTVTGFDGIPDAVRRGLTTVVQPSMEKGRRAGRLLHQPPRNGLPVVDILDTRMVRGR
CCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHCCC
TAGPPA
CCCCCC
>Mature Secondary Structure 
SRSPEPRRHATLASLAAELKVSRTTISNAYNRPDQLSAELRERIFSAAKRLGYPGPDPV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
ARSLRTRRAGAVGLMITEPLNYSFSDPAALDFVAGLAESCEEAGQGLLLVAIGPNRSVAD
HHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
GSAAVLAAGVDGFVIYSASDDDPYLPVVQQRHLPVVVVDQPKDVPGTSRVGIDDRAAMRE
CCCEEEEECCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
LTEYVLGLGHRDIGLLTMRLGLDRPDGDPRPAVAHPDRLRTPHFHVQRERIGGVFDAIAA
HHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHH
AGLDQRAVTVVESYEHLPTSGGAAAEVALATNPRLTALMCTADVLALSAMDHLRSRGIYV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEC
PGQMTVTGFDGIPDAVRRGLTTVVQPSMEKGRRAGRLLHQPPRNGLPVVDILDTRMVRGR
CCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHCCC
TAGPPA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA