| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is murF [H]
Identifier: 108801628
GI number: 108801628
Start: 4942317
End: 4944872
Strand: Reverse
Name: murF [H]
Synonym: Mmcs_4665
Alternate gene names: 108801628
Gene position: 4944872-4942317 (Counterclockwise)
Preceding gene: 108801630
Following gene: 108801627
Centisome position: 86.67
GC content: 60.95
Gene sequence:
>2556_bases ATGAAGGCGGTCGCGTTCGTCAAGAAACGGCTGGAGCCCCAAGCGCTGGTGCTACCGCATTGTCGAACGTACAGATATGG GGTAGATCGAGACACGGTGCGGGGATTGAACGGGAATGGTTACGCCCTGCTCGCTGACGCCACGCCGCTGGCCTTCCCGC ACGGTGTTCCTCGCCTGAAGGTTGCGTCGGTGCGGAACGCCTTGACCAACCTCGCATTGGCCACCAGAGCCAGCTATCCC GGGCGGATTGTGGCCGTCACGGGCAGTGCTGGAAAAACCAGCACCTGCAACATGATCGAAGATCTGCTCCAGGTCTTTGG AGTACCGAAACGGCCGACGAAGAACTTCAACACCTTTGACGGGGTCAACGGCGAGGTGGCCAATCTGACCAACGAGGCGA TCGCCGTCATCGAAGTGGCGGCCAGCTTCCTGTCTCAGCGCGGCGGGCCCCGTCCGAACGTACTTCGTCCCGAAGTGGCG ATGATTACCAGTATCGGCGAGGCGCATCTGGAGTACTTCGGATCGCCGCAAGGGGTCGCTGAGGTGAAGAGCAACGTGTT CGATCTGATGTCGCGGGGCACAGCGGTCATCCCCCGTGACGCCGACACGTACGACTACATGGTGCAACGCGCACGTGCGG CAGGCGCTACGACCGTCTCCTTCGGGGCCCATCCCAGTGCCGACGCCCACCTTCTCTCATACTCAGCGGCAGACGGAGTG GTCGAAGCGGAGATCTTCGGCGAGAGAATCACTTATGAACTCGGGGCACTTGGTCGGCATTTTGCGCGCAACAGTGTCGG AGCGTTGGGCGTCGTCGCGGCCCTTGGGCTGGACTGGCGGCGGGCCGCCGGCGCACTGGCGTCGAGTCGGGAAGTCACTG GTCGCGGCATGACGTTTGACGTCGGTTCAGCGAGCGGTCGTTTCACGTTGATCGACGACGCATACAACGCGAATCCGAGT TCGGTACGGGCCGCGATCGAGATGCTCTCCGAACGGGCCACTCCTCCGAGGGGGCGCCGAATCGCCGTTCTCGCGGACAT GCTGGAACTGGGCCCTCGAAGCGAGGAGTTTCACCGAGCCCTGGCTGAGCCCTTACTCGGCGCAGCGATTGATCGTGTGT ACCTGGTCGGTGATCAGATGCGCGCGTTGTGGGACGACCTGCCTTCCGAAATCCGTGGCCAGTACTACCCCACTGTGGAC GGTCTCCAGGCAGCGCTCGATAGAGAGTTCGCCGACGGAGATGTTGTCTTGTTCAAGGGTTCGAACGGCACCGAACTCCA CAAAGTCGTGGCGCACTTCAAGAGAGCAACAAAGCGTAGGTCAGACGCTCCGAAGGACCTGGCTCGTAGCGAGGACACGG GCTTTGTGCAACCCGCAGGCCGTCGACGGCTGGAAGTGCGCGCTCGGCATCCGAAGTCATCACAGTCAGGCTCACGGCGC ACCAGTCTCGTCTTCGTCGGCGACTTGAGCATGGGTGATTGTTACCTCAAACGCCCACACCTCTCTGTCGCTCGCCATCG ACTCGAGGAGAATCCGTGGAGCTTCGTCGAACTCTTGGCTCCTCTCGTGCAGGACAAGTCACTCCTTGTCGCCAATCTTG AAACCGTCCTGGCCGAAAGGCCGGCTGATCCGTTCCGGGGGATGAAGAAATACCAGGGATGGGACGATCCGGTTCGGACG CTTGCGGTCATGCAGCGTTTGGGCGTAGACGCGGTGTCGCTCGCGAACAATCACACGATGGATTTCGGAGTGGCGCCCTT GAGGCGGACGATCGCCCACCTCGAGTCGACCAACATCGTGCCATTCGGTGCTGGCGAGAATGAGGTGCAGGCCGCTCGAC CACTGAGTGTTTCGGCTCCTTTCGGCAATGTTCACATATTCGCCGGTTACGAGTTCCGGACTGGTTATGCACGGAAGTGG AATTTCTACGCGTCGGGTGATGCGGCCGGCGTGAATCCTCTCACCGGCCGCGCGACAGGAAGTCTCATCGCCGATATTGC GCGGACCAGGACTGACGACCCGGCGTCGGTCATCGTCGTCTATCCACACTGGAGTGGCGCACGGAATTATCAATGGGCCA CGGATGAAATGATCGGGATGAACAGCGAGTTCCTCGATGCCGGCGCCGACTTCGTTATCGGGCACGGGGCGCATCGAATG CAGGAGATAGTCTCGGGAAGAGAAGGAACGACGGTGTTCTCGCTGGGCAATTTCGTGTTCAACTCGCCCGGCCGGTATGC CAAATTCGGCTCACCTACTTTCAGTCTTGTTGCACGCCTAGAGATTGAGGATGGCGATCCGGTGACGGGAATCGGGGCGG ATCTACATATCTATCCCATAATGTCGGACAATCGTGAGACGGGTTTTCGCCCGAGGCCGGTCCGGAAATCCGAGGCGGTT CAGGTGTACAACATCCTCGCCGGACAGAGTGGCGCACGCTTCAGAGAGGACTTCGACCTCGAACACGGTGACCGGGGGTG GTACATCGGTCGGACGATTCCACTGAGCATGGCCGGCGGCCAACGACGACGTGATGCGGTCACTTCGCCCGCGTGA
Upstream 100 bases:
>100_bases GAACCGGAATCACAAAGCGCCCTCGTCGGACTTGAATGCGCATGAGTTGGCTGAGATCACGCAAGGAGTGTGGGAAGTCA TGCCACCCGACGGGTGGACC
Downstream 100 bases:
>100_bases CCCGCAGTCAGACCGCGGCATCTTGAGTCACCCGGCCACCGACGCCGAGATCGAGGACCTCGCCCGCCGGATGCTGTAAC CGTCACGTCTTGACCCTCCC
Product: Mur ligase, middle region
Products: NA
Alternate protein names: D-alanyl-D-alanine-adding enzyme; UDP-MurNAc-pentapeptide synthetase [H]
Number of amino acids: Translated: 851; Mature: 851
Protein sequence:
>851_residues MKAVAFVKKRLEPQALVLPHCRTYRYGVDRDTVRGLNGNGYALLADATPLAFPHGVPRLKVASVRNALTNLALATRASYP GRIVAVTGSAGKTSTCNMIEDLLQVFGVPKRPTKNFNTFDGVNGEVANLTNEAIAVIEVAASFLSQRGGPRPNVLRPEVA MITSIGEAHLEYFGSPQGVAEVKSNVFDLMSRGTAVIPRDADTYDYMVQRARAAGATTVSFGAHPSADAHLLSYSAADGV VEAEIFGERITYELGALGRHFARNSVGALGVVAALGLDWRRAAGALASSREVTGRGMTFDVGSASGRFTLIDDAYNANPS SVRAAIEMLSERATPPRGRRIAVLADMLELGPRSEEFHRALAEPLLGAAIDRVYLVGDQMRALWDDLPSEIRGQYYPTVD GLQAALDREFADGDVVLFKGSNGTELHKVVAHFKRATKRRSDAPKDLARSEDTGFVQPAGRRRLEVRARHPKSSQSGSRR TSLVFVGDLSMGDCYLKRPHLSVARHRLEENPWSFVELLAPLVQDKSLLVANLETVLAERPADPFRGMKKYQGWDDPVRT LAVMQRLGVDAVSLANNHTMDFGVAPLRRTIAHLESTNIVPFGAGENEVQAARPLSVSAPFGNVHIFAGYEFRTGYARKW NFYASGDAAGVNPLTGRATGSLIADIARTRTDDPASVIVVYPHWSGARNYQWATDEMIGMNSEFLDAGADFVIGHGAHRM QEIVSGREGTTVFSLGNFVFNSPGRYAKFGSPTFSLVARLEIEDGDPVTGIGADLHIYPIMSDNRETGFRPRPVRKSEAV QVYNILAGQSGARFREDFDLEHGDRGWYIGRTIPLSMAGGQRRRDAVTSPA
Sequences:
>Translated_851_residues MKAVAFVKKRLEPQALVLPHCRTYRYGVDRDTVRGLNGNGYALLADATPLAFPHGVPRLKVASVRNALTNLALATRASYP GRIVAVTGSAGKTSTCNMIEDLLQVFGVPKRPTKNFNTFDGVNGEVANLTNEAIAVIEVAASFLSQRGGPRPNVLRPEVA MITSIGEAHLEYFGSPQGVAEVKSNVFDLMSRGTAVIPRDADTYDYMVQRARAAGATTVSFGAHPSADAHLLSYSAADGV VEAEIFGERITYELGALGRHFARNSVGALGVVAALGLDWRRAAGALASSREVTGRGMTFDVGSASGRFTLIDDAYNANPS SVRAAIEMLSERATPPRGRRIAVLADMLELGPRSEEFHRALAEPLLGAAIDRVYLVGDQMRALWDDLPSEIRGQYYPTVD GLQAALDREFADGDVVLFKGSNGTELHKVVAHFKRATKRRSDAPKDLARSEDTGFVQPAGRRRLEVRARHPKSSQSGSRR TSLVFVGDLSMGDCYLKRPHLSVARHRLEENPWSFVELLAPLVQDKSLLVANLETVLAERPADPFRGMKKYQGWDDPVRT LAVMQRLGVDAVSLANNHTMDFGVAPLRRTIAHLESTNIVPFGAGENEVQAARPLSVSAPFGNVHIFAGYEFRTGYARKW NFYASGDAAGVNPLTGRATGSLIADIARTRTDDPASVIVVYPHWSGARNYQWATDEMIGMNSEFLDAGADFVIGHGAHRM QEIVSGREGTTVFSLGNFVFNSPGRYAKFGSPTFSLVARLEIEDGDPVTGIGADLHIYPIMSDNRETGFRPRPVRKSEAV QVYNILAGQSGARFREDFDLEHGDRGWYIGRTIPLSMAGGQRRRDAVTSPA >Mature_851_residues MKAVAFVKKRLEPQALVLPHCRTYRYGVDRDTVRGLNGNGYALLADATPLAFPHGVPRLKVASVRNALTNLALATRASYP GRIVAVTGSAGKTSTCNMIEDLLQVFGVPKRPTKNFNTFDGVNGEVANLTNEAIAVIEVAASFLSQRGGPRPNVLRPEVA MITSIGEAHLEYFGSPQGVAEVKSNVFDLMSRGTAVIPRDADTYDYMVQRARAAGATTVSFGAHPSADAHLLSYSAADGV VEAEIFGERITYELGALGRHFARNSVGALGVVAALGLDWRRAAGALASSREVTGRGMTFDVGSASGRFTLIDDAYNANPS SVRAAIEMLSERATPPRGRRIAVLADMLELGPRSEEFHRALAEPLLGAAIDRVYLVGDQMRALWDDLPSEIRGQYYPTVD GLQAALDREFADGDVVLFKGSNGTELHKVVAHFKRATKRRSDAPKDLARSEDTGFVQPAGRRRLEVRARHPKSSQSGSRR TSLVFVGDLSMGDCYLKRPHLSVARHRLEENPWSFVELLAPLVQDKSLLVANLETVLAERPADPFRGMKKYQGWDDPVRT LAVMQRLGVDAVSLANNHTMDFGVAPLRRTIAHLESTNIVPFGAGENEVQAARPLSVSAPFGNVHIFAGYEFRTGYARKW NFYASGDAAGVNPLTGRATGSLIADIARTRTDDPASVIVVYPHWSGARNYQWATDEMIGMNSEFLDAGADFVIGHGAHRM QEIVSGREGTTVFSLGNFVFNSPGRYAKFGSPTFSLVARLEIEDGDPVTGIGADLHIYPIMSDNRETGFRPRPVRKSEAV QVYNILAGQSGARFREDFDLEHGDRGWYIGRTIPLSMAGGQRRRDAVTSPA
Specific function: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein [H]
COG id: COG0770
COG function: function code M; UDP-N-acetylmuramyl pentapeptide synthase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family [H]
Homologues:
Organism=Escherichia coli, GI1786274, Length=388, Percent_Identity=31.1855670103093, Blast_Score=107, Evalue=2e-24,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005863 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.10 [H]
Molecular weight: Translated: 92498; Mature: 92498
Theoretical pI: Translated: 8.99; Mature: 8.99
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKAVAFVKKRLEPQALVLPHCRTYRYGVDRDTVRGLNGNGYALLADATPLAFPHGVPRLK CCHHHHHHHCCCCCEEECCCCHHEECCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCH VASVRNALTNLALATRASYPGRIVAVTGSAGKTSTCNMIEDLLQVFGVPKRPTKNFNTFD HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC GVNGEVANLTNEAIAVIEVAASFLSQRGGPRPNVLRPEVAMITSIGEAHLEYFGSPQGVA CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH EVKSNVFDLMSRGTAVIPRDADTYDYMVQRARAAGATTVSFGAHPSADAHLLSYSAADGV HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCE VEAEIFGERITYELGALGRHFARNSVGALGVVAALGLDWRRAAGALASSREVTGRGMTFD EEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEE VGSASGRFTLIDDAYNANPSSVRAAIEMLSERATPPRGRRIAVLADMLELGPRSEEFHRA CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCHHHHHH LAEPLLGAAIDRVYLVGDQMRALWDDLPSEIRGQYYPTVDGLQAALDREFADGDVVLFKG HHHHHHHHHHHHEEEECHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEC SNGTELHKVVAHFKRATKRRSDAPKDLARSEDTGFVQPAGRRRLEVRARHPKSSQSGSRR CCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCE TSLVFVGDLSMGDCYLKRPHLSVARHRLEENPWSFVELLAPLVQDKSLLVANLETVLAER EEEEEEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC PADPFRGMKKYQGWDDPVRTLAVMQRLGVDAVSLANNHTMDFGVAPLRRTIAHLESTNIV CCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEE PFGAGENEVQAARPLSVSAPFGNVHIFAGYEFRTGYARKWNFYASGDAAGVNPLTGRATG EECCCCCCCHHCCCCEEECCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHH SLIADIARTRTDDPASVIVVYPHWSGARNYQWATDEMIGMNSEFLDAGADFVIGHGAHRM HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCHHHHHCCCCEEEECCHHHH QEIVSGREGTTVFSLGNFVFNSPGRYAKFGSPTFSLVARLEIEDGDPVTGIGADLHIYPI HHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCEECCCCEEEEEE MSDNRETGFRPRPVRKSEAVQVYNILAGQSGARFREDFDLEHGDRGWYIGRTIPLSMAGG ECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEECEEEEEECCCC QRRRDAVTSPA CHHHCCCCCCC >Mature Secondary Structure MKAVAFVKKRLEPQALVLPHCRTYRYGVDRDTVRGLNGNGYALLADATPLAFPHGVPRLK CCHHHHHHHCCCCCEEECCCCHHEECCCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCCH VASVRNALTNLALATRASYPGRIVAVTGSAGKTSTCNMIEDLLQVFGVPKRPTKNFNTFD HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC GVNGEVANLTNEAIAVIEVAASFLSQRGGPRPNVLRPEVAMITSIGEAHLEYFGSPQGVA CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH EVKSNVFDLMSRGTAVIPRDADTYDYMVQRARAAGATTVSFGAHPSADAHLLSYSAADGV HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCE VEAEIFGERITYELGALGRHFARNSVGALGVVAALGLDWRRAAGALASSREVTGRGMTFD EEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEE VGSASGRFTLIDDAYNANPSSVRAAIEMLSERATPPRGRRIAVLADMLELGPRSEEFHRA CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCHHHHHH LAEPLLGAAIDRVYLVGDQMRALWDDLPSEIRGQYYPTVDGLQAALDREFADGDVVLFKG HHHHHHHHHHHHEEEECHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEC SNGTELHKVVAHFKRATKRRSDAPKDLARSEDTGFVQPAGRRRLEVRARHPKSSQSGSRR CCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCE TSLVFVGDLSMGDCYLKRPHLSVARHRLEENPWSFVELLAPLVQDKSLLVANLETVLAER EEEEEEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC PADPFRGMKKYQGWDDPVRTLAVMQRLGVDAVSLANNHTMDFGVAPLRRTIAHLESTNIV CCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEE PFGAGENEVQAARPLSVSAPFGNVHIFAGYEFRTGYARKWNFYASGDAAGVNPLTGRATG EECCCCCCCHHCCCCEEECCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHH SLIADIARTRTDDPASVIVVYPHWSGARNYQWATDEMIGMNSEFLDAGADFVIGHGAHRM HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCHHHHHCCCCEEEECCHHHH QEIVSGREGTTVFSLGNFVFNSPGRYAKFGSPTFSLVARLEIEDGDPVTGIGADLHIYPI HHHHCCCCCCEEEEECCHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCEECCCCEEEEEE MSDNRETGFRPRPVRKSEAVQVYNILAGQSGARFREDFDLEHGDRGWYIGRTIPLSMAGG ECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCCCCCCEEECEEEEEECCCC QRRRDAVTSPA CHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11557893 [H]