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The map label for this gene is mhpE [C]

Identifier: 108801622

GI number: 108801622

Start: 4936262

End: 4937323

Strand: Reverse

Name: mhpE [C]

Synonym: Mmcs_4659

Alternate gene names: 108801622

Gene position: 4937323-4936262 (Counterclockwise)

Preceding gene: 108801623

Following gene: 108801621

Centisome position: 86.54

GC content: 66.1

Gene sequence:

>1062_bases
ATGAGCACCAAAGACATCTTCTTCAACCCGATCTGGGACGTCCGGATGACGGACACGTCGCTGCGCGACGGCTCGCACCA
CAAACGTCACCAGTTCACCAAGGACGAGGTGGGCGCCATCGTCGCCGCGCTCGACACCGCAGGTGTGCCGGTCATCGAGG
TGACCCACGGTGACGGGCTCGGCGGGTCGAGCTTCAACTACGGGTTCTCGAAAACCCCTGAGCAGGAACTGATCAAGCTC
GCGGCCGAGACCGCCAAGGAAGCCAAGATCGCCTTCCTCATGCTGCCCGGGGTGGGCACCAAGGAGGACATCAAAGAGGC
GCAGAACAACGGCGGTTCGATCTGCCGCATCGCGACCCACTGCACCGAGGCCGACGTGTCGATCCAGCACTTCGGTCTGG
CGCGTGAGCTCGGGCTCGAGACCGTGGGCTTCTTGATGATGAGCCACACCATCCCGCCGGAGAAGCTCGCCCAACAGGCC
CGCATCATGGCCGACGCGGGGTGCCAGTGCGTCTACGTCGTCGACTCCGCCGGTGCACTGGTGCTCGAAGGGGTGCGCGA
TCGGGTCGCCGCGCTCGTCGCCGAACTCGGTGACGACGCCCAGGTCGGTTTTCACGGCCACGAGAATCTCGGTCTGGGCG
TGGCGAATTCGGTCGAGGCGGTGCGCGCCGGGGCCAAGCAGATCGACGGGTCGTGCCGCCGGTTCGGCGCCGGAGCGGGT
AACGCACCGGTCGAGGCGCTCATCGGGGTCTTCGACAAGATCGGCGTGAAGACCGGCATCGACTTCTTCGACATCGCCGA
CGCCGCCGAGGAAGTCGTCGCACCGGCGATGCCGGCCGAATGCCTGCTGGACCGCAACGCGCTCATCATGGGCTACTCGG
GTGTCTACTCGAGCTTCCTCAAACACGCGATCCGGCAGTCGGAGCGCTACGGCGTGCCCGCGCACCAGCTGCTGCACCGC
GCCGGCCAGCGCAAGCTGATCGGCGGTCAGGAAGATCAGCTCATCGACATCGCGCTGGAGATCAAACGAGAACAGGACAG
CGGGGCGACGGCCGCGCACTGA

Upstream 100 bases:

>100_bases
CGCCGTACGCGGGAAACCTCGACATCATGACCGCCGCGGCGGCCAAGGTGGGCGAGGAGATCGCAAAGGAATCCCTTTCT
CTGGCAGGAGGTGCGCAGGC

Downstream 100 bases:

>100_bases
CCCCGGCGCTGCTGCACCGTGTCGTGGTTTCCCCACTGTAGGCTGTGCAGCGCGTCGCCCCCCGGGCGACCGCACGCCGG
ATCCCGGTCCGGCAACACCC

Product: 4-hydroxy-2-ketovalerate aldolase

Products: NA

Alternate protein names: HOA 1; 4-hydroxy-2-keto-pentanoic acid aldolase 1; 4-hydroxy-2-oxopentanoate aldolase 1 [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSTKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKL
AAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQA
RIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAG
NAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVPAHQLLHR
AGQRKLIGGQEDQLIDIALEIKREQDSGATAAH

Sequences:

>Translated_353_residues
MSTKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKL
AAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQA
RIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAG
NAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVPAHQLLHR
AGQRKLIGGQEDQLIDIALEIKREQDSGATAAH
>Mature_352_residues
STKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLA
AETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQAR
IMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFLKHAIRQSERYGVPAHQLLHRA
GQRKLIGGQEDQLIDIALEIKREQDSGATAAH

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=330, Percent_Identity=50.9090909090909, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 37601; Mature: 37470

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGL
CCCCCEEECCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
GGSSFNYGFSKTPEQELIKLAAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATH
CCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEEC
CTEADVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHH
VLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAG
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCC
NAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECHHHHHHHH
KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQDSGATAAH
HHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
STKDIFFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVTHGDGL
CCCCEEECCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
GGSSFNYGFSKTPEQELIKLAAETAKEAKIAFLMLPGVGTKEDIKEAQNNGGSICRIATH
CCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEEC
CTEADVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHH
VLEGVRDRVAALVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAG
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCC
NAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECHHHHHHHH
KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQDSGATAAH
HHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA