| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is hdhA [H]
Identifier: 108801569
GI number: 108801569
Start: 4879167
End: 4880012
Strand: Reverse
Name: hdhA [H]
Synonym: Mmcs_4606
Alternate gene names: 108801569
Gene position: 4880012-4879167 (Counterclockwise)
Preceding gene: 108801570
Following gene: 108801557
Centisome position: 85.53
GC content: 69.03
Gene sequence:
>846_bases TTGCTGCTTTCCCAGCTCTCACTGGCGGATCGCACCTATCTGGTCACCGGCGGTGGCAGTGGAATCGGCAAGGGCGTCGC CGCCGCGATCGTCGCCGCCGGTGGTGACGTGATGCTCGCCGGACGCAACGCCGACCGACTTGCCGCCGCCGCCGACGAAC TGTCCGCCGCGGCCGGTGACGGCGCGGGGCAGGTGCGCTACGAGCCCACCGACGTCACCAACGAGGACGAAGCGGCGCGG CTGGTGGAGGCCGCCACCGCATGGCGCGGCCGGTTGCACGGCGTCGTGCACAGCGCGGGTGGTTCGGAGACCATCGGCCC GATCACCCAGATCGATTCCGATGCGTGGCGGCGCACGGTGGACCTCAACGTCAACGGCACGATGTACGTACTGAAACACG CTGCGCGAGAACTGGTTCGCGGTGGAGGCGGATCGTTCGTCGGGATCTCGTCGATCGCATCGAGCAACGTGCACCGCTGG TTCGGCGCCTACGGGCCCAGCAAGGCCGCCCTCGACCACATCATGAAGCTGGCCGCCGACGAACTCGGCCCGTCCTGGGT GCGGGTCAACGGCATCCGTCCCGGTCTGATCCAGACCGACCTCGTCGGGCCGATCCTGGAGTCGCCTGAGGTGTCCGCGG ACTACCGCGCGTGCACACCGCTGCCGCGGTTCGGGGAGGTCACCGACATCGCGAACCTGTCGGTGTTCCTGCTCAGCGAT GCCTCGTCCTGGATCACCGGGCAGATCATCAACGTCGACGGCGGCCACAACCTCCGGCGCGGCCCGGACATGTCGGGCAT GCTCGAACCGCTCTTCGGCGCCGACGGGCTACGCGGGGTGGTCTGA
Upstream 100 bases:
>100_bases TGGCGCGAGCTGGGCGCACCGAAGTTGGCCCGGCGCGACGAGCCGTGACGTATAACTAGAACGCGTTTCAGTTATACGGC CTACCTACCGGAGGATTCCC
Downstream 100 bases:
>100_bases GCGCTGCCCGACGCCCGAGACCTGCACCAGCGCCGACAGCACGACGGCCATCAGGAGCAGCGCGGGGACGTCGCCGAGCA GGTGGCCCATGTGGTGACCG
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 281; Mature: 281
Protein sequence:
>281_residues MLLSQLSLADRTYLVTGGGSGIGKGVAAAIVAAGGDVMLAGRNADRLAAAADELSAAAGDGAGQVRYEPTDVTNEDEAAR LVEAATAWRGRLHGVVHSAGGSETIGPITQIDSDAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIASSNVHRW FGAYGPSKAALDHIMKLAADELGPSWVRVNGIRPGLIQTDLVGPILESPEVSADYRACTPLPRFGEVTDIANLSVFLLSD ASSWITGQIINVDGGHNLRRGPDMSGMLEPLFGADGLRGVV
Sequences:
>Translated_281_residues MLLSQLSLADRTYLVTGGGSGIGKGVAAAIVAAGGDVMLAGRNADRLAAAADELSAAAGDGAGQVRYEPTDVTNEDEAAR LVEAATAWRGRLHGVVHSAGGSETIGPITQIDSDAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIASSNVHRW FGAYGPSKAALDHIMKLAADELGPSWVRVNGIRPGLIQTDLVGPILESPEVSADYRACTPLPRFGEVTDIANLSVFLLSD ASSWITGQIINVDGGHNLRRGPDMSGMLEPLFGADGLRGVV >Mature_281_residues MLLSQLSLADRTYLVTGGGSGIGKGVAAAIVAAGGDVMLAGRNADRLAAAADELSAAAGDGAGQVRYEPTDVTNEDEAAR LVEAATAWRGRLHGVVHSAGGSETIGPITQIDSDAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIASSNVHRW FGAYGPSKAALDHIMKLAADELGPSWVRVNGIRPGLIQTDLVGPILESPEVSADYRACTPLPRFGEVTDIANLSVFLLSD ASSWITGQIINVDGGHNLRRGPDMSGMLEPLFGADGLRGVV
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=31.0483870967742, Blast_Score=109, Evalue=3e-24, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=30.8880308880309, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=31.3492063492063, Blast_Score=101, Evalue=9e-22, Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=30.952380952381, Blast_Score=98, Evalue=7e-21, Organism=Homo sapiens, GI4503301, Length=227, Percent_Identity=28.1938325991189, Blast_Score=95, Evalue=8e-20, Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=29.4820717131474, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=31.7269076305221, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=28.6274509803922, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=211, Percent_Identity=29.3838862559242, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI19923983, Length=211, Percent_Identity=29.3838862559242, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=28.6919831223629, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=28.1081081081081, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=35.0597609561753, Blast_Score=127, Evalue=6e-31, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=27.9527559055118, Blast_Score=103, Evalue=9e-24, Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=31.0756972111554, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=27.2, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=29.5019157088123, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=28.957528957529, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.8884462151394, Blast_Score=82, Evalue=5e-17, Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=27.6264591439689, Blast_Score=81, Evalue=9e-17, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1787545, Length=266, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=2e-14, Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=32.8125, Blast_Score=112, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=28.968253968254, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=28.0898876404494, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=31.0756972111554, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=28.6764705882353, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17562906, Length=274, Percent_Identity=31.3868613138686, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=28.1954887218045, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560332, Length=281, Percent_Identity=29.8932384341637, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=29.811320754717, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=29.1187739463602, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17562990, Length=272, Percent_Identity=29.0441176470588, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.1124497991968, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=30.9160305343511, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=30.3703703703704, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=27.9352226720648, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=29.8039215686275, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI193204405, Length=275, Percent_Identity=27.6363636363636, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17565030, Length=272, Percent_Identity=27.2058823529412, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=25.5905511811024, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=26.241134751773, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17536025, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=26.8774703557312, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17536651, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=26.7175572519084, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=26.5151515151515, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=5e-20, Organism=Saccharomyces cerevisiae, GI6322226, Length=199, Percent_Identity=31.1557788944724, Blast_Score=83, Evalue=5e-17, Organism=Saccharomyces cerevisiae, GI6322227, Length=206, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=9e-13, Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=33.7254901960784, Blast_Score=114, Evalue=6e-26, Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=33.7254901960784, Blast_Score=114, Evalue=1e-25, Organism=Drosophila melanogaster, GI23397609, Length=263, Percent_Identity=32.319391634981, Blast_Score=105, Evalue=5e-23, Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=28.1746031746032, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=31.496062992126, Blast_Score=98, Evalue=7e-21, Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.1158301158301, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=28.2868525896414, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=27.9693486590038, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24644337, Length=175, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 29168; Mature: 29168
Theoretical pI: Translated: 5.10; Mature: 5.10
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLLSQLSLADRTYLVTGGGSGIGKGVAAAIVAAGGDVMLAGRNADRLAAAADELSAAAGD CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCC GAGQVRYEPTDVTNEDEAARLVEAATAWRGRLHGVVHSAGGSETIGPITQIDSDAWRRTV CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCHHHCEEE DLNVNGTMYVLKHAARELVRGGGGSFVGISSIASSNVHRWFGAYGPSKAALDHIMKLAAD EECCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHH ELGPSWVRVNGIRPGLIQTDLVGPILESPEVSADYRACTPLPRFGEVTDIANLSVFLLSD HCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEEEC ASSWITGQIINVDGGHNLRRGPDMSGMLEPLFGADGLRGVV CCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC >Mature Secondary Structure MLLSQLSLADRTYLVTGGGSGIGKGVAAAIVAAGGDVMLAGRNADRLAAAADELSAAAGD CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCC GAGQVRYEPTDVTNEDEAARLVEAATAWRGRLHGVVHSAGGSETIGPITQIDSDAWRRTV CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHCCCHHHCEEE DLNVNGTMYVLKHAARELVRGGGGSFVGISSIASSNVHRWFGAYGPSKAALDHIMKLAAD EECCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHH ELGPSWVRVNGIRPGLIQTDLVGPILESPEVSADYRACTPLPRFGEVTDIANLSVFLLSD HCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEEEC ASSWITGQIINVDGGHNLRRGPDMSGMLEPLFGADGLRGVV CCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]