| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is hdhA [C]
Identifier: 108801540
GI number: 108801540
Start: 4853651
End: 4854412
Strand: Reverse
Name: hdhA [C]
Synonym: Mmcs_4577
Alternate gene names: 108801540
Gene position: 4854412-4853651 (Counterclockwise)
Preceding gene: 108801541
Following gene: 108801539
Centisome position: 85.08
GC content: 64.96
Gene sequence:
>762_bases ATGGTCAACTACGGCGACGAGTTCAAGGACAAGGTCGCGATCGTCACCGGGGCGGGTGGCGGCATCGGTCAGGCGTACGC CGAGGCGCTGGCCCGGGAGGGCGCCGCGGTCGTGGTGGCCGACATCAACGTCGACGGCGCCCAGAAGGTGGCCGACGGCA TCAAGGGCGAGGGTGGCAATGCCCTGGCCGTGCGCGTCGACGTCTCCGATCCCGACTCCGCCAAAGAGATGGCCGCGCAG ACGCTCTCGGAGTTCGGCGGCATCGACTACCTGGTCAACAACGCCGCGATCTTCGGCGGGATGAAGCTCGACTTCTTGAT CACCGTCGACTGGGACTACTACAAGAAGTTCATGAGCGTGAACCTCGACGGCGCACTGGTGTGCACGCGCGCGGTCTACC GCAAGATGGCCAAACGCGGCGGTGGGGCGATCGTCAACCAGTCGTCGACCGCGGCGTGGCTGTACTCGAATTTCTACGGC CTGGCCAAGGTCGGCATCAACGGCCTGACCCAGCAGCTGGCCACCGAACTGGGTGGGCAGAACATCCGGGTCAACGCGAT CGCGCCGGGGCCCATCGACACCGAGGCCAACCGGACCACCACACCGCAGGAGATGGTCGCCGACATCGTCAAGGGCATCC CGTTGTCGCGGATGGGCCAACCCGAGGATCTGGTCGGGATGTGCCTGTTCCTGTTGTCGGATCAGGCGAAATGGATCACC GGGCAGATCTTCAACGTCGACGGCGGACAGATCATTCGGTGA
Upstream 100 bases:
>100_bases CTACAAGCAGTCCGGGATCGGCCGCGAGATGGGCGTCGCCGGCTTCGAGGAGTACACCGAGATCAAACTCATTGCGACGG CAGCGAATTAAGGAGCTTTG
Downstream 100 bases:
>100_bases TGAGCGCTTGCGCGAAGAGCAGAGGGCACAGATGAGCGATCTGAAGTACGGCTACATCGGCCTGGGGAACATGGGTGCGC CGATGGCCAAGCGGCTGACC
Product: short chain dehydrogenase
Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MVNYGDEFKDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINVDGAQKVADGIKGEGGNALAVRVDVSDPDSAKEMAAQ TLSEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSVNLDGALVCTRAVYRKMAKRGGGAIVNQSSTAAWLYSNFYG LAKVGINGLTQQLATELGGQNIRVNAIAPGPIDTEANRTTTPQEMVADIVKGIPLSRMGQPEDLVGMCLFLLSDQAKWIT GQIFNVDGGQIIR
Sequences:
>Translated_253_residues MVNYGDEFKDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINVDGAQKVADGIKGEGGNALAVRVDVSDPDSAKEMAAQ TLSEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSVNLDGALVCTRAVYRKMAKRGGGAIVNQSSTAAWLYSNFYG LAKVGINGLTQQLATELGGQNIRVNAIAPGPIDTEANRTTTPQEMVADIVKGIPLSRMGQPEDLVGMCLFLLSDQAKWIT GQIFNVDGGQIIR >Mature_253_residues MVNYGDEFKDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINVDGAQKVADGIKGEGGNALAVRVDVSDPDSAKEMAAQ TLSEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSVNLDGALVCTRAVYRKMAKRGGGAIVNQSSTAAWLYSNFYG LAKVGINGLTQQLATELGGQNIRVNAIAPGPIDTEANRTTTPQEMVADIVKGIPLSRMGQPEDLVGMCLFLLSDQAKWIT GQIFNVDGGQIIR
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=36.6141732283465, Blast_Score=136, Evalue=1e-32, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=34.7826086956522, Blast_Score=130, Evalue=2e-30, Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=33.7254901960784, Blast_Score=122, Evalue=4e-28, Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=30.8300395256917, Blast_Score=116, Evalue=2e-26, Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=32.5581395348837, Blast_Score=107, Evalue=1e-23, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=30.5882352941176, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=33.6099585062241, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=8e-20, Organism=Homo sapiens, GI126723191, Length=188, Percent_Identity=34.5744680851064, Blast_Score=94, Evalue=8e-20, Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=28.968253968254, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=32, Blast_Score=88, Evalue=6e-18, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=31.6326530612245, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=29.2490118577075, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI7706318, Length=249, Percent_Identity=28.1124497991968, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI142976729, Length=217, Percent_Identity=28.110599078341, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI225579078, Length=208, Percent_Identity=30.2884615384615, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI224922801, Length=180, Percent_Identity=32.7777777777778, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=29.9492385786802, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI166795268, Length=208, Percent_Identity=32.2115384615385, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI40254986, Length=188, Percent_Identity=30.3191489361702, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI4503817, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI302344755, Length=108, Percent_Identity=41.6666666666667, Blast_Score=66, Evalue=2e-11, Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=37.603305785124, Blast_Score=145, Evalue=3e-36, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=33.469387755102, Blast_Score=131, Evalue=4e-32, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=33.596837944664, Blast_Score=124, Evalue=9e-30, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=31.8725099601594, Blast_Score=115, Evalue=2e-27, Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=34.9019607843137, Blast_Score=115, Evalue=3e-27, Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=29.2181069958848, Blast_Score=111, Evalue=4e-26, Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=32.3770491803279, Blast_Score=111, Evalue=5e-26, Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=31.0077519379845, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=29.0836653386454, Blast_Score=94, Evalue=7e-21, Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=30.4182509505703, Blast_Score=92, Evalue=5e-20, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=30.8880308880309, Blast_Score=91, Evalue=6e-20, Organism=Escherichia coli, GI1787820, Length=183, Percent_Identity=32.2404371584699, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=27.0161290322581, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1787526, Length=254, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1787545, Length=246, Percent_Identity=26.4227642276423, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=35.2941176470588, Blast_Score=124, Evalue=4e-29, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=34.0080971659919, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=31.5589353612167, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.6530612244898, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=33.587786259542, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=30.1960784313725, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=31.8007662835249, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=28.5171102661597, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=30.952380952381, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=32.295719844358, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.0756972111554, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17536651, Length=253, Percent_Identity=30.0395256916996, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=31.4176245210728, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=29.7297297297297, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17568967, Length=256, Percent_Identity=32.03125, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=32.0158102766798, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=28.1368821292776, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=31.0861423220974, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17562990, Length=266, Percent_Identity=29.3233082706767, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=28.8537549407115, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=28.1368821292776, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=30.1526717557252, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=27.8625954198473, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=26.3940520446097, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=28.030303030303, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17567345, Length=201, Percent_Identity=28.3582089552239, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=28.996282527881, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=30, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=29.3532338308458, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17508651, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=32.0197044334975, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI71997099, Length=210, Percent_Identity=29.5238095238095, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17508895, Length=147, Percent_Identity=30.6122448979592, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI17558628, Length=194, Percent_Identity=30.4123711340206, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI193203117, Length=191, Percent_Identity=29.8429319371728, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=255, Percent_Identity=32.5490196078431, Blast_Score=109, Evalue=4e-25, Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=4e-24, Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=35.9183673469388, Blast_Score=121, Evalue=5e-28, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=34.5238095238095, Blast_Score=121, Evalue=5e-28, Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=32.0158102766798, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=31.3492063492063, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI18859837, Length=207, Percent_Identity=36.231884057971, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=29.1338582677165, Blast_Score=88, Evalue=7e-18, Organism=Drosophila melanogaster, GI116007234, Length=204, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=7e-17, Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=28.4552845528455, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI116007236, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=27.1653543307087, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI24641232, Length=242, Percent_Identity=26.4462809917355, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24663911, Length=225, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI281364494, Length=202, Percent_Identity=29.2079207920792, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI116007232, Length=186, Percent_Identity=32.258064516129, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI21357673, Length=256, Percent_Identity=25.390625, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24649181, Length=196, Percent_Identity=31.1224489795918, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24647946, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI45553409, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI24647948, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100
Molecular weight: Translated: 26734; Mature: 26734
Theoretical pI: Translated: 4.55; Mature: 4.55
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVNYGDEFKDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINVDGAQKVADGIKGEGGN CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCC ALAVRVDVSDPDSAKEMAAQTLSEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSV EEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCEEEECCEEEEEEEEECHHHHHHHHHC NLDGALVCTRAVYRKMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGINGLTQQLATELGGQ CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC NIRVNAIAPGPIDTEANRTTTPQEMVADIVKGIPLSRMGQPEDLVGMCLFLLSDQAKWIT EEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE GQIFNVDGGQIIR EEEEECCCCEECC >Mature Secondary Structure MVNYGDEFKDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINVDGAQKVADGIKGEGGN CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCCCC ALAVRVDVSDPDSAKEMAAQTLSEFGGIDYLVNNAAIFGGMKLDFLITVDWDYYKKFMSV EEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCEEEECCEEEEEEEEECHHHHHHHHHC NLDGALVCTRAVYRKMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGINGLTQQLATELGGQ CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC NIRVNAIAPGPIDTEANRTTTPQEMVADIVKGIPLSRMGQPEDLVGMCLFLLSDQAKWIT EEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE GQIFNVDGGQIIR EEEEECCCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+
Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]