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The map label for this gene is purD [H]

Identifier: 108801534

GI number: 108801534

Start: 4847856

End: 4849124

Strand: Reverse

Name: purD [H]

Synonym: Mmcs_4571

Alternate gene names: 108801534

Gene position: 4849124-4847856 (Counterclockwise)

Preceding gene: 108801537

Following gene: 108801532

Centisome position: 84.99

GC content: 72.1

Gene sequence:

>1269_bases
GTGCGCGTCCTGGTAATCGGATCCGGTGCCCGTGAACATGCCCTGCTGCTGGCGTTGCGCCGCGACCCCGAGGTCGAGGC
CCTGGCGGTGGCCCCGGGCAACCCGGGCACGGCCGCTGTCGCCGACCAGCACGACGTCGACATCACCTCCGGTGAGGCCG
TCGCCGAACTCGCCCGCCGGATCGGCGCCGACCTGGTGGTCATCGGACCCGAGGTGCCACTGGTGCTCGGCGTCGCCGAC
GCCGTCCGTGCCGCCGGGGTCGCGTGCTTCGGGCCGAGCCGGAGTGCCGCCCGCATCGAAGGTTCCAAGGCGTTCGCCAA
GGACGTGATGAATGCCGCAGGCGTCCGCACCGCCGCGAGCGAGATCGTCGACAACCCCGCGCACCTCGACGCCGCACTCG
ACCGGTTCGGTCCGCCTGCGGGAGAGGCCGCGTGGGTCGTCAAGGACGACGGCCTTGCCGCGGGCAAGGGTGTGGTGGTG
ACCGCCGACCGCGACGCGGCGCGCGCCCACGCCGCAAGTCTGCTCGACTCCGGCCACCCTGTGCTGCTGGAGTCGTTCCT
CGACGGTCCGGAGGTGTCGCTGTTCTGCGTCGTTGACGGTGAGACCGTGGTGCCGCTACTGCCCGCGCAGGACTTCAAAC
GCGTCGGTGACGGTGACACCGGACCCAATACCGGCGGTATGGGCGCCTACGCCCCCCTGCCCTGGCTGCCCGCCGACATC
ACCACGAGCATCGTCGACGACATCGTCAAACCCGTTGCAGCCGAACTGGTTCAACGCGGCAGCTCGTTCTCCGGCCTGCT
GTACGCGGGGCTAGCGATCACCTCACGCGGGCCGGCCGTAGTCGAGTTCAACTGCCGGTTCGGCGACCCGGAGACCCAAT
CGGTGCTGGCACTGCTCGACTCGCCGCTCGGGCAGCTGCTGCACGCCGCGGCGACCGGGCGGCTCGCGGAGTTCCCCGAA
CTGCAGTGGCGCGACGGTGCCGCGGTGACGGTCGTGGTGGCCGCCGAGAACTATCCCGGCCGGCCGCGCGTCGGCGACGT
GATCACCGGCGCCGACGCCGAGGGCGTGCTGCACGCCGGGACCGCCCGTCGCGACGACGGCGCCATCGTGTCGTCCGGCG
GCCGGGTGCTGTCGGTGGTGGGTACCGGCGCCGACCTCGACGCCGCGAGGACGGCCGCCTACTCGACGCTGGCGTCGATC
CGGTTGCCGGGCAGCCACTTCCGCAGCGACATCGGGTTGGCCGCGGCCGAGGGCAAGATCACCCTCTAG

Upstream 100 bases:

>100_bases
GTCATGACGGCCGCCTCTCAGTGTGACGCTGAACACGCTCACCCACGACCATACACTTCGCCGTGACCTGTATGCCCAGC
GCGGGGTTTAGGGTGCACAT

Downstream 100 bases:

>100_bases
GCGGCGACGAGCGGGGCCATCCAGGTGATCTCCGCGGGCAGCTGCGAACTCCAGAACCCGCCGTCGTGCCCGCCGGGGGA
GAAGCCGCCGGCTGGCGGAT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MRVLVIGSGAREHALLLALRRDPEVEALAVAPGNPGTAAVADQHDVDITSGEAVAELARRIGADLVVIGPEVPLVLGVAD
AVRAAGVACFGPSRSAARIEGSKAFAKDVMNAAGVRTAASEIVDNPAHLDAALDRFGPPAGEAAWVVKDDGLAAGKGVVV
TADRDAARAHAASLLDSGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPADI
TTSIVDDIVKPVAAELVQRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQSVLALLDSPLGQLLHAAATGRLAEFPE
LQWRDGAAVTVVVAAENYPGRPRVGDVITGADAEGVLHAGTARRDDGAIVSSGGRVLSVVGTGADLDAARTAAYSTLASI
RLPGSHFRSDIGLAAAEGKITL

Sequences:

>Translated_422_residues
MRVLVIGSGAREHALLLALRRDPEVEALAVAPGNPGTAAVADQHDVDITSGEAVAELARRIGADLVVIGPEVPLVLGVAD
AVRAAGVACFGPSRSAARIEGSKAFAKDVMNAAGVRTAASEIVDNPAHLDAALDRFGPPAGEAAWVVKDDGLAAGKGVVV
TADRDAARAHAASLLDSGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPADI
TTSIVDDIVKPVAAELVQRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQSVLALLDSPLGQLLHAAATGRLAEFPE
LQWRDGAAVTVVVAAENYPGRPRVGDVITGADAEGVLHAGTARRDDGAIVSSGGRVLSVVGTGADLDAARTAAYSTLASI
RLPGSHFRSDIGLAAAEGKITL
>Mature_422_residues
MRVLVIGSGAREHALLLALRRDPEVEALAVAPGNPGTAAVADQHDVDITSGEAVAELARRIGADLVVIGPEVPLVLGVAD
AVRAAGVACFGPSRSAARIEGSKAFAKDVMNAAGVRTAASEIVDNPAHLDAALDRFGPPAGEAAWVVKDDGLAAGKGVVV
TADRDAARAHAASLLDSGHPVLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPADI
TTSIVDDIVKPVAAELVQRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQSVLALLDSPLGQLLHAAATGRLAEFPE
LQWRDGAAVTVVVAAENYPGRPRVGDVITGADAEGVLHAGTARRDDGAIVSSGGRVLSVVGTGADLDAARTAAYSTLASI
RLPGSHFRSDIGLAAAEGKITL

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=427, Percent_Identity=40.9836065573771, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI4503915, Length=427, Percent_Identity=40.9836065573771, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI209869995, Length=427, Percent_Identity=40.9836065573771, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI209869993, Length=427, Percent_Identity=40.9836065573771, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1790438, Length=431, Percent_Identity=43.6194895591647, Blast_Score=313, Evalue=9e-87,
Organism=Caenorhabditis elegans, GI17567511, Length=425, Percent_Identity=36.7058823529412, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=451, Percent_Identity=37.6940133037694, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI62471619, Length=433, Percent_Identity=40.1847575057737, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24582400, Length=433, Percent_Identity=40.1847575057737, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 42944; Mature: 42944

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVIGSGAREHALLLALRRDPEVEALAVAPGNPGTAAVADQHDVDITSGEAVAELARR
CEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHH
IGADLVVIGPEVPLVLGVADAVRAAGVACFGPSRSAARIEGSKAFAKDVMNAAGVRTAAS
HCCCEEEECCCCCEEEEHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCHHHHHH
EIVDNPAHLDAALDRFGPPAGEAAWVVKDDGLAAGKGVVVTADRDAARAHAASLLDSGHP
HHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCH
VLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPADI
HHHHHHCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
TTSIVDDIVKPVAAELVQRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQSVLALLD
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHH
SPLGQLLHAAATGRLAEFPELQWRDGAAVTVVVAAENYPGRPRVGDVITGADAEGVLHAG
HHHHHHHHHHHCCCHHCCCCCEECCCCEEEEEEEECCCCCCCCCCCEEECCCCCCEEECC
TARRDDGAIVSSGGRVLSVVGTGADLDAARTAAYSTLASIRLPGSHFRSDIGLAAAEGKI
CCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHEECCHHHHHHCCCEEECCCCE
TL
EC
>Mature Secondary Structure
MRVLVIGSGAREHALLLALRRDPEVEALAVAPGNPGTAAVADQHDVDITSGEAVAELARR
CEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHH
IGADLVVIGPEVPLVLGVADAVRAAGVACFGPSRSAARIEGSKAFAKDVMNAAGVRTAAS
HCCCEEEECCCCCEEEEHHHHHHHCCEEEECCCCCCEEECCHHHHHHHHHHHCCHHHHHH
EIVDNPAHLDAALDRFGPPAGEAAWVVKDDGLAAGKGVVVTADRDAARAHAASLLDSGHP
HHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHCCCCH
VLLESFLDGPEVSLFCVVDGETVVPLLPAQDFKRVGDGDTGPNTGGMGAYAPLPWLPADI
HHHHHHCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
TTSIVDDIVKPVAAELVQRGSSFSGLLYAGLAITSRGPAVVEFNCRFGDPETQSVLALLD
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHH
SPLGQLLHAAATGRLAEFPELQWRDGAAVTVVVAAENYPGRPRVGDVITGADAEGVLHAG
HHHHHHHHHHHCCCHHCCCCCEECCCCEEEEEEEECCCCCCCCCCCEEECCCCCCEEECC
TARRDDGAIVSSGGRVLSVVGTGADLDAARTAAYSTLASIRLPGSHFRSDIGLAAAEGKI
CCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHHHHHEECCHHHHHHCCCEEECCCCE
TL
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]