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The map label for this gene is btuE [H]

Identifier: 108801520

GI number: 108801520

Start: 4831599

End: 4832096

Strand: Reverse

Name: btuE [H]

Synonym: Mmcs_4557

Alternate gene names: 108801520

Gene position: 4832096-4831599 (Counterclockwise)

Preceding gene: 108801521

Following gene: 108801519

Centisome position: 84.69

GC content: 67.47

Gene sequence:

>498_bases
ATGACTGAGTCGTACCTGCTCGACATCGAGCTCAACACACTCGACGGCACCTCGACGTCTCTGAGGGAGCTGGCCGACGG
CGCCGTGCTCGTGGTCAACGTCGCGTCGAAGTGCGGGCTCACCCCGCAGTACAGCGCGCTGGAGAAGCTGGCGCAGGACT
ACGGCGACCGCGGTCTGACGGTGATCGGCGTGCCGTGCAACCAGTTCATGGGGCAGGAACCGGGGACGGCCGAAGAAATC
CAGACGTTCTGCTCGACCACCTACGGCGTGACCTTCCCGCTGCTGGCCAAGACCGACGTCAACGGAGCCGACCGCCACCC
GCTCTACGCCGAGCTGACGCAGACGCCCGACGCCGGCGGTGAGGCGGGCGACGTGCAGTGGAACTTCGAGAAGTTCCTGC
TCGCGCCGGGCGGTGAGGTCGTCAACCGGTTCCGGCCGCGCACCGAACCCGACGCCCCCGAGGTGATCTCCGCCATCGAG
GCCGTCCTCCCGAAATAG

Upstream 100 bases:

>100_bases
CTCAACGATCTGATCGCCACCGAGGGGGATCCGCTCGCCCAGATCGAGCGCGCCGCCCGGATGCTGTTCGCCGGTTAGCG
GCGTGCGGTAGCGTCCGGGC

Downstream 100 bases:

>100_bases
ACAGCTGCCGTCGACGTGACGGCAACCGTCGGGACACCTCGAGTTGTCATGCTGCAGGCGTGGCTGGACAACTGATCCTC
TCGATCTCCCACGTCAGCGC

Product: glutathione peroxidase

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTESYLLDIELNTLDGTSTSLRELADGAVLVVNVASKCGLTPQYSALEKLAQDYGDRGLTVIGVPCNQFMGQEPGTAEEI
QTFCSTTYGVTFPLLAKTDVNGADRHPLYAELTQTPDAGGEAGDVQWNFEKFLLAPGGEVVNRFRPRTEPDAPEVISAIE
AVLPK

Sequences:

>Translated_165_residues
MTESYLLDIELNTLDGTSTSLRELADGAVLVVNVASKCGLTPQYSALEKLAQDYGDRGLTVIGVPCNQFMGQEPGTAEEI
QTFCSTTYGVTFPLLAKTDVNGADRHPLYAELTQTPDAGGEAGDVQWNFEKFLLAPGGEVVNRFRPRTEPDAPEVISAIE
AVLPK
>Mature_164_residues
TESYLLDIELNTLDGTSTSLRELADGAVLVVNVASKCGLTPQYSALEKLAQDYGDRGLTVIGVPCNQFMGQEPGTAEEIQ
TFCSTTYGVTFPLLAKTDVNGADRHPLYAELTQTPDAGGEAGDVQWNFEKFLLAPGGEVVNRFRPRTEPDAPEVISAIEA
VLPK

Specific function: Not essential for B12 transport; however, it is an auxiliary component of the transport system [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=164, Percent_Identity=37.8048780487805, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI75709200, Length=139, Percent_Identity=40.2877697841727, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI90903240, Length=147, Percent_Identity=38.0952380952381, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI192455698, Length=160, Percent_Identity=32.5, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI90903238, Length=129, Percent_Identity=37.2093023255814, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4557629, Length=148, Percent_Identity=34.4594594594595, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI6006001, Length=156, Percent_Identity=36.5384615384615, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI41406084, Length=171, Percent_Identity=34.5029239766082, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI33186887, Length=146, Percent_Identity=35.6164383561644, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI32967607, Length=169, Percent_Identity=34.3195266272189, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788003, Length=184, Percent_Identity=45.1086956521739, Blast_Score=163, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17506887, Length=153, Percent_Identity=37.9084967320261, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17535473, Length=157, Percent_Identity=39.4904458598726, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71993584, Length=156, Percent_Identity=35.8974358974359, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17550320, Length=183, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193210707, Length=160, Percent_Identity=36.875, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=32.2404371584699, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319721, Length=166, Percent_Identity=45.1807228915663, Blast_Score=148, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6322228, Length=137, Percent_Identity=47.4452554744526, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322826, Length=149, Percent_Identity=40.2684563758389, Blast_Score=121, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24656767, Length=150, Percent_Identity=38, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656777, Length=150, Percent_Identity=38, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656772, Length=150, Percent_Identity=38, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI85726443, Length=152, Percent_Identity=37.5, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: NA

Molecular weight: Translated: 17738; Mature: 17607

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESYLLDIELNTLDGTSTSLRELADGAVLVVNVASKCGLTPQYSALEKLAQDYGDRGLT
CCCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCE
VIGVPCNQFMGQEPGTAEEIQTFCSTTYGVTFPLLAKTDVNGADRHPLYAELTQTPDAGG
EEECCHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCC
EAGDVQWNFEKFLLAPGGEVVNRFRPRTEPDAPEVISAIEAVLPK
CCCCEEECCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TESYLLDIELNTLDGTSTSLRELADGAVLVVNVASKCGLTPQYSALEKLAQDYGDRGLT
CCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCE
VIGVPCNQFMGQEPGTAEEIQTFCSTTYGVTFPLLAKTDVNGADRHPLYAELTQTPDAGG
EEECCHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCC
EAGDVQWNFEKFLLAPGGEVVNRFRPRTEPDAPEVISAIEAVLPK
CCCCEEECCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3528129; 9097039; 9278503 [H]