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The map label for this gene is fadA [H]

Identifier: 108801456

GI number: 108801456

Start: 4772397

End: 4773608

Strand: Reverse

Name: fadA [H]

Synonym: Mmcs_4493

Alternate gene names: 108801456

Gene position: 4773608-4772397 (Counterclockwise)

Preceding gene: 108801457

Following gene: 108801455

Centisome position: 83.67

GC content: 68.89

Gene sequence:

>1212_bases
ATGTCTGAAGAAGCCTTCATCTACGAGGCGATCCGCACGCCTCGCGGCAAGCAACGCAACGGTTCGCTGCACGAGGTCAA
GCCGCTCAACCTCGTCACCGGCCTGATCGACGAACTGCGCCGCCGGTTCCCGGACCTGGACGAGAACCTGATCAGCGACG
TCGTGCTGGGCGTCGTGTCCCCGGTCGGTGATCAGGGCGGCGACATCGCCCGCACCGCGGTGCTGGCCGCCGGTCTGCCC
GACACCACCGGCGGCGTCCAGCTCAACCGCTTCTGTGCCTCAGGCCTGGAGGCCGTCAACATCGCCGCGCAGAAGGTGCG
TTCGGGCTGGGACGACCTGGTGATCGCCGGCGGCGTCGAGTCGATGAGCCGCGTGCCCATGGGTTCCGACGGTGGCGCCT
GGGCCGCCGACCCGGAGACCAACTACCGCATCGGCTTCGTGCCGCAGGGCATCGGCGCCGACCTGATCGCCACCATCGAG
GGCTTCTCGCGTGAGGACGTCGACGCCTACGCGGCGCGGTCGCAGGAGCGCGCCGCCGCGGCCTGGTCGGGCGGCTACTT
CGCCAAGTCCGTCGTGCCGGTTCGCGACCAGAACGGTCTGGTGGTCCTCGACCACGACGAGCACATGCGTCCCGGCTCGA
CCGTGGAGAGCCTGGGCAAGCTGAAGACCGCGTTCGACGGGATCGGCGCGATGGGCGGCTTCGATGATGTGGCGCTGCAG
AAGTACCACTACGTCGAGAAGATCAACCACGTCCACACCGGCGGTAACTCCTCGGGCATCGTCGACGGCGCCGCGCTGGT
GCTCGTCGGTTCGGAAAGGGCCGGCCAGTCGCAGGGCCTGACCCCCCGCGCCCGCATCGTCGCGACCGCGACCAGCGGCG
CCGATCCGGTCATCATGCTCACCGGCCCGACGCCGGCGACGAAGAAGGTGCTCGACCGTGCGGGCCTGACCGTCGACGAC
ATCGACCTGTTCGAGCTGAACGAGGCGTTCGCCTCGGTGGTGCTGAAGTTCCAGAAGGACCTGAACATCCCGGACGAGAA
GCTGAACGTCAACGGTGGTGCGATCGCGATGGGCCACCCGCTGGGTGCCACCGGCGCGATGATCACCGGAACCATGGTCG
ACGAGCTCGAGCGCCGGGGTGCCCGGCGCGCGCTGATCACGCTGTGCGTGGGCGGCGGCATGGGCGTGGCCACCATCATC
GAGCGAGTCTGA

Upstream 100 bases:

>100_bases
CGCTGGCCGAGTTGGAGACCCGAGAGTCCGCCTGAGCGCCGCTCGGCAGAACCGGTGACCGGCCAACCAACAGGTTGGTT
TGGGCTGTTACGCTGCGCGC

Downstream 100 bases:

>100_bases
GGAATAGCTATGGCTGAGAACACCATCACGTGGGAGCAGGACTCCGACGGCATCGTGACCCTCACGCTGGACGATCCGAC
CGGGTCGGCCAACGTGATGA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSEEAFIYEAIRTPRGKQRNGSLHEVKPLNLVTGLIDELRRRFPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLP
DTTGGVQLNRFCASGLEAVNIAAQKVRSGWDDLVIAGGVESMSRVPMGSDGGAWAADPETNYRIGFVPQGIGADLIATIE
GFSREDVDAYAARSQERAAAAWSGGYFAKSVVPVRDQNGLVVLDHDEHMRPGSTVESLGKLKTAFDGIGAMGGFDDVALQ
KYHYVEKINHVHTGGNSSGIVDGAALVLVGSERAGQSQGLTPRARIVATATSGADPVIMLTGPTPATKKVLDRAGLTVDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGARRALITLCVGGGMGVATII
ERV

Sequences:

>Translated_403_residues
MSEEAFIYEAIRTPRGKQRNGSLHEVKPLNLVTGLIDELRRRFPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLP
DTTGGVQLNRFCASGLEAVNIAAQKVRSGWDDLVIAGGVESMSRVPMGSDGGAWAADPETNYRIGFVPQGIGADLIATIE
GFSREDVDAYAARSQERAAAAWSGGYFAKSVVPVRDQNGLVVLDHDEHMRPGSTVESLGKLKTAFDGIGAMGGFDDVALQ
KYHYVEKINHVHTGGNSSGIVDGAALVLVGSERAGQSQGLTPRARIVATATSGADPVIMLTGPTPATKKVLDRAGLTVDD
IDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGARRALITLCVGGGMGVATII
ERV
>Mature_402_residues
SEEAFIYEAIRTPRGKQRNGSLHEVKPLNLVTGLIDELRRRFPDLDENLISDVVLGVVSPVGDQGGDIARTAVLAAGLPD
TTGGVQLNRFCASGLEAVNIAAQKVRSGWDDLVIAGGVESMSRVPMGSDGGAWAADPETNYRIGFVPQGIGADLIATIEG
FSREDVDAYAARSQERAAAAWSGGYFAKSVVPVRDQNGLVVLDHDEHMRPGSTVESLGKLKTAFDGIGAMGGFDDVALQK
YHYVEKINHVHTGGNSSGIVDGAALVLVGSERAGQSQGLTPRARIVATATSGADPVIMLTGPTPATKKVLDRAGLTVDDI
DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGARRALITLCVGGGMGVATIIE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=423, Percent_Identity=36.6430260047281, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI167614485, Length=368, Percent_Identity=36.4130434782609, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4501853, Length=399, Percent_Identity=35.5889724310777, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4557237, Length=422, Percent_Identity=31.9905213270142, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=29.2740046838407, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=51.685393258427, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787663, Length=421, Percent_Identity=43.4679334916865, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI48994986, Length=407, Percent_Identity=39.5577395577396, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788554, Length=421, Percent_Identity=37.7672209026128, Blast_Score=227, Evalue=8e-61,
Organism=Escherichia coli, GI87082165, Length=421, Percent_Identity=36.8171021377672, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1788683, Length=431, Percent_Identity=29.2343387470998, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=381, Percent_Identity=36.4829396325459, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=416, Percent_Identity=33.4134615384615, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=417, Percent_Identity=31.1750599520384, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=417, Percent_Identity=28.2973621103118, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17535917, Length=410, Percent_Identity=28.0487804878049, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=35.3086419753086, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=422, Percent_Identity=29.1469194312796, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24655093, Length=421, Percent_Identity=38.2422802850356, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI17648125, Length=373, Percent_Identity=35.1206434316354, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640423, Length=374, Percent_Identity=31.5508021390374, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI17137578, Length=404, Percent_Identity=29.9504950495049, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42327; Mature: 42195

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEAFIYEAIRTPRGKQRNGSLHEVKPLNLVTGLIDELRRRFPDLDENLISDVVLGVVS
CCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARTAVLAAGLPDTTGGVQLNRFCASGLEAVNIAAQKVRSGWDDLVIAGGVE
CCCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAWAADPETNYRIGFVPQGIGADLIATIEGFSREDVDAYAARSQERAAA
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLVVLDHDEHMRPGSTVESLGKLKTAFDGIGAMGGFDDVALQ
HCCCCCHHHEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KYHYVEKINHVHTGGNSSGIVDGAALVLVGSERAGQSQGLTPRARIVATATSGADPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATKKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMITGTMVDELERRGARRALITLCVGGGMGVATIIERV
CCCCCCEEEHHHHHHHHHCCHHEEEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
SEEAFIYEAIRTPRGKQRNGSLHEVKPLNLVTGLIDELRRRFPDLDENLISDVVLGVVS
CCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
PVGDQGGDIARTAVLAAGLPDTTGGVQLNRFCASGLEAVNIAAQKVRSGWDDLVIAGGVE
CCCCCCCCHHHHHHHHCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHH
SMSRVPMGSDGGAWAADPETNYRIGFVPQGIGADLIATIEGFSREDVDAYAARSQERAAA
HHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDQNGLVVLDHDEHMRPGSTVESLGKLKTAFDGIGAMGGFDDVALQ
HCCCCCHHHEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KYHYVEKINHVHTGGNSSGIVDGAALVLVGSERAGQSQGLTPRARIVATATSGADPVIML
HHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
TGPTPATKKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
ECCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCEEEECCC
LGATGAMITGTMVDELERRGARRALITLCVGGGMGVATIIERV
CCCCCCEEEHHHHHHHHHCCHHEEEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]