Click here to switch to the map view.

The map label for this gene is menE [H]

Identifier: 108801454

GI number: 108801454

Start: 4768678

End: 4770192

Strand: Reverse

Name: menE [H]

Synonym: Mmcs_4491

Alternate gene names: 108801454

Gene position: 4770192-4768678 (Counterclockwise)

Preceding gene: 108801455

Following gene: 108801452

Centisome position: 83.61

GC content: 71.35

Gene sequence:

>1515_bases
TTGCGTCTGCTCGGCAGGAGCGGCGACTGCCGCGTTAACCTGGCCACCGTGAGCTTTACCGAGACCTTTGCGGCAGGCTT
CACCAGCTACGGCGACCGGCCGTGCATCGAGTTCGAGGGCCGCTGGCACACCGGCGACGAGGTGACCGGTTACGCCGCCG
CGGTCGACACCGCCCTGCGGGACGCCGGCGTCGACGCGCACGCGCCGATCGGTCTGGTGGTCCGCAACCGCCTGCCGCAC
GCCGCCGCGATCGCCGGGTCGCTCGCCGGCGGGCGCTGGGTCTCGATGATCTACTCGTTCCAGTCGCCGGAGGCGATCGC
CCGCGACATCGAACAGCTGCGCCCGGCCGCCGTCGTCGCCGACGCGCAGGACTGGACGGCGCCGGTTCTCGCCGCGGCCA
CACGCTGTGGCCTTGCCGGAGTGGCGATCTCGGAGCAGGAGCCCCGGGTCGTGACGGCGCGGCGAGGATCCGCCGTAACC
GCCTCCCCGTCGGCGGGGTTGTCGATACTCACCTCCGGCACCACGGGTCCGCCGAAGCGGCAGGCCATCGACGAGGCGGT
GCTCGACCGCACCGTGTTCAGCGTGACGGGCGGGCTGTTCGCCGAGCCGACCGATCCGCCGGAACTGTCCTACTGGCCGT
TCGGGGGCATCGGGGTCTGCCAACTGATCGCCGGTTTCGCCACCGGTAAGCGGATCGTGCTGCTGGAACGCTTCAGCGTG
GACGACTGGGTGCGGGCGGTACGGACCCACCGAATCCCCCGGGCTGGGGTTCAACCGGCGGTGGTGCGGATGCTGCTGGA
CGCCGACGTGTCACCCGAGGACCTGGCGTCGCTGCAGTTCCTCATCAGCGCATCCGGTCCGCTCGATCCGGCGACTCGCG
ACGAGTTCGAGCAGCGCTTCGACATCCCGGTCCGACTGGCCTACGGCGCAACGGAATTCGCCGGTTCGGTGTGCGCGTGG
ACCCCGGAGATGGTCGAGCAGTTCGGCCCGGCCAAACGCGACAGCGTGGGGCGACCACTGCCGGACACCGAGGTGCGCAT
AGTCGACCCGGACACCGGCGTCGCGGTGCCCACCGGTGCGCGCGGGGTGCTCGAAGCCCGCATCGAGGTGCTCTCGCCGG
ACTGGATCCGCACCACCGACATCGCGTCGATGGACGACGACGGGTTCGTCACGCTGCACGGACGCGCCGACGGCGCGATC
ATCCGGGGCGGGTTCAAGATTCTGCCCGAGACGGTGCGGCAGGTGCTTCTCGGCCATCCGTCGGTGCGCGACGCGTGCGT
GGTCGGCGTTCCCGACGACCGGTTGGGTCAGGTGCCGTTCGCCGCGGTGGAACCCGCACGCGGGCAACCGGTCCCGGGAT
CGGAGGAACTGCGGGAGTGGGTACGCGCCGCGCTGCCCGTCCACCACGTGCCCGTCGCCGTCGTGACCGTCGACGAACTG
CCGCGCACCCCGTCGCTCAAAGTGCGGCTACCCGACGTGGCCGCGCTCTACGACGCCGCCCGGGTGGACACGTAG

Upstream 100 bases:

>100_bases
TGGCCGAGCGTTACGGCGACCGGTTCACCCCGCCGGACTCGCTCACCAAGTAGCGCGACCAGACGCAAAAGTGCCCAAAA
CCTCCGGGTTTTGGGCACTT

Downstream 100 bases:

>100_bases
CCGCGGTCAGAACGATCCGAGGTCCGACGACAACCAGTGCCGCGGGTCGAGGTGGATCACCACGCTCTCACCGTGCTCGC
GGCGGGCCATCTCCAGATAG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MRLLGRSGDCRVNLATVSFTETFAAGFTSYGDRPCIEFEGRWHTGDEVTGYAAAVDTALRDAGVDAHAPIGLVVRNRLPH
AAAIAGSLAGGRWVSMIYSFQSPEAIARDIEQLRPAAVVADAQDWTAPVLAAATRCGLAGVAISEQEPRVVTARRGSAVT
ASPSAGLSILTSGTTGPPKRQAIDEAVLDRTVFSVTGGLFAEPTDPPELSYWPFGGIGVCQLIAGFATGKRIVLLERFSV
DDWVRAVRTHRIPRAGVQPAVVRMLLDADVSPEDLASLQFLISASGPLDPATRDEFEQRFDIPVRLAYGATEFAGSVCAW
TPEMVEQFGPAKRDSVGRPLPDTEVRIVDPDTGVAVPTGARGVLEARIEVLSPDWIRTTDIASMDDDGFVTLHGRADGAI
IRGGFKILPETVRQVLLGHPSVRDACVVGVPDDRLGQVPFAAVEPARGQPVPGSEELREWVRAALPVHHVPVAVVTVDEL
PRTPSLKVRLPDVAALYDAARVDT

Sequences:

>Translated_504_residues
MRLLGRSGDCRVNLATVSFTETFAAGFTSYGDRPCIEFEGRWHTGDEVTGYAAAVDTALRDAGVDAHAPIGLVVRNRLPH
AAAIAGSLAGGRWVSMIYSFQSPEAIARDIEQLRPAAVVADAQDWTAPVLAAATRCGLAGVAISEQEPRVVTARRGSAVT
ASPSAGLSILTSGTTGPPKRQAIDEAVLDRTVFSVTGGLFAEPTDPPELSYWPFGGIGVCQLIAGFATGKRIVLLERFSV
DDWVRAVRTHRIPRAGVQPAVVRMLLDADVSPEDLASLQFLISASGPLDPATRDEFEQRFDIPVRLAYGATEFAGSVCAW
TPEMVEQFGPAKRDSVGRPLPDTEVRIVDPDTGVAVPTGARGVLEARIEVLSPDWIRTTDIASMDDDGFVTLHGRADGAI
IRGGFKILPETVRQVLLGHPSVRDACVVGVPDDRLGQVPFAAVEPARGQPVPGSEELREWVRAALPVHHVPVAVVTVDEL
PRTPSLKVRLPDVAALYDAARVDT
>Mature_504_residues
MRLLGRSGDCRVNLATVSFTETFAAGFTSYGDRPCIEFEGRWHTGDEVTGYAAAVDTALRDAGVDAHAPIGLVVRNRLPH
AAAIAGSLAGGRWVSMIYSFQSPEAIARDIEQLRPAAVVADAQDWTAPVLAAATRCGLAGVAISEQEPRVVTARRGSAVT
ASPSAGLSILTSGTTGPPKRQAIDEAVLDRTVFSVTGGLFAEPTDPPELSYWPFGGIGVCQLIAGFATGKRIVLLERFSV
DDWVRAVRTHRIPRAGVQPAVVRMLLDADVSPEDLASLQFLISASGPLDPATRDEFEQRFDIPVRLAYGATEFAGSVCAW
TPEMVEQFGPAKRDSVGRPLPDTEVRIVDPDTGVAVPTGARGVLEARIEVLSPDWIRTTDIASMDDDGFVTLHGRADGAI
IRGGFKILPETVRQVLLGHPSVRDACVVGVPDDRLGQVPFAAVEPARGQPVPGSEELREWVRAALPVHHVPVAVVTVDEL
PRTPSLKVRLPDVAALYDAARVDT

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI122937307, Length=260, Percent_Identity=27.3076923076923, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI38505220, Length=350, Percent_Identity=26.8571428571429, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI58082049, Length=361, Percent_Identity=25.7617728531856, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI42544132, Length=352, Percent_Identity=25.5681818181818, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI157311624, Length=361, Percent_Identity=24.6537396121884, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI157311622, Length=361, Percent_Identity=24.6537396121884, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI115511026, Length=350, Percent_Identity=23.7142857142857, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI187761345, Length=383, Percent_Identity=25.8485639686684, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI187761343, Length=383, Percent_Identity=25.8485639686684, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI145693145, Length=284, Percent_Identity=27.112676056338, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788107, Length=248, Percent_Identity=26.6129032258064, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=364, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788595, Length=184, Percent_Identity=33.1521739130435, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558820, Length=348, Percent_Identity=25.5747126436782, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=331, Percent_Identity=23.8670694864048, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=346, Percent_Identity=21.3872832369942, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=357, Percent_Identity=26.890756302521, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=365, Percent_Identity=23.8356164383562, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=189, Percent_Identity=30.6878306878307, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=189, Percent_Identity=30.6878306878307, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=189, Percent_Identity=30.6878306878307, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=359, Percent_Identity=23.1197771587744, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560140, Length=305, Percent_Identity=21.9672131147541, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=372, Percent_Identity=25.2688172043011, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538037, Length=311, Percent_Identity=21.8649517684887, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=350, Percent_Identity=28, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21355181, Length=505, Percent_Identity=24.1584158415842, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859661, Length=341, Percent_Identity=25.2199413489736, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922652, Length=512, Percent_Identity=23.6328125, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24581924, Length=370, Percent_Identity=25.9459459459459, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653035, Length=355, Percent_Identity=23.943661971831, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 53717; Mature: 53717

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGRSGDCRVNLATVSFTETFAAGFTSYGDRPCIEFEGRWHTGDEVTGYAAAVDTALR
CCCCCCCCCCEEEEEEEEHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
DAGVDAHAPIGLVVRNRLPHAAAIAGSLAGGRWVSMIYSFQSPEAIARDIEQLRPAAVVA
HCCCCCCCCEEHEECCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEE
DAQDWTAPVLAAATRCGLAGVAISEQEPRVVTARRGSAVTASPSAGLSILTSGTTGPPKR
CCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCEEEECCCCCEEEEECCCCCCHHH
QAIDEAVLDRTVFSVTGGLFAEPTDPPELSYWPFGGIGVCQLIAGFATGKRIVLLERFSV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCH
DDWVRAVRTHRIPRAGVQPAVVRMLLDADVSPEDLASLQFLISASGPLDPATRDEFEQRF
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHEEEEECCCCCCCCCHHHHHHHC
DIPVRLAYGATEFAGSVCAWTPEMVEQFGPAKRDSVGRPLPDTEVRIVDPDTGVAVPTGA
CCCEEEECCCHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCC
RGVLEARIEVLSPDWIRTTDIASMDDDGFVTLHGRADGAIIRGGFKILPETVRQVLLGHP
CHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCC
SVRDACVVGVPDDRLGQVPFAAVEPARGQPVPGSEELREWVRAALPVHHVPVAVVTVDEL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
PRTPSLKVRLPDVAALYDAARVDT
CCCCCEEEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MRLLGRSGDCRVNLATVSFTETFAAGFTSYGDRPCIEFEGRWHTGDEVTGYAAAVDTALR
CCCCCCCCCCEEEEEEEEHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHH
DAGVDAHAPIGLVVRNRLPHAAAIAGSLAGGRWVSMIYSFQSPEAIARDIEQLRPAAVVA
HCCCCCCCCEEHEECCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEE
DAQDWTAPVLAAATRCGLAGVAISEQEPRVVTARRGSAVTASPSAGLSILTSGTTGPPKR
CCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCEEEECCCCCEEEEECCCCCCHHH
QAIDEAVLDRTVFSVTGGLFAEPTDPPELSYWPFGGIGVCQLIAGFATGKRIVLLERFSV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCH
DDWVRAVRTHRIPRAGVQPAVVRMLLDADVSPEDLASLQFLISASGPLDPATRDEFEQRF
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHEEEEECCCCCCCCCHHHHHHHC
DIPVRLAYGATEFAGSVCAWTPEMVEQFGPAKRDSVGRPLPDTEVRIVDPDTGVAVPTGA
CCCEEEECCCHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCC
RGVLEARIEVLSPDWIRTTDIASMDDDGFVTLHGRADGAIIRGGFKILPETVRQVLLGHP
CHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCC
SVRDACVVGVPDDRLGQVPFAAVEPARGQPVPGSEELREWVRAALPVHHVPVAVVTVDEL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
PRTPSLKVRLPDVAALYDAARVDT
CCCCCEEEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA