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The map label for this gene is proY [C]

Identifier: 108801449

GI number: 108801449

Start: 4764693

End: 4766096

Strand: Reverse

Name: proY [C]

Synonym: Mmcs_4486

Alternate gene names: 108801449

Gene position: 4766096-4764693 (Counterclockwise)

Preceding gene: 108801451

Following gene: 108801446

Centisome position: 83.54

GC content: 68.23

Gene sequence:

>1404_bases
GTGGACACCACGCACAGCGAATCCAGCGACTACCTGGCCAAACGGACACTCAAGCAGGGCACTGCCGGCTGGCTCCTCCT
TGCCGGTCTCGGCGTCGGATACGTGATCTCCGGCGACTACTCGGGATGGAACTTCGGGCTCGCCGAGGGCGGCTTCGGTG
GGCTGCTGATCGCGGGCGTGATCATCGCCGGCATGTACCTGGCGATGGTGTTGGGGATGGCCGAGATGTCCTCGGCGCTG
CCTGCCGCGGGCGGCGGCTACACCTTCGCGCGCCGCGCGCTCGGACCGTGGGGCGGATTCGCCACGGGTACAGCCATTCT
CATCGAGTACGCGATCGCCCCGGCCGCCATCGCCACATTCATCGGCGCCTACGTCGAATCGCTCGGGTTGTTCGGTATCA
CCGACGGCTGGTGGGTGTACCTGGCGGTGTACCTGCTGTTCATCGGGATCCATCTCAGCGGCGTCGGTGAGGCGCTCAAG
GTCATGTTCGTCATCACGGCGATCGCGCTGGCCGGCCTGATCGTCTTCGCCATCGGGGCGGTCGGCCGCTTCGACGCCGC
GAACCTCACCGACATCGCGCCCACCGACGCGGCGGGCGCGTCGTCGTTTCTGCCGTTCGGCTACCTGGGGATCTGGGCGG
CCGTACCGTTCGCGATCTGGTTCTTCCTCGCCATCGAAGGCGTGCCGCTGGCCGCCGAGGAGGCCAAGGATCCGTCCCGC
AACGTCCCGCGGGGAATCCTCGCCGCGATGGGCGTGCTGTTGGTGACCGGCAGCACCGTGCTGGTGCTGGCGGCCGGCTC
CGGCGGGGCGGAGCTGATCAGCGCCTCGGGCAACCCGCTTGTGGAGGCGCTCGGCGACACGACGACGTCGAAGGTGGTCA
ACTACATCGGCCTGGCCGGGTTGGTCGCGAGCTTCTTCTCGATCATCTACGCCTACTCGCGTCAGCTGTTCGCGCTGTCC
CGCGCGGGGTATCTGCCCAGGCGGCTGTCGGTGGTCAACTCGCGCAAGGCGCCGACGCTGGCCCTGGTGGTGCCCGGGAT
CATCGGCTTCATCCTGTCGTTGACCGGGCAGGGCGCCATGCTGCTCAACATGGCGGTGTTCGGCGCCGCGCTGTCCTACG
TGCTGATGATGGTCAGCCACATCGCGCTGCGGGTGCGCGAACCGGACATGCCCCGGCCGTACCGCACGCCGGGCGGCGTC
GTCACCACCGGTTTCGCACTCGTCATCGCCGCCCTCGCGGTGGTCGCGACCTTCCTCGTGGACAGCACCGCGGCCACCTG
GTGCCTGGTGGTGTTCGCCGCGTTCATGGCCTACTTCGGCCTCTACAGCCGCCACCACCTGGTGGCCAACTCGCCCGACG
AGGAATTCGCCGCGCTGGCCGATGCGGAGAAGGACATCCTTTGA

Upstream 100 bases:

>100_bases
GCGTGTTCGGGCCGCCACCGTTGCCTGAGCGGTCAGATCGCCGGGCCGGCCCGACGCGAAACCGCTGATACGGCGTCGGT
GCACGGTCTAGCATCTGCGG

Downstream 100 bases:

>100_bases
TCAGGACGCGTGTCTAGATCGCGGGTCCCAACAGATCGTCGGCGTCCTTGATGACGTAGCCGTAGCCCTGCTCGGCGAGG
AACCGCTGCCGGTGCGCGGC

Product: ethanolamine permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MDTTHSESSDYLAKRTLKQGTAGWLLLAGLGVGYVISGDYSGWNFGLAEGGFGGLLIAGVIIAGMYLAMVLGMAEMSSAL
PAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATFIGAYVESLGLFGITDGWWVYLAVYLLFIGIHLSGVGEALK
VMFVITAIALAGLIVFAIGAVGRFDAANLTDIAPTDAAGASSFLPFGYLGIWAAVPFAIWFFLAIEGVPLAAEEAKDPSR
NVPRGILAAMGVLLVTGSTVLVLAAGSGGAELISASGNPLVEALGDTTTSKVVNYIGLAGLVASFFSIIYAYSRQLFALS
RAGYLPRRLSVVNSRKAPTLALVVPGIIGFILSLTGQGAMLLNMAVFGAALSYVLMMVSHIALRVREPDMPRPYRTPGGV
VTTGFALVIAALAVVATFLVDSTAATWCLVVFAAFMAYFGLYSRHHLVANSPDEEFAALADAEKDIL

Sequences:

>Translated_467_residues
MDTTHSESSDYLAKRTLKQGTAGWLLLAGLGVGYVISGDYSGWNFGLAEGGFGGLLIAGVIIAGMYLAMVLGMAEMSSAL
PAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATFIGAYVESLGLFGITDGWWVYLAVYLLFIGIHLSGVGEALK
VMFVITAIALAGLIVFAIGAVGRFDAANLTDIAPTDAAGASSFLPFGYLGIWAAVPFAIWFFLAIEGVPLAAEEAKDPSR
NVPRGILAAMGVLLVTGSTVLVLAAGSGGAELISASGNPLVEALGDTTTSKVVNYIGLAGLVASFFSIIYAYSRQLFALS
RAGYLPRRLSVVNSRKAPTLALVVPGIIGFILSLTGQGAMLLNMAVFGAALSYVLMMVSHIALRVREPDMPRPYRTPGGV
VTTGFALVIAALAVVATFLVDSTAATWCLVVFAAFMAYFGLYSRHHLVANSPDEEFAALADAEKDIL
>Mature_467_residues
MDTTHSESSDYLAKRTLKQGTAGWLLLAGLGVGYVISGDYSGWNFGLAEGGFGGLLIAGVIIAGMYLAMVLGMAEMSSAL
PAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATFIGAYVESLGLFGITDGWWVYLAVYLLFIGIHLSGVGEALK
VMFVITAIALAGLIVFAIGAVGRFDAANLTDIAPTDAAGASSFLPFGYLGIWAAVPFAIWFFLAIEGVPLAAEEAKDPSR
NVPRGILAAMGVLLVTGSTVLVLAAGSGGAELISASGNPLVEALGDTTTSKVVNYIGLAGLVASFFSIIYAYSRQLFALS
RAGYLPRRLSVVNSRKAPTLALVVPGIIGFILSLTGQGAMLLNMAVFGAALSYVLMMVSHIALRVREPDMPRPYRTPGGV
VTTGFALVIAALAVVATFLVDSTAATWCLVVFAAFMAYFGLYSRHHLVANSPDEEFAALADAEKDIL

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=418, Percent_Identity=23.9234449760766, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI7657683, Length=346, Percent_Identity=25.4335260115607, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786602, Length=349, Percent_Identity=24.6418338108883, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786302, Length=364, Percent_Identity=24.4505494505494, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790653, Length=353, Percent_Identity=23.5127478753541, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786789, Length=359, Percent_Identity=22.5626740947075, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=387, Percent_Identity=25.0645994832041, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=340, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321629, Length=450, Percent_Identity=22.6666666666667, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668806, Length=345, Percent_Identity=23.768115942029, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356285, Length=345, Percent_Identity=23.768115942029, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24668802, Length=345, Percent_Identity=23.768115942029, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667468, Length=428, Percent_Identity=25.4672897196262, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221512776, Length=395, Percent_Identity=26.3291139240506, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666159, Length=395, Percent_Identity=26.3291139240506, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48484; Mature: 48484

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTHSESSDYLAKRTLKQGTAGWLLLAGLGVGYVISGDYSGWNFGLAEGGFGGLLIAGV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
IIAGMYLAMVLGMAEMSSALPAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IGAYVESLGLFGITDGWWVYLAVYLLFIGIHLSGVGEALKVMFVITAIALAGLIVFAIGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGRFDAANLTDIAPTDAAGASSFLPFGYLGIWAAVPFAIWFFLAIEGVPLAAEEAKDPSR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCC
NVPRGILAAMGVLLVTGSTVLVLAAGSGGAELISASGNPLVEALGDTTTSKVVNYIGLAG
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHH
LVASFFSIIYAYSRQLFALSRAGYLPRRLSVVNSRKAPTLALVVPGIIGFILSLTGQGAM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHH
LLNMAVFGAALSYVLMMVSHIALRVREPDMPRPYRTPGGVVTTGFALVIAALAVVATFLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DSTAATWCLVVFAAFMAYFGLYSRHHLVANSPDEEFAALADAEKDIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTTHSESSDYLAKRTLKQGTAGWLLLAGLGVGYVISGDYSGWNFGLAEGGFGGLLIAGV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
IIAGMYLAMVLGMAEMSSALPAAGGGYTFARRALGPWGGFATGTAILIEYAIAPAAIATF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IGAYVESLGLFGITDGWWVYLAVYLLFIGIHLSGVGEALKVMFVITAIALAGLIVFAIGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGRFDAANLTDIAPTDAAGASSFLPFGYLGIWAAVPFAIWFFLAIEGVPLAAEEAKDPSR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCC
NVPRGILAAMGVLLVTGSTVLVLAAGSGGAELISASGNPLVEALGDTTTSKVVNYIGLAG
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCHHHHHHCCHHHHHHHHHHHHHH
LVASFFSIIYAYSRQLFALSRAGYLPRRLSVVNSRKAPTLALVVPGIIGFILSLTGQGAM
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHH
LLNMAVFGAALSYVLMMVSHIALRVREPDMPRPYRTPGGVVTTGFALVIAALAVVATFLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DSTAATWCLVVFAAFMAYFGLYSRHHLVANSPDEEFAALADAEKDIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]